rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), HSPA1A(1), IFNGR1(2), IFNGR2(17), IKBKB(4), JAK2(2), LIN7A(1), NFKBIA(2), RB1(3), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TP53(119), USH1C(1) 5180987 159 125 110 11 34 15 22 22 66 0 1.95e-07 <1.00e-15 <1.57e-13 2 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(3), DAXX(6), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(5), TNFRSF1A(2), TNFRSF1B(1), TP53(119) 5380911 143 120 108 10 35 15 20 23 50 0 3.70e-08 <1.00e-15 <1.57e-13 3 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(11), CCNE1(1), CDK4(2), MDM2(2), PCNA(1), RB1(3), TP53(119) 5074342 142 124 109 4 34 16 21 23 48 0 7.00e-11 1.44e-15 1.57e-13 4 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(7), AKT1(3), ATM(11), CSNK1A1(1), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), HSPA1A(1), MAPK8(2), MDM2(2), NFKBIB(1), NQO1(2), TP53(119) 5853817 154 127 119 10 35 16 22 28 53 0 1.45e-08 2.00e-15 1.57e-13 5 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(11), ATR(10), BRCA1(6), CDC25A(6), CDC25B(2), CDC25C(3), CDC34(1), CHEK2(1), EP300(6), MDM2(2), MYT1(12), PRKDC(9), RPS6KA1(2), TP53(119), YWHAH(1) 11825926 191 134 149 12 42 21 26 32 70 0 6.30e-09 2.33e-15 1.57e-13 6 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(7), ATM(11), ATR(10), CCNA1(3), CCNE1(1), CDC25A(6), CDK4(2), CDK6(2), CDKN2A(43), DHFR(1), GSK3B(2), RB1(3), SKP2(3), TFDP1(1), TGFB1(1), TGFB2(2), TP53(119) 8450927 217 133 160 15 36 26 29 28 98 0 6.52e-09 2.33e-15 1.57e-13 7 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), CDC42(1), DUSP10(1), DUSP8(1), GCK(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K7(12), MAP3K9(4), MAPK10(1), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(2), TP53(119), TRAF6(1), ZAK(5) 14186800 193 133 147 17 48 20 25 28 72 0 1.11e-07 2.66e-15 1.57e-13 8 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(1), MYC(2), SP1(1), SP3(1), TP53(119) 1961934 124 120 91 0 30 12 15 19 48 0 6.00e-15 2.66e-15 1.57e-13 9 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), EGFR(2), IGF1R(6), MYC(2), POLR2A(6), PPP2CA(1), RB1(3), TEP1(18), TERF1(9), TERT(6), TNKS(4), TP53(119), XRCC5(2) 7893165 181 130 132 14 47 18 19 26 70 1 1.52e-08 2.78e-15 1.57e-13 10 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(7), CDKN2A(43), MDM2(2), MYC(2), PIK3CA(6), PIK3R1(2), POLR1A(6), POLR1B(3), RB1(3), TBX2(2), TP53(119) 5728217 195 131 143 5 36 23 23 25 88 0 6.55e-15 2.89e-15 1.57e-13 11 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(11), ATR(10), BRCA1(6), BRCA2(14), CHEK2(1), FANCA(5), FANCC(2), FANCD2(8), FANCG(1), HUS1(1), MRE11A(4), RAD17(9), RAD50(1), TP53(119), TREX1(2) 12196925 194 138 146 13 37 24 25 36 72 0 7.95e-08 3.33e-15 1.57e-13 12 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAK1(1), BCL2L1(7), BIRC2(2), CASP2(3), CASP7(2), CASP8(2), CASP9(1), FAS(3), FASLG(1), MAP2K4(5), MAP3K1(3), MAPK10(1), MDM2(2), MYC(2), NFKBIA(2), PARP1(8), PRF1(8), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TP53(119), TRADD(1), TRAF2(1) 10546582 183 131 135 14 39 17 27 25 74 1 7.01e-08 3.33e-15 1.57e-13 13 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(11), ATR(10), CDC25C(3), CHEK2(1), TP53(119), YWHAH(1) 4422649 145 127 110 4 32 14 20 23 56 0 1.44e-08 3.89e-15 1.57e-13 14 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(2), ARF3(1), CDK4(2), CDKN2A(43), MDM2(2), NXT1(1), PRB1(1), TP53(119) 2387559 171 125 120 2 35 17 19 21 79 0 1.22e-15 4.00e-15 1.57e-13 15 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(11), CDC25A(6), CDC25B(2), CDC25C(3), CDK4(2), MYT1(12), RB1(3), TP53(119), YWHAH(1) 4894440 159 127 120 5 38 16 22 25 58 0 2.21e-10 4.11e-15 1.57e-13 16 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(3), ATM(11), BAD(1), BCL2L1(7), CASP7(2), CASP9(1), PTK2(3), PXN(1), STAT1(3), TLN1(11), TP53(119) 7664270 165 129 125 8 40 21 20 26 58 0 2.70e-10 4.22e-15 1.57e-13 17 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(2), NFKBIA(2), RELA(3), TP53(119) 2806342 127 120 94 2 30 13 16 21 47 0 4.10e-11 4.33e-15 1.57e-13 18 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(7), ATM(11), BRCA1(6), CHEK2(1), MAPK8(2), MDM2(2), MRE11A(4), NFKBIA(2), RAD50(1), RBBP8(13), RELA(3), TP53(119), TP73(1) 8316212 172 134 126 4 37 18 24 24 69 0 8.87e-12 4.88e-15 1.67e-13 19 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), CDKN2A(43), E2F4(3), PRB1(1) 2559686 57 44 39 4 3 8 7 5 34 0 0.00661 2.41e-12 7.82e-11 20 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAD(1), BAK1(1), BCL2L1(7), BIRC2(2), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FAS(3), FASLG(1), HELLS(1), IKBKB(4), IRF1(2), IRF2(1), IRF3(1), IRF5(1), IRF6(4), IRF7(2), MAP2K4(5), MAP3K1(3), MAPK10(1), MDM2(2), MYC(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), PRF1(8), RELA(3), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TP53(119), TP73(1), TRADD(1), TRAF2(1) 16269943 208 135 162 20 46 25 30 28 78 1 6.18e-08 1.03e-11 3.17e-10 21 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), AKT2(2), AKT3(4), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD72(2), CD81(2), CHUK(1), CR2(10), FCGR2B(2), GSK3B(2), HRAS(1), IFITM1(1), IKBKB(4), INPP5D(1), KRAS(142), LILRB3(3), LYN(1), MALT1(3), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG2(7), PPP3CA(3), PPP3CC(2), PTPN6(4), RAC2(1), RASGRP3(2), SYK(2), VAV1(6) 20892824 302 155 125 35 33 92 86 26 64 1 9.50e-12 1.45e-07 4.25e-06 22 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(3), CCND2(3), CCND3(1), CCNE1(1), CDC25A(6), CDK4(2), CDK6(2), CDK7(1), CDKN2A(43), RB1(3), RBL1(1), TFDP1(1) 4539373 67 50 45 7 2 10 8 6 41 0 0.0315 1.65e-07 4.61e-06 23 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(7), ATM(11), BUB1(2), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(4), CDC14B(1), CDC20(1), CDC25A(6), CDC25B(2), CDC25C(3), CDC6(3), CDC7(1), CDH1(1), CDK4(2), CDKN2A(43), CHEK2(1), E2F3(3), E2F4(3), E2F5(3), EP300(6), ESPL1(8), GSK3B(2), HDAC4(4), HDAC5(2), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), MPEG1(2), PCNA(1), PRKDC(9), PTPRA(1), RB1(3), RBL1(1), SKP2(3), SMAD4(41), TBC1D8(3), TFDP1(1), TGFB1(1), TP53(119) 31010499 352 148 288 27 77 42 49 51 132 1 8.88e-15 4.78e-07 1.28e-05 24 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(30), RANGAP1(4) 2331646 35 24 15 2 2 3 3 16 10 1 0.0169 1.04e-06 2.67e-05 25 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1A(2), ARPC2(1), CDC42(1), PAK1(19), PDGFRA(3), PIK3CA(6), PIK3R1(2), WASL(6) 3697475 40 34 20 2 4 5 2 4 25 0 0.0809 4.01e-06 9.88e-05 26 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(23), CRY1(1), CRY2(1), CSNK1E(1), PER1(5) 2422329 32 26 12 1 2 1 0 3 25 1 0.205 1.06e-05 0.000252 27 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), COASY(2), DPYD(4), DPYS(21), ENPP3(3), PANK1(1), PANK2(12), PANK3(1), PANK4(2), PPCS(1), UPB1(2) 3932523 51 39 23 4 5 7 3 4 32 0 0.105 2.61e-05 0.000596 28 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(5), CDK5R1(1), EGR1(23), HRAS(1), KLK2(1), NGFR(1) 2334760 32 26 12 4 3 0 3 2 24 0 0.813 8.70e-05 0.00191 29 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(2), AKT1(3), AKT2(2), AKT3(4), APAF1(3), ATM(11), BAD(1), BCL2L1(7), BIRC2(2), CAPN1(1), CAPN2(1), CASP10(2), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CSF2RB(2), DFFB(1), FAS(3), FASLG(1), IKBKB(4), IL1B(1), IL1RAP(2), IL3RA(3), IRAK3(2), IRAK4(1), NFKB2(1), NFKBIA(2), NTRK1(3), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RELA(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TP53(119), TRADD(1), TRAF2(1) 23631484 245 143 200 25 67 34 29 35 80 0 7.68e-10 0.000146 0.00309 30 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(18), CAPN1(1), CAPNS1(3), CAPNS2(2), CDK5(5), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(2), MAPT(3), PPP2CA(1) 2662891 38 29 21 5 7 6 1 2 22 0 0.251 0.000176 0.00361 31 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(2), AKT3(4), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), KRAS(142), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NOS3(9), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PRKCG(2), PTGS2(1), PTK2(3), PXN(1), RAC2(1), SH2D2A(6), SHC2(2), SPHK1(1), SPHK2(1), SRC(2) 20432635 287 154 111 36 33 86 90 25 53 0 1.38e-10 0.000196 0.00389 32 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(1), HRAS(1), IGF1R(6), IRS1(30), PIK3CA(6), PIK3R1(2), SHC1(2), SOS1(14), YWHAH(1) 5246771 66 50 31 9 8 5 3 6 44 0 0.516 0.000217 0.00417 33 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(11), HLA-DRB1(1) 837187 12 12 2 1 0 0 0 0 11 1 1.000 0.000236 0.00440 34 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(2), AKT3(4), BTK(1), FCER1A(1), FCER1G(1), FYN(9), GAB2(2), HRAS(1), INPP5D(1), KRAS(142), LYN(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(7), PRKCD(11), PRKCE(1), RAC2(1), SOS1(14), SOS2(1), SYK(2), VAV1(6) 20272827 268 153 101 35 24 81 86 22 54 1 4.12e-09 0.000275 0.00498 35 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA3(5), LTB4R(7), P2RY1(7), P2RY2(1), P2RY6(1) 1664827 22 17 18 1 7 6 3 2 4 0 0.00160 0.000349 0.00602 36 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(4), CPEB1(2), EGFR(2), ERBB2(6), ERBB4(6), ETS1(3), ETS2(2), ETV6(3), ETV7(1), FMN2(14), KRAS(142), NOTCH1(10), NOTCH2(4), NOTCH3(7), NOTCH4(5), PIWIL1(1), PIWIL2(3), PIWIL3(3), PIWIL4(1), SOS1(14), SOS2(1) 14836946 234 145 80 42 24 73 89 20 28 0 9.07e-05 0.000352 0.00602 37 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(2), COASY(2), DPYD(4), DPYS(21), ENPP3(3), ILVBL(2), PANK1(1), PANK2(12), PANK3(1), PANK4(2), PPCDC(1), PPCS(1), UPB1(2), VNN1(1) 4874218 57 41 29 4 9 8 4 4 32 0 0.0239 0.000450 0.00749 38 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ARPC1A(2), ARPC2(1), NCK1(3), NCKAP1(4), NTRK1(3), PIR(2), WASF1(1), WASF2(2), WASF3(24), WASL(6) 4258537 52 34 29 6 10 6 3 4 28 1 0.228 0.000527 0.00854 39 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC3B(2), APOBEC3G(1), APOBEC4(15) 2024717 23 19 9 1 3 2 2 1 15 0 0.238 0.000716 0.0113 40 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(2), HRAS(1), INSR(4), IRS1(30), MAPK8(2), PIK3CA(6), PIK3R1(2), RASA1(4), SHC1(2), SOS1(14), SRF(1) 7125134 69 52 35 8 8 5 2 7 47 0 0.288 0.000762 0.0117 41 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(2), HRAS(1), IGF1R(6), IRS1(30), MAPK8(2), PIK3CA(6), PIK3R1(2), RASA1(4), SHC1(2), SOS1(14), SRF(1) 6915590 71 54 37 9 8 5 3 7 48 0 0.325 0.000955 0.0144 42 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(3), ATM(11), ATR(10), BAI1(5), CASP8(2), CASP9(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(1), CCNG2(2), CDK4(2), CDK6(2), CDKN2A(43), CHEK2(1), DDB2(1), EI24(1), FAS(3), GTSE1(2), MDM2(2), PERP(1), PTEN(2), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN1(1), SESN2(3), SESN3(2), STEAP3(3), THBS1(7), TNFRSF10B(2), TP53(119), TP73(1), TSC2(8), ZMAT3(2) 18468358 258 137 202 30 63 37 32 30 96 0 1.67e-08 0.00168 0.0246 43 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(2), BRAF(4), FAS(3), FASLG(1), FCER1G(1), FYN(9), HLA-A(7), HLA-G(3), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNGR2(17), ITGAL(3), ITGB2(1), KIR2DL3(2), KIR3DL1(3), KLRC3(2), KRAS(142), LCK(1), NCR1(1), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PAK1(19), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG1(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PRF1(8), PRKCG(2), PTPN6(4), RAC2(1), SHC1(2), SHC2(2), SHC4(2), SOS1(14), SOS2(1), SYK(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(6), ZAP70(6) 31925138 379 161 149 47 42 90 89 31 126 1 5.16e-09 0.00541 0.0770 44 