Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.037 0.129 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.067 0.135 -9999.0 0.0 -0.341 17.0 17.0 CYFIP2 0.007 0.072 -9999.0 0.0 -0.657 1.0 1.0 ENAH 0.0 0.142 -9999.0 0.0 -0.412 5.0 5.0 EGFR -0.032 0.17 -9999.0 0.0 -0.657 6.0 6.0 EPHA2 0.007 0.072 -9999.0 0.0 -0.657 1.0 1.0 MYO6 -0.037 0.148 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.009 0.061 -9999.0 0.0 -0.408 2.0 2.0 AQP5 -0.145 0.199 -9999.0 0.0 -0.538 13.0 13.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.029 0.141 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.069 0.175 -9999.0 0.0 -0.622 2.0 2.0 EGF -0.051 0.193 -9999.0 0.0 -0.616 9.0 9.0 NCKAP1 0.007 0.072 -9999.0 0.0 -0.657 1.0 1.0 AQP3 -0.104 0.174 -9999.0 0.0 -0.594 6.0 6.0 cortical microtubule organization -0.067 0.135 -9999.0 0.0 -0.341 17.0 17.0 GO:0000145 -0.028 0.135 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.067 0.137 -9999.0 0.0 -0.345 17.0 17.0 MLLT4 -0.009 0.122 -9999.0 0.0 -0.657 3.0 3.0 ARF6/GDP -0.07 0.16 -9999.0 0.0 -0.603 5.0 5.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.01 0.116 -9999.0 0.0 -0.438 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.137 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.029 0.143 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.023 0.099 -9999.0 0.0 -0.401 5.0 5.0 CDH1 -0.117 0.266 -9999.0 0.0 -0.657 17.0 17.0 EGFR/EGFR/EGF/EGF -0.11 0.18 -9999.0 0.0 -0.724 3.0 3.0 RhoA/GDP -0.062 0.126 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.028 0.143 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer -0.031 0.166 -9999.0 0.0 -0.64 6.0 6.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.031 0.166 -9999.0 0.0 -0.641 6.0 6.0 IGF1 -0.073 0.219 -9999.0 0.0 -0.619 12.0 12.0 DIAPH1 -0.018 0.122 -9999.0 0.0 -0.813 2.0 2.0 Wnt receptor signaling pathway 0.067 0.135 0.341 17.0 -9999.0 0.0 17.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.07 0.16 -9999.0 0.0 -0.603 5.0 5.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.029 0.146 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 -0.024 0.156 -9999.0 0.0 -0.657 5.0 5.0 LPP -0.024 0.14 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.082 0.187 -9999.0 0.0 -0.702 5.0 5.0 SEC6/SEC8 -0.064 0.14 -9999.0 0.0 -0.586 3.0 3.0 MGAT3 -0.07 0.178 -9999.0 0.0 -0.636 2.0 2.0 HGF/MET -0.154 0.2 -9999.0 0.0 -0.682 6.0 6.0 HGF -0.134 0.264 -9999.0 0.0 -0.601 21.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.037 0.13 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.021 0.134 -9999.0 0.0 -0.453 2.0 2.0 KIAA1543 -0.073 0.224 -9999.0 0.0 -0.627 9.0 9.0 KIFC3 -0.029 0.143 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.029 0.143 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.067 0.135 -9999.0 0.0 -0.341 17.0 17.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.143 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.029 0.143 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.009 0.122 -9999.0 0.0 -0.657 3.0 3.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.006 0.16 -9999.0 0.0 -0.506 5.0 5.0 adherens junction assembly -0.052 0.219 -9999.0 0.0 -0.596 9.0 9.0 IGF-1R heterotetramer/IGF1 -0.12 0.181 -9999.0 0.0 -0.617 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.004 0.092 -9999.0 0.0 -0.484 3.0 3.0 MET -0.047 0.194 -9999.0 0.0 -0.657 8.0 8.0 PLEKHA7 -0.044 0.168 -9999.0 0.0 -0.636 2.0 2.0 mol:GTP -0.025 0.107 -9999.0 0.0 -0.435 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.007 0.158 -9999.0 0.0 -0.554 3.0 3.0 cortical actin cytoskeleton stabilization -0.037 0.129 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.028 0.143 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.037 0.13 -9999.0 0.0 -9999.0 0.0 0.0