Hybridization REF p difference q subclass Composite Element REF p difference q subclass EIF4G1|EIF4G 2.16310634779694e-05 0.705688404534357 0.000120593178889679 1 STAT5A|STAT5-ALPHA 1.9179860271934e-09 0.697506776953297 3.0550777433152e-08 1 VHL|VHL 0.00244065662685691 0.608864157325824 0.00735495172687961 1 ATM|ATM 6.54129434238836e-06 0.566551615222747 4.16868463381743e-05 1 GAB2|GAB2 2.28115612806329e-05 0.500723406232198 0.000122354233426159 1 TP53BP1|53BP1 3.43316782675088e-06 0.500475146786703 2.31998916777408e-05 1 AKT1 AKT2 AKT3|AKT 7.64463940605956e-09 0.482150315311758 8.11787898833944e-08 1 EEF2K|EEF2K 1.54989953297883e-11 0.462785342346264 5.76045993090465e-10 1 BCL2L11|BIM 3.10400673191645e-09 0.462255502660769 4.32620938260855e-08 1 XRCC5|KU80 2.1017955233744e-09 0.444318387837253 3.12466934474994e-08 1 SYK|SYK 2.14394252302374e-05 0.442253146515275 0.000120593178889679 1 CTNNB1|BETA-CATENIN 0.000109424503597636 0.436615532089341 0.000478464005926918 1 PRKAA1|AMPK_PT172 9.71653191034033e-08 0.433038748871758 9.02827756669122e-07 1 CDH1|E-CADHERIN 0.000643097606995475 0.407524940244505 0.00224079322437486 1 PARP1|PARP1 0.000750945608375398 0.400420912502193 0.00253728591920778 1 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.00324610620663711 0.387228534238132 0.00952475900105362 1 RBM15|RBM15 2.99665686030997e-05 0.382332450921648 0.000151876018147528 1 TSC2|TUBERIN 5.6251940118012e-09 0.37006191027967 6.62934729735404e-08 1 BRAF|B-RAF 1.21219178952085e-05 0.369726214568022 7.5088546961986e-05 1 MSH6|MSH6 0.000426545397064247 0.369450115111319 0.0015977648235845 1 CCNB1|CYCLIN_B1 0.00182172774433378 0.361762821542747 0.00572176460544272 1 TSC1|TSC1 6.10497094448815e-08 0.356659219047363 5.91916748096025e-07 1 BCL2|BCL-2 0.00105529883563462 0.348405901475055 0.0034106034832829 1 MAPK1|ERK2 1.26306673807133e-07 0.28989678828033 1.12665553035963e-06 1 CASP7|CASPASE-7_CLEAVEDD198 0.0119435654266915 0.289777308734396 0.0295935010016912 1 RPS6KB1|P70S6K 6.54277857325606e-06 0.286002154957692 4.16868463381743e-05 1 BAP1|BAP1-C-4 8.28989468633523e-07 0.27609922207044 6.37464315535433e-06 1 MSH2|MSH2 0.000413374454514942 0.269217263027802 0.00158935350615228 1 ANXA1|ANNEXIN-1 0.0497452295838703 0.256147104881429 0.0964624886713311 1 PTEN|PTEN 2.30442950847475e-05 0.253407165104945 0.000122354233426159 1 FOXM1|FOXM1 0.0224626152212128 0.234890960441648 0.0495956751913906 1 MTOR|MTOR 2.09173163063563e-07 0.229379228452637 1.72761538382128e-06 1 EEF2|EEF2 5.54402042115432e-07 0.227477573081209 4.41541626399076e-06 1 ERBB2|HER2 0.0167334733785384 0.214367431877692 0.0388704642022298 1 INPP4B|INPP4B 0.00952518519048393 0.210387712279451 0.0246990267148595 1 YBX1|YB-1 0.00584177802291171 0.185903888374615 0.0162839562388664 1 RPTOR|RAPTOR 0.00021521000116436 0.18542873186956 0.000905506231314194 1 RPS6|S6 0.000555125772214675 0.176293600455055 0.00196496900323607 1 CHEK2|CHK2 0.0304214997925641 0.157187378396154 0.0634018173246897 1 NOTCH1|NOTCH1 0.000712867351692159 0.155915273222308 0.00244568337580541 1 MAPK9|JNK2 2.43111821647348e-05 0.153466750956154 0.000126078921458974 1 ARID1A|ARID1A 0.00945845592299193 0.149301919776533 0.0246990267148595 1 PRKCA |PKC-ALPHA 0.000801697017156282 0.147729133632198 0.00262909462979192 1 PRKCA |PKC-ALPHA_PS657 0.000391375811528499 0.146880584972637 0.00153117203457641 1 LCK|LCK 0.0223285573123116 0.138914170577473 0.0495956751913906 1 RAF1|C-RAF 1.58036712040493e-05 0.130134165525604 9.27425968027104e-05 1 CCNE2|CYCLIN_E2 0.000429891880785066 0.124952863329121 0.0015977648235845 1 SMAD1|SMAD1 0.000345266228433028 0.118963506331319 0.00139989761710119 1 ADAR|ADAR1 0.00189515580928012 0.113185956287281 0.00586971868707593 1 RAD50|RAD50 0.000503393190347471 0.106464139442088 0.00184027346635223 1 MAP2K1|MEK1 0.0440567513170571 0.102825470723626 0.0877201387830691 1 GSK3A GSK3B|GSK3-ALPHA-BETA 0.00390941272438132 0.102417458863187 0.0113220654225589 1 PREX1|PREX1 0.0438643214625766 0.0984632192038462 0.0877201387830691 1 CDKN1B|P27_PT198 0.0107158083629002 0.0983462307064835 0.0271548325559857 1 CDKN1B|P27 0.0277740006332991 0.0924850392084615 0.0595178053769428 1 PIK3R1 PIK3R2|PI3K-P85 0.0333320991311432 0.0809993437787912 0.0688246120948605 1 BIRC2 |CIAP 0.00559202985576886 0.0790682114352747 0.0157850969346387 1 ESR1|ER-ALPHA_PS118 0.00249554194117174 0.0780699773060439 0.00742007803841731 1 PRKCD|PKC-DELTA_PS664 0.0433570708830983 0.063350287099011 0.0877201387830691 1 ERRFI1|MIG-6 0.0303512344146838 0.0575528186926373 0.0634018173246897 1 CDKN1B|P27_PT157 0.0476013546321996 0.0439870373669231 0.0931149305524606 1 ERBB3|HER3_PY1289 0.0254721888321058 -0.0441403923640659 0.05514852533553 1 DIRAS3|ARHI 0.0119373234781012 -0.0496505377317582 0.0295935010016912 1 SRSF1|SF2 0.0454552423286355 -0.0535958138053846 0.089703708312263 1 MRE11A|MRE11 0.0157319479646708 -0.0563736875721978 0.0373215361289531 1 WWTR1|TAZ 0.0211837061434168 -0.0642318204891209 0.0477168330301207 1 CHEK2|CHK2_PT68 0.0185435735037461 -0.0678364270684615 0.0426311019725297 1 PDK1|PDK1 0.00614234610069488 -0.0719728815361538 0.0169104096352464 1 PECAM1|CD31 0.0239446617559122 -0.084009259719011 0.0523496036428276 1 YAP1|YAP 0.0399037180227971 -0.0977932747651648 0.0816378818264565 1 RAF1|C-RAF_PS338 0.000284932225490424 -0.0982854159904396 0.00117666456082157 1 EIF4EBP1|4E-BP1_PS65 0.0127904507502322 -0.100804956087143 0.0313436320582613 1 RPS6KA1|P90RSK_PT359_S363 0.000543620222466562 -0.10107944177044 0.00195527918725876 1 MAPK8|JNK_PT183_PY185 4.69350207398091e-05 -0.10637783526978 0.000227532817934292 1 BRCA2|BRCA2 0.0143168735431928 -0.108899405689858 0.0344069273498484 1 JUN|C-JUN_PS73 0.00221419545524434 -0.114859264161868 0.00676391214410257 1 CHEK1|CHK1 0.00937718847259404 -0.11888112858011 0.0246990267148595 1 MTOR|MTOR_PS2448 0.000189704967506829 -0.129904697706044 0.000813542456808132 1 SETD2|SETD2 0.00711085408240629 -0.136838832036593 0.0193380543948366 1 ITGA2|CD49B 0.0280240787649282 -0.142065720097692 0.0595178053769428 1 BAD|BAD_PS112 1.47751986954084e-05 -0.147528951266484 8.90505218669209e-05 1 RET|RET_PY905 0.000790559147391321 -0.159006016356722 0.00262909462979192 1 RICTOR|RICTOR_PT1135 8.56321813545455e-11 -0.173530952063626 2.12177516022929e-09 1 FOXO3|FOXO3A_PS318_S321 4.06992815270104e-10 -0.191130519099231 7.6840547640786e-09 1 COL6A1|COLLAGEN_VI 0.000358052071838303 -0.192298111717912 0.0014258145003561 1 MAP2K1|MEK1_PS217_S221 2.59502255174628e-11 -0.194718450159451 