Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	22.0	157.0	7.0	-0.18	-0.0	1000.0	-1000.0	-0.038	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	19.0	661.0	34.0	-0.273	0.014	1000.0	-1000.0	-0.07	-1000.0
TCGA08_retinoblastoma	18.0	149.0	8.0	-0.135	0.083	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by the Hedgehog family	14.0	746.0	52.0	-0.288	0.166	1000.0	-1000.0	-0.065	-1000.0
Syndecan-1-mediated signaling events	13.0	473.0	34.0	-0.283	0.014	1000.0	-1000.0	-0.054	-1000.0
IL4-mediated signaling events	13.0	1237.0	91.0	-0.793	0.707	1000.0	-1000.0	-0.154	-1000.0
E-cadherin signaling events	11.0	56.0	5.0	-0.117	0.014	1000.0	-1000.0	-0.048	-1000.0
p75(NTR)-mediated signaling	10.0	1363.0	125.0	-0.341	0.028	1000.0	-1000.0	-0.103	-1000.0
Glucocorticoid receptor regulatory network	10.0	1238.0	114.0	-0.714	0.353	1000.0	-1000.0	-0.08	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	868.0	82.0	-0.225	0.014	1000.0	-1000.0	-0.089	-1000.0
Endothelins	10.0	975.0	96.0	-0.245	0.014	1000.0	-1000.0	-0.088	-1000.0
Signaling mediated by p38-alpha and p38-beta	10.0	457.0	44.0	-0.13	0.014	1000.0	-1000.0	-0.056	-1000.0
Integrins in angiogenesis	10.0	850.0	84.0	-0.269	0.028	1000.0	-1000.0	-0.092	-1000.0
HIF-1-alpha transcription factor network	9.0	718.0	76.0	-0.314	0.027	1000.0	-1000.0	-0.132	-1000.0
amb2 Integrin signaling	9.0	748.0	82.0	-0.32	0.014	1000.0	-1000.0	-0.086	-1000.0
Reelin signaling pathway	9.0	509.0	56.0	-0.279	0.021	1000.0	-1000.0	-0.081	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	615.0	68.0	-0.389	0.083	1000.0	-1000.0	-0.13	-1000.0
IL23-mediated signaling events	9.0	579.0	60.0	-0.471	0.014	1000.0	-1000.0	-0.164	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	757.0	93.0	-0.162	0.078	1000.0	-1000.0	-0.083	-1000.0
Syndecan-4-mediated signaling events	8.0	545.0	67.0	-0.178	0.019	1000.0	-1000.0	-0.087	-1000.0
Caspase cascade in apoptosis	7.0	527.0	74.0	-0.131	0.067	1000.0	-1000.0	-0.035	-1000.0
Thromboxane A2 receptor signaling	7.0	796.0	105.0	-0.2	0.056	1000.0	-1000.0	-0.069	-1000.0
FOXA2 and FOXA3 transcription factor networks	7.0	347.0	46.0	-0.381	0.025	1000.0	-1000.0	-0.09	-1000.0
BMP receptor signaling	7.0	620.0	81.0	-0.232	0.044	1000.0	-1000.0	-0.096	-1000.0
Ephrin B reverse signaling	7.0	380.0	48.0	-0.176	0.032	1000.0	-1000.0	-0.07	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	246.0	31.0	-0.305	0.014	1000.0	-1000.0	-0.096	-1000.0
Wnt signaling	7.0	52.0	7.0	-0.104	0.014	1000.0	-1000.0	-0.032	-1000.0
BCR signaling pathway	7.0	765.0	99.0	-0.247	0.018	1000.0	-1000.0	-0.084	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	7.0	864.0	120.0	-0.228	0.178	1000.0	-1000.0	-0.082	-1000.0
LPA4-mediated signaling events	6.0	76.0	12.0	-0.097	0.017	1000.0	-1000.0	-0.025	-1000.0
IL12-mediated signaling events	6.0	608.0	87.0	-0.286	0.028	1000.0	-1000.0	-0.142	-1000.0
Glypican 1 network	6.0	329.0	48.0	-0.212	0.019	1000.0	-1000.0	-0.046	-1000.0