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(1), IKBKB(4), MAP3K1(3), MAP3K5(2), MAP4K5(1), MAPK8(2), NFKBIA(2), RELA(3), TNFRSF9(7), TNFSF9(28), TRAF2(1) 5499808 54 40 24 7 2 3 5 4 40 0 0.747 0.00550 0.0770 45 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(2), IFNGR2(17), JAK1(1), JAK2(2), STAT1(3) 2267175 25 22 9 4 2 0 3 2 18 0 0.863 0.00701 0.0960 46 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(5), HLA-DRB1(1), IFNGR1(2), IFNGR2(17), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL2RA(1), IL4R(3) 3514311 34 29 16 4 5 1 2 2 24 0 0.419 0.00791 0.106 47 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(11), CD4(2), HLA-DRB1(1), IL1B(1), IL6(1) 1474496 16 13 6 2 0 0 1 1 13 1 0.839 0.0105 0.138 48 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(2), ACADM(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), CNDP1(2), DPYD(4), DPYS(21), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), HIBCH(10), UPB1(2) 7526227 68 48 42 5 14 6 9 5 33 1 0.00449 0.0115 0.147 49 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), HRAS(1), SHC1(2), SOS1(14), SRC(2) 2459819 21 18 10 2 2 3 0 1 15 0 0.432 0.0144 0.181 50 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), IL2RA(1), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), TOB1(8) 2958221 31 24 22 5 8 3 2 3 15 0 0.270 0.0188 0.232 51 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(23), CRY1(1), CRY2(1), CSNK1D(1), CSNK1E(1), NPAS2(4), PER1(5), PER2(5), PER3(2) 4811686 44 31 23 4 3 6 3 5 26 1 0.105 0.0277 0.332 52 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), FSHB(1), FSHR(4), GNAS(16), XPO1(2) 2725058 28 19 19 2 16 2 4 4 2 0 0.0264 0.0281 0.332 53 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 HLA-A(7), KLRC3(2), KLRC4(1), PAK1(19), PIK3CA(6), PIK3R1(2), PTPN6(4), SYK(2), VAV1(6) 5177912 49 34 30 9 7 4 5 8 24 1 0.480 0.0462 0.537 54 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(16), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 2226947 23 17 10 2 3 0 4 1 15 0 0.496 0.0626 0.714 55 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(7), ABL2(2), AKT1(3), AKT2(2), AKT3(4), ARAF(2), BAD(1), BRAF(4), BTC(1), CAMK2D(1), CBL(5), CBLB(2), CBLC(1), CRK(1), CRKL(2), EGF(4), EGFR(2), ELK1(2), ERBB2(6), ERBB3(6), ERBB4(6), GSK3B(2), HRAS(1), KRAS(142), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK9(1), MYC(2), NCK1(3), NCK2(2), NRG1(3), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), RPS6KB2(4), SHC1(2), SHC2(2), SHC4(2), SOS1(14), SOS2(1), SRC(2), STAT5A(2) 29038562 325 153 151 40 39 90 92 25 79 0 2.85e-10 0.0699 0.783 56 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), AKT2(2), AKT3(4), CARD11(3), CBL(5), CBLB(2), CBLC(1), CD3E(1), CD4(2), CD8B(2), CDC42(1), CDK4(2), CHUK(1), FYN(9), GRAP2(2), HRAS(1), IKBKB(4), ITK(1), KRAS(142), LCK(1), MALT1(3), NCK1(3), NCK2(2), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKCQ(3), PTPN6(4), PTPRC(3), RASGRP1(2), RHOA(1), SOS1(14), SOS2(1), TEC(2), VAV1(6), ZAP70(6) 28494610 356 162 147 45 42 96 88 28 101 1 2.44e-09 0.0860 0.946 57 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), FADS2(15), PLA2G12B(1), PLA2G3(2), PLA2G6(4) 2847543 25 20 11 7 2 2 3 1 17 0 0.969 0.0942 1.000 58 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(5), GRIA2(1), JUND(1), PPP1R1B(1) 1078118 8 8 4 0 0 0 1 1 6 0 0.654 0.101 1.000 59 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(5), CDK5R1(1), CSNK1D(1), DRD1(5), GRM1(17), PLCB1(1), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 4473555 45 26 35 6 14 5 5 6 15 0 0.0491 0.112 1.000 60 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(4), NR3C1(2), PPARG(1), RETN(7), RXRA(1) 1605614 16 11 10 2 3 1 2 1 9 0 0.339 0.122 1.000 61 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(2), B3GNT7(1), B4GALT2(16), CHST1(1), CHST2(2), CHST4(1), CHST6(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 3531442 32 22 19 2 6 2 6 2 16 0 0.0463 0.147 1.000 62 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL6(1), FADS1(1), FADS2(15), FASN(7), HADHA(1), HSD17B12(1), SCD(12) 4158864 43 28 19 5 5 4 4 0 29 1 0.200 0.152 1.000 63 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(3), AOC3(3), CES1(2), ESD(5) 1669202 13 9 10 1 4 2 3 0 4 0 0.153 0.156 1.000 64 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(2), ACADL(2), ACADM(2), ACADSB(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), CNDP1(2), DPYD(4), DPYS(21), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), UPB1(2) 8076794 65 41 48 5 16 9 9 6 24 1 0.000713 0.173 1.000 65 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(5), CDK5R1(1), DAB1(2), FYN(9), LRP8(3), RELN(14), VLDLR(3) 3879364 37 27 21 8 7 4 3 2 20 1 0.710 0.179 1.000 66 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(11), CCNA1(3), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(6), CDK4(2), CDK7(1), CDKN2A(43), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(3), E2F5(3), GBA2(3), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), MYC(2), MYT1(12), NACA(13), PCNA(1), POLA2(1), POLE(8), POLE2(1), PRIM1(1), RB1(3), RBL1(1), RPA1(1), RPA2(3), RPA3(2), TFDP1(1), TFDP2(4), TNXB(13), TP53(119) 21868365 298 137 238 35 68 37 43 45 104 1 2.32e-09 0.209 1.000 67 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD17B7(11), HSD3B1(2) 2258366 22 14 13 4 1 15 2 3 1 0 0.0415 0.217 1.000 68 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(9), THBS1(7) 2045120 16 16 5 3 5 2 0 0 9 0 0.487 0.225 1.000 69 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(1), RAB9A(1) 1187560 12 6 12 1 5 3 2 1 1 0 0.0706 0.238 1.000 70 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(2), PAK1(19), PIK3CA(6), PIK3R1(2), RB1(3), RELA(3), TFDP1(1) 5667021 45 33 26 9 4 4 7 5 25 0 0.761 0.271 1.000 71 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), HRAS(1), KLK2(1), NTRK1(3), PIK3CA(6), PIK3R1(2), PLCG1(1), SHC1(2), SOS1(14) 4346793 33 25 21 5 6 4 2 4 17 0 0.362 0.274 1.000 72 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(4), EPHB1(2), FYN(9), ITGA1(7), L1CAM(6), LYN(1), RAP1B(3), SELP(3) 4354846 39 26 28 5 12 5 3 4 15 0 0.0513 0.279 1.000 73 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(16), GNB1(2), PRKAR1A(1) 1907431 24 16 15 3 15 4 2 2 1 0 0.0536 0.292 1.000 74 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(6), CDC25B(2), CDK7(1) 1988514 9 9 5 1 2 0 1 0 6 0 0.632 0.301 1.000 75 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(1), CFTR(5), GNAS(16), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SLC9A3R1(1) 3735255 37 23 28 4 20 6 4 5 2 0 0.00612 0.305 1.000 76 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD4(2), FYN(9), HLA-DRB1(1), LCK(1), PTPRC(3), ZAP70(6) 2540664 23 14 15 2 4 3 1 2 13 0 0.154 0.308 1.000 77 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGT(1), AGTR2(1), BDKRB2(1), KNG1(2), NOS3(9), REN(8) 2809457 30 17 22 3 7 2 9 1 11 0 0.0846 0.352 1.000 78 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(5), EGF(4), EGFR(2), HRAS(1), PTPRB(10), RASA1(4), SHC1(2), SOS1(14), SPRY4(5), SRC(2) 6948332 49 33 34 4 2 9 5 6 26 1 0.0640 0.378 1.000 79 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(2), ELK1(2), GNAS(16), GNB1(2), HRAS(1), IGF1R(6), KLK2(1), MKNK2(3), MYC(2), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(4), SHC1(2), SOS1(14), SRC(2), STAT3(2) 9379376 66 46 44 9 21 11 5 5 24 0 0.0168 0.382 1.000 80 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(3) 515787 3 3 3 0 1 0 0 2 0 0 0.448 0.386 1.000 81 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(2), AKT1(3), AKT2(2), AKT3(4), BAD(1), BTK(1), CDKN2A(43), DAPP1(2), GSK3A(2), GSK3B(2), IARS(4), INPP5D(1), PDK1(1), PIK3CA(6), PPP1R13B(1), PTEN(2), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS1(14), SOS2(1), TEC(2), YWHAE(3), YWHAH(1) 10138451 104 68 71 13 13 15 5 12 59 0 0.0145 0.387 1.000 82 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(1), FMOD(2), KERA(2), LUM(2) 1001919 7 4 7 1 1 0 1 4 1 0 0.478 0.397 1.000 83 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(6), CDC25B(2), CDC25C(3), CSK(1), PTPRA(1), SRC(2) 2561472 15 14 9 2 3 2 2 0 8 0 0.463 0.404 1.000 84 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(1), CHRNB1(4), CHRNG(2), MUSK(7), PIK3CA(6), PIK3R1(2), PTK2(3), SRC(2), TERT(6), YWHAH(1) 4647173 37 22 32 6 7 9 2 6 13 0 0.0599 0.420 1.000 85 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(2), UGP2(6), UXS1(2) 1375884 11 9 9 3 0 2 1 4 4 0 0.765 0.425 1.000 86 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(5), CREBBP(3), DFFB(1), HMGB2(1), NME1(1), PRF1(8), SET(1) 2974230 20 15 13 4 3 2 2 1 12 0 0.629 0.444 1.000 87 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), ELK1(2), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3CA(6), PIK3R1(2), PLCG1(1), SHC1(2), SOS1(14) 5358541 33 24 22 3 4 5 2 4 18 0 0.0789 0.448 1.000 88 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(5), ADCY8(4), ARAF(2), ATF4(1), BRAF(4), CACNA1C(9), CALML3(1), CALML6(2), CAMK2D(1), CAMK4(2), CREBBP(3), EP300(6), GNAQ(1), GRIA1(3), GRIA2(1), GRIN1(8), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRM1(17), GRM5(7), HRAS(1), ITPR1(10), ITPR2(12), ITPR3(10), KRAS(142), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), RAP1B(3), RAPGEF3(4), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5) 28310183 319 157 162 50 53 85 99 28 52 2 1.17e-09 0.458 1.000 89 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3E(1), HLA-A(7), ICAM1(2), ITGAL(3), ITGB2(1), PRF1(8) 2416507 22 13 17 4 5 1 2 3 11 0 0.387 0.486 1.000 90 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(10), BMPR1A(4), BMPR2(3) 1735555 17 9 17 3 4 6 2 1 4 0 0.190 0.495 1.000 91 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(2), DFFB(1), HMGB1(6), HMGB2(1), TOP2A(2), TOP2B(6) 2673016 18 14 15 3 3 3 2 6 4 0 0.368 0.513 1.000 92 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(2), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALT2(16), FUT1(1), FUT2(3), FUT3(1), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GCNT2(1), ST8SIA1(2) 4597218 35 23 22 3 10 4 4 0 17 0 0.0479 0.518 1.000 93 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(3), NR4A3(12), WDR1(2) 3080685 25 14 15 6 5 2 1 5 12 0 0.606 0.528 1.000 94 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(6), CASP1(4), CASP10(2), CASP8(2), CASP9(1), PRF1(8) 3574525 26 17 21 5 4 4 1 3 13 1 0.475 0.537 1.000 95 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(1) 1070904 3 3 3 0 1 1 1 0 0 0 0.341 0.540 1.000 96 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(6), CDC25B(2), CDC25C(3), CDK7(1), XPO1(2) 2433002 14 12 8 2 3 0 1 0 10 0 0.635 0.543 1.000 97 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(7), ANAPC1(3), ANAPC2(4), ANAPC4(3), ANAPC5(6), ANAPC7(1), ATM(11), ATR(10), BUB1(2), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(4), CDC14B(1), CDC16(1), CDC20(1), CDC23(2), CDC25A(6), CDC25B(2), CDC25C(3), CDC27(8), CDC6(3), CDC7(1), CDK4(2), CDK6(2), CDK7(1), CDKN2A(43), CHEK2(1), CREBBP(3), CUL1(4), E2F3(3), EP300(6), ESPL1(8), GSK3B(2), MAD1L1(1), MAD2L1(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), PCNA(1), PKMYT1(2), PRKDC(9), RB1(3), RBL1(1), RBL2(2), SKP1(1), SKP2(3), SMAD2(1), SMAD3(1), SMAD4(41), SMC1A(1), SMC1B(5), TFDP1(1), TGFB1(1), TGFB2(2), TP53(119), YWHAE(3), YWHAH(1) 38274387 395 157 327 39 83 54 58 52 147 1 1.26e-12 0.545 1.000 98 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(16), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 2773813 28 16 19 3 19 4 3 2 0 0 0.0175 0.546 1.000 99 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(11), CDC25A(6), CDC25B(2), CDC25C(3), MYT1(12), YWHAH(1) 3821993 35 20 29 5 8 4 5 5 13 0 0.188 0.550 1.000 100 