8.26700041484886e-10 1 SNAI1|SNAIL 0.0188922704820559 -0.197714116886264 0.0429895542601884 1 EIF4EBP1|4E-BP1_PT70 3.17705112954999e-06 -0.210370717843187 2.21400750590515e-05 1 YBX1|YB-1_PS102 2.00252840933668e-12 -0.216009281059231 1.48854611760693e-10 1 TSC2|TUBERIN_PT1462 1.58212228199409e-09 -0.224417665552418 2.71394822218986e-08 1 MET|C-MET 0.00405450462181564 -0.225423284453077 0.0115917247521139 1 AKT1S1|PRAS40_PT246 4.52180748981636e-11 -0.230756701754835 1.26045383778631e-09 1 EGFR|EGFR_PY1068 0.00785098475861126 -0.23243672699022 0.0210936096526544 1 ERBB2|HER2_PY1248 8.58711210902205e-07 -0.268988487649341 6.38308666770639e-06 1 CAV1|CAVEOLIN-1 0.0161677132499698 -0.326338157348242 0.0379515795236133 1 CDKN1A|P21 6.99498136047295e-05 -0.34492403220011 0.000324975175705306 1 PDCD4|PDCD4 4.96231933380964e-05 -0.392413358400769 0.000235446215199904 1 RB1|RB_PS807_S811 7.4719535736853e-05 -0.423160476868681 0.000333249129386364 1 YAP1|YAP_PS127 4.20572817925297e-08 -0.451103130762747 4.26307901806097e-07 1 RPS6|S6_PS240_S244 7.24204784422375e-05 -0.482535871755495 0.000329587075359571 1 SERPINE1|PAI-1 0.00151277322137621 -0.489193529160989 0.00481926326238421 1 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.5848401639552e-07 -0.491110776093516 1.35930521754619e-06 1 MAPK1 MAPK3|MAPK_PT202_Y204 2.20016596412434e-13 -0.496737080311099 2.45318504999864e-11 1 SRC|SRC_PY416 3.45438238875581e-10 -0.497545846658352 7.6840547640786e-09 1 GSK3A GSK3B|GSK3_PS9 9.36106067827497e-07 -0.506616044887802 6.73392429437199e-06 1 RPS6|S6_PS235_S236 5.64832280940479e-09 -0.564360177382528 6.62934729735404e-08 1 SRC|SRC_PY527 4.13571043623887e-09 -0.56537478665967 5.42507898400746e-08 1 MAPK14|P38_PT180_Y182 6.41753912236938e-09 -0.605258088563846 7.15555612144186e-08 1 LCN2|LCN2A 0.0143490773252731 -0.607572216633844 0.0344069273498484 1 AKT1 AKT2 AKT3|AKT_PT308 1.40613883114141e-11 -0.622950450875714 5.76045993090465e-10 1 MYH11|MYH11 0.0099736883597317 -0.624320586991978 0.025564741427818 1 IGFBP2|IGFBP2 4.14019691911923e-05 -0.77411723910033 0.000205169758436353 1 EIF4EBP1|4E-BP1_PT37_T46 4.13491736183602e-10 -0.846074457699231 7.6840547640786e-09 1 AKT1 AKT2 AKT3|AKT_PS473 2.19409384147443e-18 -0.869396691384066 4.89282926648798e-16 1 NDRG1|NDRG1_PT346 7.78388295392315e-12 -1.61311690742978 4.33951474681216e-10 1 EIF4G1|EIF4G 5.06681373883545e-07 0.759767102016403 7.06187164850191e-06 2 EGFR|EGFR_PY1068 0.000189949008386327 0.53715656718306 0.000756404086966981 2 CDH1|E-CADHERIN 1.00798213149001e-05 0.529237879524088 7.49266717740907e-05 2 CTNNB1|BETA-CATENIN 2.26233428714334e-08 0.525149044978532 8.42552536427909e-07 2 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.000156351190216155 0.503709214542601 0.000657855007890614 2 RB1|RB_PS807_S811 4.04258994489929e-06 0.454182120154288 4.09771617142064e-05 2 GSK3A GSK3B|GSK3_PS9 2.99243503607416e-05 0.440550765358816 0.000171105900780651 2 ERBB2|HER2 2.43824979010241e-06 0.436192005285993 3.02072057329354e-05 2 TP53BP1|53BP1 1.90496016619969e-08 0.435631171551634 8.42552536427909e-07 2 VHL|VHL 0.0298873368799678 0.41297553214637 0.0687100631364208 2 STAT5A|STAT5-ALPHA 7.5761786654237e-05 0.40934254751617 0.000359465498380742 2 PDCD4|PDCD4 1.05728394863196e-05 0.404675419624456 7.553877406039e-05 2 EEF2K|EEF2K 3.72813872675306e-08 0.401966726984666 1.18767848009419e-06 2 NFKB1|NF-KB-P65_PS536 5.37483224502725e-06 0.392768533948422 4.99411496100449e-05 2 MSH6|MSH6 1.95928568449286e-05 0.385961287534794 0.000114979133589976 2 EGFR|EGFR 0.00918769641072317 0.376412931998048 0.0238239104603636 2 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 4.20877948036392e-05 0.362325959539032 0.000218269261423524 2 PRKCB|PKC-PAN_BETAII_PS660 4.38525339185493e-06 0.361462899217854 4.25178915818978e-05 2 BRAF|B-RAF 6.93750219827279e-06 0.349741133520297 5.7298629267216e-05 2 EIF4EBP1|4E-BP1_PT37_T46 0.00500794438618467 0.347022460242723 0.0139596449764898 2 XRCC5|KU80 2.89551118244946e-06 0.346180765921657 3.22849496843115e-05 2 AKT1 AKT2 AKT3|AKT 3.78405287590623e-05 0.32690410872672 0.000205815558860266 2 RPS6|S6_PS240_S244 0.00833568867060488 0.323322121460076 0.0221292687326772 2 TSC2|TUBERIN 9.14850525913694e-08 0.317706307491525 2.04011667278754e-06 2 MSH2|MSH2 1.88952040853535e-07 0.312422682055147 3.24125423925679e-06 2 BAP1|BAP1-C-4 4.17388273043688e-10 0.309982601969945 4.65387924443712e-08 2 RPS6|S6_PS235_S236 0.00284780911062217 0.3067660013393 0.00858191123876681 2 ATM|ATM 0.00426004602234553 0.300515704928683 0.0121793623459366 2 RBM15|RBM15 0.000101670791073498 0.297146004906156 0.000450775252695356 2 PXN|PAXILLIN 0.000803882281607935 0.290571399456396 0.00271614770906924 2 TSC1|TSC1 0.000232142700062818 0.280445390960801 0.000892548657138076 2 FOXM1|FOXM1 1.68891520520255e-05 0.275165487081688 0.000104618914100047 2 ACACA ACACB|ACC_PS79 0.000178596085644023 0.256138112848835 0.000724125947247584 2 BAD|BAD_PS112 1.91188096187543e-12 0.251434857223319 4.26349454498221e-10 2 SRC|SRC_PY527 0.0118954361623224 0.246849027390933 0.0301441166386124 2 MAPK1 MAPK3|MAPK_PT202_Y204 0.019573259599578 0.217056563379112 0.0479652405572076 2 RPS6KB1|P70S6K 5.66907042290086e-05 0.197912500655013 0.00028093393429042 2 MTOR|MTOR 1.68792540112976e-05 0.189953365572376 0.000104618914100047 2 ERBB2|HER2_PY1248 0.00686072453492619 0.180112474638954 0.0188881675467721 2 SHC1|SHC_PY317 0.00063879353848917 0.16986456406418 0.0022257962356732 2 JUN|C-JUN_PS73 0.000277066002491245 0.162975307193431 0.0010472155687381 2 TSC2|TUBERIN_PT1462 0.000955468173891605 0.156247119677986 0.00313337357026218 2 PTEN|PTEN 0.00806595614384281 0.155996950129977 0.0219354660984994 2 MTOR|MTOR_PS2448 8.18914022695771e-05 0.141340829168451 0.00038045380637741 2 ERBB3|HER3 0.0491237679013603 0.138383324328148 0.100500919651407 2 RPS6|S6 0.0335807103989652 0.137445198541151 0.0748849841896924 2 CHEK1|CHK1_PS345 1.33870916153671e-05 0.107292170604271 9.04642857644504e-05 2 PRKCD|PKC-DELTA_PS664 0.000569021174012897 0.105379346423163 0.00204664067427219 2 RPTOR|RAPTOR 0.0422635923127982 0.103601736777796 0.0889130291108868 2 RPS6KA1|P90RSK_PT359_S363 0.00207169482636634 0.0947446167909557 0.00632860200383142 2 AKT1S1|PRAS40_PT246 0.0175394828383615 0.0913040349962641 0.0434589408106068 2 DVL3|DVL3 0.0389311594777298 0.0912277461075611 0.0834773900339783 2 ERBB3|HER3_PY1289 0.008239973219339 -0.0586069055144976 0.0221292687326772 2 YWHAE|14-3-3_EPSILON 0.00860241851039259 -0.0600695914260622 