IL4-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.43 0.608 -9999.0 0.0 -1.322 40.0 40.0 STAT6 (cleaved dimer) -0.464 0.623 -9999.0 0.0 -1.302 46.0 46.0 IGHG1 -0.127 0.219 -9999.0 0.0 -0.655 5.0 5.0 IGHG3 -0.429 0.581 -9999.0 0.0 -1.225 45.0 45.0 AKT1 -0.202 0.314 -9999.0 0.0 -0.846 16.0 16.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.126 0.272 -9999.0 0.0 -0.839 10.0 10.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.202 0.347 -9999.0 0.0 -0.954 15.0 15.0 THY1 -0.451 0.616 -9999.0 0.0 -1.342 41.0 41.0 MYB -0.027 0.146 -9999.0 0.0 -0.51 12.0 12.0 HMGA1 0.029 0.044 -9999.0 0.0 -0.51 1.0 1.0 IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.228 0.36 -9999.0 0.0 -0.737 31.0 31.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.193 0.336 -9999.0 0.0 -0.982 12.0 12.0 SP1 0.014 0.073 -9999.0 0.0 -0.513 2.0 2.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SOCS5 0.029 0.032 -9999.0 0.0 -9999.0 0.0 0.0 STAT6 (dimer)/ETS1 -0.45 0.621 -9999.0 0.0 -1.309 44.0 44.0 SOCS1 -0.272 0.367 -9999.0 0.0 -0.766 42.0 42.0 SOCS3 -0.197 0.319 -9999.0 0.0 -0.983 9.0 9.0 FCER2 -0.378 0.497 -9999.0 0.0 -1.053 42.0 42.0 PARP14 0.025 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CCL17 -0.497 0.658 -9999.0 0.0 -1.422 44.0 44.0 GRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.144 0.256 -9999.0 0.0 -0.747 10.0 10.0 T cell proliferation -0.461 0.631 -9999.0 0.0 -1.354 43.0 43.0 IL4R/JAK1 -0.456 0.619 -9999.0 0.0 -1.319 44.0 44.0 EGR2 -0.515 0.672 -9999.0 0.0 -1.39 49.0 49.0 JAK2 -0.018 0.068 -9999.0 0.0 -0.551 1.0 1.0 JAK3 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.004 0.098 -9999.0 0.0 -0.51 5.0 5.0 JAK1 0.012 0.05 -9999.0 0.0 -0.504 1.0 1.0 COL1A2 -0.223 0.478 -9999.0 0.0 -1.591 15.0 15.0 CCL26 -0.541 0.673 -9999.0 0.0 -1.36 54.0 54.0 IL4R -0.484 0.67 -9999.0 0.0 -1.43 43.0 43.0 PTPN6 0.031 0.049 -9999.0 0.0 -0.496 1.0 1.0 IL13RA2 -0.564 0.723 -9999.0 0.0 -1.529 49.0 49.0 IL13RA1 -0.019 0.082 -9999.0 0.0 -0.551 2.0 2.0 IRF4 -0.058 0.21 -9999.0 0.0 -1.079 4.0 4.0 ARG1 -0.146 0.317 -9999.0 0.0 -1.156 10.0 10.0 CBL -0.218 0.331 -9999.0 0.0 -0.698 30.0 30.0 GTF3A 0.012 0.051 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.51 2.0 2.0 IL13RA1/JAK2 -0.02 0.095 -9999.0 0.0 -0.417 3.0 3.0 IRF4/BCL6 -0.051 0.181 -9999.0 0.0 -1.051 3.0 3.0 CD40LG 0.031 0.049 -9999.0 0.0 -0.509 1.0 1.0 MAPK14 -0.217 0.348 -9999.0 0.0 -0.791 22.0 22.0 mitosis -0.191 0.294 -9999.0 