Signaling events mediated by HDAC Class III Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations EP300 -0.02 0.156 -9999.0 0.0 -0.644 9.0 9.0 HDAC4 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 induction of apoptosis -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of S phase of mitotic cell cycle -0.011 0.032 0.329 1.0 -9999.0 0.0 1.0 CDKN1A -0.01 0.121 -9999.0 0.0 -0.846 3.0 3.0 KAT2B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BAX 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOXO3 0.026 0.114 0.467 9.0 -0.298 1.0 10.0 FOXO1 -0.008 0.133 -9999.0 0.0 -0.668 6.0 6.0 FOXO4 0.011 0.078 -9999.0 0.0 -0.316 8.0 8.0 response to UV -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XRCC6 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TAT 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 mol:Lysophosphatidic acid -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYOD1 -0.011 0.111 -9999.0 0.0 -0.482 8.0 8.0 PPARGC1A -0.044 0.18 -9999.0 0.0 -0.544 17.0 17.0 FHL2 -0.129 0.266 -9999.0 0.0 -0.594 37.0 37.0 response to nutrient levels -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KU70/SIRT1 0.023 0.034 -9999.0 0.0 -0.318 1.0 1.0 HIST2H4A 0.011 0.032 -9999.0 0.0 -0.33 1.0 1.0 SIRT1/FOXO3a 0.017 0.084 0.319 9.0 -0.252 2.0 11.0 SIRT1 0.013 0.047 -9999.0 0.0 -0.462 1.0 1.0 response to hypoxia 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/MEF2D/HDAC4 0.032 0.037 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/Histone H1b 0.0 0.09 -9999.0 0.0 -0.458 1.0 1.0 apoptosis -0.033 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/PGC1A -0.035 0.11 -9999.0 0.0 -0.332 17.0 17.0 p53/SIRT1 -0.019 0.119 0.424 3.0 -0.384 11.0 14.0 SIRT1/FOXO4 0.014 0.07 -9999.0 0.0 -0.264 7.0 7.0 FOXO1/FHL2/SIRT1 -0.07 0.189 -9999.0 0.0 -0.434 26.0 26.0 HIST1H1E -0.006 0.102 -9999.0 0.0 -0.335 11.0 11.0 SIRT1/p300 -0.007 0.12 -9999.0 0.0 -0.452 10.0 10.0 muscle cell differentiation 0.019 0.096 0.389 9.0 -9999.0 0.0 9.0 TP53 -0.021 0.143 -9999.0 0.0 -0.545 10.0 10.0 KU70/SIRT1/BAX 0.034 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MEF2D 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HIV-1 Tat/SIRT1 0.021 0.043 -9999.0 0.0 -0.317 2.0 2.0 ACSS2 0.024 0.038 -9999.0 0.0 -0.318 1.0 1.0 SIRT1/PCAF/MYOD -0.019 0.096 -9999.0 0.0 -0.39 9.0 9.0