Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.031 0.06 0.414 5.0 -0.236 1.0 6.0 KIRREL 0.015 0.07 -9999.0 0.0 -0.531 8.0 8.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.031 0.06 0.237 1.0 -0.415 5.0 6.0 PLCG1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.049 0.055 0.316 1.0 -0.317 5.0 6.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.013 0.036 -9999.0 0.0 -0.282 3.0 3.0 FYN 0.009 0.078 0.287 18.0 -0.337 5.0 23.0 mol:Ca2+ 0.046 0.049 0.306 1.0 -0.304 3.0 4.0 mol:DAG 0.047 0.05 0.311 1.0 -0.305 3.0 4.0 NPHS2 -0.004 0.031 0.254 3.0 -9999.0 0.0 3.0 mol:IP3 0.047 0.05 0.311 1.0 -0.305 3.0 4.0 regulation of endocytosis 0.039 0.051 -9999.0 0.0 -0.314 5.0 5.0 Nephrin/NEPH1/podocin/Cholesterol 0.036 0.052 0.254 2.0 -0.317 5.0 7.0 establishment of cell polarity 0.031 0.06 0.236 1.0 -0.414 5.0 6.0 Nephrin/NEPH1/podocin/NCK1-2 0.05 0.057 0.314 1.0 -0.297 5.0 6.0 Nephrin/NEPH1/beta Arrestin2 0.042 0.053 -9999.0 0.0 -0.318 5.0 5.0 NPHS1 0.024 0.058 0.26 24.0 -9999.0 0.0 24.0 Nephrin/NEPH1/podocin 0.038 0.055 0.303 1.0 -0.339 5.0 6.0 TJP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.048 0.051 0.316 1.0 -0.306 3.0 4.0 CD2AP 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.049 0.053 0.316 1.0 -0.324 4.0 5.0 GRB2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.012 0.1 0.276 15.0 -0.346 23.0 38.0 cytoskeleton organization -0.002 0.042 0.193 7.0 -0.334 3.0 10.0 Nephrin/NEPH1 0.027 0.045 0.194 1.0 -0.293 5.0 6.0 Nephrin/NEPH1/ZO-1 0.041 0.052 -9999.0 0.0 -0.331 5.0 5.0