Signaling events mediated by VEGFR1 and VEGFR2 Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations alphaV beta3 Integrin 0.024 0.06 -9999.0 0.0 -0.391 10.0 10.0 AKT1 -0.006 0.181 0.365 11.0 -0.538 31.0 42.0 PTK2B -0.059 0.183 0.369 6.0 -0.653 27.0 33.0 VEGFR2 homodimer/Frs2 -0.056 0.191 -9999.0 0.0 -0.448 80.0 80.0 CAV1 -0.12 0.242 -9999.0 0.0 -0.533 127.0 127.0 CALM1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/Frs2 -0.04 0.182 -9999.0 0.0 -0.424 74.0 74.0 endothelial cell proliferation -0.012 0.18 0.369 14.0 -0.536 29.0 43.0 mol:Ca2+ -0.041 0.171 0.355 3.0 -0.62 24.0 27.0 VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac -0.028 0.178 -9999.0 0.0 -0.652 24.0 24.0 RP11-342D11.1 -0.057 0.166 -9999.0 0.0 -0.637 24.0 24.0 CDH5 -0.085 0.219 -9999.0 0.0 -0.533 96.0 96.0 VEGFA homodimer 0.05 0.022 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHC2 0.019 0.043 -9999.0 0.0 -0.533 3.0 3.0 HRAS/GDP -0.025 0.147 -9999.0 0.0 -0.545 24.0 24.0 SH2D2A 0.021 0.025 -9999.0 0.0 -0.533 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS -0.023 0.17 -9999.0 0.0 -0.575 28.0 28.0 VEGFR2 homodimer/VEGFA homodimer/TsAd -0.039 0.181 -9999.0 0.0 -0.424 73.0 73.0 VEGFR1 homodimer 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHC/GRB2/SOS1 -0.013 0.166 -9999.0 0.0 -0.598 24.0 24.0 GRB10 -0.042 0.172 0.354 2.0 -0.633 24.0 26.0 PTPN11 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PAK1 0.023 0.016 0.377 1.0 -9999.0 0.0 1.0 VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin -0.074 0.24 -9999.0 0.0 -0.639 55.0 55.0 HRAS 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VEGF/Rho/ROCK1/Integrin Complex -0.037 0.132 -9999.0 0.0 -0.438 35.0 35.0 HIF1A 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 oxygen and reactive oxygen species metabolic process -0.029 0.175 -9999.0 0.0 -0.642 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FLT4 -0.006 0.119 -9999.0 0.0 -0.533 24.0 24.0 Nck/Pak 0.028 0.013 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/Fyn -0.041 0.186 -9999.0 0.0 -0.414 83.0 83.0 mol:GDP -0.02 0.158 -9999.0 0.0 -0.578 24.0 24.0 mol:NADP -0.016 0.166 0.348 9.0 -0.496 32.0 41.0 eNOS/Hsp90 -0.008 0.158 0.346 8.0 -0.465 32.0 40.0 PIK3R1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.042 0.173 0.356 3.0 -0.629 24.0 27.0 HIF1A/ARNT 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 SHB 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VEGFC 0.019 0.036 -9999.0 0.0 -0.533 2.0 2.0 FAK1/Vinculin -0.042 0.207 0.335 4.0 -0.618 38.0 42.0 mol:Ca ++ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.034 0.194 -9999.0 0.0 -0.674 28.0 28.0 PTPN6 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EPAS1 -0.077 0.224 -9999.0 0.0 -0.539 91.0 91.0 mol:L-citrulline -0.016 0.166 0.348 9.0 -0.496 32.0 41.0 ITGAV 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.012 0.011 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 -0.028 0.177 -9999.0 0.0 -0.652 24.0 24.0 VEGFR2 homodimer/VEGFA homodimer -0.039 0.185 -9999.0 0.0 -0.694 24.0 24.0 VEGFR2/3 heterodimer -0.072 0.217 -9999.0 0.0 -0.467 94.0 94.0 VEGFB 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MAPK11 -0.043 0.177 0.414 5.0 -0.594 29.0 34.0 VEGFR2 homodimer -0.069 0.21 -9999.0 0.0 -0.522 76.0 76.0 FLT1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NEDD4 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.05 0.169 0.341 9.0 -0.597 25.0 34.0 MAPK1 -0.049 0.169 0.317 11.0 -0.603 25.0 36.0 VEGFA145/NRP2 0.03 0.034 -9999.0 0.0 -0.383 3.0 3.0 