0.0225686979743241 2 PIK3R1 PIK3R2|PI3K-P85 0.0472473724491732 -0.0622113997830378 0.0975570745941261 2 MET|C-MET_PY1235 0.000365313624274326 -0.0625140460805732 0.00135774897021958 2 CASP9|CASPASE-9 0.0257216266770454 -0.0643073263565217 0.0603781341998013 2 TIGAR|TIGAR 0.020684448271256 -0.0672117267896175 0.0501373039618488 2 ETS1|ETS-1 0.0312058536983894 -0.0689097976264637 0.0708012854844685 2 FOXO3|FOXO3A 0.00462209729537657 -0.0749837609980484 0.0130471860363161 2 PECAM1|CD31 0.0237426877086196 -0.0798709557075387 0.056325737861938 2 CDKN1B|P27 0.0359719200601607 -0.0827539963556931 0.07942315023184 2 NRG1|HEREGULIN 0.0443418256090461 -0.0837708001735809 0.0924133374842736 2 MAP2K1|MEK1_PS217_S221 0.00390406373259668 -0.0869124427988737 0.0114553448995929 2 NRAS|N-RAS 4.10939601927879e-05 -0.0924271289029218 0.000218189360071231 2 YWHAB|14-3-3_BETA 6.33796760565885e-05 -0.0953363371934315 0.000307253646969983 2 RAF1|C-RAF_PS338 1.92328185700668e-05 -0.098287130725605 0.000114979133589976 2 NFE2L2|NRF2 0.0418900248844079 -0.101846862426087 0.0889130291108868 2 PDK1|PDK1 0.000225451862085553 -0.103156169708208 0.0008820309692119 2 ACVRL1|ACVRL1 0.0133147255514718 -0.103299241904706 0.0333616157076204 2 BID|BID 2.4346290501568e-06 -0.107528658844485 3.02072057329354e-05 2 CDH2|N-CADHERIN 0.000103092098150059 -0.11320903055063 0.000450775252695356 2 MRE11A|MRE11 2.26695749711545e-08 -0.117386657974072 8.42552536427909e-07 2 EIF4E|EIF4E 0.00117578748812536 -0.125309390005632 0.00380000883843413 2 CASP3|CASPASE-3 0.00165304034763152 -0.126292440443478 0.00519194362706801 2 MAP2K1|MEK1 0.0385837640305699 -0.129512735974964 0.0834773900339783 2 MAPK14|P38_MAPK 1.58629628883604e-05 -0.131524531452046 0.000104042374238364 2 RAB11A RAB11B|RAB11 1.20930941195441e-07 -0.142568667809914 2.45159998968939e-06 2 PREX1|PREX1 0.00120807959513659 -0.142765922969388 0.00384859642450657 2 CCND1|CYCLIN_D1 0.000783551524945723 -0.146089623267481 0.0026881844625061 2 WWTR1|TAZ 3.73951788052487e-07 -0.148399381269265 5.55941658238031e-06 2 LCK|LCK 0.00199612482638574 -0.151349134741218 0.00618244217061139 2 BRCA2|BRCA2 0.000922057321946598 -0.152674458930435 0.00306893705662823 2 STMN1|STATHMIN 6.45184431589249e-06 -0.16145387730852 5.53369724016933e-05 2 YAP1|YAP 0.000101513050285812 -0.162638695641965 0.000450775252695356 2 PARK7|DJ-1 6.16361468024578e-06 -0.164330683737538 5.49794429477924e-05 2 COL6A1|COLLAGEN_VI 0.0370927044550667 -0.168916855566466 0.0810948342498027 2 STK11|LKB1 2.60349299843663e-06 -0.171479500920096 3.05567862448089e-05 2 RAD51|RAD51 3.2609110184978e-05 -0.173570998891881 0.000181795789281252 2 DIABLO|SMAC 0.000159430700236046 -0.180060734098863 0.000658389743567375 2 PEA15|PEA15 9.85921601981122e-06 -0.21006009886902 7.49266717740907e-05 2 SETD2|SETD2 4.58133035644177e-05 -0.217168263299933 0.000232190152156026 2 CDKN2A|P16_INK4A 0.0107528121446504 -0.218785709921739 0.0275618058420349 2 G6PD|G6PD 0.0297727665211446 -0.22443968395121 0.0687100631364208 2 CLDN7|CLAUDIN-7 0.0314319608204591 -0.226785557483049 0.0708012854844685 2 CDKN1A|P21 0.00289381533761088 -0.241607348184064 0.00860427760382968 2 BAX|BAX 1.53847976608193e-08 -0.258353961142244 8.42552536427909e-07 2 CASP8|CASPASE-8 2.35227635917365e-07 -0.264772357614308 3.74684020068374e-06 2 PRDX1|PRDX1 9.1887729452639e-06 -0.292987684898573 7.31820130997803e-05 2 MET|C-MET 6.29019869784931e-08 -0.301049588317776 1.56184350182489e-06 2 PARP1|PARP_CLEAVED 3.4275044220969e-06 -0.320247697376324 3.63968326727433e-05 2 SNAI1|SNAIL 1.46642111541776e-07 -0.326340957123285 2.72509923948467e-06 2 YWHAZ|14-3-3_ZETA 1.08396447082174e-05 -0.352629108213059 7.553877406039e-05 2 ANXA1|ANNEXIN-1 0.000114771679810751 -0.376269237150162 0.000492193934573028 2 HSPA1A|HSP70 0.000596330349899368 -0.380539182445578 0.00211082012742157 2 IGFBP2|IGFBP2 0.0230324894804698 -0.411649803653229 0.0552284425176856 2 SERPINE1|PAI-1 0.00409347555122186 -0.436750019515836 0.0118551304924997 2 FN1|FIBRONECTIN 0.000557995577400986 -0.463033537846604 0.00203988547148229 2 LCN2|LCN2A 6.30340426745471e-08 -1.25536458822609 1.56184350182489e-06 2 LCN2|LCN2A 7.42211829135465e-09 1.51636700921734 6.89638491238369e-08 3 SERPINE1|PAI-1 4.97784866235621e-11 1.18847805613265 6.97390592544128e-10 3 NDRG1|NDRG1_PT346 2.06394931864815e-08 1.09525088818496 1.70466925206866e-07 3 IGFBP2|IGFBP2 1.40639581316938e-05 0.818957111649994 5.80789382105133e-05 3 YWHAZ|14-3-3_ZETA 1.52735821884188e-13 0.706283138853295 4.8657268971677e-12 3 FN1|FIBRONECTIN 1.95842426127723e-06 0.611256910123508 1.06519173235323e-05 3 EIF4EBP1|4E-BP1 6.64985837084364e-06 0.563492714780584 2.90768316999634e-05 3 CDKN2A|P16_INK4A 0.000103986628460631 0.55078602526827 0.000336072726764068 3 CDKN1A|P21 5.58161519145021e-08 0.51981012664453 4.14900062564466e-07 3 ITGA2|CD49B 2.88202145736354e-07 0.430072186977975 1.9475478333093e-06 3 TP63|P63 0.00133848959754047 0.411575551416008 0.00314192821317395 3 BAX|BAX 4.73838619045132e-10 0.392816633645311 5.87033400261469e-09 3 PRDX1|PRDX1 4.91188453113715e-06 0.325093050347998 2.23184341408593e-05 3 ASNS|ASNS 0.00326223534034148 0.324667498453719 0.0071321419695701 3 CCNE1|CYCLIN_E1 0.000362952812805238 0.316665352808353 0.0010376727853278 3 YAP1|YAP 4.660652079916e-07 0.302163027989573 2.96950118234648e-06 3 DIABLO|SMAC 8.70372825774701e-05 0.283076723548511 0.000285431088452586 3 CHEK1|CHK1 0.000150004443498205 0.272175598675198 0.00046821363644837 3 PCNA|PCNA 3.43611477438855e-06 0.269641420338519 1.70278576597477e-05 3 HSPA1A|HSP70 0.0318700522968524 0.269510685334058 0.0559608004897487 3 SRC|SRC_PY416 0.00664656266361471 0.256658414048455 0.0138521819998699 3 STMN1|STATHMIN 8.35831423176803e-12 0.246090234783818 1.86390407368427e-10 3 MAPK14|P38_PT180_Y182 0.0240043731878105 0.237460072294246 0.0434919846256763 3 TYMS|THYMIDILATE-SYNTHASE 3.37096118030369e-05 0.234378527417589 0.000129607645380642 3 EIF4EBP1|4E-BP1_PT70 3.96669798438243e-05 0.234186938516505 0.000145061010275287 3 CCNB1|CYCLIN_B1 0.00940764582596403 0.230207382941842 0.0177788560948303 3 PDK1|PDK1 5.59967790962717e-09 0.226917263783038 5.67603715384936e-08 3 ANXA1|ANNEXIN-1 0.00524686094777328 0.219275861673971 0.0111433332509852 3 PEA15|PEA15 0.00188152490668163 0.211244634371975 0.00432556756896911 3 CASP3|CASPASE-3 0.000851602846085186 0.205938153537172 0.0020868948865604 3 PARK7|DJ-1 4.8113523498189e-05 0.205084123467102 0.00017305347967897 3 EIF4E|EIF4E 2.11811551947986e-06 0.198235848136445 1.12461847820002e-05 