TCGA08_p53	6.0	42.0	7.0	-0.102	0.056	1000.0	-1000.0	-0.017	-1000.0
Glypican 2 network	6.0	25.0	4.0	-0.03	-0.027	1000.0	-1000.0	-0.021	-1000.0
Nongenotropic Androgen signaling	6.0	359.0	52.0	-0.136	0.068	1000.0	-1000.0	-0.064	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	456.0	76.0	-0.117	0.021	1000.0	-1000.0	-0.092	-1000.0
ErbB2/ErbB3 signaling events	5.0	344.0	65.0	-0.153	0.023	1000.0	-1000.0	-0.071	-1000.0
Coregulation of Androgen receptor activity	5.0	383.0	76.0	-0.158	0.025	1000.0	-1000.0	-0.052	-1000.0
ErbB4 signaling events	5.0	363.0	69.0	-0.189	0.16	1000.0	-1000.0	-0.092	-1000.0
Visual signal transduction: Cones	5.0	199.0	38.0	-0.076	0.014	1000.0	-1000.0	-0.071	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	313.0	54.0	-0.2	0.029	1000.0	-1000.0	-0.106	-1000.0
Noncanonical Wnt signaling pathway	5.0	147.0	26.0	-0.114	0.014	1000.0	-1000.0	-0.063	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	508.0	85.0	-0.145	0.014	1000.0	-1000.0	-0.077	-1000.0
Effects of Botulinum toxin	5.0	143.0	26.0	-0.118	0.014	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	747.0	125.0	-0.1	0.021	1000.0	-1000.0	-0.092	-1000.0
IL6-mediated signaling events	5.0	448.0	75.0	-0.22	0.057	1000.0	-1000.0	-0.088	-1000.0
EGFR-dependent Endothelin signaling events	5.0	110.0	21.0	-0.129	0.021	1000.0	-1000.0	-0.072	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	475.0	88.0	-0.263	0.016	1000.0	-1000.0	-0.117	-1000.0
Visual signal transduction: Rods	5.0	296.0	52.0	-0.181	0.014	1000.0	-1000.0	-0.087	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.022	-1000.0	1000.0	-1000.0	-0.015	-1000.0
Osteopontin-mediated events	4.0	178.0	38.0	-0.145	0.018	1000.0	-1000.0	-0.119	-1000.0
Syndecan-2-mediated signaling events	4.0	293.0	69.0	-0.121	0.04	1000.0	-1000.0	-0.049	-1000.0
Arf6 signaling events	4.0	300.0	62.0	-0.264	0.016	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by PTP1B	4.0	305.0	76.0	-0.159	0.023	1000.0	-1000.0	-0.084	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	257.0	61.0	-0.252	0.035	1000.0	-1000.0	-0.077	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	408.0	97.0	-0.145	0.034	1000.0	-1000.0	-0.092	-1000.0
PDGFR-alpha signaling pathway	4.0	184.0	44.0	-0.226	0.029	1000.0	-1000.0	-0.062	-1000.0
S1P1 pathway	4.0	153.0	36.0	-0.104	0.014	1000.0	-1000.0	-0.057	-1000.0
FAS signaling pathway (CD95)	4.0	216.0	47.0	-0.262	0.027	1000.0	-1000.0	-0.045	-1000.0
Syndecan-3-mediated signaling events	4.0	151.0	35.0	-0.105	0.021	1000.0	-1000.0	-0.067	-1000.0
EPHB forward signaling	4.0	398.0	85.0	-0.153	0.092	1000.0	-1000.0	-0.097	-1000.0
IL27-mediated signaling events	4.0	254.0	51.0	-0.18	0.08	1000.0	-1000.0	-0.091	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	296.0	74.0	-0.154	0.067	1000.0	-1000.0	-0.092	-1000.0
IGF1 pathway	4.0	253.0	57.0	-0.082	0.021	1000.0	-1000.0	-0.101	-1000.0
VEGFR1 specific signals	4.0	268.0	56.0	-0.099	0.014	1000.0	-1000.0	-0.068	-1000.0
