Signaling events mediated by Stem cell factor receptor (c-Kit) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MAP4K1 -0.026 0.142 0.326 3.0 -0.387 53.0 56.0 CRKL -0.038 0.135 -9999.0 0.0 -0.407 54.0 54.0 HRAS -0.033 0.149 -9999.0 0.0 -0.404 51.0 51.0 mol:PIP3 -0.006 0.135 0.249 1.0 -0.346 53.0 54.0 SPRED1 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 SPRED2 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GAB1 -0.04 0.148 -9999.0 0.0 -0.421 63.0 63.0 FOXO3 -0.026 0.144 -9999.0 0.0 -0.372 58.0 58.0 AKT1 -0.027 0.153 -9999.0 0.0 -0.388 66.0 66.0 BAD -0.026 0.144 0.266 1.0 -0.372 58.0 59.0 megakaryocyte differentiation -0.056 0.168 -9999.0 0.0 -0.445 67.0 67.0 GSK3B -0.008 0.152 0.289 7.0 -0.368 54.0 61.0 RAF1 -0.024 0.122 -9999.0 0.0 -0.33 49.0 49.0 SHC1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.042 0.148 -9999.0 0.0 -0.418 63.0 63.0 STAT1 -0.115 0.355 -9999.0 0.0 -1.028 63.0 63.0 HRAS/SPRED1 -0.014 0.13 -9999.0 0.0 -0.378 26.0 26.0 cell proliferation -0.04 0.146 -9999.0 0.0 -0.413 64.0 64.0 PIK3CA 0.012 0.011 -9999.0 0.0 -9999.0 0.0 0.0 TEC 0.019 0.036 -9999.0 0.0 -0.533 2.0 2.0 RPS6KB1 -0.033 0.154 -9999.0 0.0 -0.412 63.0 63.0 HRAS/SPRED2 -0.015 0.127 -9999.0 0.0 -0.35 37.0 37.0 LYN/TEC/p62DOK -0.013 0.153 -9999.0 0.0 -0.417 53.0 53.0 MAPK3 -0.018 0.098 0.364 2.0 -0.299 18.0 20.0 STAP1 -0.052 0.17 -9999.0 0.0 -0.469 63.0 63.0 GRAP2 -0.008 0.126 -9999.0 0.0 -0.533 27.0 27.0 JAK2 -0.095 0.317 -9999.0 0.0 -0.899 63.0 63.0 STAT1 (dimer) -0.112 0.345 -9999.0 0.0 -1.0 63.0 63.0 mol:Gleevec 0.001 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOCS1/VAV1 -0.014 0.156 -9999.0 0.0 -0.407 60.0 60.0 actin filament polymerization -0.041 0.143 -9999.0 0.0 -0.415 59.0 59.0 LYN 0.02 0.035 -9999.0 0.0 -0.533 2.0 2.0 STAP1/STAT5A (dimer) -0.078 0.239 -9999.0 0.0 -0.663 63.0 63.0 PIK3R1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CBL/CRKL/GRB2 -0.014 0.14 -9999.0 0.0 -0.379 53.0 53.0 PI3K -0.021 0.125 -9999.0 0.0 -0.402 32.0 32.0 PTEN 0.02 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SCF/KIT/EPO/EPOR -0.117 0.419 -9999.0 0.0 -1.204 63.0 63.0 MAPK8 -0.041 0.149 -9999.0 0.0 -0.421 64.0 64.0 STAT3 (dimer) -0.041 0.145 -9999.0 0.0 -0.41 63.0 63.0 positive regulation of transcription -0.013 0.082 0.344 2.0 -0.242 18.0 20.0 mol:GDP -0.032 0.152 -9999.0 0.0 -0.412 54.0 54.0 PIK3C2B -0.041 0.147 -9999.0 0.0 -0.422 61.0 61.0 CBL/CRKL -0.024 0.14 -9999.0 0.0 -0.388 55.0 55.0 FER -0.04 0.148 -9999.0 0.0 -0.421 63.0 63.0 SH2B3 -0.043 0.15 -9999.0 0.0 -0.422 64.0 64.0 PDPK1 -0.003 0.127 -9999.0 0.0 -0.328 48.0 48.0 SNAI2 -0.042 0.147 -9999.0 0.0 -0.419 62.0 62.0 positive regulation of cell proliferation -0.083 0.267 -9999.0 0.0 -0.753 64.0 64.0 KITLG 0.017 0.022 -9999.0 0.0 -9999.0 0.0 0.0 cell motility -0.083 0.267 -9999.0 0.0 -0.753 64.0 64.0 PTPN6 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EPOR -0.033 0.192 -9999.0 0.0 -0.877 14.0 14.0 STAT5A (dimer) -0.066 0.223 -9999.0 0.0 -0.622 64.0 64.0 SOCS1 0.021 0.025 -9999.0 0.0 -0.533 1.0 1.0 cell migration 0.051 0.159 0.43 67.0 -9999.0 0.0 67.0 SOS1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EPO 0.018 0.029 0.23 6.0 -9999.0 0.0 6.0 VAV1 0.019 0.043 -9999.0 0.0 -0.533 3.0 3.0 GRB10 -0.04 0.145 -9999.0 0.0 -0.418 59.0 59.0 PTPN11 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SCF/KIT -0.041 0.157 -9999.0 0.0 -0.439 64.0 64.0 GO:0007205 0.002 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.019 0.101 0.377 2.0 -0.316 18.0 20.0 CBL 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 KIT -0.158 0.457 -9999.0 0.0 -1.251 70.0 70.0 MAP2K2 -0.019 0.101 0.377 2.0 -0.312 19.0 21.0 SHC/Grb2/SOS1 -0.011 0.15 -9999.0 0.0 -0.404 55.0 55.0 STAT5A -0.066 0.23 -9999.0 0.0 -0.646 63.0 63.0 GRB2 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 response to radiation -0.041 0.144 -9999.0 0.0 -0.411 62.0 62.0 SHC/GRAP2 0.008 0.096 -9999.0 0.0 -0.391 27.0 27.0 PTPRO -0.057 0.172 -9999.0 0.0 -0.455 67.0 67.0 SH2B2 -0.042 0.146 -9999.0 0.0 -0.423 59.0 59.0 DOK1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MATK -0.052 0.162 -9999.0 0.0 -0.441 66.0 66.0 CREBBP 0.017 0.045 -9999.0 0.0 -9999.0 0.0 0.0 BCL2 -0.042 0.219 -9999.0 0.0 -0.982 17.0 17.0