Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.009 0.126 -9999.0 0.0 -0.32 19.0 19.0 epithelial cell differentiation 0.001 0.112 -9999.0 0.0 -0.346 13.0 13.0 CYFIP2 0.005 0.085 -9999.0 0.0 -0.51 4.0 4.0 ENAH 0.01 0.132 -9999.0 0.0 -0.387 7.0 7.0 EGFR -0.093 0.24 -9999.0 0.0 -0.593 28.0 28.0 EPHA2 -0.054 0.201 -9999.0 0.0 -0.598 18.0 18.0 MYO6 -0.0 0.134 -9999.0 0.0 -0.503 4.0 4.0 CTNNB1 0.008 0.077 -9999.0 0.0 -0.528 3.0 3.0 ABI1/Sra1/Nap1 0.016 0.081 -9999.0 0.0 -0.415 2.0 2.0 AQP5 -0.114 0.21 -9999.0 0.0 -0.554 24.0 24.0 CTNND1 -0.004 0.122 -9999.0 0.0 -0.668 5.0 5.0 mol:PI-4-5-P2 0.006 0.112 -9999.0 0.0 -0.319 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.149 -9999.0 0.0 -0.399 9.0 9.0 EGF -0.126 0.249 -9999.0 0.0 -0.536 40.0 40.0 NCKAP1 -0.002 0.1 -9999.0 0.0 -0.493 6.0 6.0 AQP3 -0.172 0.224 -9999.0 0.0 -0.54 36.0 36.0 cortical microtubule organization 0.001 0.112 -9999.0 0.0 -0.346 13.0 13.0 GO:0000145 0.005 0.107 -9999.0 0.0 -0.305 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.004 0.114 -9999.0 0.0 -0.349 13.0 13.0 MLLT4 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.076 0.153 -9999.0 0.0 -0.564 9.0 9.0 ARF6 -0.001 0.108 -9999.0 0.0 -0.584 5.0 5.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.022 0.165 -9999.0 0.0 -0.44 16.0 16.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.008 0.118 -9999.0 0.0 -0.416 2.0 2.0 PVRL2 0.008 0.077 -9999.0 0.0 -0.528 3.0 3.0 ZYX -0.003 0.12 -9999.0 0.0 -0.324 15.0 15.0 ARF6/GTP -0.023 0.172 -9999.0 0.0 -0.415 19.0 19.0 CDH1 -0.019 0.151 -9999.0 0.0 -0.621 9.0 9.0 EGFR/EGFR/EGF/EGF -0.14 0.195 -9999.0 0.0 -0.58 17.0 17.0 RhoA/GDP -0.032 0.092 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.003 0.152 -9999.0 0.0 -0.701 4.0 4.0 IGF-1R heterotetramer -0.043 0.193 -9999.0 0.0 -0.652 14.0 14.0 GIT1 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 IGF1R -0.043 0.194 -9999.0 0.0 -0.653 14.0 14.0 IGF1 -0.12 0.256 -9999.0 0.0 -0.574 36.0 36.0 DIAPH1 -0.014 0.09 -9999.0 0.0 -0.716 2.0 2.0 Wnt receptor signaling pathway -0.001 0.112 0.346 13.0 -9999.0 0.0 13.0 RHOA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.069 0.14 -9999.0 0.0 -0.544 8.0 8.0 CTNNA1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.002 0.157 -9999.0 0.0 -0.731 4.0 4.0 EFNA1 -0.004 0.114 -9999.0 0.0 -0.563 6.0 6.0 LPP 0.011 0.117 -9999.0 0.0 -0.51 1.0 1.0 Ephrin A1/EPHA2 -0.072 0.152 -9999.0 0.0 -0.629 6.0 6.0 SEC6/SEC8 -0.033 0.091 -9999.0 0.0 -0.595 1.0 1.0 MGAT3 -0.031 0.152 -9999.0 0.0 -0.406 9.0 9.0 HGF/MET -0.045 0.105 -9999.0 0.0 -0.52 1.0 1.0 HGF 0.003 0.084 -9999.0 0.0 -0.458 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.009 0.127 -9999.0 0.0 -0.323 19.0 19.0 actin cable formation 0.028 0.122 -9999.0 0.0 -0.353 5.0 5.0 KIAA1543 0.004 0.122 -9999.0 0.0 -0.521 1.0 1.0 KIFC3 0.011 0.108 -9999.0 0.0 -0.324 13.0 13.0 NCK1 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 EXOC3 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.006 0.116 -9999.0 0.0 -0.341 13.0 13.0 NCK1/GIT1 0.009 0.091 -9999.0 0.0 -0.433 6.0 6.0 mol:GDP 0.001 0.112 -9999.0 0.0 -0.346 13.0 13.0 EXOC4 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 STX4 0.008 0.118 -9999.0 0.0 -0.346 14.0 14.0 PIP5K1C 0.005 0.114 -9999.0 0.0 -0.324 14.0 14.0 LIMA1 -0.025 0.165 -9999.0 0.0 -0.647 10.0 10.0 ABI1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.0 0.149 -9999.0 0.0 -0.461 8.0 8.0 adherens junction assembly 0.019 0.123 -9999.0 0.0 -0.428 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.117 0.164 -9999.0 0.0 -0.607 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.057 -9999.0 0.0 -0.373 3.0 3.0 MET -0.004 0.114 -9999.0 0.0 -0.563 6.0 6.0 PLEKHA7 0.008 0.11 -9999.0 0.0 -0.324 13.0 13.0 mol:GTP -0.023 0.163 -9999.0 0.0 -0.437 16.0 16.0 establishment of epithelial cell apical/basal polarity 0.035 0.118 -9999.0 0.0 -0.506 2.0 2.0 cortical actin cytoskeleton stabilization -0.009 0.126 -9999.0 0.0 -0.32 19.0 19.0 regulation of cell-cell adhesion 0.003 0.152 -9999.0 0.0 -0.701 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.009 0.127 -9999.0 0.0 -0.323 19.0 19.0