p75(NTR)-mediated signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Sortilin/TRAF6 0.031 0.075 -9999.0 0.0 -0.371 5.0 5.0 Necdin/E2F1 -0.003 0.125 -9999.0 0.0 -0.371 15.0 15.0 proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.034 0.09 -9999.0 0.0 -0.272 10.0 10.0 NGF (dimer)/p75(NTR)/BEX1 0.018 0.047 -9999.0 0.0 -0.314 1.0 1.0 NT-4/5 (dimer)/p75(NTR) 0.017 0.022 -9999.0 0.0 -9999.0 0.0 0.0 IKBKB 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.066 0.12 -9999.0 0.0 -0.31 6.0 6.0 IKBKG 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BDNF -0.024 0.146 -9999.0 0.0 -0.51 12.0 12.0 MGDIs/NGR/p75(NTR)/LINGO1 0.019 0.094 -9999.0 0.0 -0.32 9.0 9.0 FURIN 0.013 0.097 -9999.0 0.0 -0.51 5.0 5.0 proBDNF (dimer)/p75(NTR)/Sortilin 0.005 0.113 -9999.0 0.0 -0.323 14.0 14.0 LINGO1 0.024 0.029 -9999.0 0.0 -9999.0 0.0 0.0 Sortilin/TRAF6/NRIF 0.016 0.079 -9999.0 0.0 -0.277 9.0 9.0 proBDNF (dimer) -0.024 0.146 -9999.0 0.0 -0.509 12.0 12.0 NTRK1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RTN4R -0.003 0.127 -9999.0 0.0 -0.51 9.0 9.0 neuron apoptosis -0.031 0.13 -9999.0 0.0 -0.544 5.0 5.0 IRAK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.011 0.018 -9999.0 0.0 -9999.0 0.0 0.0 ARHGDIA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Gamma Secretase 0.065 0.083 -9999.0 0.0 -0.324 5.0 5.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.035 0.075 -9999.0 0.0 -0.352 4.0 4.0 MAGEH1 0.018 0.077 -9999.0 0.0 -0.51 3.0 3.0 proNGF (dimer)/p75(NTR)/Sortilin/Necdin 0.001 0.118 -9999.0 0.0 -0.302 18.0 18.0 Mammalian IAPs/DIABLO 0.02 0.102 -9999.0 0.0 -0.287 14.0 14.0 proNGF (dimer) -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAGED1 0.017 0.087 -9999.0 0.0 -0.51 4.0 4.0 APP 0.009 0.105 -9999.0 0.0 -0.51 6.0 6.0 NT-4/5 (dimer) -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZNF274 0.028 0.044 -9999.0 0.0 -0.51 1.0 1.0 RhoA/GDP/RHOGDI 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 NGF -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell cycle arrest -0.01 0.034 -9999.0 0.0 -0.263 2.0 2.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.015 0.047 -9999.0 0.0 -0.251 4.0 4.0 NT-4/5 (dimer)/p75(NTR)/TRAF6 0.028 0.056 -9999.0 0.0 -0.324 3.0 3.0 NCSTN 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.03 0.039 -9999.0 0.0 -0.313 1.0 1.0 PSENEN 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:ceramide 0.008 0.038 -9999.0 0.0 -0.285 2.0 2.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs -0.002 0.048 -9999.0 0.0 -0.231 1.0 1.0 p75(NTR)/beta APP 0.017 0.087 -9999.0 0.0 -0.376 6.0 6.0 BEX1 0.01 0.059 -9999.0 0.0 -0.51 1.0 1.0 mol:GDP -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer) 0.0 0.132 -9999.0 0.0 -0.299 24.0 24.0 MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.032 0.094 -9999.0 0.0 -0.292 9.0 9.0 PIK3R1 0.004 0.098 -9999.0 0.0 -0.51 5.0 5.0 RAC1/GTP 0.03 0.022 -9999.0 0.0 -9999.0 0.0 0.0 MYD88 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CHUK 0.028 0.044 -9999.0 0.0 -0.51 1.0 1.0 NGF (dimer)/p75(NTR)/PKA 0.03 0.039 -9999.0 0.0 -0.314 1.0 1.0 RHOB 0.017 0.077 -9999.0 0.0 -0.51 3.0 3.0 RHOA 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MAGE-G1/E2F1 0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 NT3 (dimer) -0.007 0.115 -9999.0 0.0 -0.509 7.0 7.0 TP53 -0.034 0.106 -9999.0 0.0 -0.282 19.0 19.0 PRDM4 0.008 0.039 -9999.0 0.0 -0.286 2.0 2.0 BDNF (dimer) -0.121 0.194 -9999.0 0.0 -0.341 61.0 61.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.51 2.0 2.0 SORT1 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 activation of caspase activity 0.029 0.087 -9999.0 0.0 -0.27 10.0 10.