Class I PI3K signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ARF5/GTP -0.023 0.097 0.272 4.0 -0.316 2.0 6.0 DAPP1 -0.03 0.193 -9999.0 0.0 -0.579 10.0 10.0 Src family/SYK family/BLNK-LAT/BTK-ITK -0.026 0.237 -9999.0 0.0 -0.693 12.0 12.0 mol:DAG 0.013 0.109 0.22 1.0 -0.276 9.0 10.0 HRAS 0.006 0.086 -9999.0 0.0 -0.596 3.0 3.0 RAP1A 0.009 0.076 -9999.0 0.0 -0.653 2.0 2.0 ARF5/GDP 0.01 0.086 -9999.0 0.0 -0.288 5.0 5.0 PLCG2 -0.016 0.147 -9999.0 0.0 -0.641 8.0 8.0 PLCG1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF5 0.009 0.078 -9999.0 0.0 -0.668 2.0 2.0 mol:GTP -0.022 0.095 0.248 4.0 -0.324 9.0 13.0 ARF1/GTP -0.02 0.09 0.247 4.0 -0.31 9.0 13.0 RHOA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YES1 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 RAP1A/GTP -0.022 0.093 0.239 4.0 -0.321 9.0 13.0 ADAP1 -0.021 0.09 0.235 4.0 -0.309 9.0 13.0 ARAP3 -0.021 0.093 0.247 4.0 -0.318 9.0 13.0 INPPL1 0.005 0.085 -9999.0 0.0 -0.51 4.0 4.0 PREX1 -0.04 0.181 -9999.0 0.0 -0.584 15.0 15.0 ARHGEF6 0.002 0.102 -9999.0 0.0 -0.615 4.0 4.0 ARHGEF7 0.012 0.054 -9999.0 0.0 -0.458 2.0 2.0 ARF1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NRAS -0.006 0.113 -9999.0 0.0 -0.516 7.0 7.0 FYN 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 ARF6 -0.001 0.108 -9999.0 0.0 -0.584 5.0 5.0 FGR 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 mol:Ca2+ 0.017 0.065 -9999.0 0.0 -0.199 2.0 2.0 mol:IP4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZAP70 0.009 0.066 -9999.0 0.0 -0.458 3.0 3.0 mol:IP3 0.016 0.088 -9999.0 0.0 -0.265 6.0 6.0 LYN 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 ARF1/GDP 0.015 0.078 -9999.0 0.0 -0.273 3.0 3.0 RhoA/GDP -0.025 0.084 0.261 2.0 -0.33 1.0 3.0 PDK1/Src/Hsp90 0.033 0.043 -9999.0 0.0 -0.415 1.0 1.0 BLNK -0.007 0.127 -9999.0 0.0 -0.633 6.0 6.0 actin cytoskeleton reorganization 0.008 0.123 -9999.0 0.0 -0.42 3.0 3.0 SRC 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 PLEKHA2 0.006 0.078 -9999.0 0.0 -0.3 9.0 9.0 RAC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTEN -0.004 0.117 -9999.0 0.0 -0.644 5.0 5.0 HSP90AA1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.028 0.108 0.272 4.0 -0.422 3.0 7.0 RhoA/GTP -0.02 0.088 0.242 4.0 -9999.0 0.0 4.0 Src family/SYK family/BLNK-LAT -0.013 0.22 -9999.0 0.0 -0.742 8.0 8.0 BLK -0.035 0.159 -9999.0 0.0 -0.497 16.0 16.0 PDPK1 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 CYTH1 -0.021 0.09 0.235 4.0 -0.309 9.0 13.0 HCK -0.016 0.147 -9999.0 0.0 -0.641 8.0 8.0 CYTH3 -0.021 0.09 0.235 4.0 -0.309 9.0 13.0 CYTH2 -0.021 0.09 0.235 4.0 -0.309 9.0 13.0 KRAS -0.003 0.115 -9999.0 0.0 -0.624 5.0 5.0 GO:0030676 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOXO3 -0.012 0.068 0.203 4.0 -0.401 2.0 6.0 SGK1 -0.012 0.07 0.21 4.0 -0.547 1.0 5.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.005 0.081 -9999.0 0.0 -0.28 4.0 4.0 SOS1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SYK -0.023 0.16 -9999.0 0.0 -0.626 10.0 10.0 ARF6/GDP -0.033 0.1 0.268 2.0 -0.418 3.0 5.0 mol:PI-3-4-5-P3 -0.02 0.101 0.324 4.0 -0.324 9.0 13.0 ARAP3/RAP1A/GTP -0.022 0.094 0.24 4.0 -0.324 9.0 13.0 VAV1 -0.016 0.147 -9999.0 0.0 -0.641 8.0 8.0 mol:PI-3-4-P2 0.005 0.062 -9999.0 0.0 -0.37 4.0 4.0 RAS family/GTP/PI3K Class I 0.001 0.095 -9999.0 0.0 -0.329 9.0 9.0 PLEKHA1 -0.002 0.099 -9999.0 0.0 -0.352 11.0 11.0 Rac1/GDP 0.015 0.078 -9999.0 0.0 -0.289 2.0 2.0 LAT 0.006 0.076 -9999.0 0.0 -0.458 4.0 4.0 Rac1/GTP 0.008 0.115 -9999.0 0.0 -0.437 6.0 6.0 ITK -0.03 0.09 0.245 2.0 -0.326 1.0 3.0 Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma 0.007 0.146 0.25 1.0 -0.391 10.0 11.0 LCK -0.039 0.182 -9999.0 0.0 -0.608 14.0 14.0 BTK -0.052 0.124 0.245 1.0 -0.357 17.0 18.0