Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within Angiopoietin receptor Tie2-mediated signaling 159.0 14075.0 88.0 -0.685 0.075 1000.0 -1000.0 -0.062 -1000.0 Signaling events mediated by the Hedgehog family 137.0 7159.0 52.0 -0.412 0.214 1000.0 -1000.0 -0.036 -1000.0 Endothelins 96.0 9262.0 96.0 -0.371 0.102 1000.0 -1000.0 -0.054 -1000.0 Fc-epsilon receptor I signaling in mast cells 66.0 6427.0 97.0 -0.14 0.023 1000.0 -1000.0 -0.064 -1000.0 Thromboxane A2 receptor signaling 61.0 6490.0 105.0 -0.206 0.057 1000.0 -1000.0 -0.051 -1000.0 amb2 Integrin signaling 57.0 4708.0 82.0 -0.478 0.035 1000.0 -1000.0 -0.039 -1000.0 IL4-mediated signaling events 56.0 5122.0 91.0 -0.807 0.499 1000.0 -1000.0 -0.162 -1000.0 Signaling mediated by p38-alpha and p38-beta 56.0 2502.0 44.0 -0.103 0.022 1000.0 -1000.0 -0.034 -1000.0 TCGA08_retinoblastoma 56.0 454.0 8.0 -0.009 0.092 1000.0 -1000.0 -0.002 -1000.0 Aurora B signaling 55.0 3689.0 67.0 -0.3 0.28 1000.0 -1000.0 -0.05 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 52.0 2754.0 52.0 -0.25 0.048 1000.0 -1000.0 -0.048 -1000.0 Aurora C signaling 51.0 361.0 7.0 -0.004 0.148 1000.0 -1000.0 -0.013 -1000.0 Signaling events regulated by Ret tyrosine kinase 44.0 3683.0 82.0 -0.107 0.054 1000.0 -1000.0 -0.059 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 39.0 3064.0 78.0 -0.158 0.051 1000.0 -1000.0 -0.053 -1000.0 Nongenotropic Androgen signaling 38.0 1978.0 52.0 -0.115 0.076 1000.0 -1000.0 -0.038 -1000.0 BMP receptor signaling 37.0 3070.0 81.0 -0.262 0.146 1000.0 -1000.0 -0.049 -1000.0 Integrins in angiogenesis 36.0 3090.0 84.0 -0.314 0.121 1000.0 -1000.0 -0.043 -1000.0 Calcium signaling in the CD4+ TCR pathway 36.0 1121.0 31.0 -0.161 0.024 1000.0 -1000.0 -0.04 -1000.0 Arf6 signaling events 34.0 2115.0 62.0 -0.131 0.043 1000.0 -1000.0 -0.035 -1000.0 PLK1 signaling events 33.0 2811.0 85.0 -0.026 0.157 1000.0 -1000.0 -0.031 -1000.0 Canonical Wnt signaling pathway 31.0 1615.0 51.0 -0.322 0.151 1000.0 -1000.0 -0.051 -1000.0 IL6-mediated signaling events 30.0 2295.0 75.0 -0.461 0.048 1000.0 -1000.0 -0.058 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 29.0 2023.0 68.0 -0.173 0.039 1000.0 -1000.0 -0.079 -1000.0 Coregulation of Androgen receptor activity 28.0 2178.0 76.0 -0.321 0.091 1000.0 -1000.0 -0.029 -1000.0 Reelin signaling pathway 28.0 1592.0 56.0 -0.065 0.059 1000.0 -1000.0 -0.047 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 27.0 3401.0 125.0 -0.12 0.05 1000.0 -1000.0 -0.058 -1000.0 Presenilin action in Notch and Wnt signaling 26.0 1646.0 61.0 -0.322 0.151 1000.0 -1000.0 -0.057 -1000.0 Glypican 2 network 26.0 106.0 4.0 0.027 0.056 1000.0 -1000.0 0.012 -1000.0 Visual signal transduction: Cones 25.0 987.0 38.0 -0.036 0.125 1000.0 -1000.0 -0.028 -1000.0 LPA4-mediated signaling events 24.0 292.0 12.0 -0.093 0.0 1000.0 -1000.0 -0.026 -1000.0 HIF-1-alpha transcription factor network 24.0 1860.0 76.0 -0.118 0.116 1000.0 -1000.0 -0.11 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 24.0 2076.0 