HIV-1 Nef: Negative effector of Fas and TNF-alpha Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BAG4 0.027 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Caspase 8 (4 units) -0.009 0.172 -9999.0 0.0 -0.512 10.0 10.0 NEF -0.011 0.046 -9999.0 0.0 -0.273 3.0 3.0 NFKBIA 0.012 0.064 -9999.0 0.0 -0.605 1.0 1.0 BIRC3 -0.029 0.171 -9999.0 0.0 -0.515 15.0 15.0 CYCS -0.028 0.139 0.193 2.0 -0.382 13.0 15.0 RIPK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CD247 -0.054 0.21 -9999.0 0.0 -0.596 19.0 19.0 MAP2K7 -0.014 0.17 -9999.0 0.0 -0.608 7.0 7.0 protein ubiquitination 0.016 0.088 -9999.0 0.0 -0.325 4.0 4.0 CRADD 0.026 0.061 -9999.0 0.0 -0.51 2.0 2.0 DAXX 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 FAS -0.019 0.151 -9999.0 0.0 -0.51 13.0 13.0 BID -0.032 0.146 0.191 4.0 -0.378 16.0 20.0 NF-kappa-B/RelA/I kappa B alpha 0.026 0.109 -9999.0 0.0 -0.305 12.0 12.0 TRADD 0.027 0.044 -9999.0 0.0 -0.51 1.0 1.0 MAP3K5 0.021 0.075 -9999.0 0.0 -0.51 3.0 3.0 CFLAR 0.01 0.105 -9999.0 0.0 -0.51 6.0 6.0 FADD 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 NF-kappa-B/RelA/I kappa B alpha/ubiquitin 0.026 0.11 -9999.0 0.0 -0.307 12.0 12.0 MAPK8 -0.011 0.159 -9999.0 0.0 -0.604 6.0 6.0 APAF1 0.029 0.044 -9999.0 0.0 -0.51 1.0 1.0 TRAF1 0.023 0.064 -9999.0 0.0 -0.51 2.0 2.0 TRAF2 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG -0.03 0.152 0.199 4.0 -0.328 25.0 29.0 TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD 0.019 0.1 -9999.0 0.0 -0.364 4.0 4.0 CHUK 0.017 0.092 -9999.0 0.0 -0.353 4.0 4.0 FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0.032 0.12 -9999.0 0.0 -0.291 15.0 15.0 TCRz/NEF -0.049 0.192 -9999.0 0.0 -0.54 19.0 19.0 TNF 0.024 0.048 -9999.0 0.0 -0.51 1.0 1.0 FASLG -0.074 0.239 -9999.0 0.0 -0.649 20.0 20.0 NFKB1 0.016 0.041 -9999.0 0.0 -9999.0 0.0 0.0 TNFR1A/BAG4/TNF-alpha 0.036 0.062 -9999.0 0.0 -0.317 3.0 3.0 CASP6 -0.022 0.213 -9999.0 0.0 -0.681 11.0 11.0 CASP7 -0.045 0.215 -9999.0 0.0 -0.585 17.0 17.0 RELA 0.016 0.045 -9999.0 0.0 -0.159 2.0 2.0 CASP2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CASP3 -0.051 0.218 -9999.0 0.0 -0.582 18.0 18.0 TNFRSF1A 0.016 0.086 -9999.0 0.0 -0.51 4.0 4.0 TNFR1A/BAG4 0.028 0.061 -9999.0 0.0 -0.371 3.0 3.0 CASP8 0.021 0.075 -9999.0 0.0 -0.51 3.0 3.0 CASP9 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K14 0.019 0.103 -9999.0 0.0 -0.391 4.0 4.0 APAF-1/Caspase 9 -0.038 0.16 -9999.0 0.0 -0.455 14.0 14.0 BCL2 -0.023 0.158 -9999.0 0.0 -0.554 7.0 7.0