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IL12B(1) 830479 5 5 4 2 0 2 0 0 3 0 0.927 0.553 1.000 101 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ARPC1A(2), ARPC2(1), CDC42(1), WASF1(1), WASL(6) 2248368 15 10 13 3 3 4 2 2 4 0 0.382 0.559 1.000 102 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(2) 554983 2 2 2 0 1 1 0 0 0 0 0.477 0.560 1.000 103 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(7), ABCB11(4), ABCB4(9), ABCC1(1), ABCC3(5), GSTP1(1) 3982139 27 20 18 4 6 4 3 5 9 0 0.147 0.565 1.000 104 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(3) 454101 4 2 4 0 2 1 0 1 0 0 0.236 0.567 1.000 105 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(8), CDH1(1), CREBBP(3), EP300(6), MAP3K7(12), SKIL(1), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10) 7128531 52 33 41 8 13 5 8 7 19 0 0.122 0.568 1.000 106 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(1), LDLR(1), LPL(4) 1469397 10 5 10 0 3 3 1 1 2 0 0.0233 0.578 1.000 107 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(2), ILK(1), PDK2(3), PIK3CA(6), PIK3R1(2), PTEN(2), PTK2(3), SHC1(2), SOS1(14) 5443687 38 24 26 4 6 6 4 4 18 0 0.0858 0.585 1.000 108 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F5(14), FGA(6), FGB(4), FGG(2), PROC(1), PROS1(2), SERPINC1(3), TFPI(2) 4545514 38 19 33 9 3 7 15 10 3 0 0.293 0.587 1.000 109 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(3), CPS1(5), GLS(1), GOT1(3) 2162834 13 6 12 0 4 2 3 3 0 1 0.0265 0.595 1.000 110 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(4) 895970 5 4 5 1 4 0 0 0 1 0 0.411 0.610 1.000 111 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(4), CSAD(1), GAD1(6), GAD2(5), GGT1(1) 1618869 18 11 15 7 4 3 4 1 5 1 0.763 0.617 1.000 112 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(3), ANXA1(3), GNAS(16), GNB1(2), NOS3(9), NR3C1(2), PIK3CA(6), PIK3R1(2), RELA(3), SYT1(1) 5102734 48 29 38 7 18 5 11 7 7 0 0.0494 0.638 1.000 113 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(9), MMP2(2), MMP9(4), RECK(3) 2107969 19 11 12 6 5 3 2 0 9 0 0.654 0.638 1.000 114 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(2), AKT3(4), ELK1(2), HRAS(1), NGFR(1), NTRK1(3), PIK3CA(6), PIK3CD(2), SHC1(2), SOS1(14) 4622429 40 29 27 9 10 3 2 5 20 0 0.466 0.656 1.000 115 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 315467 1 1 1 0 0 0 0 0 1 0 0.842 0.669 1.000 116 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 619349 3 2 3 2 0 0 0 1 2 0 0.934 0.701 1.000 117 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(2), CSF3(2), EPO(2), IL6(1), IL7(1), IL9(1) 1719135 11 5 10 1 1 1 2 4 3 0 0.291 0.703 1.000 118 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 199171 2 1 2 1 2 0 0 0 0 0 0.802 0.711 1.000 119 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11A1(2), CYP11B1(7), CYP11B2(6), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2) 2675545 21 17 16 5 6 4 2 2 7 0 0.388 0.716 1.000 120 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11A1(2), CYP11B1(7), CYP11B2(6), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2) 2675545 21 17 16 5 6 4 2 2 7 0 0.388 0.716 1.000 121 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(5), AKT1(3), BAD(1), BCL2L1(7), CSF2RB(2), IGF1R(6), IL3RA(3), KIT(4), PIK3CA(6), PIK3R1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), YWHAH(1) 6119091 49 26 42 8 15 7 5 8 14 0 0.0253 0.723 1.000 122 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), NTAN1(5), SIRT1(1), SIRT2(1) 3298271 14 10 11 0 4 1 1 2 6 0 0.0506 0.726 1.000 123 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(5), UBE2F(1), UBE2G2(1) 1776018 10 5 10 1 4 1 3 1 1 0 0.127 0.743 1.000 124 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(1), BFAR(2), BTK(1), CAD(6), CASP10(2), CASP8(2), CSNK1A1(1), DAXX(6), DEDD(2), EGFR(2), EPHB2(4), FAF1(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MET(4), NFAT5(31), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PTPN13(8), RALBP1(2), ROCK1(6), SMPD1(1), TP53(119), TPX2(2), TRAF2(1) 20793911 234 138 172 31 49 32 32 32 89 0 1.61e-05 0.747 1.000 125 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), ATIC(2), DHFR(1), FTCD(2), GART(1), MTFMT(4), MTHFD1(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(2), SHMT2(4), TYMS(1) 5281751 33 16 28 7 5 4 5 5 13 1 0.213 0.764 1.000 126 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1R(9) 1818711 12 9 10 3 2 3 0 2 5 0 0.431 0.766 1.000 127 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), ESCO1(3), ESCO2(12), SH3GLB1(1) 4600520 22 17 11 4 2 2 1 3 14 0 0.718 0.770 1.000 128 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), TAT(1) 726398 4 2 4 1 0 1 2 1 0 0 0.677 0.777 1.000 129 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), FUT2(3), FUT3(1), ST3GAL4(2) 2012061 11 8 11 2 8 0 0 2 1 0 0.256 0.783 1.000 130 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(2), ACADS(1), ACAT1(2), HADHA(1) 1510553 8 4 8 0 1 4 1 1 1 0 0.0836 0.786 1.000 131 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(4), PSMB1(1), PSMB10(1), PSMB4(6), PSMB5(2), PSMB6(1) 2422803 19 15 16 6 6 0 2 2 9 0 0.727 0.789 1.000 132 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(2), BRAF(4), CACNA1A(9), CRHR1(2), GNA11(3), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(16), GNAZ(1), GRIA1(3), GRIA2(1), GRID2(10), GRM1(17), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HRAS(1), IGF1R(6), ITPR1(10), ITPR2(12), ITPR3(10), KRAS(142), LYN(1), NOS1(10), NOS3(9), NPR1(5), NPR2(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PRKCG(2), PRKG1(1), PRKG2(2), RYR1(24) 31226969 360 162 199 52 90 81 114 35 40 0 3.08e-12 0.791 1.000 133 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(2), TPI1(3) 1074702 6 3 6 1 3 2 0 1 0 0 0.295 0.792 1.000 134 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(2), ST6GALNAC5(25), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3) 4584426 55 39 31 13 10 5 7 2 31 0 0.510 0.799 1.000 135 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(3), EP300(6), IKBKB(4), IL1B(1), MAP2K3(1), MAP2K6(3), MAP3K7(12), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(3), TGFBR1(8), TGFBR2(10), TLR2(2) 8346272 59 34 49 8 14 8 10 6 21 0 0.0208 0.802 1.000 136 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(11), CCND2(3), CDK4(2), EGR1(23), ESR2(3), FSHR(4), GJA4(2), LHCGR(2), MLH1(1), NCOR1(9), NRIP1(1), PGR(4), PRLR(2), SMPD1(1), ZP2(1) 9796804 69 39 53 9 13 6 14 10 26 0 0.0438 0.803 1.000 137 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(6), CYP17A1(1), HSD11B1(1), HSD3B1(2) 1918022 14 10 11 4 2 3 3 2 4 0 0.527 0.806 1.000 138 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(4), PSMB1(1), PSMB4(6), PSMB5(2), PSMB6(1), UBE3A(6) 3595993 24 17 20 5 8 1 2 3 10 0 0.401 0.811 1.000 139 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2), HLA-DRB1(1) 659834 3 2 3 1 0 0 0 1 2 0 0.905 0.813 1.000 140 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(2), BDH2(1), HMGCS2(1), OXCT1(2), OXCT2(1) 2017978 9 5 9 1 1 5 0 1 2 0 0.148 0.816 1.000 141 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNAQ(1), GNB1(2), HTR2C(5), PLCB1(1), TUB(2) 1981498 12 8 12 4 4 3 0 4 1 0 0.505 0.820 1.000 142 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(1), GHR(1), HRAS(1), IGF1R(6), PIK3CA(6), PIK3R1(2), SHC1(2) 3702073 22 15 21 4 6 3 3 4 6 0 0.161 0.821 1.000 143 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), HRAS(1), JAK2(2), PIK3CA(6), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SOS1(14), STAT1(3), STAT3(2), STAT5A(2), THPO(1) 8338252 41 28 30 6 5 6 3 5 22 0 0.299 0.829 1.000 144 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADH(1), HADHA(1), HADHB(2), HSD17B4(3), MECR(2), PPT1(1), PPT2(3) 2366220 13 6 13 0 3 3 1 2 4 0 0.0205 0.830 1.000 145 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(3) 1273098 4 3 4 2 2 1 1 0 0 0 0.786 0.843 1.000 146 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(5), ADRB2(1), GNAS(16), PLCE1(6), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RAP2B(2) 4250619 39 22 30 5 21 3 5 7 3 0 0.0195 0.846 1.000 147 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), HRAS(1), IL3RA(3), JAK2(2), PTPN6(4), SHC1(2), SOS1(14), STAT5A(2) 4937040 30 20 19 7 7 2 3 3 15 0 0.696 0.847 1.000 148 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(1), DHCR7(1), FDFT1(2), FDPS(1), GGCX(2), HMGCR(7), HSD17B7(11), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(2), NSDHL(2), SQLE(2), VKORC1(3) 5437667 42 26 31 8 11 16 8 2 5 0 0.0186 0.851 1.000 149 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3) 3500482 31 14 31 6 7 7 5 5 7 0 0.104 0.852 1.000 150 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(3), NDUFV2(3) 1948449 13 8 11 3 3 5 0 2 3 0 0.432 0.853 1.000 151 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(1), GLS(1), OAT(2), PRODH(2) 1579580 9 4 9 1 3 1 2 1 2 0 0.224 0.854 1.000 152 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(2), GPR171(2), GPR18(2), GPR34(1), GPR39(4), GPR65(3), GPR75(1) 2740159 16 11 16 4 2 5 1 4 4 0 0.340 0.854 1.000 153 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPT(2), ENPP3(3), FLAD1(5), RFK(1), TYR(4) 2699666 16 9 13 2 5 3 2 1 5 0 0.261 0.856 1.000 154 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(1), HADHA(1) 1347131 3 3 3 1 1 0 1 0 1 0 0.656 0.858 1.000 155 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(3), NR1H4(1), RXRA(1) 1506654 6 4 6 1 2 3 1 0 0 0 0.194 0.860 1.000 156 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(5), CDC25C(3), GNAI1(1), GNAS(16), GNB1(2), HRAS(1), MYT1(12), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RPS6KA1(2), SRC(2) 5832264 57 29 45 9 26 11 6 7 7 0 0.00738 0.865 1.000 157 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(1), CD3E(1), CD4(2), CD58(2), CSF3(2), IL6(1) 1737423 11 4 10 1 1 1 1 3 5 0 0.264 0.867 1.000 158 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAD(1), BAK1(1), BCL2L1(7), CASP9(1), CES1(2) 3149463 15 9 9 3 2 3 3 0 7 0 0.694 0.867 1.000 159 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 3608520 19 12 19 3 12 1 3 1 2 0 0.0811 0.869 1.000 160 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), AFMID(2), GRHPR(6), HAO1(1), HAO2(1), MDH2(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1) 3705075 18 11 13 1 3 3 1 0 11 0 0.127 0.873 1.000 161 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(4), AGT(1), AGTR2(1), CMA1(1), COL4A1(5), COL4A2(6), COL4A3(2), COL4A4(13), COL4A5(5), COL4A6(6), REN(8) 7073773 52 29 40 6 7 8 15 2 19 1 0.108 0.880 1.000 162 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO3(1), FARS2(2), GOT1(3), PAH(1), TAT(1) 2284627 11 7 10 2 3 2 4 2 0 0 0.335 0.883 1.000 163 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(1), CD80(1), CD86(5), HLA-DRB1(1), ITK(1), LCK(1), PIK3CA(6), PIK3R1(2) 3530838 18 13 16 4 5 2 2 3 6 0 0.327 0.885 1.000 164 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(2), ARFGAP1(2), ARFGAP3(9), ARFGEF2(3), CLTB(1), COPA(6), GBF1(3), GPLD1(2), KDELR2(1) 4497289 29 18 20 7 5 3 3 4 13 1 0.599 0.890 1.000 165 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(4), CAMP(2), CREB1(2), CREB5(1), SNX13(4), SRC(2), TERF2IP(1) 3154681 19 10 19 2 2 2 4 4 7 0 0.191 0.890 1.000 166 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3CA(6), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SOS1(14), SRF(1), STAT1(3), STAT3(2), STAT5A(2) 9740882 55 33 44 8 9 7 5 9 25 0 0.130 0.891 1.000 167 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(16), GNB1(2), PPP2CA(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 4368150 38 19 29 5 20 7 3 4 4 0 0.0111 0.892 1.000 168 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), OXCT1(2) 933559 4 2 4 0 0 3 0 0 1 0 0.324 0.894 1.000 