BCR signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations JUN -0.097 0.206 -9999.0 0.0 -0.497 26.0 26.0 IKBKB -0.004 0.12 -9999.0 0.0 -0.311 11.0 11.0 AKT1 -0.004 0.142 0.235 15.0 -0.258 20.0 35.0 IKBKG -0.009 0.117 0.208 1.0 -0.305 10.0 11.0 CALM1 -0.071 0.244 0.323 1.0 -0.642 20.0 21.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.509 2.0 2.0 MAP3K1 -0.129 0.285 -9999.0 0.0 -0.672 28.0 28.0 MAP3K7 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.077 0.264 0.341 1.0 -0.653 22.0 23.0 DOK1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AP-1 -0.052 0.118 0.193 1.0 -0.277 25.0 26.0 LYN 0.027 0.044 -9999.0 0.0 -0.509 1.0 1.0 BLNK 0.013 0.096 -9999.0 0.0 -0.509 5.0 5.0 SHC1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BCR complex -0.052 0.201 -9999.0 0.0 -0.473 26.0 26.0 CD22 -0.116 0.307 -9999.0 0.0 -0.826 21.0 21.0 CAMK2G -0.061 0.225 0.306 2.0 -0.586 20.0 22.0 CSNK2A1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 INPP5D 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC/GRB2/SOS1 -0.047 0.169 -9999.0 0.0 -0.366 28.0 28.0 GO:0007205 -0.081 0.274 0.34 1.0 -0.673 22.0 23.0 SYK 0.009 0.105 -9999.0 0.0 -0.509 6.0 6.0 ELK1 -0.074 0.251 0.324 1.0 -0.659 20.0 21.0 NFATC1 -0.124 0.276 -9999.0 0.0 -0.629 28.0 28.0 B-cell antigen/BCR complex -0.052 0.201 -9999.0 0.0 -0.473 26.0 26.0 PAG1/CSK 0.027 0.082 -9999.0 0.0 -0.371 6.0 6.0 NFKBIB 0.016 0.052 0.125 1.0 -0.125 5.0 6.0 HRAS -0.067 0.228 0.274 1.0 -0.55 23.0 24.0 NFKBIA 0.016 0.051 0.125 1.0 -0.12 6.0 7.0 NF-kappa-B/RelA/I kappa B beta 0.023 0.045 0.126 1.0 -9999.0 0.0 1.0 RasGAP/Csk -0.036 0.221 -9999.0 0.0 -0.429 31.0 31.0 mol:GDP -0.074 0.257 0.331 1.0 -0.633 22.0 23.0 PTEN 0.025 0.045 -9999.0 0.0 -0.51 1.0 1.0 CD79B -0.051 0.189 -9999.0 0.0 -0.509 22.0 22.0 NF-kappa-B/RelA/I kappa B alpha 0.023 0.045 0.126 1.0 -9999.0 0.0 1.0 GRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K/BCAP/CD19 -0.122 0.26 -9999.0 0.0 -0.631 27.0 27.0 PIK3R1 0.004 0.098 -9999.0 0.0 -0.51 5.0 5.0 mol:IP3 -0.082 0.28 0.342 1.0 -0.686 22.0 23.0 CSK 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.09 0.234 0.309 1.0 -0.613 21.0 22.0 CHUK -0.016 0.128 -9999.0 0.0 -0.326 13.0 13.0 IBTK 0.029 0.044 -9999.0 0.0 -0.509 1.0 1.0 CARD11/BCL10/MALT1/TAK1 -0.041 0.216 0.301 1.0 -0.574 18.0 19.0 PTPN6 -0.113 0.282 -9999.0 0.0 -0.763 21.0 21.0 RELA 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCL2A1 0.009 0.043 -9999.0 0.0 -0.116 2.0 2.0 VAV2 -0.174 0.371 -9999.0 0.0 -0.823 31.0 31.0 ubiquitin-dependent protein catabolic process 0.019 0.051 0.127 1.0 -0.119 5.0 6.0 BTK -0.098 0.354 -9999.0 0.0 -1.209 14.0 14.0 CD19 -0.159 0.362 -9999.0 0.0 -0.9 25.0 25.0 MAP4K1 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CD72 -0.036 0.173 -9999.0 0.0 -0.51 18.0 18.0 PAG1 0.008 0.105 -9999.0 0.0 -0.51 6.0 6.0 MAPK14 -0.104 0.231 -9999.0 0.0 -0.551 27.0 27.0 SH3BP5 0.026 0.046 -9999.0 0.0 -0.509 1.0 1.0 PIK3AP1 -0.095 0.291 -9999.0 0.0 -0.726 22.0 22.