Integrins in angiogenesis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.01 0.091 -9999.0 0.0 -0.389 24.0 24.0 alphaV beta3 Integrin 0.026 0.08 -9999.0 0.0 -0.35 20.0 20.0 PTK2 -0.16 0.188 0.335 2.0 -0.517 62.0 64.0 IGF1R 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI4KB 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MFGE8 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1B -0.167 0.242 -9999.0 0.0 -0.476 183.0 183.0 VEGFA 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ILK -0.17 0.245 -9999.0 0.0 -0.482 185.0 185.0 ROCK1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.152 0.224 -9999.0 0.0 -0.454 171.0 171.0 PTK2B -0.018 0.094 0.353 2.0 -0.339 26.0 28.0 alphaV/beta3 Integrin/JAM-A -0.086 0.173 -9999.0 0.0 -0.311 172.0 172.0 CBL 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin/ANGPTL3 0.035 0.056 -9999.0 0.0 -0.336 10.0 10.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.043 0.067 -9999.0 0.0 -0.307 16.0 16.0 VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.091 0.156 -9999.0 0.0 -0.436 50.0 50.0 alphaV/beta3 Integrin/Syndecan-1 0.035 0.057 -9999.0 0.0 -0.336 11.0 11.0 PI4KA 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 0.015 0.109 -9999.0 0.0 -0.33 40.0 40.0 PI4 Kinase 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.012 0.011 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Osteopontin 0.093 0.098 0.253 1.0 -0.353 10.0 11.0 RPS6KB1 -0.036 0.098 0.322 2.0 -0.446 11.0 13.0 TLN1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.08 0.162 -9999.0 0.0 -0.55 38.0 38.0 GPR124 0.018 0.026 -9999.0 0.0 -0.533 1.0 1.0 MAPK1 -0.078 0.162 -9999.0 0.0 -0.555 37.0 37.0 PXN 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Tumstatin -0.19 0.193 -9999.0 0.0 -0.347 292.0 292.0 cell adhesion 0.025 0.054 -9999.0 0.0 -0.326 9.0 9.0 ANGPTL3 0.007 0.028 0.23 4.0 -9999.0 0.0 4.0 VEGFR2 homodimer/VEGFA homodimer/Src 0.024 0.077 -9999.0 0.0 -0.333 20.0 20.0 IGF-1R heterotetramer 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.016 0.003 -9999.0 0.0 -9999.0 0.0 0.0 TGFBR2 -0.007 0.121 -9999.0 0.0 -0.533 25.0 25.0 ITGB3 0.01 0.082 -9999.0 0.0 -0.533 11.0 11.0 IGF1 0.003 0.104 0.23 1.0 -0.533 18.0 19.0 RAC1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-matrix adhesion 0.029 0.054 -9999.0 0.0 -0.335 9.0 9.0 apoptosis 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CD47 0.019 0.026 -9999.0 0.0 -0.533 1.0 1.0 alphaV/beta3 Integrin/CD47 0.031 0.055 -9999.0 0.0 -0.336 9.0 9.0 VCL 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Del1 0.013 0.103 -9999.0 0.0 -0.353 34.0 34.0 CSF1 0.017 0.05 -9999.0 0.0 -0.533 4.0 4.0 PIK3C2A -0.17 0.245 -9999.0 0.0 -0.481 185.0 185.0 PI4 Kinase/Pyk2 -0.086 0.16 -9999.0 0.0 -0.313 129.0 129.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.029 0.097 -9999.0 0.0 -0.359 26.0 26.0 FAK1/Vinculin -0.126 0.153 0.315 2.0 -0.423 53.0 55.0 alphaV beta3/Integrin/ppsTEM5 0.029 0.055 -9999.0 0.0 -0.336 9.0 9.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VTN -0.184 0.269 0.23 2.0 -0.533 185.0 187.0 BCAR1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 FGF2 0.008 0.085 -9999.0 0.0 -0.533 12.0 12.0 F11R -0.018 0.056 -9999.0 0.0 -0.391 11.0 11.0 alphaV/beta3 Integrin/Lactadherin 0.036 0.055 -9999.0 0.0 -0.336 10.0 10.0 alphaV/beta3 Integrin/TGFBR2 0.013 0.108 -9999.0 0.0 -0.391 30.0 30.0 alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.049 0.035 -9999.0 0.0 -0.309 3.0 3.0 HSP90AA1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Talin 0.032 0.047 -9999.0 0.0 -0.306 8.0 8.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 0.009 0.085 -9999.0 0.0 -0.533 12.0 12.0 alphaV/beta3 Integrin/Pyk2 0.02 0.094 -9999.0 0.0 -0.34 26.0 26.0 SDC1 0.021 0.025 -9999.0 0.0 -0.533 1.0 1.0 VAV3 -0.012 0.04 -9999.0 0.0 -0.293 4.0 4.0 PTPN11 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IRS1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FAK1/Paxillin -0.129 0.152 0.34 1.0 -0.417 56.0 57.0 cell migration -0.119 0.137 0.255 3.0 -0.386 51.0 54.0 ITGAV 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.048 0.13 -9999.0 0.0 -0.3 80.0 80.0 SPP1 0.121 0.114 0.231 246.0 -0.301 6.0 252.0 KDR -0.007 0.121 -9999.0 0.0 -0.533 25.0 25.0 mol:PI-4-5-P2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Caspase 8 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 COL4A3 -0.314 0.271 -9999.0 0.0 -0.533 301.0 301.0 angiogenesis -0.107 0.185 0.273 1.0 -0.561 40.0 41.0 Rac1/GTP 0.019 0.036 -9999.0 0.0 -0.273 4.0 4.0 EDIL3 -0.009 0.126 -9999.0 0.0 -0.533 27.0 27.0 cell proliferation 0.013 0.108 -9999.0 0.0 -0.389 30.0 30.0