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.037 0.069 -9999.0 0.0 -0.293 5.0 5.0 RHOC 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 -0.038 0.101 -9999.0 0.0 -0.355 6.0 6.0 DIABLO 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMPD2 0.009 0.038 -9999.0 0.0 -0.286 2.0 2.0 APH1B 0.029 0.044 -9999.0 0.0 -0.51 1.0 1.0 APH1A 0.013 0.096 -9999.0 0.0 -0.51 5.0 5.0 proNGF (dimer)/p75(NTR)/Sortilin 0.028 0.048 -9999.0 0.0 -0.314 2.0 2.0 PSEN1 0.028 0.044 -9999.0 0.0 -0.51 1.0 1.0 APAF-1/Pro-Caspase 9 0.044 0.034 -9999.0 0.0 -0.371 1.0 1.0 NT3 (dimer)/p75(NTR) 0.006 0.092 -9999.0 0.0 -0.371 7.0 7.0 MAPK8 -0.026 0.097 -9999.0 0.0 -0.35 5.0 5.0 MAPK9 -0.03 0.095 -9999.0 0.0 -0.35 5.0 5.0 APAF1 0.029 0.044 -9999.0 0.0 -0.51 1.0 1.0 NTF3 -0.007 0.115 -9999.0 0.0 -0.51 7.0 7.0 NTF4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NDN -0.035 0.169 -9999.0 0.0 -0.51 17.0 17.0 RAC1/GDP 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA-B-C/GDP 0.038 0.063 -9999.0 0.0 -0.251 4.0 4.0 p75 CTF/Sortilin/TRAF6/NRIF 0.057 0.082 -9999.0 0.0 -0.293 7.0 7.0 RhoA-B-C/GTP 0.03 0.039 -9999.0 0.0 -0.312 1.0 1.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.019 0.123 -9999.0 0.0 -0.282 18.0 18.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.012 0.12 -9999.0 0.0 -0.296 17.0 17.0 PRKACB 0.027 0.045 -9999.0 0.0 -0.51 1.0 1.0 proBDNF (dimer)/p75 ECD -0.002 0.117 -9999.0 0.0 -0.371 13.0 13.0 ChemicalAbstracts:86-01-1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 -0.027 0.156 -9999.0 0.0 -0.51 14.0 14.0 BIRC2 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 neuron projection morphogenesis -0.029 0.066 -9999.0 0.0 -0.325 2.0 2.0 BAD -0.035 0.098 -9999.0 0.0 -0.357 5.0 5.0 RIPK2 0.026 0.046 -9999.0 0.0 -0.51 1.0 1.0 NGFR 0.021 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CYCS 0.0 0.065 -9999.0 0.0 -0.32 5.0 5.0 ADAM17 0.027 0.045 -9999.0 0.0 -0.51 1.0 1.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.038 0.064 -9999.0 0.0 -0.294 4.0 4.0 BCL2L11 -0.034 0.097 -9999.0 0.0 -0.357 5.0 5.0 BDNF (dimer)/p75(NTR) -0.006 0.116 -9999.0 0.0 -0.379 12.0 12.0 PI3K 0.005 0.065 -9999.0 0.0 -0.287 5.0 5.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.043 0.052 -9999.0 0.0 -0.287 2.0 2.0 NDNL2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 YWHAE 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PRKCI -0.004 0.103 -9999.0 0.0 -0.51 6.0 6.0 NGF (dimer)/p75(NTR) 0.017 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ChemicalAbstracts:146-91-8 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.034 0.079 -9999.0 0.0 -0.339 5.0 5.0 TRAF6 0.021 0.075 -9999.0 0.0 -0.51 3.0 3.0 RAC1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLG 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 oligodendrocyte cell fate commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP6 -0.015 0.087 -9999.0 0.0 -0.278 14.0 14.0 SQSTM1 0.028 0.019 -9999.0 0.0 -9999.0 0.0 0.0 NGFRAP1 0.003 0.12 -9999.0 0.0 -0.51 8.0 8.0 CASP3 -0.035 0.096 -9999.0 0.0 -0.335 6.0 6.0 E2F1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CASP9 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex 0.057 0.066 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/TRKA 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MMP7 -0.046 0.189 -9999.0 0.0 -0.51 22.0 22.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.045 0.076 -9999.0 0.0 -0.277 6.0 6.0 MMP3 -0.131 0.224 -9999.0 0.0 -0.51 39.0 39.0 APAF-1/Caspase 9 -0.025 0.089 -9999.0 0.0 -0.427 2.0 2.0