Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	165.0	8614.0	52.0	-0.644	0.345	1000.0	-1000.0	-0.097	-1000.0
Angiopoietin receptor Tie2-mediated signaling	158.0	13905.0	88.0	-0.749	0.06	1000.0	-1000.0	-0.126	-1000.0
Aurora B signaling	139.0	9321.0	67.0	-0.625	0.005	1000.0	-1000.0	-0.085	-1000.0
FOXM1 transcription factor network	129.0	6583.0	51.0	-0.707	0.002	1000.0	-1000.0	-0.206	-1000.0
Endothelins	81.0	7816.0	96.0	-0.437	0.036	1000.0	-1000.0	-0.089	-1000.0
TCGA08_p53	67.0	470.0	7.0	-0.193	0.097	1000.0	-1000.0	-0.037	-1000.0
TCGA08_retinoblastoma	64.0	516.0	8.0	-0.278	0.087	1000.0	-1000.0	-0.03	-1000.0
Glypican 2 network	61.0	247.0	4.0	-0.085	-0.068	1000.0	-1000.0	-0.044	-1000.0
amb2 Integrin signaling	60.0	4929.0	82.0	-0.68	0.0	1000.0	-1000.0	-0.097	-1000.0
Thromboxane A2 receptor signaling	58.0	6091.0	105.0	-0.181	0.041	1000.0	-1000.0	-0.08	-1000.0
Visual signal transduction: Cones	53.0	2031.0	38.0	-0.288	0.009	1000.0	-1000.0	-0.079	-1000.0
Fc-epsilon receptor I signaling in mast cells	53.0	5224.0	97.0	-0.258	0.033	1000.0	-1000.0	-0.111	-1000.0
Aurora C signaling	51.0	363.0	7.0	-0.412	0.0	1000.0	-1000.0	-0.051	-1000.0
IL4-mediated signaling events	50.0	4603.0	91.0	-0.806	0.45	1000.0	-1000.0	-0.181	-1000.0
Glucocorticoid receptor regulatory network	50.0	5731.0	114.0	-0.56	0.361	1000.0	-1000.0	-0.088	-1000.0
Signaling events regulated by Ret tyrosine kinase	50.0	4171.0	82.0	-0.204	0.0	1000.0	-1000.0	-0.103	-1000.0
PLK1 signaling events	45.0	3828.0	85.0	-0.38	0.072	1000.0	-1000.0	-0.063	-1000.0
BMP receptor signaling	43.0	3557.0	81.0	-0.387	0.037	1000.0	-1000.0	-0.101	-1000.0
Arf6 signaling events	42.0	2638.0	62.0	-0.302	0.015	1000.0	-1000.0	-0.069	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	42.0	2188.0	52.0	-0.382	0.057	1000.0	-1000.0	-0.078	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	39.0	3060.0	78.0	-0.129	0.036	1000.0	-1000.0	-0.091	-1000.0
Nectin adhesion pathway	38.0	2435.0	63.0	-0.273	0.0	1000.0	-1000.0	-0.084	-1000.0
Glypican 1 network	37.0	1779.0	48.0	-0.223	0.032	1000.0	-1000.0	-0.059	-1000.0
Signaling mediated by p38-alpha and p38-beta	36.0	1620.0	44.0	-0.126	0.0	1000.0	-1000.0	-0.059	-1000.0
Nongenotropic Androgen signaling	35.0	1835.0	52.0	-0.152	0.048	1000.0	-1000.0	-0.07	-1000.0
HIF-1-alpha transcription factor network	32.0	2455.0	76.0	-0.442	0.017	1000.0	-1000.0	-0.214	-1000.0
Integrins in angiogenesis	32.0	2711.0	84.0	-0.461	0.031	1000.0	-1000.0	-0.115	-1000.0
FOXA2 and FOXA3 transcription factor networks	31.0	1448.0	46.0	-0.768	0.072	1000.0	-1000.0	-0.119	-1000.0
Calcium signaling in the CD4+ TCR pathway	30.0	935.0	31.0	-0.21	0.012	1000.0	-1000.0	-0.133	-1000.0
Syndecan-3-mediated signaling events	28.0	990.0	35.0	-0.343	0.0	1000.0	-1000.0	-0.078	-1000.0
IL23-mediated signaling events	28.0	1713.0	60.0	-0.241	0.018	1000.0	-1000.0	-0.18	-1000.0
Coregulation of Androgen receptor activity	27.0	2092.0	76.0	-0.396	0.031	1000.0	-1000.0	-0.073	-1000.0