0.0 -0.782 16.0 16.0 STAT6 -0.561 0.836 -9999.0 0.0 -1.649 45.0 45.0 SPI1 0.004 0.095 -9999.0 0.0 -0.45 5.0 5.0 RPS6KB1 -0.184 0.284 -9999.0 0.0 -0.752 16.0 16.0 STAT6 (dimer) -0.562 0.843 -9999.0 0.0 -1.653 45.0 45.0 STAT6 (dimer)/PARP14 -0.481 0.682 -9999.0 0.0 -1.431 43.0 43.0 mast cell activation 0.008 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.205 0.347 -9999.0 0.0 -0.846 21.0 21.0 FRAP1 -0.202 0.313 -9999.0 0.0 -0.845 16.0 16.0 LTA -0.441 0.608 -9999.0 0.0 -1.322 41.0 41.0 FES 0.019 0.076 -9999.0 0.0 -0.51 3.0 3.0 T-helper 1 cell differentiation 0.515 0.732 1.502 45.0 -9999.0 0.0 45.0 CCL11 -0.557 0.701 -9999.0 0.0 -1.447 53.0 53.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.175 0.316 -9999.0 0.0 -0.955 11.0 11.0 IL2RG 0.024 0.066 -9999.0 0.0 -0.501 2.0 2.0 IL10 -0.444 0.606 -9999.0 0.0 -1.322 41.0 41.0 IRS1 0.004 0.114 -9999.0 0.0 -0.51 7.0 7.0 IRS2 -0.005 0.134 -9999.0 0.0 -0.51 10.0 10.0 IL4 -0.098 0.245 -9999.0 0.0 -1.097 6.0 6.0 IL5 -0.445 0.607 -9999.0 0.0 -1.321 41.0 41.0 IL4/IL4R/JAK1/IL13RA1/JAK2 -0.357 0.517 -9999.0 0.0 -1.034 43.0 43.0 COL1A1 -0.333 0.609 -9999.0 0.0 -1.555 28.0 28.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL4/IL4R/JAK1 -0.473 0.649 -9999.0 0.0 -1.406 42.0 42.0 IL2R gamma/JAK3 0.04 0.054 -9999.0 0.0 -0.366 2.0 2.0 TFF3 -0.531 0.674 -9999.0 0.0 -1.376 52.0 52.0 ALOX15 -0.463 0.611 -9999.0 0.0 -1.298 45.0 45.0 MYBL1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 T-helper 2 cell differentiation -0.485 0.554 -9999.0 0.0 -1.158 50.0 50.0 SHC1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CEBPB 0.017 0.059 -9999.0 0.0 -0.507 1.0 1.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.2 0.338 -9999.0 0.0 -0.941 15.0 15.0 mol:PI-3-4-5-P3 -0.202 0.314 -9999.0 0.0 -0.844 16.0 16.0 PI3K -0.216 0.34 -9999.0 0.0 -0.928 16.0 16.0 DOK2 -0.029 0.165 -9999.0 0.0 -0.51 16.0 16.0 ETS1 0.025 0.066 -9999.0 0.0 -0.482 2.0 2.0 IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.128 0.231 -9999.0 0.0 -0.682 9.0 9.0 ITGB3 -0.447 0.61 -9999.0 0.0 -1.326 41.0 41.0 PIGR -0.544 0.697 -9999.0 0.0 -1.434 51.0 51.0 IGHE 0.03 0.067 0.209 3.0 -0.259 1.0 4.0 MAPKKK cascade -0.125 0.228 -9999.0 0.0 -0.667 9.0 9.0 BCL6 -0.003 0.103 -9999.0 0.0 -0.51 6.0 6.0 OPRM1 -0.447 0.612 -9999.0 0.0 -1.335 41.0 41.0 RETNLB -0.419 0.617 -9999.0 0.0 -1.357 37.0 37.0 SELP -0.522 0.714 -9999.0 0.0 -1.494 47.0 47.0 AICDA -0.435 0.597 -9999.0 0.0 -1.291 42.0 42.0