VEGFR1/2 heterodimer -0.058 0.192 -9999.0 0.0 -0.443 83.0 83.0 KDR -0.069 0.21 -9999.0 0.0 -0.524 76.0 76.0 VEGFA165/NRP1/VEGFR2 homodimer -0.035 0.177 -9999.0 0.0 -0.667 24.0 24.0 SRC 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 platelet activating factor biosynthetic process -0.046 0.174 0.367 8.0 -0.612 25.0 33.0 PI3K -0.036 0.152 -9999.0 0.0 -0.607 23.0 23.0 VEGFR2 homodimer/VEGFA homodimer/NCK1 -0.037 0.173 -9999.0 0.0 -0.431 64.0 64.0 FES -0.045 0.179 0.357 1.0 -0.67 24.0 25.0 GAB1 -0.046 0.18 -9999.0 0.0 -0.608 31.0 31.0 VEGFR2 homodimer/VEGFA homodimer/Src -0.04 0.18 -9999.0 0.0 -0.416 75.0 75.0 CTNNB1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SOS1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARNT 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 eNOS/Caveolin-1 -0.065 0.191 0.332 4.0 -0.471 57.0 61.0 VEGFR2 homodimer/VEGFA homodimer/Yes -0.04 0.181 -9999.0 0.0 -0.414 79.0 79.0 PI3K/GAB1 -0.007 0.162 -9999.0 0.0 -0.534 27.0 27.0 VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak -0.018 0.164 -9999.0 0.0 -0.621 22.0 22.0 PRKACA 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2/3 heterodimer/VEGFC homodimer -0.058 0.21 -9999.0 0.0 -0.472 78.0 78.0 HSP90AA1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 -0.043 0.177 0.358 3.0 -0.652 24.0 27.0 actin cytoskeleton reorganization -0.039 0.179 -9999.0 0.0 -0.421 73.0 73.0 PTK2 -0.058 0.213 0.315 4.0 -0.624 44.0 48.0 EDG1 -0.057 0.166 -9999.0 0.0 -0.637 24.0 24.0 mol:DAG -0.042 0.173 0.356 3.0 -0.629 24.0 27.0 CaM/Ca2+ -0.031 0.161 -9999.0 0.0 -0.591 23.0 23.0 MAP2K3 -0.045 0.134 -9999.0 0.0 -0.555 23.0 23.0 VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 -0.034 0.179 -9999.0 0.0 -0.66 24.0 24.0 PLCG1 -0.043 0.175 0.358 3.0 -0.639 24.0 27.0 VEGFR2 homodimer/VEGFA homodimer/Src/Shb -0.029 0.174 -9999.0 0.0 -0.638 24.0 24.0 IQGAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 YES1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/SHP2 -0.041 0.184 -9999.0 0.0 -0.423 76.0 76.0 VEGFR2 homodimer/VEGFA homodimer/SHP1 -0.039 0.178 -9999.0 0.0 -0.41 78.0 78.0 cell migration -0.056 0.201 0.406 2.0 -0.575 44.0 46.0 mol:PI-3-4-5-P3 -0.033 0.142 -9999.0 0.0 -0.559 23.0 23.0 FYN 0.021 0.025 -9999.0 0.0 -0.533 1.0 1.0 VEGFB/NRP1 -0.037 0.163 -9999.0 0.0 -0.603 24.0 24.0 mol:NO -0.016 0.166 0.348 9.0 -0.496 32.0 41.0 PXN 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GTP -0.036 0.141 -9999.0 0.0 -0.545 24.0 24.0 VEGFR2 homodimer/VEGFA homodimer/GRB10 -0.043 0.173 -9999.0 0.0 -0.66 24.0 24.0 VHL 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ITGB3 0.01 0.082 -9999.0 0.0 -0.533 11.0 11.0 NOS3 -0.022 0.185 0.366 8.0 -0.571 32.0 40.0 VEGFR2 homodimer/VEGFA homodimer/Sck -0.042 0.187 -9999.0 0.0 -0.437 72.0 72.0 RAC1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA -0.054 0.161 0.351 3.0 -0.593 25.0 28.0 PRKCB -0.066 0.175 0.351 3.0 -0.636 26.0 29.0 VCL 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA165/NRP1 -0.037 0.173 -9999.0 0.0 -0.639 24.0 24.0 VEGFR1/2 heterodimer/VEGFA homodimer -0.042 0.183 -9999.0 0.0 -0.424 75.0 75.0 VEGFA165/NRP2 0.03 0.034 -9999.0 0.0 -0.383 3.0 3.0 MAPKKK cascade -0.036 0.143 -9999.0 0.0 -0.543 24.0 24.0 NRP2 0.019 0.043 -9999.0 0.0 -0.533 3.0 3.0 VEGFC homodimer 0.019 0.035 -9999.0 0.0 -0.532 2.0 2.0 NCK1 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 FAK1/Paxillin -0.042 0.209 0.378 4.0 -0.609 40.0 44.0 MAP3K13 -0.037 0.144 -9999.0 0.0 -0.583 23.0 23.0 PDPK1 -0.035 0.126 -9999.0 0.0 -0.499 23.0 23.0