Aurora A signaling	27.0	1660.0	60.0	-0.489	0.028	1000.0	-1000.0	-0.069	-1000.0
Canonical Wnt signaling pathway	27.0	1421.0	51.0	-0.467	0.164	1000.0	-1000.0	-0.079	-1000.0
LPA4-mediated signaling events	26.0	323.0	12.0	-0.141	0.017	1000.0	-1000.0	-0.034	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	26.0	1795.0	68.0	-0.227	0.015	1000.0	-1000.0	-0.165	-1000.0
Presenilin action in Notch and Wnt signaling	25.0	1573.0	61.0	-0.467	0.016	1000.0	-1000.0	-0.076	-1000.0
Reelin signaling pathway	24.0	1392.0	56.0	-0.13	0.003	1000.0	-1000.0	-0.115	-1000.0
IL6-mediated signaling events	24.0	1813.0	75.0	-0.477	0.05	1000.0	-1000.0	-0.116	-1000.0
Regulation of Androgen receptor activity	22.0	1600.0	70.0	-0.417	0.018	1000.0	-1000.0	-0.083	-1000.0
Syndecan-1-mediated signaling events	21.0	725.0	34.0	-0.356	0.0	1000.0	-1000.0	-0.083	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	21.0	2703.0	125.0	-0.202	0.0	1000.0	-1000.0	-0.13	-1000.0
Visual signal transduction: Rods	21.0	1135.0	52.0	-0.179	0.0	1000.0	-1000.0	-0.092	-1000.0
ErbB4 signaling events	20.0	1439.0	69.0	-0.384	0.198	1000.0	-1000.0	-0.107	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	20.0	686.0	33.0	-0.269	0.0	1000.0	-1000.0	-0.076	-1000.0
IL12-mediated signaling events	19.0	1723.0	87.0	-0.163	0.019	1000.0	-1000.0	-0.147	-1000.0
Osteopontin-mediated events	19.0	739.0	38.0	-0.289	0.0	1000.0	-1000.0	-0.125	-1000.0
Plasma membrane estrogen receptor signaling	19.0	1644.0	86.0	-0.181	0.031	1000.0	-1000.0	-0.1	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2369.0	120.0	-0.267	0.129	1000.0	-1000.0	-0.086	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	18.0	975.0	54.0	-0.15	0.02	1000.0	-1000.0	-0.11	-1000.0
HIF-2-alpha transcription factor network	18.0	791.0	43.0	-0.375	0.206	1000.0	-1000.0	-0.12	-1000.0
Wnt signaling	18.0	132.0	7.0	-0.094	0.0	1000.0	-1000.0	-0.063	-1000.0
Ephrin A  reverse signaling	17.0	121.0	7.0	-0.024	0.002	1000.0	-1000.0	-0.037	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1602.0	93.0	-0.066	0.035	1000.0	-1000.0	-0.103	-1000.0
PDGFR-alpha signaling pathway	16.0	720.0	44.0	-0.202	0.021	1000.0	-1000.0	-0.073	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	15.0	1275.0	85.0	-0.159	0.011	1000.0	-1000.0	-0.092	-1000.0
p75(NTR)-mediated signaling	15.0	1936.0	125.0	-0.345	0.0	1000.0	-1000.0	-0.12	-1000.0
Regulation of nuclear SMAD2/3 signaling	12.0	1647.0	136.0	-0.335	0.094	1000.0	-1000.0	-0.097	-1000.0
Caspase cascade in apoptosis	11.0	864.0	74.0	-0.071	0.035	1000.0	-1000.0	-0.064	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	314.0	28.0	-0.181	0.02	1000.0	-1000.0	-0.063	-1000.0
Noncanonical Wnt signaling pathway	11.0	299.0	26.0	-0.103	0.0	1000.0	-1000.0	-0.099	-1000.0
Syndecan-2-mediated signaling events	11.0	775.0	69.0	-0.168	0.031	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by HDAC Class III	11.0	443.0	40.0	-0.147	0.05	1000.0	-1000.0	-0.048	-1000.0
FAS signaling pathway (CD95)	11.0	536.0	47.0	-0.19	0.009	1000.0	-1000.0	-0.058	-1000.0