FOXM1 transcription factor network	4.0	209.0	51.0	-0.145	0.142	1000.0	-1000.0	-0.17	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	496.0	136.0	-0.231	0.227	1000.0	-1000.0	-0.071	-1000.0
BARD1 signaling events	3.0	205.0	57.0	-0.054	0.045	1000.0	-1000.0	-0.065	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	243.0	65.0	-0.244	0.072	1000.0	-1000.0	-0.063	-1000.0
Nectin adhesion pathway	3.0	250.0	63.0	-0.129	0.026	1000.0	-1000.0	-0.075	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	157.0	52.0	-0.16	0.035	1000.0	-1000.0	-0.067	-1000.0
HIF-2-alpha transcription factor network	3.0	157.0	43.0	-0.125	0.024	1000.0	-1000.0	-0.084	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	50.0	15.0	-0.023	0.019	1000.0	-1000.0	-0.033	-1000.0
Retinoic acid receptors-mediated signaling	3.0	209.0	58.0	-0.144	0.02	1000.0	-1000.0	-0.079	-1000.0
IL2 signaling events mediated by PI3K	3.0	183.0	58.0	-0.094	0.038	1000.0	-1000.0	-0.088	-1000.0
Canonical Wnt signaling pathway	3.0	189.0	51.0	-0.252	0.055	1000.0	-1000.0	-0.064	-1000.0
LPA receptor mediated events	3.0	396.0	102.0	-0.151	0.038	1000.0	-1000.0	-0.092	-1000.0
IL2 signaling events mediated by STAT5	3.0	73.0	22.0	-0.062	0.016	1000.0	-1000.0	-0.048	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	111.0	33.0	-0.138	0.027	1000.0	-1000.0	-0.059	-1000.0
Regulation of Androgen receptor activity	3.0	249.0	70.0	-0.315	0.028	1000.0	-1000.0	-0.072	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	52.0	17.0	-0.04	0.022	1000.0	-1000.0	-0.041	-1000.0
Aurora B signaling	3.0	241.0	67.0	-0.135	0.015	1000.0	-1000.0	-0.075	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	66.0	28.0	-0.044	0.023	1000.0	-1000.0	-0.037	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	-0.008	0.002	1000.0	-1000.0	-0.019	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	44.0	17.0	-0.039	0.028	1000.0	-1000.0	-0.069	-1000.0
Cellular roles of Anthrax toxin	2.0	87.0	39.0	-0.062	0.018	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	2.0	16.0	7.0	-0.021	0.0	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	2.0	153.0	68.0	-0.165	0.037	1000.0	-1000.0	-0.105	-1000.0
Signaling events mediated by HDAC Class III	2.0	97.0	40.0	-0.123	0.031	1000.0	-1000.0	-0.044	-1000.0
TRAIL signaling pathway	2.0	125.0	48.0	-0.04	0.032	1000.0	-1000.0	-0.077	-1000.0
IL1-mediated signaling events	2.0	150.0	62.0	-0.088	0.065	1000.0	-1000.0	-0.114	-1000.0
Regulation of p38-alpha and p38-beta	2.0	134.0	54.0	-0.159	0.033	1000.0	-1000.0	-0.059	-1000.0
Regulation of Telomerase	2.0	258.0	102.0	-0.161	0.037	1000.0	-1000.0	-0.114	-1000.0
Plasma membrane estrogen receptor signaling	2.0	215.0	86.0	-0.073	0.04	1000.0	-1000.0	-0.088	-1000.0
S1P3 pathway	2.0	104.0	42.0	-0.095	0.021	1000.0	-1000.0	-0.037	-1000.0
Rapid glucocorticoid signaling	2.0	41.0	20.0	-0.05	0.014	1000.0	-1000.0	-0.041	-1000.0
PDGFR-beta signaling pathway	2.0	282.0	97.0	-0.088	0.023	1000.0	-1000.0	-0.088	-1000.0
