Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.006 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.007 0.089 -9999.0 0.0 -0.533 13.0 13.0 ENAH 0.006 0.067 0.259 11.0 -9999.0 0.0 11.0 EGFR 0.023 0.081 0.365 12.0 -0.533 6.0 18.0 EPHA2 0.018 0.043 -9999.0 0.0 -0.533 3.0 3.0 MYO6 -0.009 0.029 0.345 1.0 -9999.0 0.0 1.0 CTNNB1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.031 0.06 -9999.0 0.0 -0.336 11.0 11.0 AQP5 -0.136 0.221 -9999.0 0.0 -0.471 148.0 148.0 CTNND1 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.01 0.025 0.343 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.082 0.122 0.343 1.0 -0.276 134.0 135.0 EGF 0.015 0.068 0.23 3.0 -0.533 7.0 10.0 NCKAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.056 0.16 -9999.0 0.0 -0.463 64.0 64.0 cortical microtubule organization 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.01 0.024 0.194 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.048 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.019 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.037 -9999.0 0.0 -0.309 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.01 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.046 0.039 -9999.0 0.0 -0.291 3.0 3.0 CDH1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.031 0.058 -9999.0 0.0 -0.298 12.0 12.0 RhoA/GDP 0.045 0.016 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.011 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.003 0.104 0.23 1.0 -0.533 18.0 19.0 DIAPH1 -0.016 0.165 -9999.0 0.0 -0.579 19.0 19.0 Wnt receptor signaling pathway -0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.019 0.022 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.011 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.008 0.022 0.338 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 0.036 0.029 -9999.0 0.0 -0.277 3.0 3.0 SEC6/SEC8 -0.016 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.083 0.124 0.345 1.0 -0.28 134.0 135.0 HGF/MET -0.023 0.124 -9999.0 0.0 -0.274 89.0 89.0 HGF -0.09 0.222 -9999.0 0.0 -0.533 100.0 100.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.046 0.102 0.33 25.0 -9999.0 0.0 25.0 KIAA1543 -0.01 0.024 0.195 5.0 -9999.0 0.0 5.0 KIFC3 -0.01 0.027 0.345 1.0 -9999.0 0.0 1.0 NCK1 0.019 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.018 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.028 0.345 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.028 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.009 0.028 0.345 1.0 -9999.0 0.0 1.0 PIP5K1C -0.01 0.026 0.345 1.0 -9999.0 0.0 1.0 LIMA1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.015 0.084 0.307 17.0 -9999.0 0.0 17.0 adherens junction assembly -0.014 0.092 0.314 3.0 -0.65 7.0 10.0 IGF-1R heterotetramer/IGF1 0.029 0.058 -9999.0 0.0 -0.274 16.0 16.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.039 0.377 1.0 -0.533 2.0 3.0 PLEKHA7 -0.01 0.026 0.345 1.0 -9999.0 0.0 1.0 mol:GTP 0.041 0.036 -9999.0 0.0 -0.307 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.024 0.089 0.341 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.017 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.011 0.02 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0