85.0 -0.107 0.031 1000.0 -1000.0 -0.049 -1000.0 IL12-mediated signaling events 23.0 2031.0 87.0 -0.163 0.044 1000.0 -1000.0 -0.084 -1000.0 TCR signaling in naïve CD8+ T cells 23.0 2211.0 93.0 -0.061 0.032 1000.0 -1000.0 -0.047 -1000.0 IL23-mediated signaling events 23.0 1393.0 60.0 -0.195 0.025 1000.0 -1000.0 -0.128 -1000.0 Plasma membrane estrogen receptor signaling 23.0 2021.0 86.0 -0.109 0.037 1000.0 -1000.0 -0.053 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 23.0 779.0 33.0 -0.159 0.091 1000.0 -1000.0 -0.034 -1000.0 Regulation of Androgen receptor activity 23.0 1628.0 70.0 -0.35 0.14 1000.0 -1000.0 -0.042 -1000.0 Glucocorticoid receptor regulatory network 22.0 2583.0 114.0 -0.33 0.063 1000.0 -1000.0 -0.053 -1000.0 Syndecan-1-mediated signaling events 21.0 743.0 34.0 -0.09 0.148 1000.0 -1000.0 -0.051 -1000.0 Nectin adhesion pathway 21.0 1351.0 63.0 -0.031 0.12 1000.0 -1000.0 -0.046 -1000.0 Wnt signaling 21.0 151.0 7.0 0.007 0.054 1000.0 -1000.0 -0.011 -1000.0 FOXM1 transcription factor network 21.0 1076.0 51.0 0.022 0.308 1000.0 -1000.0 -0.129 -1000.0 ErbB4 signaling events 20.0 1397.0 69.0 -0.127 0.16 1000.0 -1000.0 -0.054 -1000.0 Glypican 1 network 20.0 976.0 48.0 -0.135 0.082 1000.0 -1000.0 -0.036 -1000.0 TCGA08_p53 20.0 141.0 7.0 -0.032 0.022 1000.0 -1000.0 -0.015 -1000.0 Caspase cascade in apoptosis 18.0 1336.0 74.0 -0.063 0.082 1000.0 -1000.0 -0.037 -1000.0 S1P1 pathway 18.0 662.0 36.0 -0.104 0.022 1000.0 -1000.0 -0.042 -1000.0 FAS signaling pathway (CD95) 18.0 847.0 47.0 -0.193 0.059 1000.0 -1000.0 -0.041 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 18.0 2180.0 120.0 -0.135 0.06 1000.0 -1000.0 -0.045 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 17.0 941.0 54.0 -0.065 0.071 1000.0 -1000.0 -0.05 -1000.0 JNK signaling in the CD4+ TCR pathway 17.0 301.0 17.0 -0.037 0.032 1000.0 -1000.0 -0.031 -1000.0 Visual signal transduction: Rods 16.0 860.0 52.0 -0.036 0.092 1000.0 -1000.0 -0.036 -1000.0 Noncanonical Wnt signaling pathway 15.0 408.0 26.0 -0.051 0.054 1000.0 -1000.0 -0.043 -1000.0 PDGFR-alpha signaling pathway 15.0 666.0 44.0 -0.12 0.044 1000.0 -1000.0 -0.042 -1000.0 Syndecan-3-mediated signaling events 15.0 535.0 35.0 -0.235 0.055 1000.0 -1000.0 -0.034 -1000.0 p75(NTR)-mediated signaling 14.0 1867.0 125.0 -0.046 0.143 1000.0 -1000.0 -0.078 -1000.0 Ephrin B reverse signaling 14.0 681.0 48.0 -0.057 0.062 1000.0 -1000.0 -0.03 -1000.0 BCR signaling pathway 14.0 1386.0 99.0 -0.093 0.052 1000.0 -1000.0 -0.045 -1000.0 Osteopontin-mediated events 13.0 506.0 38.0 -0.048 0.124 1000.0 -1000.0 -0.051 -1000.0 Signaling events mediated by PTP1B 13.0 1032.0 76.0 -0.044 0.058 1000.0 -1000.0 -0.035 -1000.0 Effects of Botulinum toxin 13.0 346.0 26.0 -0.031 0.029 1000.0 -1000.0 -0.014 -1000.0 EGFR-dependent Endothelin signaling events 13.0 276.0 21.0 -0.025 0.049 1000.0 -1000.0 -0.04 -1000.0 S1P4 pathway 13.0 333.0 25.0 -0.026 0.032 1000.0 -1000.0 -0.028 -1000.0 Aurora A signaling 12.0 760.0 60.0 -0.037 0.201 1000.0 -1000.0 -0.028 -1000.0 HIF-2-alpha transcription factor network 12.0 523.0 43.0 -0.07 0.064 1000.0 -1000.0 -0.065 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 12.0 900.0 74.0 -0.136 0.048 1000.0 -1000.0 -0.07 -1000.0 IGF1 pathway 12.0 728.0 57.0 -0.053 0.056 1000.0 -1000.0 -0.048 -1000.0 Ras signaling in the CD4+ TCR pathway 12.0 219.0 17.0 -0.02 0.03 1000.0 -1000.0 -0.031 -1000.0 Sphingosine 1-phosphate (S1P) pathway 11.0 330.0 28.0 -0.109 0.043 1000.0 -1000.0 -0.03 -1000.0 Hedgehog signaling events mediated by Gli proteins 11.0 725.0 65.0 -0.512 0.055 1000.0 -1000.0 -0.056 -1000.0 Syndecan-2-mediated signaling events 10.0 731.0 69.0 -0.028 0.082 1000.0 -1000.0 -0.04 -1000.0 Syndecan-4-mediated signaling events 10.0 713.0 67.0 -0.032 0.082 1000.0 -1000.0 -0.046 -1000.0 Regulation of nuclear SMAD2/3 signaling 9.0 1322.0 136.0 -0.216 0.144 1000.0 -1000.0 -0.045 -1000.0 LPA receptor mediated events 9.0 945.0 102.0 -0.06 0.041 1000.0 -1000.0 -0.068 -1000.0 ErbB2/ErbB3 signaling events 8.0 581.0 65.0 -0.036 0.033 1000.0 -1000.0 -0.053 -1000.0 Cellular roles of Anthrax toxin 8.0 348.0 39.0 -0.06 0.023 1000.0 -1000.0 -0.027 -1000.0 mTOR signaling pathway 8.0 456.0 53.0 -0.017 0.092 1000.0 -1000.0 -0.036 -1000.0 Retinoic acid receptors-mediated signaling 8.0 505.0 58.0 -0.151 0.045 1000.0 -1000.0 -0.055 -1000.0 IL2 signaling events mediated by PI3K 8.0 482.0 58.0 -0.019 0.116 1000.0 -1000.0 -0.043 -1000.0 EPHB forward signaling 8.0 741.0 85.0 -0.043 0.07 1000.0 -1000.0 -0.066 -1000.0 IL27-mediated signaling events 8.0 421.0 51.0 -0.062 0.029 1000.0 -1000.0 -0.057 -1000.0 IL2 signaling events mediated by STAT5 8.0 184.0 22.0 0.003 0.074 1000.0 -1000.0 -0.047 -1000.0 PDGFR-beta signaling pathway 8.0 808.0 97.0 -0.045 0.064 1000.0 -1000.0 -0.059 -1000.0 FOXA2 and FOXA3 transcription factor networks 7.0 356.0 46.0 -0.227 0.045 1000.0 -1000.0 -0.106 -1000.0 Regulation of p38-alpha and p38-beta 7.0 422.0 54.0 -0.035 0.052 1000.0 -1000.0 -0.047 -1000.0 TCGA08_rtk_signaling 7.0 193.0 26.0 -0.063 0.081 1000.0 -1000.0 -0.01 -1000.0 Insulin Pathway 7.0 518.0 74.0 -0.082 0.059 1000.0 -1000.0 -0.065 -1000.0 Ephrin A reverse signaling 6.0 43.0 7.0 -0.011 0.029 1000.0 -1000.0 -0.016 -1000.0 IFN-gamma pathway 6.0 444.0 68.0 -0.03 0.064 1000.0 -1000.0 -0.068 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 6.0 578.0 83.0 -0.063 0.041 1000.0 -1000.0 -0.042 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 6.0 302.0 45.0 -0.018 0.051 1000.0 -1000.0 -0.055 -1000.0 Class I PI3K signaling events 6.0 484.0 73.0 -0.029 0.042 1000.0 -1000.0 -0.042 -1000.0 S1P3 pathway 6.0 293.0 42.0 -0.109 0.042 1000.0 -1000.0 -0.041 -1000.0 Signaling events mediated by PRL 6.0 234.0 34.0 -0.034 0.064 1000.0 -1000.0 -0.044 -1000.0 E-cadherin signaling in keratinocytes 6.0 296.0 43.0 -0.049 0.063 1000.0 -1000.0 -0.037 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 5.0 194.0 34.0 -0.031 0.05 1000.0 -1000.0 -0.031 -1000.0 EPO signaling pathway 5.0 296.0 55.0 -0.01 0.06 1000.0 -1000.0 -0.046 -1000.0 Ceramide signaling pathway 5.0 448.0 76.0 -0.011 0.059 1000.0 -1000.0 -0.036 -1000.0 Signaling events mediated by HDAC Class III 5.0 207.0 40.0 -0.076 0.041 1000.0 -1000.0 -0.028 -1000.0 ceramide signaling pathway 5.0 260.0 49.0 -0.0 0.033 1000.0 -1000.0 -0.039 -1000.0 Signaling events mediated by HDAC Class II 4.0 326.0 75.0 -0.034 0.054 1000.0 -1000.0 -0.03 -1000.0 BARD1 signaling events 4.0 257.0 57.0 -0.041 0.089 1000.0 -1000.0 -0.046 -1000.0 a4b1 and a4b7 Integrin signaling 4.0 20.0 5.0 0.016 0.027 1000.0 -1000.0 0.006 -1000.0 TRAIL signaling pathway 4.0 206.0 48.0 -0.034 0.06 1000.0 -1000.0 -0.036 -1000.0 IL1-mediated signaling events 4.0 302.0 62.0 -0.019 0.04 1000.0 -1000.0 -0.039 -1000.0 Signaling events mediated by HDAC Class I 4.0 498.0 104.0 -0.042 0.055 1000.0 -1000.0 -0.038 -1000.0 FoxO family signaling 4.0 265.0 64.0 -0.021 0.07 1000.0 -1000.0 -0.062 -1000.0 VEGFR1 specific signals 4.0 250.0 56.0 -0.12 0.054 1000.0 -1000.0 -0.057 -1000.0 Arf6 downstream pathway 3.0 136.0 43.0 -0.044 0.045 1000.0 -1000.0 -0.022 -1000.0 Insulin-mediated glucose transport 3.0 96.0 32.0 -0.009 0.042 1000.0 -1000.0 -0.034 -1000.0 Class I PI3K signaling events mediated by Akt 3.0 263.0 68.0 -0.033 0.047 1000.0 -1000.0 -0.036 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 3.0 127.0 37.0 -0.013 0.05 1000.0 -1000.0 -0.037 -1000.0 Paxillin-dependent events mediated by a4b1 3.0 113.0 36.0 -0.04 0.041 1000.0 -1000.0 -0.035 -1000.0 E-cadherin signaling in the nascent adherens junction 3.0 263.0 76.0 -0.012 0.059 1000.0 -1000.0 -0.061 -1000.0 Regulation of Telomerase 3.0 403.0 102.0 -0.042 0.065 1000.0 -1000.0 -0.045 -1000.0 p38 MAPK signaling pathway 3.0 143.0 44.0 -0.002 0.054 1000.0 -1000.0 -0.035 -1000.0 Canonical NF-kappaB pathway 2.0 84.0 39.0 -0.006 0.046 1000.0 -1000.0 -0.038 -1000.0 Signaling mediated by p38-gamma and p38-delta 2.0 30.0 15.0 -0.011 0.022 1000.0 -1000.0 -0.033 -1000.0 Arf6 trafficking events 2.0 203.0 71.0 -0.05 0.04 1000.0 -1000.0 -0.03 -1000.0 Class IB PI3K non-lipid kinase events 2.0 6.0 3.0 -0.019 0.019 1000.0 -1000.0 -0.009 -1000.0 Circadian rhythm pathway 1.0 31.0 22.0 -0.006 0.047 1000.0 -1000.0 -0.043 -1000.0 S1P5 pathway 1.0 32.0 17.0 -0.015 0.03 1000.0 -1000.0 -0.014 -1000.0 Rapid glucocorticoid signaling 1.0 27.0 20.0 -0.01 0.024 1000.0 -1000.0 -0.017 -1000.0 Arf1 pathway 1.0 68.0 54.0 -0.005 0.03 1000.0 -1000.0 -0.017 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 16.0 23.0 0.003 0.042 1000.0 -1000.0 -0.031 -1000.0 PLK2 and PLK4 events 0.0 1.0 3.0 -0.01 0.022 1000.0 -1000.0 -0.027 -1000.0 Atypical NF-kappaB pathway 0.0 11.0 31.0 -0.008 0.023 1000.0 -1000.0 -0.031 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 10.0 27.0 -0.01 0.053 1000.0 -1000.0 -0.038 -1000.0 E-cadherin signaling events 0.0 0.0 5.0 0.021 0.041 1000.0 -1000.0 0.005 -1000.0 Alternative NF-kappaB pathway 0.0 4.0 13.0 -0.0 0.06 1000.0 -1000.0 0.0 -1000.0 Total 2460 159831 7203 -13.5079037791 9.24770807733 131000 -131000 -5.70076529273 -131000