Canonical Wnt signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations HDAC1 0.04 0.041 0.406 1.0 -9999.0 0.0 1.0 AES 0.039 0.035 0.376 1.0 -9999.0 0.0 1.0 FBXW11 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 LRP6/FZD1 0.037 0.051 -9999.0 0.0 -0.373 2.0 2.0 SMAD4 0.021 0.075 -9999.0 0.0 -0.51 3.0 3.0 DKK2 0.01 0.089 -9999.0 0.0 -0.509 4.0 4.0 TLE1 0.026 0.079 0.276 1.0 -0.496 3.0 4.0 MACF1 0.021 0.075 -9999.0 0.0 -0.51 3.0 3.0 CTNNB1 0.018 0.123 0.302 2.0 -0.38 5.0 7.0 WIF1 -0.063 0.182 -9999.0 0.0 -0.509 21.0 21.0 beta catenin/RanBP3 0.031 0.176 0.435 17.0 -0.37 3.0 20.0 KREMEN2 -0.099 0.207 -9999.0 0.0 -0.509 30.0 30.0 DKK1 -0.094 0.204 -9999.0 0.0 -0.509 29.0 29.0 beta catenin/beta TrCP1 0.033 0.12 0.304 2.0 -0.366 4.0 6.0 FZD1 0.027 0.045 -9999.0 0.0 -0.511 1.0 1.0 AXIN2 -0.047 0.269 0.795 1.0 -1.389 5.0 6.0 AXIN1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RAN 0.033 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Axin1/APC/GSK3/beta catenin 0.015 0.122 -9999.0 0.0 -0.582 5.0 5.0 beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 0.019 0.138 -9999.0 0.0 -0.448 7.0 7.0 Axin1/APC/GSK3 0.031 0.061 0.248 1.0 -0.273 2.0 3.0 Axin1/APC/GSK3/beta catenin/Macf1 0.032 0.104 -9999.0 0.0 -0.378 4.0 4.0 HNF1A 0.035 0.041 0.248 2.0 -9999.0 0.0 2.0 CTBP1 0.036 0.033 0.246 2.0 -9999.0 0.0 2.0 MYC -0.001 0.347 0.588 15.0 -1.443 6.0 21.0 RANBP3 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DKK2/LRP6/Kremen 2 -0.054 0.151 -9999.0 0.0 -0.32 35.0 35.0 NKD1 0.026 0.025 -9999.0 0.0 -9999.0 0.0 0.0 TCF4 0.006 0.119 -9999.0 0.0 -0.459 9.0 9.0 TCF3 0.035 0.045 0.284 1.0 -0.386 1.0 2.0 WNT1/LRP6/FZD1/Axin1 0.064 0.054 -9999.0 0.0 -0.294 2.0 2.0 Ran/GTP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CtBP/CBP/TCF/TLE1/AES 0.029 0.192 0.497 14.0 -0.432 3.0 17.0 LEF1 0.022 0.094 0.377 1.0 -0.498 4.0 5.0 DVL1 0.034 0.078 0.248 1.0 -0.453 2.0 3.0 CSNK2A1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 beta catenin/TCF/CtBP/CBP/TLE1/AES 0.001 0.171 -9999.0 0.0 -0.52 10.0 10.0 DKK1/LRP6/Kremen 2 -0.118 0.186 -9999.0 0.0 -0.356 53.0 53.0 LRP6 0.027 0.045 -9999.0 0.0 -0.511 1.0 1.0 CSNK1A1 0.036 0.06 0.414 1.0 -0.506 1.0 2.0 NLK 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 -0.068 0.451 0.599 5.0 -1.52 12.0 17.0 WNT1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GSK3A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GSK3B 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 FRAT1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PPP2R5D 0.033 0.058 0.205 1.0 -0.264 3.0 4.0 APC 0.035 0.068 -9999.0 0.0 -0.277 2.0 2.0 WNT1/LRP6/FZD1 0.05 0.086 0.239 18.0 -0.266 2.0 20.0 CREBBP 0.037 0.032 0.248 2.0 -9999.0 0.0 2.0