E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.005 0.147 -9999.0 0.0 -0.522 8.0 8.0 KLHL20 -0.047 0.096 -9999.0 0.0 -0.288 13.0 13.0 CYFIP2 0.005 0.085 -9999.0 0.0 -0.51 4.0 4.0 Rac1/GDP 0.03 0.098 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.006 0.136 -9999.0 0.0 -0.482 9.0 9.0 AP1M1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 RAP1A 0.009 0.078 -9999.0 0.0 -0.668 2.0 2.0 CTNNB1 0.008 0.077 -9999.0 0.0 -0.528 3.0 3.0 CDC42/GTP -0.023 0.06 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.037 0.063 -9999.0 0.0 -0.226 9.0 9.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.019 0.1 -9999.0 0.0 -0.37 8.0 8.0 RAPGEF1 0.026 0.118 -9999.0 0.0 -0.416 8.0 8.0 CTNND1 -0.004 0.122 -9999.0 0.0 -0.668 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.001 0.136 -9999.0 0.0 -0.518 8.0 8.0 CRK 0.017 0.126 -9999.0 0.0 -0.458 8.0 8.0 E-cadherin/gamma catenin/alpha catenin -0.021 0.155 -9999.0 0.0 -0.437 17.0 17.0 alphaE/beta7 Integrin 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 -0.002 0.1 -9999.0 0.0 -0.493 6.0 6.0 Rap1/GTP/I-afadin 0.028 0.051 -9999.0 0.0 -0.38 2.0 2.0 DLG1 0.007 0.135 -9999.0 0.0 -0.496 8.0 8.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.064 -9999.0 0.0 -0.266 5.0 5.0 MLLT4 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.024 0.064 -9999.0 0.0 -0.379 3.0 3.0 PI3K -0.04 0.083 -9999.0 0.0 -0.353 5.0 5.0 ARF6 -0.001 0.108 -9999.0 0.0 -0.584 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.039 0.177 -9999.0 0.0 -0.486 20.0 20.0 TIAM1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.004 0.114 -9999.0 0.0 -0.35 13.0 13.0 AKT1 -0.026 0.058 -9999.0 0.0 -0.292 3.0 3.0 PIK3R1 -0.038 0.168 -9999.0 0.0 -0.523 16.0 16.0 CDH1 -0.019 0.151 -9999.0 0.0 -0.621 9.0 9.0 RhoA/GDP 0.031 0.097 -9999.0 0.0 -0.33 1.0 1.0 actin cytoskeleton organization 0.0 0.09 -9999.0 0.0 -0.235 8.0 8.0 CDC42/GDP 0.031 0.097 -9999.0 0.0 -0.33 1.0 1.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.018 0.124 -9999.0 0.0 -0.314 21.0 21.0 ITGB7 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.005 0.121 -9999.0 0.0 -0.37 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.006 0.094 -9999.0 0.0 -0.359 8.0 8.0 mol:GDP 0.021 0.109 -9999.0 0.0 -0.373 2.0 2.0 CDC42/GTP/IQGAP1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.034 0.18 -9999.0 0.0 -0.65 12.0 12.0 p120 catenin/RhoA/GDP 0.023 0.109 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.019 0.057 -9999.0 0.0 -0.373 3.0 3.0 RHOA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.016 0.101 -9999.0 0.0 -0.215 27.0 27.0 NME1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.004 0.137 -9999.0 0.0 -0.496 8.0 8.0 regulation of cell-cell adhesion -0.02 0.053 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.022 0.04 -9999.0 0.0 -0.257 1.0 1.0 Rap1/GTP -0.026 0.069 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.004 0.136 -9999.0 0.0 -0.362 17.0 17.0 CCND1 -0.022 0.125 -9999.0 0.0 -0.269 27.0 27.0 VAV2 -0.043 0.236 -9999.0 0.0 -0.645 18.0 18.0 RAP1/GDP 0.03 0.096 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.005 0.133 -9999.0 0.0 -0.479 8.0 8.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.008 0.077 -9999.0 0.0 -0.528 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.007 0.135 -9999.0 0.0 -0.67 1.0 1.0 E-cadherin/beta catenin -0.026 0.093 -9999.0 0.0 -0.4 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.005 0.133 -9999.0 0.0 -0.496 8.0 8.0 PIK3CA -0.003 0.107 -9999.0 0.0 -0.528 6.0 6.0 Rac1/GTP -0.089 0.166 -9999.0 0.0 -0.524 13.0 13.0 E-cadherin/beta catenin/alpha catenin 0.006 0.109 -9999.0 0.0 -0.415 8.0 8.0 ITGAE 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.006 0.138 -9999.0 0.0 -0.531 8.0 8.0