3 WWTR1|TAZ 0.000186591992004647 0.193049527863778 0.000562297489419409 3 BRCA2|BRCA2 0.000510788247042545 0.180726165746599 0.00135602117964866 3 NFE2L2|NRF2 0.000117448722844485 0.173530128305916 0.000374158074204574 3 MAP2K1|MEK1_PS217_S221 3.03869287270545e-06 0.172128049949649 1.54006479684844e-05 3 RAB11A RAB11B|RAB11 9.55015914704431e-06 0.156778423487956 4.0182745090394e-05 3 RAF1|C-RAF_PS338 3.81834666654689e-08 0.150101716316661 2.93617691944813e-07 3 ACVRL1|ACVRL1 0.000716411028029093 0.140798281500223 0.00179505235112908 3 RAD51|RAD51 0.00179454930111961 0.136346132894892 0.00416858848072576 3 XRCC1|XRCC1 0.000151172115803958 0.136288663445244 0.00046821363644837 3 COL6A1|COLLAGEN_VI 0.0447485249377776 0.134623393434092 0.0773559772180187 3 YBX1|YB-1_PS102 0.0036641799695534 0.128953633611297 0.00793312750689717 3 MAPK14|P38_MAPK 0.00114805169055496 0.128544265553418 0.00272356943610379 3 NRG1|HEREGULIN 0.00796486503789633 0.125686813709769 0.0158586152093829 3 ERBB3|HER3_PY1289 4.51627712293727e-06 0.123029673456842 2.14282935832981e-05 3 MRE11A|MRE11 0.00034926264063004 0.109629977123062 0.00101150089429219 3 YWHAE|14-3-3_EPSILON 1.2419457135435e-07 0.109574382796309 8.9339965845226e-07 3 SRSF1|SF2 0.00195971820881566 0.10814035959245 0.00445935878128461 3 YWHAB|14-3-3_BETA 3.96803660394284e-05 0.105637841199788 0.000145061010275287 3 NRAS|N-RAS 0.000450351182252869 0.0986497926240103 0.00123985572398012 3 CCND1|CYCLIN_D1 0.0260027345921237 0.0952197740716516 0.0463888785123487 3 MET|C-MET_PY1235 3.1046488963252e-05 0.0951961934122337 0.000121462579628161 3 BID|BID 0.00245499874779842 0.0934158270156686 0.00547464720759048 3 CHEK2|CHK2_PT68 0.000612987583891315 0.0923517375294413 0.00157122104836509 3 SMAD3|SMAD3 0.00842660383521221 0.0906648687976469 0.0166294925243568 3 CDH2|N-CADHERIN 0.0277978397346007 0.0873237568337794 0.0491977639747298 3 SMAD4|SMAD4 0.00616007677053256 0.0859160804147987 0.0129594067908374 3 RICTOR|RICTOR_PT1135 0.0175541293448343 0.0834303730338464 0.0323518251561822 3 TIGAR|TIGAR 0.0140608426509428 0.0669964466075053 0.026129732593002 3 MAPK8|JNK_PT183_PY185 0.00698516735495054 0.06610822710455 0.0144230770384627 3 SCD|SCD 0.0114932484621288 0.061672939600368 0.0215377681265103 3 CHEK1|CHK1_PS345 0.00214880058759488 -0.0674972819684956 0.00484022758619857 3 RPS6KA1|P90RSK_PT359_S363 0.0073006597440513 -0.0782167364014163 0.0149362121369123 3 GATA3|GATA3 0.0324179246760802 -0.0828120800668563 0.0564781031466085 3 SMAD1|SMAD1 0.000766388142559126 -0.104194385145589 0.00189893950878539 3 AR|AR 0.00103488418590455 -0.106796372994257 0.00250846927670342 3 BECN1|BECLIN 0.00876848542263786 -0.110201276545389 0.0168566573211055 3 NOTCH1|NOTCH1 0.000464939572743318 -0.11936018706931 0.00126440883807024 3 ADAR|ADAR1 0.0073835721517506 -0.123451555688513 0.0149685144530944 3 MAPK9|JNK2 6.63937178726079e-05 -0.158889253220196 0.000227781524393716 3 LCK|LCK 0.00928262970961909 -0.164530208104885 0.0176925335491031 3 RAD50|RAD50 6.91743801411211e-05 -0.164712585090052 0.000233725557143485 3 PRKCA |PKC-ALPHA 0.0241838838277303 -0.169857312042991 0.0434919846256763 3 JUN|C-JUN_PS73 0.000418533808777539 -0.169905673301717 0.00116666299196739 3 PARP1|PARP_CLEAVED 0.00873603176440317 -0.172442006980428 0.0168566573211055 3 RPS6KA1|P90RSK 8.00764022653117e-05 -0.175289061439222 0.000266522950823351 3 ERCC1|ERCC1 0.000313392640309511 -0.175915439143694 0.000919559984066065 3 RAF1|C-RAF 8.49464539506528e-07 -0.176898035326252 5.11974573810691e-06 3 TSC2|TUBERIN_PT1462 7.64206326688385e-06 -0.178250083526207 3.27726943945211e-05 3 BAD|BAD_PS112 5.91838369780453e-05 -0.184298759311531 0.000206218681970377 3 KIT|C-KIT 0.00860544044759134 -0.197741125600703 0.0168334492966041 3 PRKCD|PKC-DELTA_PS664 5.68817281636976e-07 -0.227376217981878 3.52350705014016e-06 3 MTOR|MTOR_PS2448 0.000523587556539008 -0.22848348212362 0.0013736473542141 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 0.00773162392864145 -0.233279092824969 0.0155329021269103 3 XBP1|XBP1 0.000576526598479991 -0.238318234125181 0.00149494687745393 3 MACC1|MACC1 0.00486231694173228 -0.258008361554255 0.0104259295962144 3 ERBB3|HER3 5.0041332154393e-06 -0.262215197403981 2.23184341408593e-05 3 PRKCA |PKC-ALPHA_PS657 1.41271119000408e-08 -0.269714890787387 1.21167152065735e-07 3 STAT3|STAT3_PY705 2.3582463116216e-06 -0.278167258607505 1.22299750579446e-05 3 BCL2|BCL-2 5.02547626693585e-05 -0.28456149978906 0.000177885905956618 3 INPP4B|INPP4B 4.75507136529394e-06 -0.287593270808576 2.20912690512614e-05 3 RPTOR|RAPTOR 1.47917793429722e-09 -0.290358812933367 1.73608778604358e-08 3 RPS6KB1|P70S6K 0.000157983599126575 -0.290983525409892 0.000482607432948305 3 MSH2|MSH2 3.00648983923623e-05 -0.309419163014553 0.000119722720383871 3 TGM2|TRANSGLUTAMINASE 9.38454481182144e-07 -0.328068702334839 5.50724603430574e-06 3 MSH6|MSH6 0.000277483443459655 -0.335137489919873 0.000825050771886707 3 CAV1|CAVEOLIN-1 0.0189198138203206 -0.336061014285547 0.0345829383764877 3 KEAP1|KEAP1 0.0476168855170845 -0.340412823981019 0.0816812728485373 3 GSK3A GSK3B|GSK3_PS9 0.00250580852408358 -0.34464153444937 0.00553262674129345 3 MAPK1|ERK2 0.000404576626573138 -0.364864797514498 0.00114203275602291 3 BAP1|BAP1-C-4 1.29988468175453e-06 -0.412382968057489 7.24685710078151e-06 3 PTEN|PTEN 2.32589506788979e-05 -0.417722145990911 9.43044727526224e-05 3 SYK|SYK 1.25978372950624e-06 -0.447012851231348 7.20337876102286e-06 3 PRKAA1|AMPK_PT172 3.42091607143197e-07 -0.454791180978867 2.24371848214509e-06 3 MTOR|MTOR 7.37211056559316e-09 -0.470826417940058 6.89638491238369e-08 3 NFKB1|NF-KB-P65_PS536 2.5454187863534e-10 -0.497199921687131 3.33899052562828e-09 3 RBM15|RBM15 2.51176043888978e-08 -0.502329338939054 2.00043777811579e-07 3 SYP|SYNAPTOPHYSIN 0.000486095645999278 -0.503860240384688 0.00130601601274505 3 NKX2-1|TTF1 0.00070769542181445 -0.552650072808576 0.00179336453482525 3 PRKCB|PKC-PAN_BETAII_PS660 1.62657219454405e-18 -0.588172310160087 3.62725599383323e-16 3 ERBB2|HER2 4.73894423681413e-11 -0.611083154949091 6.97390592544128e-10 3 CDH1|E-CADHERIN 0.00111532514169715 -0.630630890608621 0.00267438179138134 3 XRCC5|KU80 4.47885537862291e-14 -0.640285920758392 1.66464124905485e-12 3 PXN|PAXILLIN 8.6049857627789e-09 -0.661847560561001 7.67564730039878e-08 3 EEF2K|EEF2K 1.20025451087604e-11 -0.680352454922772 2.19304069218306e-10 3 TSC1|TSC1 4.29115439048179e-12 -0.699564237774339 1.1961592863468e-10 3 BRAF|B-RAF 1.89758558698086e-09 -0.745539085119159 