169 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(3), UBE2D1(1), UBE2E1(1), UBE2E3(2), UBE2G2(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(6) 2939320 19 8 17 1 8 4 4 1 2 0 0.0121 0.897 1.000 170 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), GRHPR(6), HAO1(1), HAO2(1), MDH2(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1) 3535783 16 10 11 0 2 3 1 0 10 0 0.0660 0.900 1.000 171 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPO(2), EPOR(2), HRAS(1), JAK2(2), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(2), SOS1(14), STAT5A(2) 6054711 35 19 24 6 7 3 4 3 18 0 0.343 0.907 1.000 172 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(4), CSF1(2), IL1B(1), IL6R(1), SELL(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(2), TNFSF8(3) 3810223 28 15 23 9 6 1 5 5 11 0 0.698 0.909 1.000 173 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(2), AKT3(4), BPNT1(2), ILK(1), PDK1(1), PIK3CA(6), PIK3CD(2), PTEN(2), RBL2(2), SHC1(2), SOS1(14) 5692594 41 26 28 9 7 4 4 7 19 0 0.534 0.909 1.000 174 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(3), IDH2(5), OGDH(5), SDHA(6), SUCLA2(1) 2602372 20 10 19 5 3 3 5 6 3 0 0.402 0.910 1.000 175 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(6) 1835786 10 6 9 2 4 0 1 3 2 0 0.436 0.912 1.000 176 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(1), FUT2(3), FUT9(1), GCNT2(1), ST8SIA1(2) 1747926 8 4 8 1 6 1 1 0 0 0 0.134 0.914 1.000 177 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(2), ACADS(1), ACSL1(2), ACSL3(4), ACSL4(3), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1), SCP2(1) 4680162 19 10 19 1 5 4 4 2 4 0 0.0188 0.916 1.000 178 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(8), AXIN1(4), BTRC(2), CREBBP(3), CSNK1A1(1), CSNK1D(1), CSNK2A1(1), CTNNB1(9), DVL1(4), FZD1(5), GSK3B(2), MAP3K7(12), MYC(2), NLK(2), PPARD(2), PPP2CA(1), TLE1(3), WIF1(2), WNT1(1) 8376009 65 34 56 9 14 11 10 11 19 0 0.0192 0.917 1.000 179 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(2) 1563637 14 6 12 2 6 2 3 0 3 0 0.0911 0.917 1.000 180 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2) 4201480 24 15 20 4 3 5 6 1 9 0 0.270 0.920 1.000 181 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2) 4201480 24 15 20 4 3 5 6 1 9 0 0.270 0.920 1.000 182 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2) 4201480 24 15 20 4 3 5 6 1 9 0 0.270 0.920 1.000 183 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(2), ATP6V0C(1), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(2), SHMT2(4), TYMS(1) 4968172 28 12 26 6 4 4 6 4 9 1 0.172 0.922 1.000 184 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), FH(3), IDH1(1), IDH2(5), MDH2(1), SUCLA2(1) 2458559 15 8 14 2 1 3 5 2 4 0 0.334 0.923 1.000 185 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1) 2228147 8 7 8 2 6 1 1 0 0 0 0.311 0.925 1.000 186 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1) 2228147 8 7 8 2 6 1 1 0 0 0 0.311 0.925 1.000 187 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRP9(1), SRPR(2) 2079787 12 4 12 0 3 4 3 1 1 0 0.0352 0.927 1.000 188 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(4), SPCS1(1) 859342 7 3 7 2 1 1 2 3 0 0 0.638 0.929 1.000 189 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(3), CPOX(3), HMBS(1), PPOX(2) 2123550 9 7 9 2 3 2 1 1 2 0 0.547 0.931 1.000 190 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(5), CR2(10), FCGR2B(2), HLA-DRB1(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3) 4215423 28 18 24 7 6 6 1 5 10 0 0.323 0.932 1.000 191 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3) 4908489 46 22 44 8 11 7 9 7 12 0 0.0419 0.933 1.000 192 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 4859222 27 17 22 4 3 4 5 6 9 0 0.266 0.935 1.000 193 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(2), CCR2(1), CCR3(11), CCR4(4), CCR7(1), CD4(2), CXCR4(3), IFNGR1(2), IFNGR2(17), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL4R(3), TGFB1(1), TGFB2(2) 5597321 55 39 28 11 5 4 4 4 37 1 0.854 0.937 1.000 194 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), CALML3(1), CALML6(2), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(3), CTNNB1(9), DCT(3), DVL1(4), DVL2(4), DVL3(2), EDN1(4), EDNRB(2), EP300(6), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(16), GSK3B(2), HRAS(1), KIT(4), KRAS(142), LEF1(3), MITF(3), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), POMC(1), PRKACB(1), PRKACG(3), PRKCG(2), TCF7(2), TCF7L1(4), TCF7L2(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(7), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1) 31132235 342 155 185 71 87 94 97 32 31 1 3.02e-09 0.940 1.000 195 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), CREB1(2), HRAS(1), MAPK7(4), MEF2A(2), MEF2C(2), MEF2D(2), NTRK1(3), PIK3CA(6), PIK3R1(2), PLCG1(1), RPS6KA1(2), SHC1(2) 5343108 32 20 30 4 7 7 5 3 10 0 0.0500 0.941 1.000 196 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(2), ERBB3(6), NRG1(3), UBE2D1(1) 2852820 16 7 16 2 1 4 5 3 3 0 0.195 0.941 1.000 197 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(4), FBXW7(6), RB1(3), TFDP1(1) 2336974 16 9 16 6 2 4 3 3 4 0 0.749 0.943 1.000 198 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF3(2), EPO(2), FLT3(4), IL6(1), IL9(1), TGFB1(1), TGFB2(2) 2336734 14 8 12 3 2 2 4 2 4 0 0.518 0.944 1.000 199 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(4), EGFR(2), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PIK3CA(6), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SOS1(14), SRF(1), STAT1(3), STAT3(2), STAT5A(2) 10445354 58 35 47 9 7 9 6 10 26 0 0.146 0.945 1.000 200 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(6), HDC(1), TH(1), TPH1(2) 1705181 11 5 11 5 3 0 3 1 3 1 0.702 0.946 1.000 201 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11) 4179890 32 18 24 5 4 7 8 11 2 0 0.0734 0.946 1.000 202 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(6), MEF2A(2), MEF2C(2), MEF2D(2), YWHAH(1) 2235400 16 7 16 2 3 3 7 1 2 0 0.126 0.948 1.000 203 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1), SQLE(2) 907943 6 4 5 3 2 2 1 0 1 0 0.727 0.949 1.000 204 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(3), FUT3(1), FUT5(1), FUT6(2) 1434162 8 5 8 2 5 2 0 0 1 0 0.284 0.950 1.000 205 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(4), LPO(6), MPO(2), TPO(7) 2349521 23 12 23 5 11 1 6 2 3 0 0.140 0.950 1.000 206 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), CD80(1), HLA-DRB1(1) 1100222 4 2 4 1 0 0 1 1 2 0 0.845 0.950 1.000 207 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFLAR(3) 1072663 5 3 5 3 1 0 1 1 2 0 0.841 0.950 1.000 208 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(2), KEAP1(2), MAFF(2), MAPK8(2), NFE2L2(1) 2522256 9 5 9 1 2 0 1 3 3 0 0.315 0.951 1.000 209 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), TPO(7), TYR(4) 2706020 27 13 26 8 12 2 7 2 4 0 0.356 0.954 1.000 210 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(7), PRKACB(1), PRKACG(3), PRKAR2B(1) 2811189 12 7 12 4 2 3 2 2 3 0 0.702 0.954 1.000 211 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL1(1), FOSL2(3), IFNAR1(2), IFNAR2(1), MAPK8(2), RELA(3), TNFRSF11A(5), TRAF6(1) 3108588 18 9 17 5 1 3 3 5 6 0 0.638 0.955 1.000 212 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3E(1), CD4(2) 890226 3 1 3 1 0 0 0 1 2 0 0.839 0.957 1.000 213 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(3), TAT(1), TYR(4) 1296960 9 4 9 3 2 1 4 2 0 0 0.695 0.958 1.000 214 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), JUNB(1), MAF(2), MAP2K3(1), NFATC1(4), NFATC2(10), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 3489258 30 16 26 6 14 6 2 2 6 0 0.0228 0.958 1.000 215 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(3), GPI(3), HK1(3), PFKL(2), PGAM1(1), PGK1(3), PKLR(2), TPI1(3) 2596957 22 9 22 6 10 8 1 2 1 0 0.0956 0.958 1.000 216 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(18), GPRC5A(2), GPRC5B(5), GPRC5C(6), GRM1(17), GRM2(5), GRM3(3), GRM4(4), GRM5(7), GRM7(5), GRM8(5) 5821743 82 43 60 15 22 15 8 7 30 0 0.0360 0.959 1.000 217 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(2), CDO1(4), GOT1(3), LDHAL6B(2), LDHB(1), SULT1B1(4), SULT1C4(1), SULT4A1(1) 3517773 18 11 13 5 1 2 3 3 9 0 0.835 0.959 1.000 218 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3) 1552564 13 2 13 4 5 3 1 2 2 0 0.424 0.960 1.000 219 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(2), CREB1(2), EDN1(4), EP300(6), EPO(2), HIF1A(1), NOS3(9) 4761020 26 12 24 2 7 2 7 2 8 0 0.0431 0.961 1.000 220 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(1), CASP9(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(6), PIK3R1(2), PPP2CA(1), RELA(3), YWHAH(1) 3961219 22 14 21 5 2 4 5 4 7 0 0.425 0.961 1.000 221 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A2(2), EIF4G1(8), EIF4G2(1), EIF4G3(7), GHR(1), IRS1(30), PABPC1(16), PDK2(3), PIK3CA(6), PIK3R1(2), PTEN(2) 7820950 81 58 42 14 9 9 9 7 47 0 0.684 0.962 1.000 222 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(6), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), WBSCR17(2) 3980509 24 12 23 7 11 3 6 2 2 0 0.381 0.962 1.000 223 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), ATP6V0C(1), CAT(1), EPX(4), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), SHMT1(2), SHMT2(4), TPO(7) 3314319 33 14 32 7 11 8 8 1 5 0 0.0670 0.965 1.000 224 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(2), FDPS(1), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(2), NQO2(2), SQLE(2), VKORC1(3) 3149254 27 13 25 6 8 7 7 1 4 0 0.122 0.966 1.000 225 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPO(2), EPOR(2), GRIN1(8), HIF1A(1), JAK2(2), NFKBIA(2), RELA(3) 3579488 20 12 15 4 5 1 5 0 9 0 0.547 0.968 1.000 226 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2), PNPO(1), PSAT1(2) 1349692 5 4 5 3 1 1 3 0 0 0 0.831 0.970 1.000 227 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(3), HK2(3), HK3(4), PGM1(1), TGDS(1) 2852929 13 7 13 4 8 1 2 0 2 0 0.322 0.970 1.000 228 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA4(3), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(7), LDLR(1), LPL(4), LRP1(21), SCARB1(1), SOAT1(1) 7616519 50 27 50 9 20 10 5 3 11 1 0.00956 0.972 1.000 229 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BCL2L1(7), BIK(1), BIRC2(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1) 3795124 20 11 14 4 2 3 3 2 10 0 0.587 0.974 1.000 230 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2) 4469067 24 15 20 6 3 5 6 1 9 0 0.498 0.974 1.000 231 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(1), HRAS(1), INSR(4), IRS1(30), JAK2(2), PIK3CA(6), PIK3R1(2), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(2), SOS1(14), SRF(1), STAT5A(2) 9233752 72 51 37 11 10 5 6 6 45 0 0.585 0.976 1.000 232 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(5), ARHGEF1(3), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(2), MAP3K7(12), PIK3CA(6), PIK3R1(2), PLCB1(1), PPP1R12B(1), ROCK1(6) 7267551 41 26 32 9 5 9 4 6 17 0 0.348 0.976 1.000 233 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 594511 3 1 3 1 0 1 2 0 0 0 0.756 0.979 1.000 234 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), ESCO1(3), ESCO2(12), SH3GLB1(1) 6939077 39 19 28 9 8 8 2 5 16 0 0.410 0.980 1.000 235 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), SQLE(2) 1204816 6 4 5 3 2 2 1 0 1 0 0.730 0.980 1.000 236 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), HSD3B7(3), PON1(1), PON2(1), RDH11(2) 2505610 13 5 13 2 3 2 3 4 1 0 0.207 0.980 1.000 237 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGP2(6), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), XYLB(2) 7511754 44 25 36 6 4 9 7 