Signaling events mediated by Stem cell factor receptor (c-Kit) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MAP4K1 -0.055 0.159 -9999.0 0.0 -0.405 18.0 18.0 CRKL -0.07 0.16 -9999.0 0.0 -0.418 20.0 20.0 HRAS -0.047 0.161 -9999.0 0.0 -0.395 17.0 17.0 mol:PIP3 -0.037 0.168 -9999.0 0.0 -0.444 13.0 13.0 SPRED1 0.024 0.063 -9999.0 0.0 -0.51 2.0 2.0 SPRED2 0.026 0.045 -9999.0 0.0 -0.51 1.0 1.0 GAB1 -0.076 0.173 -9999.0 0.0 -0.423 25.0 25.0 FOXO3 -0.067 0.171 -9999.0 0.0 -0.431 17.0 17.0 AKT1 -0.07 0.184 -9999.0 0.0 -0.441 21.0 21.0 BAD -0.067 0.172 -9999.0 0.0 -0.421 19.0 19.0 megakaryocyte differentiation -0.081 0.169 -9999.0 0.0 -0.422 23.0 23.0 GSK3B -0.044 0.181 0.368 1.0 -0.43 16.0 17.0 RAF1 -0.033 0.135 0.259 1.0 -0.334 14.0 15.0 SHC1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.076 0.174 -9999.0 0.0 -0.428 24.0 24.0 STAT1 -0.172 0.39 -9999.0 0.0 -0.999 23.0 23.0 HRAS/SPRED1 -0.03 0.146 -9999.0 0.0 -0.337 16.0 16.0 cell proliferation -0.071 0.171 0.274 1.0 -0.423 23.0 24.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.51 2.0 2.0 TEC 0.029 0.015 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 -0.068 0.179 -9999.0 0.0 -0.423 24.0 24.0 HRAS/SPRED2 -0.026 0.139 -9999.0 0.0 -0.331 15.0 15.0 LYN/TEC/p62DOK -0.038 0.177 -9999.0 0.0 -0.418 21.0 21.0 MAPK3 -0.022 0.103 0.232 1.0 -0.287 5.0 6.0 STAP1 -0.094 0.196 -9999.0 0.0 -0.473 26.0 26.0 GRAP2 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 -0.145 0.324 -9999.0 0.0 -0.848 21.0 21.0 STAT1 (dimer) -0.168 0.379 -9999.0 0.0 -0.971 23.0 23.0 mol:Gleevec 0.002 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOCS1/VAV1 -0.055 0.199 -9999.0 0.0 -0.448 24.0 24.0 actin filament polymerization -0.072 0.17 -9999.0 0.0 -0.415 24.0 24.0 LYN 0.027 0.044 -9999.0 0.0 -0.51 1.0 1.0 STAP1/STAT5A (dimer) -0.119 0.255 -9999.0 0.0 -0.624 25.0 25.0 PIK3R1 0.004 0.099 -9999.0 0.0 -0.51 5.0 5.0 CBL/CRKL/GRB2 -0.043 0.168 -9999.0 0.0 -0.397 18.0 18.0 PI3K -0.055 0.162 -9999.0 0.0 -0.457 13.0 13.0 PTEN 0.025 0.044 -9999.0 0.0 -0.509 1.0 1.0 SCF/KIT/EPO/EPOR -0.168 0.448 -9999.0 0.0 -1.295 18.0 18.0 MAPK8 -0.071 0.174 0.276 1.0 -0.432 23.0 24.0 STAT3 (dimer) -0.075 0.17 -9999.0 0.0 -0.419 24.0 24.0 positive regulation of transcription -0.016 0.088 0.216 1.0 -0.242 4.0 5.0 mol:GDP -0.047 0.164 -9999.0 0.0 -0.397 20.0 20.0 PIK3C2B -0.073 0.178 -9999.0 0.0 -0.452 22.0 22.0 CBL/CRKL -0.053 0.166 -9999.0 0.0 -0.402 19.0 19.0 FER -0.075 0.175 -9999.0 0.0 -0.435 24.0 24.0 SH2B3 -0.077 0.175 -9999.0 0.0 -0.43 24.0 24.0 PDPK1 -0.033 0.158 -9999.0 0.0 -0.412 14.0 14.0 SNAI2 -0.107 0.193 -9999.0 0.0 -0.42 33.0 33.0 positive regulation of cell proliferation -0.127 0.283 -9999.0 0.0 -0.715 23.0 23.0 KITLG -0.025 0.155 -9999.0 0.0 -0.527 13.0 13.0 cell motility -0.127 0.283 -9999.0 0.0 -0.715 23.0 23.0 PTPN6 0.03 0.045 -9999.0 0.0 -0.504 1.0 1.0 EPOR -0.035 0.184 -9999.0 0.0 -0.724 6.0 6.0 STAT5A (dimer) -0.103 0.238 -9999.0 0.0 -0.594 23.0 23.0 SOCS1 0.026 0.046 -9999.0 0.0 -0.51 1.0 1.0 cell migration 0.074 0.17 0.42 24.0 -9999.0 0.0 24.0 SOS1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EPO 0.019 0.027 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 0.01 0.105 -9999.0 0.0 -0.51 6.0 6.0 GRB10 -0.089 0.189 -9999.0 0.0 -0.452 26.0 26.0 PTPN11 0.031 0.044 -9999.0 0.0 -0.506 1.0 1.0 SCF/KIT -0.076 0.182 -9999.0 0.0 -0.444 24.0 24.0 GO:0007205 0.003 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.027 0.109 0.24 1.0 -0.302 7.0 8.0 CBL 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 KIT -0.176 0.452 -9999.0 0.0 -1.218 22.0 22.0 MAP2K2 -0.026 0.11 0.24 1.0 -0.302 7.0 8.0 SHC/Grb2/SOS1 -0.04 0.18 -9999.0 0.0 -0.42 21.0 21.0 STAT5A -0.106 0.244 -9999.0 0.0 -0.613 23.0 23.0 GRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 response to radiation -0.105 0.189 -9999.0 0.0 -0.412 33.0 33.0 SHC/GRAP2 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PTPRO -0.083 0.172 -9999.0 0.0 -0.431 23.0 23.0 SH2B2 -0.074 0.173 -9999.0 0.0 -0.423 24.0 24.0 DOK1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MATK -0.076 0.174 -9999.0 0.0 -0.429 24.0 24.0 CREBBP 0.011 0.062 -9999.0 0.0 -0.177 2.0 2.0 BCL2 -0.11 0.367 -9999.0 0.0 -1.183 14.0 14.0