2.11580792948366e-08 3 GAB2|GAB2 7.72813290678033e-17 -0.768534864914408 5.74457879404005e-15 3 TSC2|TUBERIN 1.04024991333872e-14 -0.784154375628806 4.63951461349069e-13 3 TP53BP1|53BP1 6.08394720839933e-12 -0.792340412570146 1.5074669194145e-10 3 CTNNB1|BETA-CATENIN 1.68640009194398e-07 -0.86526328770397 1.17521006407346e-06 3 AKT1 AKT2 AKT3|AKT 5.00369931870226e-11 -0.90814677457115 6.97390592544128e-10 3 RICTOR|RICTOR 2.62486179963969e-16 -0.919419976998941 1.46336045329913e-14 3 MYH11|MYH11 3.45716293165052e-05 -0.970026668171908 0.000130669039620011 3 TUBA1B|ACETYL-A-TUBULIN-LYS40 1.10838520546853e-11 -1.04502237291051 2.19304069218306e-10 3 ATM|ATM 1.27845421517398e-11 -1.05517725609775 2.19304069218306e-10 3 STAT5A|STAT5-ALPHA 2.71867129108225e-17 -1.18577674846465 3.03131848955671e-15 3 VHL|VHL 3.05883895759075e-09 -1.28510588283969 3.24819565496542e-08 3 EIF4G1|EIF4G 3.58409507281925e-06 -1.45155493689932 1.73750695921455e-05 3 NDRG1|NDRG1_PT346 5.31980133745513e-17 1.6557202722312 1.18631569825249e-14 4 IGFBP2|IGFBP2 1.77281848802789e-08 1.19860947915483 8.03796580399111e-07 4 VHL|VHL 4.44220868847095e-07 1.16530177900555 1.4151607678986e-05 4 AKT1 AKT2 AKT3|AKT_PS473 6.767827745689e-09 1.11035260686177 5.03075195762882e-07 4 GSK3A GSK3B|GSK3_PS9 1.8022344851998e-08 0.854215674881943 8.03796580399111e-07 4 TFRC|TFRC 8.4232722578009e-07 0.762573050598072 2.347987141862e-05 4 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 5.49751360343883e-09 0.699100195902247 5.03075195762882e-07 4 AKT1 AKT2 AKT3|AKT_PT308 2.28690054628213e-06 0.693843373365279 5.09978821820915e-05 4 EIF4EBP1|4E-BP1_PT37_T46 8.17344132991068e-06 0.57547500927704 0.000131693417892408 4 CDH1|E-CADHERIN 8.267748208492e-06 0.55690373210069 0.000131693417892408 4 CTNNB1|BETA-CATENIN 1.96230185912445e-06 0.545542585106181 4.86214793983058e-05 4 TP63|P63 0.000404367711580072 0.530539462637061 0.00333977776601319 4 MYH11|MYH11 0.0249891786980833 0.522589207143724 0.0599202887061567 4 PARP1|PARP_CLEAVED 0.00742479063114816 0.507174126252905 0.0298098014934653 4 RB1|RB_PS807_S811 7.8390655397582e-06 0.490998547842613 0.000131693417892408 4 SNAI1|SNAIL 0.00712346279587402 0.473329323159686 0.0294172630274057 4 GAPDH|GAPDH 0.0109169893457786 0.451333441663325 0.0369642017486423 4 MET|C-MET 0.00775322191309859 0.444168980286362 0.0298098014934653 4 CASP8|CASPASE-8 0.0046956829004812 0.390048490187779 0.0222681619488588 4 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.0239845484343618 0.379434824241029 0.0581364597919857 4 RICTOR|RICTOR 0.0156527841519649 0.361975872999425 0.0441844413403566 4 BRAF|B-RAF 0.000441188938019038 0.340715353116652 0.00351057261479009 4 MSH6|MSH6 0.00251565784218167 0.32985729888603 0.0143844025335003 4 RBM15|RBM15 3.02916398071559e-05 0.32316957777008 0.00039735503982328 4 AKT1 AKT2 AKT3|AKT 0.000174933940299429 0.314309873019091 0.00177319403121694 4 RPS6|S6_PS240_S244 0.0343159925505842 0.277854674560146 0.0780863912120436 4 PRKCB|PKC-PAN_BETAII_PS660 0.000318168716071658 0.261354226444962 0.00272890860322999 4 KRT5|CK5 0.0341261568340925 0.257580867389254 0.0780863912120436 4 MSH2|MSH2 0.00446216163906188 0.25070619041457 0.02211248990024 4 SRC|SRC_PY527 0.0140806777333152 0.250132757001979 0.0407791056432375 4 CHEK2|CHK2 0.00438448817829237 0.233244684189312 0.02211248990024 4 ERCC1|ERCC1 0.031943006262703 0.232694447674946 0.0749820041745555 4 PDCD4|PDCD4 0.0442780625767838 0.223750129522219 0.0975825585472377 4 AKT1S1|PRAS40_PT246 4.76725075861682e-05 0.216520668599093 0.000559524694300816 4 XRCC5|KU80 0.0137058991609412 0.212738652698187 0.0407522068385318 4 MAPK14|P38_PT180_Y182 0.0126712863622345 0.208246469872877 0.0400813691144743 4 TSC2|TUBERIN_PT1462 0.000456531864703644 0.207007929151896 0.00351057261479009 4 BAD|BAD_PS112 1.55991064115529e-07 0.20179463584389 5.79766788296049e-06 4 YAP1|YAP_PS127 0.00614326141820664 0.199385403426574 0.0263451403126939 4 TSC1|TSC1 0.00249417355501299 0.196701280487996 0.0143844025335003 4 RB1|RB 0.0104000002253606 0.191708424533457 0.0368126992104034 4 JUN|C-JUN_PS73 0.00124910914487717 0.162681188324288 0.00819268645022379 4 NF2|NF2 0.00578719903641706 0.162496282092645 0.025934880000077 4 TSC2|TUBERIN 0.0191501376823851 0.155289306564232 0.0502409494490809 4 GSK3A GSK3B|GSK3-ALPHA-BETA 0.00633488463129198 0.145862255441131 0.0266543259014738 4 MAPK1|ERK2 0.0329522445404493 0.13734854609622 0.0765453180470854 4 RPS6KB1|P70S6K 0.0111058363998163 0.123073034180245 0.0369642017486423 4 PIK3CA |PI3K-P110-ALPHA 0.0135782920100823 0.119754448057911 0.0407522068385318 4 MTOR|MTOR 0.0100551458981747 0.117304584282403 0.0367589759884091 4 MTOR|MTOR_PS2448 0.0180059360143968 0.113695871893436 0.0494675897790074 4 BAP1|BAP1-C-4 0.0208464478558456 0.108948285862406 0.0522332345152086 4 CTNNA1|ALPHA-CATENIN 0.0189395232377351 0.102776170010313 0.0502409494490809 4 CDKN1B|P27_PT157 0.0225201603715203 -0.0418828795817265 0.0551867666247146 4 CCNE2|CYCLIN_E2 0.0442950010951662 -0.0586656883274805 0.0975825585472377 4 ESR1|ER-ALPHA_PS118 0.00766616254101448 -0.0610245763991189 0.0298098014934653 4 MS4A1|CD20 0.0181898760622359 -0.0634839565268165 0.0494675897790074 4 ERBB3|HER3_PY1289 0.011042403642765 -0.0680181778613842 0.0369642017486423 4 TIGAR|TIGAR 0.011781315891815 -0.0727229332190652 0.0386357859393345 4 MET|C-MET_PY1235 0.000247541499936086 -0.0747707987424978 0.00220807017942989 4 NRAS|N-RAS 0.0102585987103614 -0.0750833970277742 0.0368126992104034 4 MAPK14|P38_MAPK 0.0150387498732189 -0.0778169853033457 0.0429954002785617 4 RAF1|C-RAF_PS338 0.00183028479348002 -0.079247190856404 0.0116615288270298 4 AR|AR 0.028326449231991 -0.0795426970388839 0.0671999806248297 4 YWHAE|14-3-3_EPSILON 0.00429670039193572 -0.0806630604716511 0.02211248990024 4 MAPK9|JNK2 0.0186887966904178 -0.0845722198168178 0.0502120682164237 4 ERRFI1|MIG-6 0.00409850116956684 -0.0855459529858894 0.0217610895431763 4 ANXA7|ANNEXIN_VII 0.0196109196922214 -0.0859941351179287 0.0502670700156939 4 SMAD3|SMAD3 0.000185542847013704 -0.0868600285025539 0.00179895890800243 4 MRE11A|MRE11 0.00593129542602657 -0.0941206785822372 0.025934880000077 4 PECAM1|CD31 0.0127856689399708 -0.108926171328502 0.0400813691144743 4 RAD51|RAD51 0.0105662439308032 -0.110770946281637 0.0368167561963924 4 CHEK1|CHK1 0.0140671341333576 -0.11130557493647 0.0407791056432375 4 YWHAB|14-3-3_BETA 0.000835914893050921 -0.112001902597561 0.00582528191094861 4 NRG1|HEREGULIN 0.0047931469665705 -0.113526270542268 