Ras signaling in the CD4+ TCR pathway	11.0	194.0	17.0	-0.057	0.008	1000.0	-1000.0	-0.074	-1000.0
JNK signaling in the CD4+ TCR pathway	10.0	175.0	17.0	-0.044	0.022	1000.0	-1000.0	-0.079	-1000.0
Effects of Botulinum toxin	10.0	275.0	26.0	-0.071	0.005	1000.0	-1000.0	-0.07	-1000.0
BCR signaling pathway	10.0	1072.0	99.0	-0.113	0.04	1000.0	-1000.0	-0.117	-1000.0
EGFR-dependent Endothelin signaling events	10.0	228.0	21.0	-0.065	0.0	1000.0	-1000.0	-0.091	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	9.0	313.0	34.0	-0.029	0.0	1000.0	-1000.0	-0.077	-1000.0
S1P1 pathway	9.0	329.0	36.0	-0.061	0.01	1000.0	-1000.0	-0.09	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	734.0	74.0	-0.171	0.068	1000.0	-1000.0	-0.108	-1000.0
Syndecan-4-mediated signaling events	9.0	625.0	67.0	-0.168	0.01	1000.0	-1000.0	-0.109	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	582.0	65.0	-0.598	0.044	1000.0	-1000.0	-0.092	-1000.0
IL2 signaling events mediated by STAT5	8.0	183.0	22.0	-0.148	0.06	1000.0	-1000.0	-0.073	-1000.0
S1P4 pathway	8.0	218.0	25.0	-0.065	0.003	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by PTP1B	7.0	546.0	76.0	-0.102	0.033	1000.0	-1000.0	-0.093	-1000.0
TRAIL signaling pathway	7.0	368.0	48.0	-0.096	0.046	1000.0	-1000.0	-0.075	-1000.0
Cellular roles of Anthrax toxin	6.0	265.0	39.0	-0.092	0.017	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	6.0	384.0	58.0	-0.221	0.034	1000.0	-1000.0	-0.086	-1000.0
Regulation of p38-alpha and p38-beta	6.0	339.0	54.0	-0.087	0.036	1000.0	-1000.0	-0.09	-1000.0
IL27-mediated signaling events	6.0	310.0	51.0	-0.118	0.011	1000.0	-1000.0	-0.107	-1000.0
LPA receptor mediated events	6.0	703.0	102.0	-0.102	0.035	1000.0	-1000.0	-0.104	-1000.0
IGF1 pathway	6.0	344.0	57.0	-0.021	0.04	1000.0	-1000.0	-0.115	-1000.0
S1P3 pathway	6.0	272.0	42.0	-0.181	0.041	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by PRL	6.0	220.0	34.0	-0.127	0.028	1000.0	-1000.0	-0.068	-1000.0
BARD1 signaling events	5.0	303.0	57.0	-0.127	0.022	1000.0	-1000.0	-0.077	-1000.0
Ephrin B reverse signaling	5.0	275.0	48.0	-0.071	0.04	1000.0	-1000.0	-0.079	-1000.0
IL2 signaling events mediated by PI3K	5.0	305.0	58.0	-0.226	0.074	1000.0	-1000.0	-0.105	-1000.0
Arf6 trafficking events	5.0	409.0	71.0	-0.085	0.032	1000.0	-1000.0	-0.082	-1000.0
Insulin Pathway	5.0	382.0	74.0	-0.105	0.032	1000.0	-1000.0	-0.11	-1000.0
ErbB2/ErbB3 signaling events	4.0	277.0	65.0	-0.078	0.054	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by HDAC Class II	4.0	350.0	75.0	-0.081	0.0	1000.0	-1000.0	-0.074	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	20.0	5.0	-0.009	-0.001	1000.0	-1000.0	-0.042	-1000.0
IL1-mediated signaling events	4.0	298.0	62.0	-0.061	0.042	1000.0	-1000.0	-0.119	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	385.0	83.0	-0.069	0.05	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by HDAC Class I	4.0	416.0	104.0	-0.081	0.041	1000.0	-1000.0	-0.093	-1000.0