11 13 0 0.0977 0.980 1.000 238 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), MIOX(1), UGDH(2) 2391158 9 7 9 3 5 1 1 2 0 0 0.480 0.981 1.000 239 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1), HSD3B7(3), RDH11(2) 1349588 6 2 6 0 1 0 2 2 1 0 0.192 0.981 1.000 240 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACOT11(1), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), EHHADH(1), ESCO1(3), ESCO2(12), GCDH(2), HADHA(1), SH3GLB1(1) 7221647 29 19 18 5 4 4 3 3 15 0 0.416 0.982 1.000 241 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(2), UXS1(2) 1087579 5 4 5 3 0 1 1 2 1 0 0.924 0.982 1.000 242 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1), COQ7(1) 1160684 2 2 2 2 0 1 0 0 1 0 0.953 0.982 1.000 243 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACPT(2), ENPP3(3), FLAD1(5), MTMR2(1), MTMR6(2), PHPT1(1), RFK(1), TYR(4) 4191351 20 10 17 5 7 4 3 1 5 0 0.526 0.982 1.000 244 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(3), SP1(1), SP3(1) 1851811 6 2 6 0 1 0 3 1 1 0 0.354 0.982 1.000 245 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(3), CASP9(1), DAXX(6), FAS(3), FASLG(1), MAPKAPK3(1) 3164573 19 9 15 7 3 5 3 2 6 0 0.737 0.983 1.000 246 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3), MASP1(2) 5814449 48 22 46 9 11 7 9 8 13 0 0.0531 0.984 1.000 247 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNAS(16), GNB1(2), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTPRC(3), ZAP70(6) 6541313 50 25 41 7 26 8 6 5 5 0 0.00332 0.984 1.000 248 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNAS(16), GNB1(2), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTPRC(3), ZAP70(6) 6541313 50 25 41 7 26 8 6 5 5 0 0.00332 0.984 1.000 249 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(6), PIK3R1(2), PLCB1(1), PLCG1(1), VAV1(6) 3559335 19 11 18 5 3 4 1 5 5 1 0.437 0.986 1.000 250 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(1), BCL2L1(7), CASP9(1), CDC42(1), CHUK(1), ELK1(2), HRAS(1), PIK3CA(6), PIK3R1(2), RALBP1(2), RALGDS(2), RELA(3), RHOA(1) 5414471 33 22 26 8 5 5 4 5 14 0 0.545 0.986 1.000 251 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), FBP2(1), GOT1(3), GPT(2), GPT2(3), MDH2(1), ME1(2), ME2(4), ME3(2), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TPI1(3) 5038960 32 13 32 3 6 10 10 3 3 0 0.00276 0.987 1.000 252 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F11(1), F12(3), F13B(2), F5(14), F8(9), FGA(6), FGB(4), FGG(2), LPA(8), PLAT(2), PLG(1), SERPINE1(2), SERPINF2(1), VWF(5) 9802554 64 32 56 15 14 11 18 11 9 1 0.134 0.987 1.000 253 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), FDFT1(2), FDPS(1), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NSDHL(2), SQLE(2) 3727666 23 12 22 7 7 6 5 0 5 0 0.407 0.987 1.000 254 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), CSNK1D(1), DRD1(5), EGF(4), EGFR(2), GJA1(1), GNA11(3), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(16), GRM1(17), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HRAS(1), HTR2A(3), HTR2B(1), HTR2C(5), ITPR1(10), ITPR2(12), ITPR3(10), KRAS(142), MAP3K2(2), MAPK7(4), NPR1(5), NPR2(1), PDGFC(2), PDGFRA(3), PDGFRB(7), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PRKACB(1), PRKACG(3), PRKCG(2), PRKG1(1), PRKG2(2), SOS1(14), SOS2(1), SRC(2), TJP1(6), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4) 37290692 392 162 219 63 95 102 107 35 53 0 2.13e-12 0.988 1.000 255 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(3), AOC3(3), CES1(2), DDHD1(3), ESCO1(3), ESCO2(12), LIPA(1), PLA1A(2), SH3GLB1(1) 7056043 30 21 19 5 6 3 5 3 13 0 0.367 0.988 1.000 256 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(4), GGT1(1), SHMT1(2), SHMT2(4) 1580415 12 8 12 6 3 4 2 1 2 0 0.698 0.988 1.000 257 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(2), KARS(2) 1305213 4 2 4 3 1 0 1 1 1 0 0.952 0.988 1.000 258 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT2A1(1), SUOX(1) 1680152 11 3 11 4 1 2 1 4 3 0 0.685 0.989 1.000 259 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(1), FUT2(3), FUT9(1), GBGT1(1), HEXA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2) 2825903 17 7 17 2 10 3 3 0 1 0 0.0346 0.989 1.000 260 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(2), ADSL(2), ADSS(3), AGXT(2), AGXT2(2), ASL(3), ASNS(3), ASPA(1), CAD(6), CRAT(5), DARS(1), DDO(2), GAD1(6), GAD2(5), GOT1(3), GPT(2), GPT2(3), PC(3) 7277473 55 29 49 11 15 9 13 6 11 1 0.0792 0.991 1.000 261 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(9), CACNA1D(35), CACNA1F(2), CACNA1S(6), CALML3(1), CALML6(2), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), ELK1(2), FSHB(1), GNA11(3), GNAQ(1), GNAS(16), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(10), ITPR2(12), ITPR3(10), KRAS(142), LHB(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(9), MMP2(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLD2(5), PRKACB(1), PRKACG(3), PRKCD(11), SOS1(14), SOS2(1), SRC(2) 36245360 395 165 194 65 72 95 106 32 87 3 1.72e-09 0.991 1.000 262 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(2), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1), LMNB1(1), LMNB2(1), PRF1(8) 5391730 32 17 27 4 6 6 5 2 13 0 0.145 0.991 1.000 263 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(4), LARS2(2), PDHA1(4), PDHA2(2) 2770266 14 8 12 3 4 5 2 3 0 0 0.282 0.991 1.000 264 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(1), EPX(4), LPO(6), MPO(2), MTHFR(1), SHMT1(2), SHMT2(4), TPO(7) 3242080 29 11 29 7 11 7 6 2 3 0 0.101 0.991 1.000 265 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(5), COL4A2(6), COL4A3(2), COL4A4(13), COL4A5(5), COL4A6(6), SLC2A1(3) 7073361 40 21 32 9 6 5 12 2 14 1 0.553 0.991 1.000 266 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(4), PSMB1(1), PSMB4(6), PSMB5(2), PSMB6(1), PSMD1(4), PSMD11(2), PSMD12(2), PSMD2(1) 4427515 27 18 24 9 8 2 4 4 9 0 0.741 0.992 1.000 267 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(4), ACSS1(1), ACSS2(2), FH(3), IDH1(1), IDH2(5), MDH2(1), SUCLA2(1) 3670897 21 11 20 6 6 3 5 2 5 0 0.562 0.992 1.000 268 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), PC(3), PCK1(3), SDHA(6), SUCLA2(1), SUCLG1(3) 5728549 34 15 32 7 5 6 11 7 5 0 0.237 0.992 1.000 269 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCC2(20), ABCG2(1), BCHE(6), CES1(2), CYP3A5(1), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1) 6285540 49 36 29 10 3 5 5 7 27 2 0.780 0.992 1.000 270 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(1), SHMT1(2), SHMT2(4) 1199303 8 4 8 6 2 3 2 0 1 0 0.888 0.992 1.000 271 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(2), ACADS(1), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH5A1(1), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), L2HGDH(2), OXCT1(2), PDHA1(4), PDHA2(2) 7184162 38 20 36 7 11 11 7 4 4 1 0.0300 0.993 1.000 272 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(2), ESR1(1), GREB1(8), MTA1(1), PDZK1(1), TUBA8(4) 3131290 17 9 17 4 4 9 1 1 2 0 0.0759 0.994 1.000 273 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT2(16), B4GALT5(2), DDOST(1), DPAGT1(8), MAN1A1(2), MAN1B1(2), MGAT1(1), MGAT2(5), MGAT3(3), MGAT4B(1), MGAT5(2), ST6GAL1(1) 5613770 45 34 24 10 9 3 2 4 27 0 0.802 0.994 1.000 274 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(2), PGAP1(1), PIGB(3), PIGG(2), PIGL(2), PIGM(1), PIGO(9), PIGP(2), PIGQ(6), PIGS(3), PIGW(2) 6750883 33 14 32 3 9 6 6 5 7 0 0.00658 0.994 1.000 275 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(4), CHAT(4), PCYT1A(2), PDHA1(4), PDHA2(2), SLC18A3(3) 1985491 19 13 17 9 6 5 5 1 2 0 0.609 0.994 1.000 276 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), ACE2(4), AGT(1), AGTR2(1), ANPEP(3), CMA1(1), CPA3(1), CTSG(2), ENPEP(3), LNPEP(2), MME(2), NLN(1), REN(8), THOP1(1) 5900213 38 19 30 6 4 9 9 5 11 0 0.0932 0.994 1.000 277 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(2), CSF3(2), HLA-DRB1(1), IL12B(1), IL6(1), IL7(1), TGFB1(1), TGFB2(2) 3750033 13 7 11 5 1 2 1 3 6 0 0.893 0.995 1.000 278 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(2), CASP10(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1), PRF1(8), SCAP(3), SREBF2(5) 5239941 29 16 23 6 6 6 2 2 13 0 0.313 0.995 1.000 279 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), AKAP1(2), AKAP10(2), AKAP11(6), AKAP12(5), AKAP2(9), AKAP3(2), AKAP4(1), AKAP5(1), AKAP6(6), AKAP7(2), AKAP9(9), ARHGEF1(3), GNA11(3), GNA14(1), GNA15(4), GNAI2(1), GNAL(3), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB2(1), GNB3(2), GNB5(1), GNG13(1), HRAS(1), ITPR1(10), KRAS(142), PALM2(1), PDE1B(2), PDE1C(1), PDE4A(2), PDE4C(2), PDE4D(2), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCI(3), PRKCQ(3), PRKD1(1), PRKD3(4), RHOA(1), RRAS(2), USP5(2) 32867723 328 156 175 70 59 97 105 30 35 2 2.59e-06 0.995 1.000 280 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(2), IL10RB(2), IL6(1), JAK1(1), STAT1(3), STAT3(2), STAT5A(2) 3385568 15 7 15 5 7 2 2 1 3 0 0.589 0.995 1.000 281 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(2) 1893310 21 7 20 4 7 7 0 3 4 0 0.0524 0.995 1.000 282 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), PRKCE(1) 2212858 14 4 13 4 6 3 1 1 2 1 0.282 0.995 1.000 283 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(5), AKT1(3), CAMK2D(1), CREB1(2), GNAS(16), HRAS(1), PIK3CA(6), PIK3R1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RPS6KA1(2), RPS6KA5(4), SOS1(14) 8218175 65 41 42 10 22 7 5 7 24 0 0.0836 0.995 1.000 284 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(8), AXIN1(4), CD14(3), CTNNB1(9), DVL1(4), FZD1(5), GJA1(1), GNAI1(1), GSK3B(2), LBP(1), LEF1(3), LY96(1), PIK3CA(6), PIK3R1(2), PPP2CA(1), RELA(3), TLR4(1), WNT1(1) 8672495 59 26 56 8 15 10 8 15 11 0 0.00893 0.995 1.000 285 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), MUT(2) 1381953 4 2 4 2 0 1 0 1 2 0 0.814 0.995 1.000 286 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(5), COL4A2(6), COL4A3(2), COL4A4(13), COL4A5(5), COL4A6(6), F10(4), F11(1), F12(3), F5(14), F8(9), FGA(6), FGB(4), FGG(2), KLKB1(2), PROC(1), PROS1(2), SERPINC1(3), SERPING1(1) 12428152 89 45 73 15 12 14 28 11 22 2 0.0940 0.995 1.000 287 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(3), DHFR(1), IMPDH1(3), MTHFD2(1), POLB(1), POLD1(2), POLG(5), PRPS2(1), RRM1(2) 3606928 21 9 20 4 5 7 1 1 7 0 0.0954 0.996 1.000 288 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11) 3939251 30 17 22 6 3 8 7 10 2 0 0.162 0.996 1.000 289 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), ME1(2), PC(3), PDHA1(4), SLC25A1(1) 2584347 13 7 11 5 4 7 1 1 0 0 0.386 0.996 1.000 290 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(17), ABAT(2), ADSL(2), ADSS(3), ADSSL1(1), AGXT(2), AGXT2(2), ASL(3), ASNS(3), ASPA(1), ASRGL1(1), ASS1(4), CAD(6), CRAT(5), DARS(1), DARS2(2), DDO(2), DLAT(4), GAD1(6), GAD2(5), GOT1(3), GPT(2), GPT2(3), NARS2(2), PC(3), PDHA1(4), PDHA2(2) 10588636 92 49 71 17 22 16 16 8 29 1 0.0312 0.996 1.000 291 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(5), DYRK1B(3), GLI2(5), GLI3(14), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SMO(2), SUFU(1) 4721277 41 21 40 13 18 7 7 5 4 0 0.220 0.996 1.000 292 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELL(1) 2929624 14 6 14 4 4 2 1 3 4 0 0.326 0.996 1.000 293 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ACPT(2), ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), CYP3A5(1), CYP3A7(3), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), PON1(1), PON2(1) 5058800 29 13 28 8 10 5 2 6 6 0 0.324 0.997 1.000 294 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(6), CAPN2(1), CAPNS1(3), CAPNS2(2), EP300(6), MEF2D(2), NFATC1(4), NFATC2(10), PPP3CA(3), PPP3CC(2), SYT1(1) 