Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MET/RANBP9 0.031 0.03 0.266 1.0 -0.391 2.0 3.0 CRKL -0.048 0.175 0.31 3.0 -0.604 31.0 34.0 mol:PIP3 0.012 0.019 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.011 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PTK2B 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 -0.046 0.168 0.425 2.0 -0.572 31.0 33.0 RANBP10 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.012 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET/SHIP2 -0.033 0.15 0.253 1.0 -0.336 95.0 96.0 MAP3K5 -0.042 0.165 0.337 2.0 -0.543 34.0 36.0 HGF/MET/CIN85/CBL/ENDOPHILINS -0.021 0.147 0.254 1.0 -0.313 97.0 98.0 AP1 -0.026 0.119 -9999.0 0.0 -0.344 58.0 58.0 mol:SU11274 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis -0.107 0.305 -9999.0 0.0 -0.784 80.0 80.0 STAT3 (dimer) -0.042 0.116 -9999.0 0.0 -0.345 21.0 21.0 GAB1/CRKL/SHP2/PI3K -0.02 0.136 -9999.0 0.0 -0.528 22.0 22.0 INPP5D 0.021 0.025 -9999.0 0.0 -0.533 1.0 1.0 CBL/CRK -0.045 0.168 -9999.0 0.0 -0.577 31.0 31.0 PTPN11 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 GO:0007205 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTEN 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ELK1 -0.004 0.075 0.304 19.0 -9999.0 0.0 19.0 mol:SU5416 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHP2/GRB2/SOS1GAB1 -0.029 0.087 -9999.0 0.0 -0.306 21.0 21.0 PAK1 0.012 0.048 0.389 1.0 -9999.0 0.0 1.0 HGF/MET/RANBP10 -0.033 0.151 0.253 1.0 -0.334 98.0 99.0 HRAS -0.056 0.157 -9999.0 0.0 -0.604 14.0 14.0 DOCK1 -0.047 0.165 0.399 1.0 -0.569 31.0 32.0 GAB1 -0.057 0.18 -9999.0 0.0 -0.652 30.0 30.0 CRK -0.056 0.17 -9999.0 0.0 -0.615 30.0 30.0 mol:PHA665752 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.09 0.214 -9999.0 0.0 -0.496 99.0 99.0 JUN 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:200958 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.035 0.089 0.175 1.0 -0.208 99.0 100.0 PIK3R1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 cell morphogenesis 0.018 0.161 0.334 19.0 -0.434 15.0 34.0 GRB2/SHC -0.009 0.09 -9999.0 0.0 -0.282 8.0 8.0 FOS -0.043 0.178 -9999.0 0.0 -0.533 58.0 58.0 GLMN 0.003 0.001 -9999.0 0.0 -9999.0 0.0 0.0 cell motility -0.004 0.075 0.302 19.0 -9999.0 0.0 19.0 HGF/MET/MUC20 -0.044 0.145 0.237 1.0 -0.333 99.0 100.0 cell migration -0.009 0.088 -9999.0 0.0 -0.278 8.0 8.0 GRB2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CBL 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MET/RANBP10 0.03 0.03 0.266 1.0 -0.391 2.0 3.0 HGF/MET/Paxillin/FAK1/FAK12/RasGAP -0.036 0.113 -9999.0 0.0 -0.269 87.0 87.0 MET/MUC20 0.015 0.028 0.247 1.0 -0.388 2.0 3.0 RAP1B -0.039 0.161 0.369 4.0 -0.53 31.0 35.0 RAP1A -0.046 0.157 0.352 3.0 -0.532 31.0 34.0 HGF/MET/RANBP9 -0.033 0.152 0.253 1.0 -0.336 98.0 99.0 RAF1 -0.052 0.149 -9999.0 0.0 -0.576 13.0 13.0 STAT3 -0.042 0.117 -9999.0 0.0 -0.349 21.0 21.0 cell proliferation -0.057 0.157 0.249 4.0 -0.364 82.0 86.0 RPS6KB1 -0.007 0.043 -9999.0 0.0 -0.302 3.0 3.0 MAPK3 -0.005 0.103 0.738 7.0 -9999.0 0.0 7.0 MAPK1 -0.002 0.106 0.675 9.0 -9999.0 0.0 9.0 RANBP9 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.023 0.154 0.337 3.0 -0.491 32.0 35.0 SRC -0.043 0.103 -9999.0 0.0 -0.326 16.0 16.0 PI3K -0.001 0.064 -9999.0 0.0 -0.264 6.0 6.0 MET/Glomulin 0.013 0.033 0.271 1.0 -0.34 2.0 3.0 SOS1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.051 0.14 -9999.0 0.0 -0.533 13.0 13.0 MET 0.02 0.039 0.377 1.0 -0.533 2.0 3.0 MAP4K1 -0.044 0.178 0.353 2.0 -0.579 35.0 37.0 PTK2 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K2 -0.05 0.14 -9999.0 0.0 -0.532 13.0 13.0 BAD 0.01 0.041 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.039 0.148 0.321 2.0 -0.494 32.0 34.0 SHP2/GRB2/SOS1/GAB1 -0.032 0.159 -9999.0 0.0 -0.536 30.0 30.0 INPPL1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PXN 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 SH3KBP1 0.02 0.035 -9999.0 0.0 -0.533 2.0 2.0 HGS -0.036 0.082 0.155 1.0 -0.197 93.0 94.0 PLCgamma1/PKC 0.016 0.003 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.09 0.222 -9999.0 0.0 -0.533 100.0 100.0 RASA1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PTPRJ 0.021 0.025 -9999.0 0.0 -0.533 1.0 1.0 NCK/PLCgamma1 -0.011 0.091 -9999.0 0.0 -0.259 4.0 4.0 PDPK1 0.008 0.021 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET/SHIP -0.034 0.154 0.253 1.0 -0.338 99.0 100.0