EPHB forward signaling	4.0	413.0	85.0	-0.072	0.033	1000.0	-1000.0	-0.104	-1000.0
Regulation of Telomerase	4.0	408.0	102.0	-0.118	0.025	1000.0	-1000.0	-0.132	-1000.0
p38 MAPK signaling pathway	4.0	219.0	44.0	-0.069	0.034	1000.0	-1000.0	-0.074	-1000.0
IFN-gamma pathway	3.0	242.0	68.0	-0.069	0.065	1000.0	-1000.0	-0.119	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	137.0	45.0	-0.027	0.061	1000.0	-1000.0	-0.105	-1000.0
TCGA08_rtk_signaling	3.0	90.0	26.0	-0.065	0.038	1000.0	-1000.0	-0.035	-1000.0
Class I PI3K signaling events	3.0	253.0	73.0	-0.054	0.026	1000.0	-1000.0	-0.092	-1000.0
VEGFR1 specific signals	3.0	212.0	56.0	-0.202	0.043	1000.0	-1000.0	-0.093	-1000.0
Circadian rhythm pathway	2.0	59.0	22.0	-0.032	0.038	1000.0	-1000.0	-0.072	-1000.0
EPO signaling pathway	2.0	117.0	55.0	-0.007	0.066	1000.0	-1000.0	-0.114	-1000.0
Ceramide signaling pathway	2.0	171.0	76.0	-0.028	0.041	1000.0	-1000.0	-0.07	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	107.0	37.0	-0.012	0.025	1000.0	-1000.0	-0.092	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	79.0	36.0	-0.01	0.02	1000.0	-1000.0	-0.083	-1000.0
PDGFR-beta signaling pathway	2.0	231.0	97.0	-0.044	0.054	1000.0	-1000.0	-0.104	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.003	-1000.0	1000.0	-1000.0	-0.033	-1000.0
Insulin-mediated glucose transport	1.0	53.0	32.0	-0.057	0.034	1000.0	-1000.0	-0.074	-1000.0
S1P5 pathway	1.0	26.0	17.0	-0.01	0.006	1000.0	-1000.0	-0.07	-1000.0
FoxO family signaling	1.0	98.0	64.0	-0.089	0.081	1000.0	-1000.0	-0.097	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	15.0	15.0	-0.001	0.027	1000.0	-1000.0	-0.07	-1000.0
Rapid glucocorticoid signaling	1.0	31.0	20.0	-0.007	0.007	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in keratinocytes	1.0	62.0	43.0	-0.023	0.043	1000.0	-1000.0	-0.09	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	-0.001	0.036	1000.0	-1000.0	-0.085	-1000.0
Canonical NF-kappaB pathway	0.0	33.0	39.0	-0.019	0.072	1000.0	-1000.0	-0.101	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.001	0.019	1000.0	-1000.0	-0.029	-1000.0
Arf6 downstream pathway	0.0	21.0	43.0	-0.024	0.025	1000.0	-1000.0	-0.052	-1000.0
mTOR signaling pathway	0.0	14.0	53.0	-0.004	0.03	1000.0	-1000.0	-0.07	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	60.0	68.0	-0.057	0.043	1000.0	-1000.0	-0.076	-1000.0
ceramide signaling pathway	0.0	45.0	49.0	-0.013	0.044	1000.0	-1000.0	-0.059	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.001	0.03	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	52.0	76.0	-0.026	0.053	1000.0	-1000.0	-0.1	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.001	0.025	1000.0	-1000.0	-0.058	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.0	1000.0	-1000.0	-0.051	-1000.0
Arf1 pathway	0.0	32.0	54.0	-0.022	0.022	1000.0	-1000.0	-0.058	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.001	0.0	1000.0	-1000.0	-0.078	-1000.0
Total	2715	168473	7203	-24.936240564	-994.699286097	131000	-131000	-11.5065057207	-131000