Presenilin action in Notch and Wnt signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Delta 1/NOTCH/NOTCH(cleaved) 0.025 0.119 -9999.0 0.0 -0.457 7.0 7.0 HDAC1 0.033 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AES 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DTX1 0.028 0.044 -9999.0 0.0 -0.51 1.0 1.0 LRP6/FZD1 0.037 0.05 -9999.0 0.0 -0.37 2.0 2.0 TLE1 0.021 0.074 -9999.0 0.0 -0.5 3.0 3.0 AP1 -0.023 0.103 -9999.0 0.0 -0.276 19.0 19.0 NCSTN 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADAM10 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.017 0.191 -9999.0 0.0 -0.828 6.0 6.0 NICD/RBPSUH 0.027 0.115 -9999.0 0.0 -0.437 8.0 8.0 WIF1 -0.063 0.182 -9999.0 0.0 -0.509 21.0 21.0 NOTCH1 0.003 0.114 -9999.0 0.0 -0.464 8.0 8.0 PSENEN 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 KREMEN2 -0.099 0.207 -9999.0 0.0 -0.51 30.0 30.0 DKK1 -0.094 0.205 -9999.0 0.0 -0.51 29.0 29.0 beta catenin/beta TrCP1 0.011 0.084 -9999.0 0.0 -0.3 4.0 4.0 APH1B 0.029 0.044 -9999.0 0.0 -0.509 1.0 1.0 APH1A 0.013 0.096 -9999.0 0.0 -0.509 5.0 5.0 AXIN1 0.001 0.101 -9999.0 0.0 -0.54 4.0 4.0 CtBP/CBP/TCF1/TLE1/AES 0.02 0.073 0.265 2.0 -0.336 1.0 3.0 PSEN1 0.028 0.044 -9999.0 0.0 -0.51 1.0 1.0 FOS -0.03 0.156 -9999.0 0.0 -0.51 14.0 14.0 JUN 0.002 0.114 -9999.0 0.0 -0.51 7.0 7.0 MAP3K7 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 -0.003 0.082 -9999.0 0.0 -0.297 6.0 6.0 MAPK3 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DKK2/LRP6/Kremen 2 -0.055 0.151 -9999.0 0.0 -0.32 35.0 35.0 HNF1A 0.028 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CTBP1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MYC -0.034 0.289 -9999.0 0.0 -1.459 6.0 6.0 NKD1 0.026 0.024 -9999.0 0.0 -9999.0 0.0 0.0 FZD1 0.026 0.045 -9999.0 0.0 -0.509 1.0 1.0 NOTCH1 precursor/Deltex homolog 1 0.028 0.119 -9999.0 0.0 -0.445 8.0 8.0 apoptosis -0.023 0.103 -9999.0 0.0 -0.275 19.0 19.0 Delta 1/NOTCHprecursor 0.024 0.12 -9999.0 0.0 -0.456 7.0 7.0 DLL1 0.019 0.076 -9999.0 0.0 -0.51 3.0 3.0 PPARD 0.024 0.031 -9999.0 0.0 -9999.0 0.0 0.0 Gamma Secretase 0.065 0.083 -9999.0 0.0 -0.324 5.0 5.0 APC -0.009 0.126 -9999.0 0.0 -0.486 8.0 8.0 DVL1 0.007 0.055 -9999.0 0.0 -0.315 3.0 3.0 CSNK2A1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DKK1/LRP6/Kremen 2 -0.119 0.186 -9999.0 0.0 -0.357 53.0 53.0 LRP6 0.027 0.045 -9999.0 0.0 -0.509 1.0 1.0 CSNK1A1 0.027 0.044 -9999.0 0.0 -0.509 1.0 1.0 NLK 0.019 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 -0.099 0.392 -9999.0 0.0 -1.433 12.0 12.0 WNT1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Axin1/APC/beta catenin 0.006 0.123 -9999.0 0.0 -0.428 8.0 8.0 DKK2 0.01 0.089 -9999.0 0.0 -0.51 4.0 4.0 NOTCH1 precursor/DVL1 0.013 0.133 -9999.0 0.0 -0.476 8.0 8.0 GSK3B 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 FRAT1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH/Deltex homolog 1 0.029 0.118 -9999.0 0.0 -0.446 8.0 8.0 PPP2R5D 0.017 0.049 -9999.0 0.0 -0.34 2.0 2.0 MAPK1 0.026 0.044 -9999.0 0.0 -0.51 1.0 1.0 WNT1/LRP6/FZD1 -0.001 0.125 -9999.0 0.0 -0.289 21.0 21.0 RBPJ 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0