E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.023 0.134 -9999.0 0.0 -0.396 14.0 14.0 KLHL20 -0.007 0.107 0.206 1.0 -0.306 9.0 10.0 CYFIP2 0.025 0.046 -9999.0 0.0 -0.51 1.0 1.0 Rac1/GDP 0.001 0.102 -9999.0 0.0 -0.295 1.0 1.0 ENAH -0.023 0.139 -9999.0 0.0 -0.402 15.0 15.0 AP1M1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 CTNNB1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.074 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.031 0.058 -9999.0 0.0 -0.2 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.052 0.082 -9999.0 0.0 -0.287 7.0 7.0 RAPGEF1 -0.016 0.122 -9999.0 0.0 -0.402 8.0 8.0 CTNND1 0.015 0.096 -9999.0 0.0 -0.51 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.019 0.146 -9999.0 0.0 -0.412 15.0 15.0 CRK -0.016 0.127 -9999.0 0.0 -0.404 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.017 0.124 -9999.0 0.0 -0.334 16.0 16.0 alphaE/beta7 Integrin 0.045 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.047 -9999.0 0.0 -0.51 1.0 1.0 Rap1/GTP/I-afadin 0.051 0.044 -9999.0 0.0 -0.287 2.0 2.0 DLG1 -0.018 0.108 -9999.0 0.0 -0.38 9.0 9.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.009 0.043 -9999.0 0.0 -0.252 2.0 2.0 MLLT4 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.053 0.044 -9999.0 0.0 -0.288 2.0 2.0 PI3K -0.01 0.057 -9999.0 0.0 -0.331 2.0 2.0 ARF6 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.002 0.135 -9999.0 0.0 -0.389 16.0 16.0 TIAM1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.039 0.095 -9999.0 0.0 -0.271 12.0 12.0 AKT1 0.005 0.054 0.156 1.0 -0.22 3.0 4.0 PIK3R1 0.004 0.098 -9999.0 0.0 -0.51 5.0 5.0 CDH1 0.005 0.113 -9999.0 0.0 -0.51 7.0 7.0 RhoA/GDP 0.005 0.1 0.25 1.0 -0.284 2.0 3.0 actin cytoskeleton organization -0.003 0.079 0.156 2.0 -0.223 8.0 10.0 CDC42/GDP 0.003 0.102 0.25 1.0 -0.289 2.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.102 -9999.0 0.0 -0.267 20.0 20.0 ITGB7 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.043 0.102 -9999.0 0.0 -0.288 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.07 -9999.0 0.0 -0.268 7.0 7.0 mol:GDP -0.014 0.108 -9999.0 0.0 -0.324 5.0 5.0 CDC42/GTP/IQGAP1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.004 0.134 -9999.0 0.0 -0.51 10.0 10.0 p120 catenin/RhoA/GDP 0.008 0.11 0.257 1.0 -0.293 1.0 2.0 RAC1/GTP/IQGAP1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.037 -9999.0 0.0 -0.371 1.0 1.0 RHOA 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.076 0.13 1.0 -0.227 12.0 13.0 NME1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.025 0.14 -9999.0 0.0 -0.402 15.0 15.0 regulation of cell-cell adhesion 0.0 0.061 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.002 0.045 -9999.0 0.0 -0.14 6.0 6.0 Rap1/GTP 0.009 0.082 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.043 0.12 -9999.0 0.0 -0.289 16.0 16.0 CCND1 -0.011 0.093 0.149 1.0 -0.286 12.0 13.0 VAV2 -0.041 0.224 -9999.0 0.0 -0.667 12.0 12.0 RAP1/GDP 0.013 0.092 0.265 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.024 0.136 -9999.0 0.0 -0.39 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.045 -9999.0 0.0 -0.51 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.025 0.111 -9999.0 0.0 -0.278 16.0 16.0 E-cadherin/beta catenin -0.004 0.083 -9999.0 0.0 -0.349 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.025 0.139 -9999.0 0.0 -0.402 15.0 15.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.51 2.0 2.0 Rac1/GTP -0.062 0.154 -9999.0 0.0 -0.532 10.0 10.0 E-cadherin/beta catenin/alpha catenin 0.039 0.082 -9999.0 0.0 -0.314 7.0 7.0 ITGAE 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.02 0.149 -9999.0 0.0 -0.421 15.0 15.0