IL12-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations IL12/IL12R/TYK2/JAK2/SOCS1 0.009 0.118 -9999.0 0.0 -0.402 23.0 23.0 TBX21 -0.122 0.463 -9999.0 0.0 -1.316 58.0 58.0 B2M 0.021 0.011 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.014 0.031 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB1 -0.017 0.138 -9999.0 0.0 -0.562 29.0 29.0 GADD45B -0.063 0.353 -9999.0 0.0 -1.104 40.0 40.0 IL12RB2 0.036 0.074 0.238 45.0 -0.29 1.0 46.0 GADD45G -0.048 0.317 -9999.0 0.0 -1.032 33.0 33.0 natural killer cell activation -0.0 0.017 0.042 4.0 -0.042 33.0 37.0 RELB 0.023 0.016 0.377 1.0 -9999.0 0.0 1.0 RELA 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IL18 0.016 0.047 -9999.0 0.0 -0.546 3.0 3.0 IL2RA 0.021 0.039 0.23 3.0 -0.533 2.0 5.0 IFNG 0.016 0.052 0.23 2.0 -0.533 4.0 6.0 STAT3 (dimer) -0.047 0.283 -9999.0 0.0 -0.765 50.0 50.0 HLA-DRB5 -0.002 0.007 -9999.0 0.0 -0.023 49.0 49.0 FASLG -0.078 0.387 -9999.0 0.0 -1.179 43.0 43.0 NF kappa B2 p52/RelB -0.057 0.336 -9999.0 0.0 -0.927 48.0 48.0 CD4 0.0 0.092 -9999.0 0.0 -0.534 14.0 14.0 SOCS1 0.021 0.025 -9999.0 0.0 -0.533 1.0 1.0 EntrezGene:6955 -0.002 0.01 -9999.0 0.0 -0.028 59.0 59.0 CD3D 0.006 0.076 -9999.0 0.0 -0.537 9.0 9.0 CD3E 0.007 0.072 -9999.0 0.0 -0.537 8.0 8.0 CD3G -0.017 0.133 -9999.0 0.0 -0.538 30.0 30.0 IL12Rbeta2/JAK2 0.034 0.065 -9999.0 0.0 -9999.0 0.0 0.0 CCL3 -0.067 0.336 -9999.0 0.0 -1.041 38.0 38.0 CCL4 -0.07 0.349 -9999.0 0.0 -1.074 39.0 39.0 HLA-A 0.0 0.006 -9999.0 0.0 -0.042 8.0 8.0 IL18/IL18R 0.031 0.109 -9999.0 0.0 -0.406 24.0 24.0 NOS2 -0.093 0.412 -9999.0 0.0 -1.191 52.0 52.0 IL12/IL12R/TYK2/JAK2/SPHK2 0.01 0.115 -9999.0 0.0 -0.387 23.0 23.0 IL1R1 -0.064 0.331 -9999.0 0.0 -0.997 40.0 40.0 IL4 -0.007 0.031 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.013 0.029 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:6957 -0.002 0.009 -9999.0 0.0 -0.025 56.0 56.0 TCR/CD3/MHC I/CD8 -0.047 0.263 -9999.0 0.0 -0.999 26.0 26.0 RAB7A -0.019 0.279 0.493 2.0 -0.801 37.0 39.0 lysosomal transport -0.015 0.266 0.49 2.0 -0.752 37.0 39.0 FOS -0.163 0.464 -9999.0 0.0 -1.134 84.0 84.0 STAT4 (dimer) -0.051 0.326 0.439 2.0 -0.907 47.0 49.0 STAT5A (dimer) -0.061 0.335 -9999.0 0.0 -0.926 49.0 49.0 GZMA -0.071 0.351 -9999.0 0.0 -1.109 38.0 38.0 GZMB -0.07 0.355 -9999.0 0.0 -1.139 36.0 36.0 HLX 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LCK -0.074 0.365 -9999.0 0.0 -1.023 48.0 48.0 TCR/CD3/MHC II/CD4 -0.039 0.167 -9999.0 0.0 -0.356 70.0 70.0 IL2/IL2R 0.044 0.067 -9999.0 0.0 -0.422 8.0 8.0 MAPK14 -0.054 0.341 -9999.0 0.0 -1.001 42.0 42.0 CCR5 -0.071 0.357 -9999.0 0.0 -1.157 36.0 36.0 IL1B 0.002 0.09 -9999.0 0.0 -0.563 11.0 11.0 STAT6 0.006 0.091 -9999.0 0.0 -9999.0 0.0 0.0 STAT4 0.013 0.07 -9999.0 0.0 -0.533 8.0 8.0 STAT3 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NFKB2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IL12B 0.013 0.03 -9999.0 0.0 -9999.0 0.0 0.0 CD8A 0.014 0.067 -9999.0 0.0 -0.538 7.0 7.0 CD8B 0.009 0.092 0.231 4.0 -0.54 13.0 17.0 T-helper 1 cell differentiation -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 natural killer cell mediated cytotoxicity -0.008 0.118 0.399 23.0 -9999.0 0.0 23.0 IL2RB 0.019 0.043 -9999.0 0.0 -0.533 3.0 3.0 proteasomal ubiquitin-dependent protein catabolic process -0.04 0.294 0.435 2.0 -0.807 47.0 49.0 IL2RG 0.015 0.065 -9999.0 0.0 -0.533 7.0 7.0 IL12 0.013 0.058 -9999.0 0.0 -0.402 6.0 6.0 STAT5A 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CD247 0.002 0.087 -9999.0 0.0 -0.541 12.0 12.0 IL2 0.001 0.02 -9999.0 0.0 -9999.0 0.0 0.0 SPHK2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FRAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12A 0.004 0.066 -9999.0 0.0 -0.544 6.0 6.0 IL12/IL12R/TYK2/JAK2 -0.091 0.4 -9999.0 0.0 -1.091 51.0 51.0 MAP2K3 -0.061 0.353 -9999.0 0.0 -1.032 43.0 43.0 RIPK2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K6 -0.052 0.333 -9999.0 0.0 -0.988 41.0 41.0 regulation of dendritic cell antigen processing and presentation -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HLA-DRA -0.002 0.008 -9999.0 0.0 -0.026 54.0 54.0 IL18RAP -0.004 0.114 -9999.0 0.0 -0.542 21.0 21.0 IL12Rbeta1/TYK2 -0.002 0.113 -9999.0 0.0 -0.429 29.0 29.0 EOMES -0.062 0.257 -9999.0 0.0 -0.934 30.0 30.0 STAT1 (dimer) -0.043 0.278 -9999.0 0.0 -0.767 45.0 45.0 T cell proliferation -0.026 0.239 0.429 2.0 -0.649 44.0 46.0 T-helper 1 cell lineage commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL18R1 0.014 0.059 -9999.0 0.0 -0.544 5.0 5.0 CD8-positive alpha-beta T cell lineage commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA -0.046 0.262 -9999.0 0.0 -0.748 40.0 40.0 ATF2 -0.045 0.309 0.439 1.0 -0.918 40.0 41.0