6774478 40 24 36 8 12 9 1 5 13 0 0.0731 0.997 1.000 295 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), EHHADH(1), GCDH(2), HADHA(1) 2167501 6 2 6 1 1 2 2 0 1 0 0.344 0.997 1.000 296 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), FBP2(1), GOT1(3), GPT(2), GPT2(3), MDH2(1), ME1(2), ME3(2), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TKTL1(1), TPI1(3) 5622414 29 13 29 3 6 8 10 2 3 0 0.00976 0.997 1.000 297 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(8), AXIN1(4), BMP2(3), BMP4(2), BMP5(3), BMP7(2), BMPR1A(4), BMPR2(3), CHRD(2), CTNNB1(9), DVL1(4), FZD1(5), GATA4(1), GSK3B(2), MAP3K7(12), MEF2C(2), NKX2-5(1), RFC1(4), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), WNT1(1) 10271663 93 46 82 10 30 16 10 16 21 0 0.000140 0.997 1.000 298 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), MTMR6(2), NFS1(2), PHPT1(1), TPK1(1) 1778486 7 4 7 4 3 2 1 0 1 0 0.917 0.997 1.000 299 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(5), CSF1R(5), EGF(4), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SH3KBP1(2), SRC(2) 5383141 28 13 25 4 4 7 5 3 9 0 0.158 0.998 1.000 300 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAT1(2), EHHADH(1), HADHA(1), HADHB(2) 2317983 7 2 7 1 0 3 1 0 3 0 0.287 0.998 1.000 301 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), FGA(6), FGB(4), FGG(2), PLAT(2), PLG(1), SERPINE1(2) 3713527 20 8 19 7 3 4 5 5 3 0 0.605 0.998 1.000 302 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKBIA(2), PLCB1(1), RELA(3) 2303338 7 4 7 5 1 1 2 1 2 0 0.971 0.998 1.000 303 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(1), ARSB(2), ARSE(1), CYP11B1(7), CYP11B2(6), HSD11B1(1), HSD17B2(2), HSD3B1(2), STS(4), SULT2A1(1), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 7610270 48 30 38 13 10 10 6 5 17 0 0.461 0.998 1.000 304 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(4), BAIAP2(4), CASP1(4), CASP7(2), CASP8(2), INSR(4), ITCH(3), MAGI1(2), MAGI2(12), RERE(13), WWP1(2), WWP2(6) 6713708 58 33 48 13 17 8 5 7 21 0 0.190 0.998 1.000 305 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(1), LEPR(7), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2) 4006041 17 6 17 3 2 6 1 2 6 0 0.186 0.998 1.000 306 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1D1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), BAAT(1), CEL(14), CYP27A1(3), CYP7A1(2), HADHB(2) 6498338 45 26 35 13 12 8 5 3 17 0 0.533 0.998 1.000 307 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GCK(1), GFPT1(2), GNE(2), GNPDA1(2), GNPDA2(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(4), RENBP(1) 4735333 25 12 25 7 13 4 4 1 3 0 0.241 0.998 1.000 308 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ICAM1(2), ITGA4(1), ITGAL(3), ITGB2(1), SELE(2), SELL(1) 3371748 14 7 14 6 4 1 2 3 4 0 0.649 0.998 1.000 309 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GPHN(2), SRC(2), UBQLN1(3) 3369458 22 7 21 5 8 4 5 2 2 1 0.176 0.998 1.000 310 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(3), CHST12(1), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT2A1(1), SULT2B1(1), SUOX(1) 2614353 16 8 16 5 5 2 2 4 3 0 0.477 0.998 1.000 311 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(2), FARSB(1), GOT1(3), PAH(1), TAT(1) 2417060 10 7 9 3 3 2 4 1 0 0 0.559 0.999 1.000 312 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3) 1731493 9 2 9 3 3 0 1 2 3 0 0.580 0.999 1.000 313 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), EHHADH(1), HADHA(1) 3389833 10 8 10 3 6 1 2 0 1 0 0.363 0.999 1.000 314 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), CREB1(2), SYT1(1) 3259789 9 5 9 2 3 0 2 0 4 0 0.467 0.999 1.000 315 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ARG2(1), ASL(3), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), OAT(2), ODC1(1), PYCR1(1) 4978972 23 7 22 2 8 3 7 3 1 1 0.0216 0.999 1.000 316 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1) 3702314 21 6 21 7 10 5 2 2 2 0 0.330 0.999 1.000 317 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3) 3822350 18 11 18 6 11 3 1 2 1 0 0.365 0.999 1.000 318 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(4), EGFR(2), HGS(2) 3566725 11 3 11 1 0 5 3 2 1 0 0.138 0.999 1.000 319 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), DDC(1), EPX(4), ESCO1(3), ESCO2(12), GOT1(3), HPD(3), LPO(6), MPO(2), SH3GLB1(1), TAT(1), TPO(7) 9553582 56 28 45 9 20 6 9 5 16 0 0.0329 0.999 1.000 320 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(3), ANXA6(3), CYP11A1(2), EDN1(4), EDNRB(2), HSD11B1(1), PRL(4), PTGDR(2), PTGDS(2), PTGFR(2), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1) 5838229 31 15 29 9 12 2 6 6 5 0 0.401 0.999 1.000 321 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(3), GRIN1(8), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), NOS1(10), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1) 7220370 63 30 57 14 24 8 7 9 15 0 0.0471 0.999 1.000 322 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), CREB1(2), DAXX(6), ELK1(2), HRAS(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K5(2), MAP3K7(12), MAP3K9(4), MAPKAPK5(1), MAX(1), MEF2A(2), MEF2C(2), MEF2D(2), MYC(2), RPS6KA5(4), SHC1(2), STAT1(3), TGFB1(1), TGFB2(2), TGFBR1(8), TRADD(1), TRAF2(1) 10334717 73 44 59 18 16 8 11 7 31 0 0.507 0.999 1.000 323 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(2), IARS(4), ILVBL(2), LARS2(2), PDHA1(4), PDHA2(2), VARS(4), VARS2(3) 5171584 25 13 23 6 10 7 3 3 2 0 0.200 0.999 1.000 324 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), CP(5), CPOX(3), EPRS(1), GUSB(1), HMBS(1), PPOX(2), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 7562210 36 21 31 5 4 6 4 8 14 0 0.195 0.999 1.000 325 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), NAT1(2), NAT2(1), XDH(5) 2197664 18 8 18 8 8 2 1 4 3 0 0.735 0.999 1.000 326 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), SP1(1), SP3(1), SYT1(1) 5867296 31 14 27 7 8 7 2 4 10 0 0.194 0.999 1.000 327 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(4), FURIN(2), NOTCH1(10), PSEN1(1) 2727017 17 6 17 8 8 7 1 1 0 0 0.337 0.999 1.000 328 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), DDC(1), EPX(4), GOT1(3), HPD(3), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), TAT(1), TPO(7) 6156453 44 20 43 8 19 7 10 3 5 0 0.0152 1.000 1.000 329 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(3), ASRGL1(1), CA5A(3), CA5B(2), CA6(1), CA8(1), CA9(1), CPS1(5), GLS(1), GLUD2(3), HAL(1) 5914428 22 11 21 5 4 8 3 2 4 1 0.312 1.000 1.000 330 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(5), AKT1(3), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(4), ITGB3(1), PDGFRA(3), PIK3CA(6), PIK3R1(2), PLCB1(1), PTK2(3), SMPD1(1), SPHK1(1), SRC(2) 7631321 36 16 35 6 8 11 3 6 8 0 0.0383 1.000 1.000 331 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), FUT1(1), FUT2(3), FUT9(1), GBGT1(1), HEXA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2) 2995892 15 7 15 3 8 3 3 0 1 0 0.121 1.000 1.000 332 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(3), EP300(6), ESR1(1), SRC(2) 4210565 12 7 12 3 3 3 4 1 1 0 0.321 1.000 1.000 333 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3), THY1(1) 2968478 13 5 13 3 7 1 0 2 3 0 0.215 1.000 1.000 334 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(1), CDC34(1), CUL1(4), RB1(3), SKP2(3), TFDP1(1) 2406145 16 8 16 8 3 5 4 3 1 0 0.829 1.000 1.000 335 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ICAM1(2), ITGA4(1), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELL(1), SELP(3) 4461888 18 8 18 7 5 3 2 3 5 0 0.485 1.000 1.000 336 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(4), RB1(3), SKP2(3), TFDP1(1) 2396592 12 7 12 6 2 3 3 3 1 0 0.865 1.000 1.000 337 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH18A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AMD1(1), AOC2(3), AOC3(3), ARG1(1), ARG2(1), ASL(3), ASS1(4), CPS1(5), ODC1(1), SAT2(1) 8279665 30 16 28 3 17 4 4 2 2 1 0.00407 1.000 1.000 338 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(2), CREBBP(3), EP300(6), NCOA3(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RXRA(1) 5765837 26 13 26 8 9 4 6 3 3 1 0.351 1.000 1.000 339 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(3), JAK1(1), JAK2(2), TYK2(2) 2909471 8 5 8 4 2 0 3 1 2 0 0.897 1.000 1.000 340 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(3), JAK1(1), JAK2(2), TYK2(2) 2909471 8 5 8 4 2 0 3 1 2 0 0.897 1.000 1.000 341 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 2411659 7 3 7 5 3 0 2 0 2 0 0.901 1.000 1.000 342 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD4(2), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3), THY1(1) 3117056 15 5 15 4 7 1 0 3 4 0 0.317 1.000 1.000 343 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(2), CD3E(1), CD4(2), IL12B(1), IL12RB1(1), IL12RB2(2), JAK2(2), STAT4(1), TYK2(2) 4135444 14 6 14 6 2 1 3 2 6 0 0.902 1.000 1.000 344 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(1), ARSE(1), CARM1(2), CYP11B1(7), CYP11B2(6), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD17B7(11), HSD3B1(2), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), STS(4), SULT2A1(1), SULT2B1(1), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 13968706 98 53 69 16 14 30 15 21 18 0 0.00295 1.000 1.000 345 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(2), GSK3B(2), PPP1CA(1) 3225117 11 3 11 4 2 3 4 0 2 0 0.702 1.000 1.000 346 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), GSS(1), NOX1(4), RELA(3), XDH(5) 2786464 14 7 14 7 5 3 3 2 1 0 0.849 1.000 1.000 347 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT1(2), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), GRHPR(6), HAGH(2), LDHB(1), MDH2(1), ME1(2), ME2(4), ME3(2), PC(3), PCK1(3), PDHA1(4), PDHA2(2), PKLR(2) 10286541 55 26 49 9 13 22 5 3 12 0 0.00824 1.000 1.000 348 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GNT2(2), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALNT1(1), B4GALT2(16), FUT1(1), FUT2(3), FUT3(1), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GBGT1(1), GCNT2(1), PIGB(3), PIGG(2), PIGL(2), PIGM(1), PIGO(9), PIGP(2), PIGQ(6), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(2), ST6GALNAC5(25), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3), UGCG(1) 13747340 113 62 75 14 26 13 16 8 50 0 0.00343 1.000 1.000 349 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(4), FH(3), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), OGDH(5), PC(3), PDHA1(4), PDHA2(2), PDK1(1), PDK2(3), PDK4(1), SDHA(6), SUCLA2(1), SUCLG1(3) 7938626 46 19 43 10 9 10 13 8 6 0 0.112 1.000 1.000 350 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CYP2C9(2), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), EHHADH(1), ESCO1(3), ESCO2(12), HADHA(1), SH3GLB1(1) 8608216 33 23 22 8 9 3 3 3 15 0 0.557 1.000 1.000 351 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(3), BDKRB2(1), CHRM1(1), CHRNA1(4), FLT1(4), FLT4(11), KDR(1), NOS3(9), PDE2A(1), PDE3A(14), PDE3B(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKG1(1), PRKG2(2), RYR2(26), SLC7A1(1), SYT1(1), TNNI1(1) 11514108 95 51 80 15 35 11 15 6 28 0 0.00144 1.000 1.000 352 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(3), HK2(3), HK3(4), ISYNA1(1), PGM1(1), TGDS(1) 3276862 14 7 14 5 9 1 2 0 2 0 0.350 1.000 1.000 353 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(7), NT5C1B(3), NT5C2(6), NT5E(1), NT5M(1), NUDT12(1) 6012517 30 13 26 8 8 4 7 3 8 0 0.436 1.000 1.000 354 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(3), FBL(1), GPT(2), LDHB(1), NCL(2) 2528350 12 3 11 6 3 1 5 1 2 0 0.885 1.000 1.000 355 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), MBTPS1(3), SCAP(3), SREBF2(5) 