0.0222681619488588 4 CDH2|N-CADHERIN 0.00265225883376199 -0.113852563331311 0.0147863429982231 4 GATA3|GATA3 0.00465946296910624 -0.117228832005044 0.0222681619488588 4 CASP3|CASPASE-3 0.00760185639629698 -0.117317210507675 0.0298098014934653 4 PRKCA |PKC-ALPHA 0.013401517471491 -0.117984297015643 0.0407522068385318 4 BAX|BAX 0.0446341747615168 -0.118750743784255 0.0975825585472377 4 PRKCA |PKC-ALPHA_PS657 0.0165859179042298 -0.119415203187652 0.0462332461580406 4 TYMS|THYMIDILATE-SYNTHASE 0.0347352505293604 -0.120225669604167 0.0782420289701754 4 RAB11A RAB11B|RAB11 4.65818177022269e-05 -0.121496571584664 0.000559524694300816 4 PARK7|DJ-1 0.0129410698486195 -0.121496776208211 0.0400813691144743 4 ETS1|ETS-1 0.000736439853185623 -0.12445087067303 0.00529761571807722 4 ESR1|ER-ALPHA 0.00973028398277242 -0.127574155780552 0.0361642221359708 4 STMN1|STATHMIN 0.0024478322280433 -0.132651441612757 0.0143844025335003 4 PGR|PR 0.000123100492270436 -0.139099056369493 0.00137257048881536 4 CASP9|CASPASE-9 0.00588456680689533 -0.139488663191886 0.025934880000077 4 PDK1|PDK1 1.38804662640806e-05 -0.14461636802471 0.000206356265125998 4 AXL|AXL 0.000717065943527986 -0.146140181220395 0.00529761571807722 4 ERBB3|HER3 0.0194435348084643 -0.147051153195441 0.0502670700156939 4 CCNE1|CYCLIN_E1 0.0224548725550509 -0.147539657334121 0.0551867666247146 4 BCL2L11|BIM 0.00885540393653904 -0.148658320377666 0.0334704250482747 4 BRCA2|BRCA2 0.0119867354753882 -0.153941614288377 0.0387397392900227 4 ACVRL1|ACVRL1 1.57106152137021e-05 -0.175320315975418 0.000218966699540973 4 PREX1|PREX1 0.00023341755500564 -0.177882188635743 0.00216883811526074 4 COL6A1|COLLAGEN_VI 0.00282703937056307 -0.186040995986783 0.0153763360886723 4 PEA15|PEA15 0.00106579964497213 -0.194561351595773 0.00720222184329652 4 KIT|C-KIT 0.0465965436324273 -0.19655219893315 0.0999137425964547 4 CDKN1B|P27 5.19659177866431e-06 -0.199068568674946 0.000105349087876558 4 INPP4B|INPP4B 0.000170524282664419 -0.209043777278572 0.00177319403121694 4 CASP7|CASPASE-7_CLEAVEDD198 0.0451442696375516 -0.259765472329268 0.0977395352346991 4 CAV1|CAVEOLIN-1 0.0203653984661841 -0.353934509451475 0.0516077711131711 4 HSPA1A|HSP70 0.00247408789827965 -0.355295692854744 0.0143844025335003 4 MYH11|MYH11 3.50241707334313e-08 1.44190363707101 3.81763460994401e-06 5 LCN2|LCN2A 0.000234473094742542 0.982041732582043 0.0014198648514965 5 CAV1|CAVEOLIN-1 0.000800214947935017 0.744083112031208 0.00363430955520487 5 HSPA1A|HSP70 0.0312104066296148 0.384836998517971 0.0673650360916438 5 COL6A1|COLLAGEN_VI 0.00230109610499566 0.376791951077005 0.00895783840873311 5 MAPK1 MAPK3|MAPK_PT202_Y204 0.0150305880779516 0.305694730588696 0.0364074244554828 5 PRDX1|PRDX1 0.00349832674799978 0.303276303266184 0.0122618594282864 5 PEA15|PEA15 0.00491902456450915 0.264917330806087 0.0159295251318097 5 PECAM1|CD31 4.07869897352251e-05 0.261094249435072 0.000469346015497614 5 KIT|C-KIT 0.00939219248131373 0.251086300951208 0.0269407626437683 5 MAP2K1|MEK1_PS217_S221 4.09063041030031e-05 0.242367946072754 0.000469346015497614 5 ACVRL1|ACVRL1 7.15524691509659e-08 0.233174192630821 3.88546435995658e-06 5 BRCA2|BRCA2 0.000271002377630667 0.232536994620522 0.00159671671144555 5 ESR1|ER-ALPHA 8.60064845881971e-05 0.213815169896522 0.000646531504835413 5 MRE11A|MRE11 5.97306872310449e-05 0.213291912023671 0.000566143035494252 5 CDH2|N-CADHERIN 0.000501545548532321 0.211393039402609 0.00255431931612136 5 BAX|BAX 0.0178892093180635 0.20010930145343 0.0407031809642399 5 RAF1|C-RAF_PS338 3.21545246451516e-06 0.195674811682222 7.00968637264305e-05 5 RAD51|RAD51 3.15363834073356e-05 0.195215624167053 0.000404407740164657 5 ARAF|A-RAF_PS299 0.025512066565035 0.194642429642995 0.0561780859714912 5 PREX1|PREX1 0.00127519498367528 0.193418030149082 0.00537569549533418 5 MAPK8|JNK_PT183_PY185 5.57381467704569e-05 0.175511736535362 0.000566143035494252 5 YWHAB|14-3-3_BETA 6.86820595095511e-05 0.169680808751787 0.000604629615601088 5 PDK1|PDK1 2.16211571943527e-05 0.167018734349469 0.000294588266773056 5 FOXO3|FOXO3A_PS318_S321 6.94082901971964e-05 0.163559649041642 0.000604629615601088 5 CASP9|CASPASE-9 0.00047151035209025 0.162114440254312 0.00250705504282133 5 WWTR1|TAZ 0.00058057674330112 0.162033927840483 0.00282639615948189 5 CASP3|CASPASE-3 0.0481535545166838 0.157238776385228 0.10191723188968 5 YAP1|YAP 0.0107692784386079 0.156317764174396 0.0293462837452065 5 RPS6KB1|P70S6K_PT389 0.0113875671664046 0.155326802762222 0.0306480202750148 5 STMN1|STATHMIN 0.00190898264471609 0.154969289329179 0.00756651302814741 5 RAB11A RAB11B|RAB11 0.000769683649045696 0.15446420127314 0.00357002203174387 5 NRAS|N-RAS 1.11026070463955e-05 0.147171645112174 0.00017983992565846 5 CDKN1B|P27 0.000465105008746856 0.145495408282609 0.00250705504282133 5 PARK7|DJ-1 0.0148936684777657 0.142000464876039 0.0364074244554828 5 FOXO3|FOXO3A 7.02557419951868e-06 0.139728195831208 0.000139234106863188 5 MAPK14|P38_MAPK 0.0174771256527397 0.130808864406087 0.0407031809642399 5 BID|BID 0.00970680572065532 0.127972362860966 0.0271292775269597 5 RICTOR|RICTOR_PT1135 0.0124771326385432 0.124436428878551 0.0322408550408181 5 BCL2L1|BCL-XL 0.0175847864327005 0.123772880014203 0.0407031809642399 5 EIF4E|EIF4E 0.00690702634247289 0.112992034894589 0.0206264622282067 5 CHEK2|CHK2_PT68 0.0105151099880203 0.10389158914599 0.029016379460613 5 IRS1|IRS1 0.00178285319265254 0.100240066690725 0.00719744437033803 5 ANXA7|ANNEXIN_VII 0.00114174560103037 0.0984557176810628 0.00497801082049241 5 YWHAE|14-3-3_EPSILON 0.00798735709657841 0.0965233111285991 0.0235303222574878 5 ERBB3|HER3_PY1289 0.000503833626574396 0.0961357556829952 0.00255431931612136 5 AR|AR 0.022912129373136 0.0931697673871498 0.0509677979933025 5 SMAD3|SMAD3 0.0179243365714084 0.0734371268932367 0.0407031809642399 5 SMAD1|SMAD1 0.000728077577171633 -0.0992681736712077 0.00345045460485687 5 CHEK1|CHK1_PS345 1.23743068113619e-05 -0.104787710036618 0.00017983992565846 5 MAP2K1|MEK1 0.0367899009714755 -0.105490899360676 0.0786293961939378 5 EIF4EBP1|4E-BP1_PS65 0.0125709755893098 -0.112172176470048 0.0322408550408181 5 RAD50|RAD50 0.0160581982056616 -0.115411352694589 0.0384690902069696 5 PIK3CA |PI3K-P110-ALPHA 0.00494271416578916 -0.149349607634879 0.0159295251318097 5 BCL2L11|BIM 0.0187482229273273 -0.168714826094976 0.0421351814243026 5 ARID1A|ARID1A 0.00240235187518308 -0.170078176399381 0.00902952946189503 5 PCNA|PCNA 0.00136043236957239 -0.178659930893237 0.00559574068993927 5 GSK3A GSK3B|GSK3-ALPHA-BETA 