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.115 0.36 -9999.0 0.0 -0.771 27.0 27.0 RAF1 -0.063 0.21 0.261 1.0 -0.552 20.0 21.0 RasGAP/p62DOK/SHIP -0.04 0.202 -9999.0 0.0 -0.403 31.0 31.0 CD79A -0.022 0.151 -9999.0 0.0 -0.509 13.0 13.0 re-entry into mitotic cell cycle -0.052 0.119 0.197 1.0 -0.279 25.0 26.0 RASA1 0.026 0.044 -9999.0 0.0 -0.51 1.0 1.0 MAPK3 -0.051 0.171 0.237 1.0 -0.472 18.0 19.0 MAPK1 -0.043 0.173 0.334 3.0 -0.461 17.0 20.0 CD72/SHP1 -0.095 0.312 0.347 2.0 -0.724 25.0 27.0 NFKB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.102 0.231 -9999.0 0.0 -0.554 27.0 27.0 actin cytoskeleton organization -0.135 0.288 0.353 1.0 -0.656 30.0 31.0 NF-kappa-B/RelA 0.046 0.089 0.236 1.0 -0.245 1.0 2.0 Calcineurin -0.035 0.219 0.304 1.0 -0.567 19.0 20.0 PI3K -0.108 0.213 -9999.0 0.0 -0.562 23.0 23.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.088 0.295 0.374 1.0 -0.703 23.0 24.0 SOS1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Bam32/HPK1 -0.163 0.374 -9999.0 0.0 -0.855 32.0 32.0 DAPP1 -0.207 0.44 -9999.0 0.0 -1.002 33.0 33.0 cytokine secretion -0.111 0.247 -9999.0 0.0 -0.566 28.0 28.0 mol:DAG -0.082 0.28 0.342 1.0 -0.686 22.0 23.0 PLCG2 0.013 0.096 -9999.0 0.0 -0.509 5.0 5.0 MAP2K1 -0.058 0.191 0.25 1.0 -0.531 18.0 19.0 B-cell antigen/BCR complex/FcgammaRIIB -0.061 0.236 -9999.0 0.0 -0.495 30.0 30.0 mol:PI-3-4-5-P3 -0.047 0.158 0.236 7.0 -0.364 20.0 27.0 ETS1 -0.056 0.202 0.293 2.0 -0.515 21.0 23.0 B-cell antigen/BCR complex/LYN/SYK/BLNK -0.025 0.212 -9999.0 0.0 -0.41 30.0 30.0 B-cell antigen/BCR complex/LYN -0.121 0.329 -9999.0 0.0 -0.858 22.0 22.0 MALT1 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 TRAF6 0.021 0.075 -9999.0 0.0 -0.509 3.0 3.0 RAC1 -0.153 0.318 -9999.0 0.0 -0.729 30.0 30.0 B-cell antigen/BCR complex/LYN/SYK -0.07 0.309 0.385 1.0 -0.74 22.0 23.0 CARD11 -0.074 0.254 0.323 1.0 -0.646 21.0 22.0 FCGR2B -0.025 0.165 -9999.0 0.0 -0.51 16.0 16.0 PPP3CA 0.028 0.044 -9999.0 0.0 -0.51 1.0 1.0 BCL10 0.028 0.045 -9999.0 0.0 -0.51 1.0 1.0 IKK complex 0.015 0.06 0.129 6.0 -0.13 3.0 9.0 PTPRC -0.024 0.161 -9999.0 0.0 -0.509 15.0 15.0 PDPK1 -0.015 0.127 0.224 12.0 -0.253 16.0 28.0 PPP3CB 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PPP3CC 0.022 0.062 -9999.0 0.0 -0.51 2.0 2.0 POU2F2 0.019 0.032 -9999.0 0.0 -9999.0 0.0 0.0