EPHB forward signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Ephrin A5/EPHB2 -0.033 0.143 -9999.0 0.0 -0.366 23.0 23.0 cell-cell adhesion 0.144 0.189 0.56 18.0 -9999.0 0.0 18.0 Ephrin B/EPHB2/RasGAP -0.073 0.208 -9999.0 0.0 -0.42 34.0 34.0 ITSN1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA -0.003 0.107 -9999.0 0.0 -0.528 6.0 6.0 SHC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B1/EPHB3 -0.066 0.208 -9999.0 0.0 -0.496 27.0 27.0 Ephrin B1/EPHB1 -0.113 0.2 -9999.0 0.0 -0.354 56.0 56.0 HRAS/GDP -0.125 0.187 -9999.0 0.0 -0.58 15.0 15.0 Ephrin B/EPHB1/GRB7 -0.099 0.207 -9999.0 0.0 -0.61 11.0 11.0 Endophilin/SYNJ1 -0.07 0.193 -9999.0 0.0 -0.57 10.0 10.0 KRAS -0.003 0.115 -9999.0 0.0 -0.626 5.0 5.0 Ephrin B/EPHB1/Src -0.098 0.205 -9999.0 0.0 -0.628 10.0 10.0 endothelial cell migration -0.047 0.176 -9999.0 0.0 -0.464 16.0 16.0 GRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB7 0.012 0.054 -9999.0 0.0 -0.458 2.0 2.0 PAK1 -0.074 0.212 -9999.0 0.0 -0.587 13.0 13.0 HRAS 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 RRAS -0.079 0.199 -9999.0 0.0 -0.611 9.0 9.0 DNM1 0.005 0.085 -9999.0 0.0 -0.51 4.0 4.0 cell-cell signaling 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.093 0.194 -9999.0 0.0 -0.597 10.0 10.0 lamellipodium assembly -0.144 0.189 -9999.0 0.0 -0.56 18.0 18.0 Ephrin B/EPHB1/Src/p52 SHC/GRB2 -0.055 0.151 -9999.0 0.0 -0.497 8.0 8.0 PIK3R1 -0.038 0.168 -9999.0 0.0 -0.523 16.0 16.0 EPHB2 -0.07 0.216 -9999.0 0.0 -0.576 23.0 23.0 EPHB3 -0.044 0.197 -9999.0 0.0 -0.668 14.0 14.0 EPHB1 -0.123 0.23 -9999.0 0.0 -0.487 43.0 43.0 EPHB4 -0.013 0.137 -9999.0 0.0 -0.589 8.0 8.0 mol:GDP -0.088 0.208 -9999.0 0.0 -0.547 16.0 16.0 Ephrin B/EPHB2 -0.081 0.207 -9999.0 0.0 -0.432 33.0 33.0 Ephrin B/EPHB3 -0.067 0.212 -9999.0 0.0 -0.442 31.0 31.0 JNK cascade -0.127 0.232 -9999.0 0.0 -0.455 39.0 39.0 Ephrin B/EPHB1 -0.106 0.205 -9999.0 0.0 -0.452 28.0 28.0 RAP1/GDP -0.065 0.19 -9999.0 0.0 -0.547 11.0 11.0 EFNB2 -0.038 0.173 -9999.0 0.0 -0.556 15.0 15.0 EFNB3 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EFNB1 -0.062 0.22 -9999.0 0.0 -0.668 18.0 18.0 Ephrin B2/EPHB1-2 -0.126 0.203 -9999.0 0.0 -0.461 30.0 30.0 RAP1B 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 RAP1A 0.009 0.078 -9999.0 0.0 -0.668 2.0 2.0 CDC42/GTP -0.15 0.199 -9999.0 0.0 -0.602 17.0 17.0 Rap1/GTP -0.136 0.179 -9999.0 0.0 -0.544 17.0 17.0 axon guidance -0.033 0.142 -9999.0 0.0 -0.364 23.0 23.0 MAPK3 -0.031 0.136 -9999.0 0.0 -0.472 6.0 6.0 MAPK1 -0.033 0.142 -9999.0 0.0 -0.48 7.0 7.0 Rac1/GDP -0.07 0.191 -9999.0 0.0 -0.536 12.0 12.0 actin cytoskeleton reorganization -0.126 0.162 -9999.0 0.0 -0.441 24.0 24.0 CDC42/GDP -0.07 0.191 -9999.0 0.0 -0.536 12.0 12.0 PI3K -0.045 0.18 -9999.0 0.0 -0.471 16.0 16.0 EFNA5 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 Ephrin B2/EPHB4 -0.03 0.154 -9999.0 0.0 -0.395 20.0 20.0 Ephrin B/EPHB2/Intersectin/N-WASP -0.058 0.176 -9999.0 0.0 -0.535 10.0 10.0 CDC42 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP -0.151 0.194 -9999.0 0.0 -0.534 23.0 23.0 PTK2 0.034 0.072 -9999.0 0.0 -0.652 1.0 1.0 MAP4K4 -0.129 0.235 -9999.0 0.0 -0.461 39.0 39.0 SRC 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 KALRN 0.006 0.076 -9999.0 0.0 -0.458 4.0 4.0 Intersectin/N-WASP 0.014 0.083 -9999.0 0.0 -0.492 4.0 4.0 neuron projection morphogenesis -0.077 0.195 -9999.0 0.0 -0.463 19.0 19.0 MAP2K1 -0.042 0.143 -9999.0 0.0 -0.463 8.0 8.0 WASL 0.001 0.109 -9999.0 0.0 -0.668 4.0 4.0 Ephrin B1/EPHB1-2/NCK1 -0.137 0.237 -9999.0 0.0 -0.483 38.0 38.0 cell migration -0.037 0.153 -9999.0 0.0 -0.482 8.0 8.0 NRAS -0.006 0.113 -9999.0 0.0 -0.518 7.0 7.0 SYNJ1 -0.072 0.197 -9999.0 0.0 -0.583 10.0 10.0 PXN 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TF -0.066 0.199 -9999.0 0.0 -0.576 11.0 11.0 HRAS/GTP -0.15 0.195 -9999.0 0.0 -0.592 17.0 17.0 Ephrin B1/EPHB1-2 -0.141 0.231 -9999.0 0.0 -0.493 35.0 35.0 cell adhesion mediated by integrin 0.066 0.173 0.432 22.0 -9999.0 0.0 22.0 RAC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.128 0.225 -9999.0 0.0 -0.571 20.0 20.0 RAC1-CDC42/GTP -0.155 0.2 -9999.0 0.0 -0.579 20.0 20.0 RASA1 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 RAC1-CDC42/GDP -0.06 0.182 -9999.0 0.0 -0.534 10.0 10.0 ruffle organization -0.106 0.223 -9999.0 0.0 -0.571 18.0 18.0 NCK1 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 receptor internalization -0.066 0.197 -9999.0 0.0 -0.558 12.0 12.0 Ephrin B/EPHB2/KALRN -0.077 0.212 -9999.0 0.0 -0.616 11.0 11.0 ROCK1 -0.051 0.192 -9999.0 0.0 -0.446 27.0 27.0 RAS family/GDP -0.123 0.163 -9999.0 0.0 -0.447 23.0 23.0 Rac1/GTP -0.154 0.205 -9999.0 0.0 -0.608 18.0 18.0 Ephrin B/EPHB1/Src/Paxillin -0.065 0.162 -9999.0 0.0 -0.543 8.0 8.0