3485307 12 8 10 8 4 2 0 2 4 0 0.944 1.000 1.000 356 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), HRAS(1), MYC(2), NFKBIA(2), PLCB1(1), RELA(3) 4325454 11 6 11 5 2 2 3 1 3 0 0.935 1.000 1.000 357 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BAD(1), BCL2L1(7), CBL(5), CFLAR(3), CRKL(2), HRAS(1), IL2RA(1), IL2RB(2), IRS1(30), JAK1(1), JAK3(3), MYC(2), PIK3CA(6), PIK3R1(2), PTPN6(4), SHC1(2), SOS1(14), STAT5A(2), SYK(2) 10178207 93 65 52 23 13 8 8 9 55 0 0.941 1.000 1.000 358 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(1), CDC42(1), CREB1(2), CREB5(1), DUSP10(1), ELK1(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K10(4), MAP3K4(2), MAP3K5(2), MAP3K7(12), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), MKNK2(3), MYEF2(2), NR2C2(1), SRF(1), TRAF6(1) 9502701 52 35 42 14 9 5 9 5 24 0 0.629 1.000 1.000 359 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), IL4R(3), IRS1(30), JAK1(1), JAK3(3), SHC1(2), STAT6(5) 4170275 47 37 23 15 7 5 3 3 29 0 0.982 1.000 1.000 360 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(7), NT5E(1), NT5M(1) 4055340 20 7 20 6 7 3 5 3 2 0 0.374 1.000 1.000 361 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), EGFR(2), ELK1(2), GNAQ(1), HRAS(1), MAP2K4(5), MAP3K1(3), MAPK8(2), MEF2A(2), MEF2C(2), MEF2D(2), PAK1(19), PTK2(3), SHC1(2), SOS1(14), SRC(2), SYT1(1) 9399720 64 40 35 10 5 7 6 6 40 0 0.408 1.000 1.000 362 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(2), AKT3(4), BAD(1), GSK3A(2), GSK3B(2), IL4R(3), IRS1(30), IRS2(4), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(2), SOS1(14), SOS2(1), STAT6(5) 10420600 92 58 55 22 18 13 5 10 46 0 0.621 1.000 1.000 363 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(2), RELA(3), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(2), TRAF2(1), TRAF5(1), TRAF6(1) 4098821 13 4 13 4 2 1 5 1 4 0 0.718 1.000 1.000 364 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3), MASP1(2) 5970004 48 22 46 11 11 7 9 8 13 0 0.119 1.000 1.000 365 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), ASPA(1), CNDP1(2), DDC(1), HAL(1), HDC(1), PRPS1(1), PRPS2(1) 6815696 26 18 26 5 12 5 4 2 3 0 0.0577 1.000 1.000 366 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(1), AGTR2(1), EDN1(4), EDNRB(2), EGF(4), EGFR(2), HRAS(1), MYC(2), PLCG1(1), RELA(3) 5719904 23 11 21 6 3 4 5 1 10 0 0.566 1.000 1.000 367 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2E1(1), GTF2E2(4), GTF2F1(6), GTF2H1(1), GTF2H4(1), GTF2I(6), GTF2IRD1(2), STON1(2), TAF1(10), TAF1L(7), TAF2(2), TAF4(4), TAF4B(2), TAF5(1), TAF5L(4), TAF6(2), TAF6L(3), TAF7L(1), TAF9(2) 10032117 62 36 48 15 11 5 9 9 28 0 0.794 1.000 1.000 368 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(1), ETV5(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), JAK2(2), MAP2K6(3), MAPK8(2), STAT4(1), TYK2(2) 5232124 18 9 18 6 4 1 4 1 8 0 0.672 1.000 1.000 369 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(6), CTNNB1(9), PTK2(3), PXN(1), SRC(2), VCL(3) 5463774 36 12 36 4 16 10 1 8 1 0 0.00144 1.000 1.000 370 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(2), ATG7(3), BECN1(3), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(1), ULK1(3), ULK3(1) 5960733 25 11 24 6 6 6 1 7 5 0 0.305 1.000 1.000 371 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(4), ACACB(8), AKT1(3), AKT2(2), AKT3(4), ARAF(2), BAD(1), BRAF(4), CALML3(1), CALML6(2), CBL(5), CBLB(2), CBLC(1), CRK(1), CRKL(2), ELK1(2), EXOC7(1), FASN(7), FBP2(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(2), GYS1(3), GYS2(2), HRAS(1), IKBKB(4), INPP5D(1), INSR(4), IRS1(30), IRS2(4), IRS4(4), KRAS(142), LIPE(2), MAPK10(1), MAPK8(2), MAPK9(1), MKNK2(3), PCK1(3), PCK2(5), PDE3A(14), PDE3B(1), PFKL(2), PFKM(3), PFKP(1), PHKA2(7), PHKB(4), PHKG1(2), PHKG2(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(4), PPP1R3C(2), PPP1R3D(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAG3(4), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCI(3), PTPRF(28), PYGB(2), PYGL(2), PYGM(2), RPS6KB2(4), SHC1(2), SHC2(2), SHC4(2), SOCS4(3), SORBS1(1), SOS1(14), SOS2(1), TRIP10(1), TSC1(1), TSC2(8) 45562125 437 167 229 86 77 109 99 33 117 2 1.57e-06 1.000 1.000 372 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(4), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), OGDH(5), OGDHL(2), PC(3), PCK1(3), PCK2(5), SDHA(6), SUCLA2(1), SUCLG1(3) 8286680 49 22 45 13 12 7 12 8 9 1 0.307 1.000 1.000 373 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(2), CASP7(2), CASP8(2), CFLAR(3), DAXX(6), DFFB(1), FAF1(1), LMNB1(1), LMNB2(1), MAP2K4(5), MAP3K1(3), MAP3K7(12), MAPK8(2), PAK1(19), PAK2(3), PRKDC(9), PTPN13(8), RB1(3), SPTAN1(3) 11653561 86 48 56 17 9 7 11 14 45 0 0.630 1.000 1.000 374 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(2), KARS(2) 1921201 6 2 6 3 1 0 3 1 1 0 0.905 1.000 1.000 375 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(2), AKT3(4), BCR(2), BTK(1), CD19(1), CDKN2A(43), DAPP1(2), FLOT2(1), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), PDK1(1), PHF11(1), PIK3CA(6), PLCG2(7), PPP1R13B(1), PREX1(9), PTEN(2), PTPRC(3), RPS6KA1(2), RPS6KA2(2), SAG(1), SYK(2), TEC(2), VAV1(6) 15587638 137 76 111 24 31 14 12 19 60 1 0.0130 1.000 1.000 376 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(3), AKT2(2), AKT3(4), BRD4(6), CBL(5), CDC42(1), CDKN2A(43), F2RL2(2), FLOT2(1), GSK3A(2), GSK3B(2), INPPL1(5), IRS1(30), IRS2(4), IRS4(4), LNPEP(2), PARD3(7), PARD6A(1), PDK1(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), PTEN(2), RPS6KA1(2), RPS6KA2(2), SHC1(2), SORBS1(1), SOS1(14), SOS2(1), YWHAE(3), YWHAH(1) 16760578 163 92 104 31 21 20 11 16 95 0 0.280 1.000 1.000 377 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(2), HDAC5(2), MEF2A(2), MEF2C(2), MEF2D(2), PPARA(1), PPP3CA(3), PPP3CC(2), SYT1(1), YWHAH(1) 5710031 24 11 24 6 5 5 5 3 6 0 0.261 1.000 1.000 378 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(8), FASN(7), MCAT(1), OLAH(3), OXSM(1) 4566051 24 8 22 5 8 6 4 1 4 1 0.0922 1.000 1.000 379 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1D1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), BAAT(1), CEL(14), CYP27A1(3), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(3), SOAT1(1) 8909345 57 27 47 15 16 10 9 5 17 0 0.303 1.000 1.000 380 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(2), JAK3(3), STAT3(2), TYK2(2) 3330983 10 4 10 9 3 2 3 0 2 0 0.981 1.000 1.000 381 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCR(2), CRKL(2), HRAS(1), JAK2(2), MAP2K4(5), MAP3K1(3), MAPK8(2), MYC(2), PIK3CA(6), PIK3R1(2), SOS1(14), STAT1(3), STAT5A(2) 7837127 49 31 37 10 8 3 6 9 23 0 0.553 1.000 1.000 382 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(8), ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), ATP7A(4), ATP7B(1), COX4I1(1), COX6A1(1), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(3), NDUFV2(3), SDHA(6), SHMT1(2), UQCRB(1), UQCRFS1(1), UQCRH(2) 10661584 64 32 56 17 12 12 10 12 17 1 0.419 1.000 1.000 383 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(3), CA5A(3), CA5B(2), CA6(1), CA8(1), CA9(1), CPS1(5), GLS(1), HAL(1) 5286534 18 8 17 4 3 6 2 2 4 1 0.396 1.000 1.000 384 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC2(4), ANAPC4(3), ANAPC5(6), ANAPC7(1), BTRC(2), CDC16(1), CDC20(1), CDC23(2), CDC27(8), CUL1(4), CUL2(2), CUL3(1), FBXW11(2), FBXW7(6), ITCH(3), SKP1(1), SKP2(3), SMURF2(1), TCEB1(2), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(2), WWP1(2), WWP2(6) 11300214 69 36 64 15 18 13 12 12 14 0 0.0981 1.000 1.000 385 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKM(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RBKS(1), RPE(2), RPIA(1), TALDO1(1), TKT(1) 5708618 30 13 30 9 12 4 8 3 3 0 0.223 1.000 1.000 386 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NFAT5(31), PDE6B(3), PDE6C(1), PDE6G(1), SLC6A13(1) 10084291 75 46 44 14 14 7 10 3 41 0 0.456 1.000 1.000 387 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(6), CPS1(5), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(2), GLS(1), GOT1(3), GPT(2), GPT2(3), GSS(1), NADSYN1(4), PPAT(2), QARS(2) 9262877 51 20 51 12 10 11 15 6 7 2 0.154 1.000 1.000 388 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(3), LDHB(1) 1906164 4 2 4 2 1 0 2 1 0 0 0.898 1.000 1.000 389 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(2), AKT3(4), ARHGEF11(6), CDC42(1), DLG4(3), LPA(8), MAP2K4(5), MAP3K1(3), MAP3K5(2), MAPK8(2), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(7), PIK3CB(3), PLD2(5), PLD3(2), PTK2(3), RDX(4), ROCK1(6), ROCK2(2), SRF(1), TBXA2R(1) 13790702 79 40 74 19 17 13 15 14 20 0 0.163 1.000 1.000 390 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(1), ARG2(1), ASL(3), ASS1(4), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), EPRS(1), GLUD2(3), GOT1(3), LAP3(2), NOS1(10), NOS3(9), OAT(2), P4HA1(5), P4HA2(2), P4HA3(2), PARS2(2), PRODH(2), PYCR1(1), RARS(1), RARS2(4) 10102622 76 34 74 13 28 12 19 8 8 1 0.00643 1.000 1.000 391 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1), SYT1(1) 3848791 8 3 8 7 0 2 1 2 3 0 0.942 1.000 1.000 392 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), CREB1(2), ELK1(2), GNAI1(1), GNAQ(1), GNAS(16), GNB1(2), HRAS(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1) 9891939 67 33 54 12 29 13 4 8 13 0 0.00722 1.000 1.000 393 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(6), CPS1(5), EARS2(1), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLUD2(3), GOT1(3), GPT(2), GPT2(3), GSR(1), GSS(1), NADSYN1(4), NAGK(1), PPAT(2), QARS(2) 11030353 59 23 59 14 11 13 19 7 7 2 0.122 1.000 1.000 394 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TNFAIP3(2), TRAF6(1) 5092817 19 7 19 7 2 5 7 2 3 0 0.727 1.000 1.000 395 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), GCK(1), GMDS(1), GMPPA(5), HK1(3), HK2(3), HK3(4), PFKFB1(2), PFKFB3(1), PFKFB4(3), PFKM(3), PFKP(1), PMM2(2), TPI1(3) 6703874 37 17 37 11 18 6 9 2 2 0 0.148 1.000 1.000 396 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(4), EEF1A2(1), EEF1D(1), EEF1G(3), EEF2(6), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B2(3), EIF2B3(2), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(8), EIF4G3(7), EIF5(2), EIF5B(12), ETF1(1), GSPT2(1), PABPC1(16), PABPC3(5), SLC35A4(2) 12409203 85 47 60 12 12 14 15 9 35 0 0.108 1.000 1.000 397 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(3), ADCY8(4), CACNA1A(9), CACNA1B(12), GNAS(16), GNB1(2), GNB3(2), GNG13(1), GRM4(4), ITPR3(10), KCNB1(9), PLCB2(5), PRKACB(1), PRKACG(3), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R1(7), TAS1R2(3), TAS1R3(2), TAS2R1(4), TAS2R10(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R4(4), TAS2R41(1), TAS2R42(1), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(1) 16415056 124 56 107 24 54 15 17 14 24 0 0.000542 1.000 1.000 398 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(1), EGR2(3), EGR3(2), GNAQ(1), MAP3K1(3), MYC(2), NFATC1(4), NFATC2(10), NFKBIA(2), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RELA(3), SYT1(1), VIPR2(1) 7830539 48 24 42 15 14 7 5 6 16 0 0.545 1.000 1.000 399 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(4), EXTL1(3), EXTL2(2), EXTL3(6), GLCE(2), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), NDST1(3), NDST3(3), NDST4(3) 5896020 36 12 36 9 13 7 10 3 3 0 0.122 1.000 1.000 400 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(3), CHUK(1), ELK1(2), IKBKB(4), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K7(12), MAPK8(2), NFKBIA(2), PPARA(1), RELA(3), TLR10(1), TLR2(2), TLR3(3), TLR4(1), TLR6(4), TLR9(5), TRAF6(1) 10246239 60 32 50 14 13 6 8 10 23 0 0.338 1.000 1.000 401 