0.00496884270166542 -0.182084051275073 0.0159295251318097 5 EGFR|EGFR 0.0145325114689097 -0.19050271172744 0.0360009943207081 5 DVL3|DVL3 0.0128446846905447 -0.196753162040097 0.0325597821225435 5 RB1|RB 0.00868525487433157 -0.205495709330725 0.0252451408347238 5 RPTOR|RAPTOR 0.00354356488065158 -0.206811953642029 0.0122618594282864 5 NF2|NF2 0.000175943064127151 -0.208696368616908 0.00112810552881526 5 MTOR|MTOR 0.0097046084464915 -0.214154795444348 0.0271292775269597 5 TP53|P53 0.0165323980654693 -0.224985358355266 0.0391745954160033 5 PRKAA1|AMPK_PT172 0.0122402562181439 -0.24370062283314 0.0321491066934382 5 KRT5|CK5 0.00397505069921112 -0.260967807040248 0.0135400164441879 5 PRKCB|PKC-PAN_BETAII_PS660 0.00562068492903182 -0.262186264725314 0.0177581060076657 5 CLDN7|CLAUDIN-7 0.0284863362857916 -0.280055977462126 0.0621002131030257 5 EEF2|EEF2 0.000304338592323554 -0.284860050697681 0.00170117469555217 5 ASNS|ASNS 0.00661477451073723 -0.334706238591981 0.0200280672686211 5 TSC2|TUBERIN 0.00239629443705452 -0.34146382943913 0.00902952946189503 5 YBX1|YB-1 0.000282343655822863 -0.349010075536135 0.00161976097287853 5 BAP1|BAP1-C-4 7.76588497102315e-05 -0.357387830503478 0.000604629615601088 5 EEF2K|EEF2K 0.00340302830636075 -0.363358985768599 0.0122618594282864 5 ERBB2|HER2 0.0131151131424215 -0.367582693324155 0.0328631570695159 5 ATM|ATM 0.0120852579691489 -0.388931247077198 0.0321291004545666 5 EGFR|EGFR_PY1068 0.000166839220625841 -0.395859400812657 0.00110215000292222 5 RB1|RB_PS807_S811 0.00612080674030167 -0.40999989208744 0.0187934629490953 5 NFKB1|NF-KB-P65_PS536 0.000990505524465261 -0.41323288784628 0.00440673886394749 5 MAPK1|ERK2 0.0034361616727134 -0.42612064258715 0.0122618594282864 5 FOXM1|FOXM1 2.17540490670935e-07 -0.431431634044155 6.77483242375197e-06 5 CHEK2|CHK2 7.04733838592423e-08 -0.431828679379614 3.88546435995658e-06 5 RPS6KB1|P70S6K 5.61409057488871e-05 -0.436447774601449 0.000566143035494252 5 STAT5A|STAT5-ALPHA 0.00596190213623901 -0.444561815016522 0.0185670666528586 5 TP53BP1|53BP1 0.000583430399893051 -0.469105711944444 0.00282639615948189 5 KEAP1|KEAP1 0.00257807334239899 -0.471743498846528 0.00952576251937254 5 TSC1|TSC1 5.85581106440955e-05 -0.507954252138068 0.000566143035494252 5 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 8.95733858665467e-05 -0.520380581941932 0.000650899937296906 5 BRAF|B-RAF 0.000161446189214213 -0.535524477054203 0.00109985216402183 5 XRCC5|KU80 3.85031519428324e-07 -0.590662445055942 1.04921089044218e-05 5 AKT1 AKT2 AKT3|AKT 0.000202212002970825 -0.591947960139034 0.00125949190421828 5 MSH2|MSH2 1.56015237531732e-07 -0.601042489854203 5.6685536303196e-06 5 TFRC|TFRC 0.00477815696456662 -0.636641567332657 0.0159295251318097 5 GSK3A GSK3B|GSK3_PS9 0.00014420069986976 -0.640887746270048 0.00101405653456799 5 TUBA1B|ACETYL-A-TUBULIN-LYS40 7.4828460524506e-05 -0.677122960214203 0.000604629615601088 5 RBM15|RBM15 4.66859038301693e-07 -0.74278412377942 1.13083633721966e-05 5 MSH6|MSH6 1.13352563009618e-09 -0.805143528626763 2.47108587360967e-07 5 CCNB1|CYCLIN_B1 8.91161550448757e-08 -0.816695720515652 3.88546435995658e-06 5 CDH1|E-CADHERIN 0.00128227598971274 -0.864282860862512 0.00537569549533418 5 GAPDH|GAPDH 1.19977568133312e-05 -0.904934265739614 0.00017983992565846 5 CTNNB1|BETA-CATENIN 7.88425151139508e-06 -0.955264999622319 0.000143230569123677 5 VHL|VHL 7.55655806777541e-05 -1.19641040921111 0.000604629615601088 5 MYH11|MYH11 5.07580836834302e-06 1.4211998070013 5.65952633070247e-05 6 CAV1|CAVEOLIN-1 2.89728606725591e-05 1.32244585602051 0.000184598512285162 6 RICTOR|RICTOR 1.81246795956189e-05 1.24315850988811 0.0001347267849941 6 NKX2-1|TTF1 0.00494526498122713 1.02361090611604 0.0140969334740332 6 STAT5A|STAT5-ALPHA 7.66939902653486e-08 0.786806501227155 2.57100653356084e-06 6 PXN|PAXILLIN 2.86052931262531e-05 0.771107032008048 0.000184598512285162 6 CTLA4|CTLA4 2.4522550451444e-05 0.702891391802434 0.0001708915234585 6 TGM2|TRANSGLUTAMINASE 0.000592542820701788 0.7024511738554 0.00249315186823583 6 GAB2|GAB2 8.21570312229024e-08 0.648215175542316 2.57100653356084e-06 6 ATM|ATM 1.41097612621292e-06 0.599047090789979 2.24748340103915e-05 6 HSPA1A|HSP70 0.014087991148866 0.533782505692887 0.0327252294395533 6 MET|C-MET 0.00639685246747676 0.507890446106179 0.0167823305911449 6 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.00884768604265624 0.483627372792056 0.0216816921704653 6 SYP|SYNAPTOPHYSIN 0.0064849761602796 0.473721561897638 0.0168156939970041 6 SNAI1|SNAIL 0.0223867020846874 0.467173851710021 0.0458605446217948 6 PRKCB|PKC-PAN_BETAII_PS660 4.47123601311936e-05 0.464426216120716 0.000276968230812671 6 PARP1|PARP_CLEAVED 0.0334348665411528 0.455119619767653 0.0631862308362464 6 STAT3|STAT3_PY705 2.57745766022217e-05 0.441862614556854 0.000174173654008953 6 TSC1|TSC1 1.84935741163307e-06 0.415611457258307 2.57754189246359e-05 6 COL6A1|COLLAGEN_VI 0.00175369041934143 0.406129539024663 0.00565789822544757 6 NFKB1|NF-KB-P65_PS536 0.0032441598910138 0.376649667406802 0.00986938222474538 6 AKT1 AKT2 AKT3|AKT 6.75046740013452e-06 0.370302490497664 6.54501839230434e-05 6 LCK|LCK 5.69784397159955e-05 0.361438702360073 0.000319377612688404 6 TSC2|TUBERIN 8.80737901099482e-09 0.354642056356438 9.82022759725922e-07 6 MAPK1 MAPK3|MAPK_PT202_Y204 0.00581851774867232 0.353065909423936 0.0156328850355895 6 SRC|SRC_PY527 0.0032750416351173 0.348359553844496 0.00986938222474538 6 PRKCA |PKC-ALPHA_PS657 8.95234108636917e-06 0.310568976764019 7.9854882490413e-05 6 MACC1|MACC1 0.0223525945312453 0.30967940423622 0.0458605446217948 6 XBP1|XBP1 0.0107748800850189 0.300870768627986 0.0257736027549276 6 CASP8|CASPASE-8 0.0205453164326786 0.300030079573468 0.044053899658532 6 PECAM1|CD31 0.000933283070188494 0.291890111196521 0.0034687020775339 6 PTEN|PTEN 0.000179990705833824 0.284828192154465 0.000863218812136951 6 SYK|SYK 0.0363838857826415 0.270362633482087 0.0674477648563392 6 ESR1|ER-ALPHA 0.0166782372349964 0.259944485613967 0.0375681505394363 6 YAP1|YAP_PS127 0.0365972177023186 0.251278610857477 0.0674477648563392 6 INPP4B|INPP4B 0.00316416172806512 0.249086967990395 0.00980011201886836 6 PREX1|PREX1 0.00014818506390177 0.240329118965472 0.000754033798075396 6 MTOR|MTOR_PS2448 8.27634890808554e-05 0.233986325364226 0.000439434715834066 6 PRKCA |PKC-ALPHA 0.000230747012731536 0.216237321757269 0.00105013436406393 6 MAPK1|ERK2 0.00203633137789659 0.197749812196002 0.00639580137001323 6 PRKCD|PKC-DELTA_PS664 4.75069708874905e-05 