Integrins in angiogenesis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.033 0.061 -9999.0 0.0 -0.371 3.0 3.0 alphaV beta3 Integrin 0.029 0.095 -9999.0 0.0 -0.322 9.0 9.0 PTK2 0.001 0.142 0.305 1.0 -0.547 6.0 7.0 IGF1R -0.008 0.139 -9999.0 0.0 -0.51 11.0 11.0 PI4KB 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MFGE8 0.028 0.044 -9999.0 0.0 -0.51 1.0 1.0 SRC 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1B 0.016 0.039 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA 0.025 0.061 -9999.0 0.0 -0.51 2.0 2.0 ILK 0.017 0.039 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.011 0.05 -9999.0 0.0 -0.283 2.0 2.0 PTK2B 0.009 0.093 -9999.0 0.0 -0.341 7.0 7.0 alphaV/beta3 Integrin/JAM-A 0.023 0.108 -9999.0 0.0 -0.3 13.0 13.0 CBL 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin/ANGPTL3 0.039 0.079 -9999.0 0.0 -0.314 6.0 6.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.028 0.167 -9999.0 0.0 -0.321 34.0 34.0 VEGF/Rho/ROCK/alphaV/beta3 Integrin 0.004 0.088 -9999.0 0.0 -0.36 6.0 6.0 alphaV/beta3 Integrin/Syndecan-1 0.014 0.128 -9999.0 0.0 -0.353 15.0 15.0 PI4KA 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 -0.066 0.193 -9999.0 0.0 -0.363 38.0 38.0 PI4 Kinase 0.042 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.51 2.0 2.0 alphaV/beta3 Integrin/Osteopontin -0.052 0.162 -9999.0 0.0 -0.337 34.0 34.0 RPS6KB1 -0.094 0.162 -9999.0 0.0 -0.476 16.0 16.0 TLN1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.058 0.187 -9999.0 0.0 -0.63 12.0 12.0 GPR124 0.026 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.059 0.192 -9999.0 0.0 -0.644 12.0 12.0 PXN 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.004 0.098 -9999.0 0.0 -0.51 5.0 5.0 alphaV/beta3 Integrin/Tumstatin 0.04 0.083 -9999.0 0.0 -0.317 7.0 7.0 cell adhesion 0.018 0.085 -9999.0 0.0 -0.283 9.0 9.0 ANGPTL3 0.026 0.046 -9999.0 0.0 -0.51 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/Src 0.047 0.059 -9999.0 0.0 -0.317 3.0 3.0 IGF-1R heterotetramer -0.008 0.139 -9999.0 0.0 -0.509 11.0 11.0 Rac1/GDP 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 TGFBR2 0.025 0.046 -9999.0 0.0 -0.51 1.0 1.0 ITGB3 0.024 0.048 -9999.0 0.0 -0.51 1.0 1.0 IGF1 -0.049 0.181 -9999.0 0.0 -0.51 20.0 20.0 RAC1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-matrix adhesion 0.033 0.073 -9999.0 0.0 -0.312 5.0 5.0 apoptosis 0.013 0.096 -9999.0 0.0 -0.508 5.0 5.0 CD47 0.013 0.087 -9999.0 0.0 -0.51 4.0 4.0 alphaV/beta3 Integrin/CD47 0.025 0.092 -9999.0 0.0 -0.317 9.0 9.0 VCL 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 alphaV/beta3 Integrin/Del1 -0.013 0.142 -9999.0 0.0 -0.369 18.0 18.0 CSF1 0.03 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIK3C2A 0.011 0.068 -9999.0 0.0 -0.471 2.0 2.0 PI4 Kinase/Pyk2 0.009 0.09 -9999.0 0.0 -0.356 5.0 5.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.045 0.101 -9999.0 0.0 -0.363 7.0 7.0 FAK1/Vinculin 0.017 0.127 0.293 1.0 -0.424 7.0 8.0 alphaV beta3/Integrin/ppsTEM5 0.034 0.074 -9999.0 0.0 -0.313 5.0 5.0 RHOA 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 VTN 0.03 0.014 -9999.0 0.0 -9999.0 0.0 0.0 BCAR1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 FGF2 0.016 0.077 -9999.0 0.0 -0.51 3.0 3.0 F11R -0.007 0.086 -9999.0 0.0 -0.371 8.0 8.0 alphaV/beta3 Integrin/Lactadherin 0.041 0.078 -9999.0 0.0 -0.317 6.0 6.0 alphaV/beta3 Integrin/TGFBR2 0.037 0.089 -9999.0 0.0 -0.357 6.0 6.0 alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.061 0.07 -9999.0 0.0 -0.284 5.0 5.0 HSP90AA1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Talin 0.038 0.071 -9999.0 0.0 -0.285 6.0 6.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 -0.011 0.134 -9999.0 0.0 -0.51 10.0 10.0 alphaV/beta3 Integrin/Pyk2 0.034 0.097 -9999.0 0.0 -0.343 7.0 7.0 SDC1 -0.008 0.139 -9999.0 0.0 -0.51 11.0 11.0 VAV3 -0.05 0.13 -9999.0 0.0 -0.292 31.0 31.0 PTPN11 0.029 0.044 -9999.0 0.0 -0.51 1.0 1.0 IRS1 0.004 0.114 -9999.0 0.0 -0.51 7.0 7.0 FAK1/Paxillin 0.02 0.124 0.293 1.0 -0.427 6.0 7.0 cell migration 0.013 0.117 0.261 2.0 -0.383 7.0 9.0 ITGAV 0.013 0.097 -9999.0 0.0 -0.51 5.0 5.0 PI3K -0.004 0.103 -9999.0 0.0 -0.307 11.0 11.0 SPP1 -0.103 0.216 -9999.0 0.0 -0.51 33.0 33.0 KDR 0.021 0.062 -9999.0 0.0 -0.51 2.0 2.0 mol:PI-4-5-P2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Caspase 8 0.013 0.096 -9999.0 0.0 -0.509 5.0 5.0 COL4A3 0.028 0.044 -9999.0 0.0 -0.51 1.0 1.0 angiogenesis -0.05 0.195 -9999.0 0.0 -0.643 12.0 12.0 Rac1/GTP -0.038 0.127 -9999.0 0.0 -0.272 30.0 30.0 EDIL3 -0.041 0.159 -9999.0 0.0 -0.51 15.0 15.0 cell proliferation 0.037 0.088 -9999.0 0.0 -0.356 6.0 6.0