IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.142 0.248 -9999.0 0.0 -0.749 13.0 13.0 CRP -0.149 0.25 -9999.0 0.0 -0.744 15.0 15.0 cell cycle arrest -0.172 0.276 -9999.0 0.0 -0.655 57.0 57.0 TIMP1 -0.106 0.212 -9999.0 0.0 -0.659 8.0 8.0 IL6ST -0.018 0.139 -9999.0 0.0 -0.735 18.0 18.0 Rac1/GDP -0.064 0.186 -9999.0 0.0 -0.7 20.0 20.0 AP1 -0.007 0.164 -9999.0 0.0 -0.546 15.0 15.0 GAB2 -0.004 0.124 -9999.0 0.0 -0.731 14.0 14.0 TNFSF11 -0.16 0.261 -9999.0 0.0 -0.673 35.0 35.0 HSP90B1 -0.0 0.05 -9999.0 0.0 -9999.0 0.0 0.0 GAB1 0.014 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAPK14 -0.028 0.174 -9999.0 0.0 -0.716 17.0 17.0 AKT1 0.042 0.057 -9999.0 0.0 -9999.0 0.0 0.0 FOXO1 0.049 0.053 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K6 -0.051 0.18 -9999.0 0.0 -0.748 17.0 17.0 mol:GTP -0.002 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.075 0.201 -9999.0 0.0 -0.731 17.0 17.0 MITF -0.069 0.193 -9999.0 0.0 -0.649 27.0 27.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 A2M -0.468 0.694 -9999.0 0.0 -1.458 165.0 165.0 CEBPB 0.016 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1/GAB family/SHP2 0.029 0.121 0.228 4.0 -0.623 6.0 10.0 STAT3 -0.18 0.288 -9999.0 0.0 -0.694 57.0 57.0 STAT1 -0.007 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CEBPD -0.144 0.254 -9999.0 0.0 -0.834 12.0 12.0 PIK3CA 0.01 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUN 0.006 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIAS3/MITF -0.085 0.166 -9999.0 0.0 -0.638 24.0 24.0 MAPK11 -0.028 0.174 -9999.0 0.0 -0.716 17.0 17.0 STAT3 (dimer)/FOXO1 -0.189 0.31 -9999.0 0.0 -0.771 56.0 56.0 GRB2/SOS1/GAB family -0.03 0.174 -9999.0 0.0 -0.668 19.0 19.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.051 0.193 -9999.0 0.0 -0.561 37.0 37.0 GRB2 0.014 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LBP -0.11 0.211 -9999.0 0.0 -0.679 7.0 7.0 PIK3R1 0.008 0.005 -9999.0 0.0 -9999.0 0.0 0.0 JAK1 0.011 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MYC -0.142 0.248 -9999.0 0.0 -0.749 13.0 13.0 FGG -0.477 0.573 -9999.0 0.0 -1.079 234.0 234.0 macrophage differentiation -0.172 0.276 -9999.0 0.0 -0.655 57.0 57.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.089 0.199 -9999.0 0.0 -0.532 62.0 62.0 JUNB -0.14 0.243 -9999.0 0.0 -0.741 14.0 14.0 FOS -0.084 0.243 -9999.0 0.0 -0.737 61.0 61.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.07 0.192 -9999.0 0.0 -0.497 59.0 59.0 STAT1/PIAS1 -0.084 0.176 -9999.0 0.0 -0.488 50.0 50.0 GRB2/SOS1/GAB family/SHP2/PI3K 0.02 0.061 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) -0.178 0.286 -9999.0 0.0 -0.683 57.0 57.0 PRKCD -0.09 0.219 -9999.0 0.0 -0.737 16.0 16.0 IL6R -0.004 0.105 -9999.0 0.0 -0.736 10.0 10.0 SOCS3 -0.014 0.173 -9999.0 0.0 -0.838 10.0 10.0 gp130 (dimer)/JAK1/JAK1/LMO4 -0.011 0.092 -9999.0 0.0 -0.465 19.0 19.0 Rac1/GTP -0.105 0.17 -9999.0 0.0 -0.702 21.0 21.0 HCK -0.004 0.081 -9999.0 0.0 -0.735 6.0 6.0 MAPKKK cascade 0.044 0.13 -9999.0 0.0 -0.563 14.0 14.0 bone resorption -0.153 0.251 -9999.0 0.0 -0.637 35.0 35.0 IRF1 -0.142 0.248 -9999.0 0.0 -0.749 13.0 13.0 mol:GDP -0.065 0.194 -9999.0 0.0 -0.723 21.0 21.0 SOS1 0.015 0.013 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.068 0.197 -9999.0 0.0 -0.741 21.0 21.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.043 0.185 -9999.0 0.0 -0.811 17.0 17.0 PTPN11 -0.006 0.014 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA -0.098 0.229 -9999.0 0.0 -0.59 86.0 86.0 gp130 (dimer)/TYK2/TYK2/LMO4 -0.014 0.091 -9999.0 0.0 -0.472 18.0 18.0 gp130 (dimer)/JAK2/JAK2/LMO4 -0.014 0.091 -9999.0 0.0 -0.472 18.0 18.0 IL6 -0.114 0.277 -9999.0 0.0 -0.739 82.0 82.0 PIAS3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPRE 0.011 0.049 -9999.0 0.0 -0.731 2.0 2.0 PIAS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.075 0.175 -9999.0 0.0 -0.462 62.0 62.0 LMO4 0.007 0.029 -9999.0 0.0 -0.595 1.0 1.0 STAT3 (dimer)/PIAS3 -0.213 0.226 -9999.0 0.0 -0.659 57.0 57.0 MCL1 0.05 0.051 -9999.0 0.0 -9999.0 0.0 0.0