0.187782856964953 0.000278790908102905 6 PIK3R1 PIK3R2|PI3K-P85 5.39819416998352e-06 0.174662861794133 5.73236809479202e-05 6 BECN1|BECLIN 0.0105204708339925 0.174031505046469 0.025500706478047 6 RPTOR|RAPTOR 0.0281517082803482 0.170024323636812 0.0550686925133127 6 RB1|RB 0.0279597183903195 0.163672903661215 0.0550686925133127 6 PEA15|PEA15_PS116 0.0410466032395404 0.162788052125389 0.0738176816323993 6 TSC2|TUBERIN_PT1462 0.00776015753551665 0.162323300634735 0.0194439902294406 6 MTOR|MTOR 0.000346787159070755 0.161182904613448 0.00151634385240742 6 ETS1|ETS-1 0.00445307416085818 0.159778446241693 0.0131337495665768 6 RAF1|C-RAF 0.000727961998174965 0.149199561044393 0.00284799167707048 6 MS4A1|CD20 0.0165736784939602 0.126316385090602 0.0375681505394363 6 GATA3|GATA3 0.0314060862153724 0.12209669790784 0.0598594634703252 6 RPS6KA1|P90RSK 0.0238677396431775 0.12073658412487 0.0483864176402598 6 MAPK9|JNK2 0.00499398091680998 0.117697357994029 0.0140969334740332 6 RAB11A RAB11B|RAB11 0.0430073439083641 0.114559233293094 0.0761535850098256 6 PGR|PR 0.0382491102431545 0.109420490222482 0.0699143572477332 6 ACVRL1|ACVRL1 0.0111678283269597 0.0923951279057632 0.0262150075464422 6 CDKN1B|P27 0.0345544583664037 0.0910141907416926 0.0647533127370422 6 FOXO3|FOXO3A_PS318_S321 0.0276552497887133 0.0894782341850986 0.0550635777043131 6 STK11|LKB1 0.0407107776750705 0.0748055036549844 0.0738089709068351 6 BIRC2 |CIAP 0.0494457045842911 -0.054534135528297 0.0861436884554447 6 ESR1|ER-ALPHA_PS118 0.00551749102944884 -0.0647076541887331 0.0153800062445886 6 CHEK1|CHK1_PS345 0.0268486599983225 -0.0673107995334891 0.0539391998164497 6 TIGAR|TIGAR 0.00447607608547012 -0.0709365286690031 0.0131337495665768 6 SMAD4|SMAD4 0.0177799848276237 -0.0806624785246625 0.0392567981837632 6 BAK1|BAK 0.0311452617946528 -0.0820533579400312 0.0598594634703252 6 CHEK2|CHK2_PT68 0.0188476110971993 -0.0860184843943406 0.040805992958014 6 YBX1|YB-1_PS102 0.0179726139403057 -0.0912436373507269 0.039293067732237 6 SMAD3|SMAD3 0.00496511009538645 -0.0968696673922637 0.0140969334740332 6 STMN1|STATHMIN 0.0161030695227972 -0.119868118265576 0.0370204587998327 6 SRSF1|SF2 0.00066159800421526 -0.130783931570353 0.00268247918072733 6 YAP1|YAP 0.00116284570574703 -0.142353317534528 0.00412352839251718 6 EZH2|EZH2 0.000807611649921581 -0.150911140025769 0.00310512755056056 6 NFE2L2|NRF2 5.72874641593549e-05 -0.154399010397996 0.000319377612688404 6 BAP1|BAP1-C-4 0.00164462042312313 -0.15523645946703 0.00539338756406556 6 CTNNA1|ALPHA-CATENIN 0.000225699305870426 -0.161294464375205 0.00104856135852302 6 CCNE2|CYCLIN_E2 7.81574659014592e-06 -0.164341055855919 7.26213120667725e-05 6 EEF2|EEF2 0.00574086868650063 -0.173598283160177 0.0156123624035322 6 CHEK1|CHK1 0.000964971973176422 -0.175119654652908 0.0035276844265302 6 EIF4E|EIF4E 2.36416381752115e-05 -0.178835759253634 0.000170067268163618 6 EIF4EBP1|4E-BP1_PS65 0.00118546468876658 -0.184156761274403 0.00413060352492105 6 PIK3CA |PI3K-P110-ALPHA 2.40053332083059e-06 -0.18813827302622 3.14893488556013e-05 6 SRC|SRC 0.000148777969126984 -0.188953631292056 0.000754033798075396 6 KRT5|CK5 0.0172278279333819 -0.199005016083751 0.0384180562914416 6 ARAF|A-RAF_PS299 0.0207838585754126 -0.202981782504413 0.0441409567839715 6 EGFR|EGFR_PY1068 0.00688031562831921 -0.206869209241693 0.017488912843416 6 CDH3|P-CADHERIN 0.00116494299878288 -0.222357839259346 0.00412352839251718 6 BCL2L11|BIM 0.0305294255954648 -0.229760872373572 0.059200538328597 6 GSK3A GSK3B|GSK3-ALPHA-BETA 3.77142902362794e-07 -0.235456369307632 8.41028672269031e-06 6 PRDX1|PRDX1 0.00123595735141294 -0.242427093910436 0.00424028445177055 6 XRCC1|XRCC1 2.26674497775121e-10 -0.256220349944185 5.0548413003852e-08 6 RPS6|S6 0.0224161406447338 -0.257633022062046 0.0458605446217948 6 DIABLO|SMAC 0.0217455266161839 -0.259756782971184 0.0457476644849907 6 CASP3|CASPASE-3 5.12926682429425e-07 -0.262063636810308 9.68341099128992e-06 6 EIF4EBP1|4E-BP1_PT70 6.09035068022227e-06 -0.263347285877726 6.17340091677076e-05 6 BAX|BAX 1.5056000013462e-05 -0.267031756351246 0.000119910285821501 6 TYMS|THYMIDILATE-SYNTHASE 4.92950170886406e-06 -0.271806392870437 5.65952633070247e-05 6 ANXA1|ANNEXIN-1 0.00564625024091523 -0.274260941330997 0.0155446148607913 6 DVL3|DVL3 1.19780607236145e-05 -0.279032692884476 9.89299089394827e-05 6 CDKN1A|P21 0.00690145439560809 -0.279656618889149 0.017488912843416 6 ACACA ACACB|ACC_PS79 0.00624571916077854 -0.285425810148754 0.0165808972958764 6 RAB25|RAB25 0.00153727862941501 -0.304019012913032 0.00511661394566488 6 EIF4EBP1|4E-BP1_PT37_T46 0.00877816475318719 -0.325664615913551 0.0216816921704653 6 CHEK2|CHK2 0.0001819340097329 -0.336497943561527 0.000863218812136951 6 EGFR|EGFR 2.59375431674019e-07 -0.338974812581257 6.42674680703403e-06 6 MSH2|MSH2 6.97053242424379e-05 -0.345195986742212 0.000379128958684479 6 CD274|CD274 0.043028483010036 -0.359614915526127 0.0761535850098256 6 PARP1|PARP1 0.0108642092330188 -0.364077320114121 0.0257736027549276 6 CDKN2A|P16_INK4A 4.25145916893467e-08 -0.38456586572942 2.57100653356084e-06 6 PCNA|PCNA 9.2233418244335e-08 -0.438517319471703 2.57100653356084e-06 6 RB1|RB_PS807_S811 0.00064268746171101 -0.444039558819574 0.00265406118447324 6 FOXM1|FOXM1 0.000160802809433581 -0.445996923794652 0.000796867255637524 6 CCNE1|CYCLIN_E1 1.28670352533211e-06 -0.452180895820093 2.20719143191585e-05 6 CLDN7|CLAUDIN-7 0.00177602186449027 -0.475524478563084 0.00565789822544757 6 ASNS|ASNS 0.000847875586305669 -0.487814363962357 0.00320468230078244 6 ITGA2|CD49B 1.67367435410556e-05 -0.504406118823728 0.000128699786539841 6 MSH6|MSH6 7.96639522255987e-08 -0.580017598042316 2.57100653356084e-06 6 LCN2|LCN2A 0.0468803845255662 -0.590406967631353 0.0823175255842619 6 YWHAZ|14-3-3_ZETA 7.54960952195162e-08 -0.637759075146677 2.57100653356084e-06 6 EIF4EBP1|4E-BP1 5.2108041208735e-07 -0.678403415802959 9.68341099128992e-06 6 CDH1|E-CADHERIN 0.000679719566177366 -0.697750557359034 0.00270674041531344 6 TP63|P63 0.00141608144219903 -0.787974111519685 0.00478463881227854 6 SERPINE1|PAI-1 0.00057280082125513 -0.818263679157061 0.00245643429115181 6 CCNB1|CYCLIN_B1 1.04659685394487e-05 -0.862847754298287 8.97658070883485e-05 6 IGFBP2|IGFBP2 3.47707088162805e-06 -1.07230050056516 4.30770448112808e-05 6 TFRC|TFRC 4.73008781358999e-05 -1.08441722307606 0.000278790908102905 6 NDRG1|NDRG1_PT346 0.000261772768426225 -1.17640672395405 0.00116750654718096 6 GAPDH|GAPDH 1.7740545914113e-06 -1.25838759455478 2.57754189246359e-05 6