BMP receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BMP7/BMPR2/BMPR1A-1B/FS -0.062 0.204 -9999.0 0.0 -0.362 43.0 43.0 SMAD6-7/SMURF1 0.048 0.064 -9999.0 0.0 -0.317 4.0 4.0 NOG 0.031 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SMAD9 -0.035 0.175 -9999.0 0.0 -0.631 10.0 10.0 SMAD4 0.021 0.075 -9999.0 0.0 -0.51 3.0 3.0 SMAD5 -0.046 0.148 -9999.0 0.0 -0.439 12.0 12.0 BMP7/USAG1 -0.161 0.24 -9999.0 0.0 -0.459 55.0 55.0 SMAD5/SKI -0.038 0.155 0.284 1.0 -0.423 12.0 13.0 SMAD1 0.01 0.095 -9999.0 0.0 -0.441 5.0 5.0 BMP2 -0.062 0.194 -9999.0 0.0 -0.51 24.0 24.0 SMAD1/SMAD1/SMAD4 0.014 0.106 -9999.0 0.0 -0.439 4.0 4.0 BMPR1A 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 BMPR1B 0.026 0.024 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A-1B/BAMBI 0.022 0.106 -9999.0 0.0 -0.344 10.0 10.0 AHSG 0.017 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CER1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CER1 -0.018 0.142 -9999.0 0.0 -0.331 24.0 24.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.066 0.168 -9999.0 0.0 -0.439 17.0 17.0 BMP2-4 (homodimer) -0.037 0.159 -9999.0 0.0 -0.386 25.0 25.0 RGMB 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/BMPR2/BMPR1A-1B 0.038 0.098 -9999.0 0.0 -0.322 8.0 8.0 RGMA -0.062 0.198 -9999.0 0.0 -0.51 25.0 25.0 SMURF1 0.021 0.075 -9999.0 0.0 -0.51 3.0 3.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.061 0.155 -9999.0 0.0 -0.42 17.0 17.0 BMP2-4/USAG1 -0.131 0.208 -9999.0 0.0 -0.38 57.0 57.0 SMAD6/SMURF1/SMAD5 -0.04 0.155 0.284 1.0 -0.407 13.0 14.0 SOSTDC1 -0.151 0.237 -9999.0 0.0 -0.51 46.0 46.0 BMP7/BMPR2/BMPR1A-1B -0.015 0.152 -9999.0 0.0 -0.298 32.0 32.0 SKI 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BMP6 (homodimer) 0.005 0.099 -9999.0 0.0 -0.509 5.0 5.0 HFE2 0.022 0.062 -9999.0 0.0 -0.51 2.0 2.0 ZFYVE16 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CHRD -0.022 0.108 -9999.0 0.0 -0.326 14.0 14.0 SMAD5/SMAD5/SMAD4 -0.041 0.163 0.284 1.0 -0.423 14.0 15.0 MAPK1 0.026 0.044 -9999.0 0.0 -0.51 1.0 1.0 TAK1/TAB family -0.041 0.15 -9999.0 0.0 -0.388 15.0 15.0 BMP7 (homodimer) -0.077 0.21 -9999.0 0.0 -0.509 29.0 29.0 NUP214 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/FETUA 0.009 0.069 -9999.0 0.0 -0.371 4.0 4.0 SMAD1/SKI 0.022 0.11 -9999.0 0.0 -0.437 6.0 6.0 SMAD6 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/FETUA -0.02 0.109 -9999.0 0.0 -0.326 14.0 14.0 MAP3K7IP1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GREM1 -0.037 0.174 -9999.0 0.0 -0.51 18.0 18.0 BMPR2 (homodimer) 0.024 0.062 -9999.0 0.0 -0.509 2.0 2.0 GADD34/PP1CA 0.054 0.047 -9999.0 0.0 -0.309 2.0 2.0 BMPR1A-1B (homodimer) 0.034 0.054 -9999.0 0.0 -0.371 2.0 2.0 CHRDL1 0.025 0.048 -9999.0 0.0 -0.51 1.0 1.0 ENDOFIN/SMAD1 0.022 0.109 -9999.0 0.0 -0.435 6.0 6.0 SMAD6-7/SMURF1/SMAD1 0.037 0.116 -9999.0 0.0 -0.472 3.0 3.0 SMAD6/SMURF1 0.021 0.075 -9999.0 0.0 -0.509 3.0 3.0 BAMBI -0.007 0.128 -9999.0 0.0 -0.51 9.0 9.0 SMURF2 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 BMP2-4/CHRDL1 -0.017 0.146 -9999.0 0.0 -0.344 23.0 23.0 BMP2-4/GREM1 -0.056 0.185 -9999.0 0.0 -0.375 35.0 35.0 SMAD7 0.026 0.045 -9999.0 0.0 -0.51 1.0 1.0 SMAD8A/SMAD8A/SMAD4 -0.032 0.178 -9999.0 0.0 -0.609 10.0 10.0 SMAD1/SMAD6 0.015 0.115 -9999.0 0.0 -0.439 6.0 6.0 TAK1/SMAD6 0.037 0.059 -9999.0 0.0 -0.371 3.0 3.0 BMP7 -0.077 0.21 -9999.0 0.0 -0.51 29.0 29.0 BMP6 0.005 0.099 -9999.0 0.0 -0.51 5.0 5.0 MAP3K7IP2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.061 0.157 -9999.0 0.0 -0.431 16.0 16.0 PPM1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1/SMURF2 0.019 0.121 -9999.0 0.0 -0.488 6.0 6.0 SMAD7/SMURF1 0.032 0.068 -9999.0 0.0 -0.371 4.0 4.0 CTDSPL 0.026 0.045 -9999.0 0.0 -0.51 1.0 1.0 PPP1CA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PPP1R15A 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.119 0.23 -9999.0 0.0 -0.523 30.0 30.0 CHRD 0.016 0.018 -9999.0 0.0 -9999.0 0.0 0.0 BMPR2 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 BMP2-4/BMPR2/BMPR1A-1B/RGM -0.076 0.173 -9999.0 0.0 -0.476 17.0 17.0 BMP4 0.018 0.066 -9999.0 0.0 -0.51 2.0 2.0 FST -0.067 0.201 -9999.0 0.0 -0.51 26.0 26.0 BMP2-4/NOG -0.016 0.143 -9999.0 0.0 -0.332 24.0 24.0 BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.009 0.158 -9999.0 0.0 -0.299 31.0 31.0