Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.111 -9999.0 0.0 -0.292 18.0 18.0 epithelial cell differentiation 0.034 0.092 -9999.0 0.0 -0.269 12.0 12.0 CYFIP2 0.025 0.046 -9999.0 0.0 -0.51 1.0 1.0 ENAH -0.014 0.108 0.282 2.0 -0.33 6.0 8.0 EGFR -0.033 0.169 -9999.0 0.0 -0.51 17.0 17.0 EPHA2 -0.015 0.145 -9999.0 0.0 -0.51 12.0 12.0 MYO6 -0.01 0.094 0.359 1.0 -0.282 14.0 15.0 CTNNB1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.051 -9999.0 0.0 -0.317 2.0 2.0 AQP5 -0.063 0.172 -9999.0 0.0 -0.477 20.0 20.0 CTNND1 0.015 0.096 -9999.0 0.0 -0.51 5.0 5.0 mol:PI-4-5-P2 -0.006 0.083 0.356 1.0 -0.255 13.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.106 0.356 1.0 -0.282 19.0 20.0 EGF -0.032 0.15 -9999.0 0.0 -0.51 13.0 13.0 NCKAP1 0.025 0.047 -9999.0 0.0 -0.51 1.0 1.0 AQP3 -0.099 0.193 -9999.0 0.0 -0.474 29.0 29.0 cortical microtubule organization 0.034 0.092 -9999.0 0.0 -0.269 12.0 12.0 GO:0000145 -0.025 0.074 0.343 1.0 -0.244 13.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.039 0.095 -9999.0 0.0 -0.271 12.0 12.0 MLLT4 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.056 0.112 -9999.0 0.0 -0.425 8.0 8.0 ARF6 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.022 0.124 -9999.0 0.0 -0.349 13.0 13.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.013 0.058 -9999.0 0.0 -0.273 1.0 1.0 PVRL2 0.027 0.045 -9999.0 0.0 -0.51 1.0 1.0 ZYX -0.011 0.081 -9999.0 0.0 -0.259 14.0 14.0 ARF6/GTP 0.022 0.131 -9999.0 0.0 -0.34 14.0 14.0 CDH1 0.005 0.113 -9999.0 0.0 -0.51 7.0 7.0 EGFR/EGFR/EGF/EGF -0.043 0.154 -9999.0 0.0 -0.318 32.0 32.0 RhoA/GDP 0.036 0.089 -9999.0 0.0 -0.255 12.0 12.0 actin cytoskeleton organization -0.034 0.094 -9999.0 0.0 -0.31 13.0 13.0 IGF-1R heterotetramer -0.008 0.139 -9999.0 0.0 -0.509 11.0 11.0 GIT1 0.024 0.062 -9999.0 0.0 -0.51 2.0 2.0 IGF1R -0.008 0.139 -9999.0 0.0 -0.51 11.0 11.0 IGF1 -0.049 0.181 -9999.0 0.0 -0.51 20.0 20.0 DIAPH1 0.013 0.172 -9999.0 0.0 -0.585 9.0 9.0 Wnt receptor signaling pathway -0.034 0.092 0.269 12.0 -9999.0 0.0 12.0 RHOA 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.104 -9999.0 0.0 -0.416 7.0 7.0 CTNNA1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.035 0.097 -9999.0 0.0 -0.318 13.0 13.0 EFNA1 0.019 0.075 -9999.0 0.0 -0.51 3.0 3.0 LPP -0.02 0.065 0.351 1.0 -0.263 3.0 4.0 Ephrin A1/EPHA2 -0.0 0.129 -9999.0 0.0 -0.307 20.0 20.0 SEC6/SEC8 -0.007 0.067 -9999.0 0.0 -0.25 10.0 10.0 MGAT3 -0.024 0.108 0.359 1.0 -0.286 19.0 20.0 HGF/MET 0.021 0.093 -9999.0 0.0 -0.255 14.0 14.0 HGF 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.112 -9999.0 0.0 -0.294 18.0 18.0 actin cable formation 0.036 0.124 0.339 6.0 -0.286 5.0 11.0 KIAA1543 -0.024 0.073 0.345 1.0 -0.248 12.0 13.0 KIFC3 -0.003 0.079 0.359 1.0 -0.259 11.0 12.0 NCK1 0.02 0.062 -9999.0 0.0 -0.51 2.0 2.0 EXOC3 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.082 0.359 1.0 -0.262 12.0 13.0 NCK1/GIT1 0.027 0.068 -9999.0 0.0 -0.371 4.0 4.0 mol:GDP 0.034 0.092 -9999.0 0.0 -0.269 12.0 12.0 EXOC4 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.0 0.076 0.359 1.0 -0.259 10.0 11.0 PIP5K1C -0.006 0.084 0.359 1.0 -0.259 13.0 14.0 LIMA1 0.0 0.127 -9999.0 0.0 -0.51 9.0 9.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.011 0.131 0.331 4.0 -0.389 6.0 10.0 adherens junction assembly -0.014 0.103 0.347 1.0 -0.484 3.0 4.0 IGF-1R heterotetramer/IGF1 -0.038 0.149 -9999.0 0.0 -0.288 36.0 36.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.042 0.036 -9999.0 0.0 -0.371 1.0 1.0 MET 0.02 0.076 -9999.0 0.0 -0.51 3.0 3.0 PLEKHA7 -0.004 0.081 0.359 1.0 -0.259 12.0 13.0 mol:GTP 0.02 0.123 -9999.0 0.0 -0.347 13.0 13.0 establishment of epithelial cell apical/basal polarity 0.015 0.114 0.439 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization -0.015 0.111 -9999.0 0.0 -0.292 18.0 18.0 regulation of cell-cell adhesion -0.034 0.094 -9999.0 0.0 -0.31 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.112 -9999.0 0.0 -0.294 18.0 18.0