Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.136 0.276 -9999.0 0.0 -0.562 43.0 43.0 IHH -0.015 0.089 -9999.0 0.0 -0.363 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.045 0.144 -9999.0 0.0 -0.322 30.0 30.0 LRPAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.045 0.143 0.32 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.117 0.234 -9999.0 0.0 -0.582 20.0 20.0 SMO -0.13 0.239 -9999.0 0.0 -0.599 21.0 21.0 AKT1 -0.093 0.212 -9999.0 0.0 -0.73 12.0 12.0 ARRB2 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.128 0.235 -9999.0 0.0 -0.588 21.0 21.0 STIL -0.077 0.157 -9999.0 0.0 -0.457 11.0 11.0 DHH N/PTCH2 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.301 42.0 42.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.51 2.0 2.0 DHH 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.249 0.45 -9999.0 0.0 -0.959 43.0 43.0 determination of left/right symmetry -0.128 0.235 -9999.0 0.0 -0.588 21.0 21.0 PIK3R1 0.004 0.098 -9999.0 0.0 -0.51 5.0 5.0 skeletal system development -0.245 0.444 -9999.0 0.0 -0.945 43.0 43.0 IHH N/Hhip -0.055 0.156 -9999.0 0.0 -0.422 21.0 21.0 DHH N/Hhip -0.024 0.136 -9999.0 0.0 -0.371 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.128 0.235 -9999.0 0.0 -0.588 21.0 21.0 pancreas development -0.058 0.179 -9999.0 0.0 -0.509 20.0 20.0 HHAT -0.007 0.14 -9999.0 0.0 -0.51 11.0 11.0 PI3K 0.004 0.075 -9999.0 0.0 -0.371 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.056 0.188 -9999.0 0.0 -0.51 22.0 22.0 somite specification -0.128 0.235 -9999.0 0.0 -0.588 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.069 0.164 -9999.0 0.0 -0.373 19.0 19.0 SHH Np/Cholesterol/PTCH2 0.007 0.086 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/Megalin 0.001 0.091 -9999.0 0.0 -0.293 13.0 13.0 SHH -0.013 0.104 -9999.0 0.0 -0.371 12.0 12.0 catabolic process -0.07 0.173 -9999.0 0.0 -0.337 43.0 43.0 SMO/Vitamin D3 -0.103 0.204 -9999.0 0.0 -0.517 19.0 19.0 SHH Np/Cholesterol/Hhip -0.043 0.127 -9999.0 0.0 -0.297 29.0 29.0 LRP2 0.02 0.052 -9999.0 0.0 -0.51 1.0 1.0 receptor-mediated endocytosis -0.102 0.195 -9999.0 0.0 -0.506 18.0 18.0 SHH Np/Cholesterol/BOC -0.001 0.085 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/CDO 0.006 0.087 -9999.0 0.0 -0.289 12.0 12.0 mesenchymal cell differentiation 0.043 0.126 0.295 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.07 0.163 -9999.0 0.0 -0.374 19.0 19.0 IHH N/PTCH2 0.015 0.06 -9999.0 0.0 -0.324 1.0 1.0 CDON 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.063 0.18 -9999.0 0.0 -0.339 43.0 43.0 Megalin/LRPAP1 0.034 0.044 -9999.0 0.0 -0.371 1.0 1.0 PTCH2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.082 -9999.0 0.0 -0.285 12.0 12.0 PTCH1 -0.07 0.174 -9999.0 0.0 -0.338 43.0 43.0 HHIP -0.058 0.179 -9999.0 0.0 -0.51 20.0 20.0