Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.06 0.243 -9999.0 0.0 -0.758 26.0 26.0 IHH -0.062 0.162 -9999.0 0.0 -0.42 48.0 48.0 SHH Np/Cholesterol/GAS1 -0.067 0.169 -9999.0 0.0 -0.446 40.0 40.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.066 0.168 0.443 40.0 -9999.0 0.0 40.0 SMO/beta Arrestin2 -0.02 0.125 -9999.0 0.0 -0.58 4.0 4.0 SMO -0.028 0.131 -9999.0 0.0 -0.555 6.0 6.0 AKT1 0.004 0.065 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.008 0.101 -9999.0 0.0 -0.49 12.0 12.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.028 0.129 -9999.0 0.0 -0.546 6.0 6.0 STIL -0.064 0.16 -9999.0 0.0 -0.491 18.0 18.0 DHH N/PTCH2 -0.042 0.146 -9999.0 0.0 -0.374 46.0 46.0 DHH N/PTCH1 -0.036 0.145 -9999.0 0.0 -0.5 13.0 13.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.014 0.12 -9999.0 0.0 -0.548 14.0 14.0 PTHLH -0.057 0.259 -9999.0 0.0 -0.834 23.0 23.0 determination of left/right symmetry -0.028 0.129 -9999.0 0.0 -0.546 6.0 6.0 PIK3R1 0.009 0.034 -9999.0 0.0 -0.408 2.0 2.0 skeletal system development -0.056 0.254 -9999.0 0.0 -0.82 23.0 23.0 IHH N/Hhip -0.118 0.203 -9999.0 0.0 -0.442 72.0 72.0 DHH N/Hhip -0.088 0.194 -9999.0 0.0 -0.405 75.0 75.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.028 0.129 -9999.0 0.0 -0.546 6.0 6.0 pancreas development -0.107 0.23 -9999.0 0.0 -0.53 66.0 66.0 HHAT -0.017 0.135 -9999.0 0.0 -0.653 13.0 13.0 PI3K 0.016 0.024 -9999.0 0.0 -0.278 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.03 0.16 -9999.0 0.0 -0.629 20.0 20.0 somite specification -0.028 0.129 -9999.0 0.0 -0.546 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.07 0.164 -9999.0 0.0 -0.526 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.073 0.161 -9999.0 0.0 -0.404 47.0 47.0 SHH Np/Cholesterol/Megalin -0.193 0.197 -9999.0 0.0 -0.416 112.0 112.0 SHH -0.064 0.164 -9999.0 0.0 -0.367 63.0 63.0 catabolic process -0.031 0.142 -9999.0 0.0 -0.526 9.0 9.0 SMO/Vitamin D3 -0.061 0.162 -9999.0 0.0 -0.514 16.0 16.0 SHH Np/Cholesterol/Hhip -0.11 0.192 -9999.0 0.0 -0.448 58.0 58.0 LRP2 -0.253 0.286 -9999.0 0.0 -0.535 147.0 147.0 receptor-mediated endocytosis -0.153 0.186 -9999.0 0.0 -0.545 27.0 27.0 SHH Np/Cholesterol/BOC -0.054 0.141 -9999.0 0.0 -0.408 28.0 28.0 SHH Np/Cholesterol/CDO -0.048 0.143 -9999.0 0.0 -0.432 26.0 26.0 mesenchymal cell differentiation 0.109 0.19 0.444 58.0 -9999.0 0.0 58.0 mol:Vitamin D3 -0.068 0.166 -9999.0 0.0 -0.527 16.0 16.0 IHH N/PTCH2 -0.067 0.159 -9999.0 0.0 -0.413 41.0 41.0 CDON 0.003 0.074 -9999.0 0.0 -0.555 5.0 5.0 IHH N/PTCH1 -0.031 0.143 -9999.0 0.0 -0.532 9.0 9.0 Megalin/LRPAP1 -0.177 0.213 -9999.0 0.0 -0.384 147.0 147.0 PTCH2 -0.044 0.162 -9999.0 0.0 -0.488 34.0 34.0 SHH Np/Cholesterol -0.05 0.128 -9999.0 0.0 -0.397 25.0 25.0 PTCH1 -0.031 0.142 -9999.0 0.0 -0.529 9.0 9.0 HHIP -0.107 0.231 -9999.0 0.0 -0.531 66.0 66.0