Presenilin action in Notch and Wnt signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Delta 1/NOTCH/NOTCH(cleaved) 0.029 0.068 -9999.0 0.0 -9999.0 0.0 0.0 HDAC1 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AES 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DTX1 0.023 0.013 0.23 2.0 -9999.0 0.0 2.0 LRP6/FZD1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 TLE1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AP1 -0.051 0.148 -9999.0 0.0 -0.34 87.0 87.0 NCSTN 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADAM10 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.01 0.171 -9999.0 0.0 -0.754 23.0 23.0 NICD/RBPSUH 0.025 0.067 -9999.0 0.0 -9999.0 0.0 0.0 WIF1 -0.322 0.267 0.23 1.0 -0.533 307.0 308.0 NOTCH1 0.01 0.064 -9999.0 0.0 -0.4 7.0 7.0 PSENEN 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 KREMEN2 0.151 0.112 0.231 317.0 -0.301 6.0 323.0 DKK1 0.021 0.089 0.244 21.0 -0.51 10.0 31.0 beta catenin/beta TrCP1 -0.001 0.105 0.276 2.0 -0.42 12.0 14.0 APH1B 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 APH1A 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AXIN1 -0.002 0.081 0.26 1.0 -0.524 8.0 9.0 CtBP/CBP/TCF1/TLE1/AES 0.01 0.033 -9999.0 0.0 -9999.0 0.0 0.0 PSEN1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.043 0.178 -9999.0 0.0 -0.533 58.0 58.0 JUN 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 -0.008 0.109 0.257 4.0 -0.423 15.0 19.0 MAPK3 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DKK2/LRP6/Kremen 2 0.026 0.191 -9999.0 0.0 -0.37 80.0 80.0 HNF1A 0.025 0.026 0.229 8.0 -9999.0 0.0 8.0 CTBP1 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYC 0.02 0.018 -9999.0 0.0 -9999.0 0.0 0.0 NKD1 -0.022 0.152 0.23 4.0 -0.533 40.0 44.0 FZD1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH1 precursor/Deltex homolog 1 0.028 0.069 -9999.0 0.0 -0.41 1.0 1.0 apoptosis -0.051 0.147 -9999.0 0.0 -0.338 87.0 87.0 Delta 1/NOTCHprecursor 0.027 0.068 -9999.0 0.0 -9999.0 0.0 0.0 DLL1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PPARD 0.006 0.132 -9999.0 0.0 -0.949 9.0 9.0 Gamma Secretase 0.055 0.027 -9999.0 0.0 -9999.0 0.0 0.0 APC -0.018 0.111 0.26 1.0 -0.42 26.0 27.0 DVL1 -0.042 0.089 -9999.0 0.0 -0.37 21.0 21.0 CSNK2A1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 -0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DKK1/LRP6/Kremen 2 0.11 0.106 0.312 15.0 -0.357 10.0 25.0 LRP6 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CSNK1A1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NLK 0.009 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.004 0.151 -9999.0 0.0 -1.354 6.0 6.0 WNT1 0.018 0.022 0.23 3.0 -9999.0 0.0 3.0 Axin1/APC/beta catenin -0.014 0.134 0.323 4.0 -0.459 26.0 30.0 DKK2 -0.074 0.21 -9999.0 0.0 -0.533 86.0 86.0 NOTCH1 precursor/DVL1 -0.027 0.113 -9999.0 0.0 -0.542 13.0 13.0 GSK3B 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 FRAT1 0.02 0.025 -9999.0 0.0 -0.533 1.0 1.0 NOTCH/Deltex homolog 1 0.03 0.069 -9999.0 0.0 -0.41 1.0 1.0 PPP2R5D 0.015 0.09 0.271 39.0 -0.41 5.0 44.0 MAPK1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WNT1/LRP6/FZD1 -0.163 0.17 -9999.0 0.0 -0.31 279.0 279.0 RBPJ 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0