E-cadherin signaling in keratinocytes	2.0	111.0	43.0	-0.117	0.017	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	190.0	78.0	-0.06	0.045	1000.0	-1000.0	-0.072	-1000.0
p38 MAPK signaling pathway	2.0	112.0	44.0	-0.157	0.028	1000.0	-1000.0	-0.07	-1000.0
Circadian rhythm pathway	1.0	23.0	22.0	-0.011	0.039	1000.0	-1000.0	-0.038	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.013	0.021	1000.0	-1000.0	-0.023	-1000.0
Aurora A signaling	1.0	104.0	60.0	-0.125	0.042	1000.0	-1000.0	-0.061	-1000.0
PLK1 signaling events	1.0	116.0	85.0	-0.029	0.027	1000.0	-1000.0	-0.043	-1000.0
Insulin-mediated glucose transport	1.0	44.0	32.0	-0.146	0.034	1000.0	-1000.0	-0.068	-1000.0
Ceramide signaling pathway	1.0	117.0	76.0	-0.073	0.035	1000.0	-1000.0	-0.068	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	66.0	37.0	-0.052	0.037	1000.0	-1000.0	-0.061	-1000.0
S1P5 pathway	1.0	26.0	17.0	-0.029	0.026	1000.0	-1000.0	-0.036	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	161.0	83.0	-0.147	0.05	1000.0	-1000.0	-0.076	-1000.0
FoxO family signaling	1.0	100.0	64.0	-0.146	0.107	1000.0	-1000.0	-0.064	-1000.0
Atypical NF-kappaB pathway	1.0	37.0	31.0	-0.045	0.03	1000.0	-1000.0	-0.047	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	64.0	45.0	-0.059	0.058	1000.0	-1000.0	-0.096	-1000.0
TCGA08_rtk_signaling	1.0	48.0	26.0	-0.047	0.041	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events	1.0	83.0	73.0	-0.159	0.04	1000.0	-1000.0	-0.071	-1000.0
Insulin Pathway	1.0	114.0	74.0	-0.133	0.039	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by PRL	1.0	64.0	34.0	-0.074	0.021	1000.0	-1000.0	-0.043	-1000.0
S1P4 pathway	1.0	44.0	25.0	-0.029	0.021	1000.0	-1000.0	-0.054	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	-0.009	0.045	1000.0	-1000.0	-0.064	-1000.0
Canonical NF-kappaB pathway	0.0	22.0	39.0	-0.023	0.08	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by HDAC Class II	0.0	49.0	75.0	-0.05	0.039	1000.0	-1000.0	-0.07	-1000.0
Arf6 downstream pathway	0.0	42.0	43.0	-0.028	0.027	1000.0	-1000.0	-0.047	-1000.0
EPO signaling pathway	0.0	27.0	55.0	-0.029	0.083	1000.0	-1000.0	-0.095	-1000.0
mTOR signaling pathway	0.0	31.0	53.0	-0.012	0.034	1000.0	-1000.0	-0.064	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	56.0	68.0	-0.146	0.055	1000.0	-1000.0	-0.056	-1000.0
ceramide signaling pathway	0.0	42.0	49.0	-0.023	0.047	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by HDAC Class I	0.0	79.0	104.0	-0.05	0.043	1000.0	-1000.0	-0.072	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	27.0	36.0	-0.051	0.044	1000.0	-1000.0	-0.075	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.036	1000.0	-1000.0	-0.061	-1000.0
Arf6 trafficking events	0.0	28.0	71.0	-0.047	0.047	1000.0	-1000.0	-0.083	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.004	0.039	1000.0	-1000.0	-0.055	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.016	1000.0	-1000.0	-0.069	-1000.0
Total	571	35903	7203	-19.3945853277	-994.061419476	131000	-131000	-9.33731650869	-131000