Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.207 0.407 -9999.0 0.0 -0.815 23.0 23.0 IHH -0.058 0.139 -9999.0 0.0 -0.528 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.03 0.147 -9999.0 0.0 -0.417 10.0 10.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.03 0.145 0.414 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.093 0.239 -9999.0 0.0 -0.631 11.0 11.0 SMO -0.105 0.252 -9999.0 0.0 -0.648 12.0 12.0 AKT1 -0.022 0.108 -9999.0 0.0 -0.315 1.0 1.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.027 0.151 -9999.0 0.0 -0.581 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.103 0.248 -9999.0 0.0 -0.636 12.0 12.0 STIL -0.101 0.243 -9999.0 0.0 -0.642 12.0 12.0 DHH N/PTCH2 -0.091 0.204 -9999.0 0.0 -0.444 21.0 21.0 DHH N/PTCH1 -0.14 0.286 -9999.0 0.0 -0.666 16.0 16.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.031 0.163 -9999.0 0.0 -0.626 6.0 6.0 PTHLH -0.225 0.435 -9999.0 0.0 -0.985 18.0 18.0 determination of left/right symmetry -0.103 0.248 -9999.0 0.0 -0.636 12.0 12.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.221 0.428 -9999.0 0.0 -0.968 18.0 18.0 IHH N/Hhip -0.259 0.257 -9999.0 0.0 -0.495 46.0 46.0 DHH N/Hhip -0.231 0.266 -9999.0 0.0 -0.477 44.0 44.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.103 0.248 -9999.0 0.0 -0.636 12.0 12.0 pancreas development -0.288 0.307 -9999.0 0.0 -0.597 43.0 43.0 HHAT 0.007 0.072 -9999.0 0.0 -0.657 1.0 1.0 PI3K 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.052 0.196 -9999.0 0.0 -0.626 9.0 9.0 somite specification -0.103 0.248 -9999.0 0.0 -0.636 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.11 0.248 -9999.0 0.0 -0.63 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.054 0.142 -9999.0 0.0 -0.322 19.0 19.0 SHH Np/Cholesterol/Megalin -0.102 0.194 -9999.0 0.0 -0.388 26.0 26.0 SHH 0.001 0.082 -9999.0 0.0 -0.432 3.0 3.0 catabolic process -0.134 0.291 -9999.0 0.0 -0.776 12.0 12.0 SMO/Vitamin D3 -0.101 0.242 -9999.0 0.0 -0.625 12.0 12.0 SHH Np/Cholesterol/Hhip -0.167 0.198 -9999.0 0.0 -0.359 43.0 43.0 LRP2 -0.173 0.296 -9999.0 0.0 -0.638 25.0 25.0 receptor-mediated endocytosis -0.184 0.248 -9999.0 0.0 -0.626 16.0 16.0 SHH Np/Cholesterol/BOC -0.015 0.106 -9999.0 0.0 -0.325 9.0 9.0 SHH Np/Cholesterol/CDO -0.036 0.165 -9999.0 0.0 -0.472 10.0 10.0 mesenchymal cell differentiation 0.166 0.197 0.356 43.0 -9999.0 0.0 43.0 mol:Vitamin D3 -0.109 0.25 -9999.0 0.0 -0.633 13.0 13.0 IHH N/PTCH2 -0.102 0.206 -9999.0 0.0 -0.456 21.0 21.0 CDON -0.063 0.214 -9999.0 0.0 -0.657 10.0 10.0 IHH N/PTCH1 -0.135 0.294 -9999.0 0.0 -0.783 12.0 12.0 Megalin/LRPAP1 -0.119 0.222 -9999.0 0.0 -0.468 25.0 25.0 PTCH2 -0.094 0.23 -9999.0 0.0 -0.577 16.0 16.0 SHH Np/Cholesterol -0.005 0.063 -9999.0 0.0 -0.337 3.0 3.0 PTCH1 -0.135 0.293 -9999.0 0.0 -0.78 12.0 12.0 HHIP -0.288 0.307 -9999.0 0.0 -0.598 43.0 43.0