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(2), ACADS(1), ACAT1(2), ACSM1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH5A1(1), BDH1(2), BDH2(1), DDHD1(3), EHHADH(1), GAD1(6), GAD2(5), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(2), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(2), PLA1A(2), RDH11(2) 11371578 58 26 56 11 15 15 13 9 5 1 0.0120 1.000 1.000 402 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP2(3), CASP8(2), CRADD(2), DFFB(1), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(5), MAP3K1(3), MAP3K7(12), MAPK8(2), PAK1(19), PAK2(3), PRKDC(9), RB1(3), SPTAN1(3), TNFRSF1A(2), TRADD(1), TRAF2(1) 11063885 76 41 49 10 13 3 11 9 40 0 0.191 1.000 1.000 403 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IKBKB(4), IL1B(1), IL1RAP(2), IL1RN(2), IL6(1), IRAK3(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), MAP3K7(12), MAPK8(2), NFKBIA(2), RELA(3), TGFB1(1), TGFB2(2), TRAF6(1) 8345786 43 25 33 10 6 5 6 6 20 0 0.537 1.000 1.000 404 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKL(2), PFKM(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RBKS(1), RPE(2), RPIA(1), TALDO1(1), TKT(1), TKTL1(1) 6814642 33 14 33 8 13 5 8 3 4 0 0.106 1.000 1.000 405 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CRKL(2), GNAQ(1), HRAS(1), MAP2K3(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PAK1(19), PLCG1(1), SHC1(2), SOS1(14), SRC(2), SYT1(1) 8015284 56 40 27 14 6 5 3 5 37 0 0.937 1.000 1.000 406 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), MANBA(2), NEU4(2) 4699040 20 11 20 7 7 3 4 0 6 0 0.526 1.000 1.000 407 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(4), APC(8), AXIN1(4), BTRC(2), CTNNB1(9), DVL1(4), FZD1(5), GSK3B(2), NOTCH1(10), PSEN1(1), WNT1(1) 6166393 50 17 50 10 17 15 6 9 3 0 0.0109 1.000 1.000 408 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT2(16), FBP2(1), GAA(2), GANAB(4), GCK(1), GLB1(2), HK1(3), HK2(3), HK3(4), LCT(6), MGAM(1), PFKM(3), PFKP(1), PGM1(1) 9141302 49 31 36 13 16 5 6 1 21 0 0.446 1.000 1.000 409 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(8), AXIN1(4), CREBBP(3), CTNNB1(9), DVL1(4), EP300(6), FZD1(5), GSK3B(2), LDB1(2), LEF1(3), TRRAP(11), WNT1(1) 9286604 58 21 57 12 20 10 9 13 6 0 0.0276 1.000 1.000 410 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(11), GNAQ(1), GNAS(16), GNB1(2), HRAS(1), LIMK1(1), NOX1(4), PLCB1(1), PPP1R12B(1), PTK2(3), ROCK2(2) 7128914 43 28 24 11 17 6 3 3 13 1 0.538 1.000 1.000 411 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(2), MARS2(2), METTL2B(2), METTL6(1), PAPSS1(2), PAPSS2(4), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), SCLY(2), SEPHS2(5) 6970474 44 24 35 14 11 9 10 11 3 0 0.316 1.000 1.000 412 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(2), ACVR1C(2), BAIAP2(4), CDC42(1), CDH1(1), CREBBP(3), CSNK2A1(1), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTNND1(3), EGFR(2), EP300(6), ERBB2(6), FARP2(3), FER(6), FGFR1(1), FYN(9), IGF1R(6), INSR(4), IQGAP1(3), LEF1(3), LMO7(7), MAP3K7(12), MET(4), MLLT4(5), NLK(2), PARD3(7), PTPN6(4), PTPRB(10), PTPRF(28), PTPRJ(3), PTPRM(6), PVRL1(19), PVRL2(1), PVRL3(1), PVRL4(4), RAC2(1), RHOA(1), SMAD2(1), SMAD3(1), SMAD4(41), SORBS1(1), SRC(2), SSX2IP(2), TCF7(2), TCF7L1(4), TCF7L2(1), TGFBR1(8), TGFBR2(10), TJP1(6), VCL(3), WASF1(1), WASF2(2), WASF3(24), WASL(6), YES1(1) 33477707 329 123 237 38 67 38 34 40 148 2 4.14e-06 1.000 1.000 413 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(6), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1R(6), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(2), MEF2C(2), MEF2D(2), NFATC1(4), NFATC2(10), PIK3CA(6), PIK3R1(2), PPP3CA(3), PPP3CC(2), SYT1(1), YWHAH(1) 9779759 66 31 61 14 18 12 9 8 19 0 0.0283 1.000 1.000 414 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(3), CPO(2), HBB(1), HMBS(1) 2254333 7 5 7 4 4 1 1 0 1 0 0.788 1.000 1.000 415 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3) 4694728 22 6 22 3 7 6 5 1 3 0 0.0509 1.000 1.000 416 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(2), RELA(3), TANK(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 6882445 38 14 38 10 10 6 9 5 8 0 0.265 1.000 1.000 417 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MIOX(1), OCRL(1), PIK3C2A(5), PIK3C2B(12), PIK3CA(6), PIK3CB(3), PIK3CG(5), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7) 12613388 66 27 64 14 22 9 7 12 16 0 0.0535 1.000 1.000 418 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), CASP8(2), MAP2K4(5), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(3), SMPD1(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 5793492 22 9 22 8 6 1 5 4 6 0 0.768 1.000 1.000 419 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5(5), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(11), NCF2(1), PAK1(19), PDGFRA(3), PIK3CA(6), PIK3R1(2), PPP1R12B(1), RALBP1(2), TRIO(9), VAV1(6), WASF1(1) 9745699 73 38 49 16 14 10 6 9 32 2 0.425 1.000 1.000 420 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(3), ADCY3(7), ADCY9(5), ARF1(2), ARF3(1), ARF4(1), ARL4D(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), ERO1L(1), GNAS(16), PDIA4(2), PLCG1(1), PLCG2(7), SEC61A1(1), SEC61A2(2), SEC61B(1), SEC61G(1), TRIM23(1) 10380642 74 33 61 17 28 12 12 6 16 0 0.0802 1.000 1.000 421 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(2), AKT3(4), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(4), ITPKB(3), LYN(1), NFAT5(31), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), PLCG2(7), PPP1R13B(1), SHC1(2), SOS1(14), SOS2(1), SYK(2), VAV1(6) 14810358 105 60 66 25 21 12 6 12 53 1 0.566 1.000 1.000 422 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(5), DDX20(1), E2F4(3), ETS1(3), ETS2(2), HDAC5(2), HRAS(1), NCOR2(5), RBL1(1), RBL2(2), SIN3A(6) 7447741 33 15 30 10 6 7 7 5 8 0 0.424 1.000 1.000 423 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(2), CASP10(2), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), DFFB(1), GAS2(4), NFKBIA(2), RELA(3), SPTAN1(3), TNFRSF10A(2), TNFRSF10B(2), TNFSF12(2), TRADD(1), TRAF2(1) 9463044 37 15 37 8 12 7 6 3 9 0 0.133 1.000 1.000 424 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1B(2), ACVR1C(2), ACVR2A(9), ACVRL1(1), AMH(2), AMHR2(5), BMP2(3), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMP8A(1), BMP8B(1), BMPR1A(4), BMPR2(3), CHRD(2), COMP(4), CREBBP(3), CUL1(4), DCN(1), E2F4(3), E2F5(3), EP300(6), GDF5(2), GDF6(1), GDF7(2), INHBA(2), INHBB(2), INHBC(1), LEFTY2(1), LTBP1(2), MYC(2), NODAL(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), RBL1(1), RBL2(2), RHOA(1), ROCK1(6), ROCK2(2), RPS6KB2(4), SKP1(1), SMAD2(1), SMAD3(1), SMAD4(41), SMAD7(1), SMAD9(3), SMURF2(1), SP1(1), TFDP1(1), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), THBS1(7), THBS2(4), THBS3(1), THBS4(34), ZFYVE16(5), ZFYVE9(4) 27975284 239 108 196 39 53 34 30 28 94 0 0.000890 1.000 1.000 425 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CEL(14), DGAT1(3), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), GLB1(2), LCT(6), LIPF(2), LIPG(4), LPL(4), PNLIP(2), PPAP2B(2), PPAP2C(1) 13629084 90 37 80 27 33 12 8 8 29 0 0.206 1.000 1.000 426 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), MAN2B1(2), MAN2B2(2), MANBA(2), NEU4(2) 5782790 24 13 24 9 9 3 5 0 7 0 0.511 1.000 1.000 427 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2M1(1), ARF1(2), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(2), GSK3B(2), LYN(1), PFKL(2), PFKM(3), PFKP(1), PLCG1(1), PRKCE(1) 7157597 25 10 23 7 7 8 3 2 5 0 0.246 1.000 1.000 428 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(9), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAR2B(1), PRKCE(1) 5042466 21 8 21 9 6 4 4 5 2 0 0.820 1.000 1.000 429 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CANX(2), CD4(2), CD8B(2), CREB1(2), CTSB(2), CTSS(2), HLA-A(7), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(3), HSP90AA1(10), HSP90AB1(7), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL3(2), KIR3DL1(3), KLRC3(2), KLRC4(1), LGMN(1), NFYC(1), PDIA3(2), RFX5(1), TAP1(4), TAP2(1), TAPBP(1) 13070707 73 41 62 17 10 16 8 14 25 0 0.237 1.000 1.000 430 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(6), DIAPH1(7), FYN(9), GSN(6), HRAS(1), ITGA1(7), MYLK(11), PIK3CA(6), PIK3R1(2), PTK2(3), PXN(1), ROCK1(6), SHC1(2), SRC(2), TLN1(11) 10419698 80 41 68 13 19 18 9 9 24 1 0.0111 1.000 1.000 431 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT2(16), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(2), HK1(3), HK2(3), HK3(4), HSD3B7(3), LCT(6), MGAM(1), PFKL(2), PFKM(3), PFKP(1), PGM1(1), RDH11(2), UGP2(6) 10862136 59 34 44 15 19 7 6 4 23 0 0.340 1.000 1.000 432 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(4), F2RL1(2), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(2), PLD2(5), PLD3(2), PTK2(3), RASAL1(6), SRC(2), TEC(2), VAV1(6) 7752533 47 15 44 12 15 12 7 4 8 1 0.0855 1.000 1.000 433 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(2), ACACA(4), ACADL(2), ACADM(2), ACADSB(3), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3) 9192870 34 14 34 6 9 8 5 6 6 0 0.0831 1.000 1.000 434 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B1(1), EIF2B2(3), EIF2B3(2), EIF2B5(1), ELAVL1(1), FLT1(4), FLT4(11), HIF1A(1), HRAS(1), KDR(1), NOS3(9), PIK3CA(6), PIK3R1(2), PLCG1(1), PTK2(3), PXN(1), SHC1(2) 9544945 50 26 50 12 14 12 11 3 10 0 0.119 1.000 1.000 435 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(4), ERBB4(6), PSEN1(1) 2533711 11 3 11 5 1 5 1 3 1 0 0.778 1.000 1.000 436 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(3), AKT2(2), AKT3(4), BAD(1), BCL2L1(7), CDC42(1), CDKN2A(43), CREB1(2), CREB5(1), ERBB4(6), F2RL2(2), GSK3A(2), GSK3B(2), IFI27(1), INPPL1(5), IRS1(30), IRS2(4), IRS4(4), MET(4), MYC(2), NOLC1(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PARD3(7), PARD6A(1), PDK1(1), PIK3CA(6), PIK3CD(2), PPP1R13B(1), PREX1(9), PTEN(2), PTK2(3), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS1(14), SOS2(1), TSC1(1), TSC2(8), YWHAE(3), YWHAH(1) 21757173 222 110 136 45 29 22 17 21 133 0 0.486 1.000 1.000 437 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(8), ACAT1(2), ACOT12(3), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), GRHPR(6), HAGH(2), LDHAL6B(2), LDHB(1), MDH2(1), ME1(2), ME2(4), ME3(2), PC(3), PCK1(3), PCK2(5), PDHA1(4), PDHA2(2), PKLR(2) 13002680 72 33 64 15 21 22 6 4 18 1 0.0213 1.000 1.000 438 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(2), ACAT1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(6), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(7), OGDH(5), OGDHL(2), PLOD1(2), RDH11(2), SETD1A(30), SETDB1(3), SHMT1(2), SHMT2(4), SPCS1(1), SUV39H2(3), TMLHE(1) 16272607 95 55 67 23 21 13 15 7 39 0 0.382 1.000 1.000 439 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3E(1), ELK1(2), FYN(9), HRAS(1), LCK(1), MAP2K4(5), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKBIA(2), PIK3CA(6), PIK3R1(2), PLCG1(1), PPP3CA(3), PPP3CC(2), RASA1(4), RELA(3), SHC1(2), SOS1(14), SYT1(1), VAV1(6), ZAP70(6) 13399013 97 50 74 14 18 15 8 13 42 1 0.0200 1.000 1.000 440 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(2), CASP8(2), CFLAR(3), MAP2K4(5), MAP3K7(12), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 7736955 39 21 30 12 9 3 7 6 14 0 0.724 1.000 1.000 441 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(3), GPI(3), HK1(3), HK2(3), HK3(4), LDHAL6B(2), LDHB(1), MDH2(1), PC(3), PCK1(3), PDHA1(4), PDHA2(2), PFKL(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PKLR(2), TPI1(3) 11801608 61 25 59 13 25 17 10 4 5 0 0.00700 1.000 1.000 442 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(3), EP300(6), FYN(9), IL7(1), IL7R(3), JAK1(1), JAK3(3), LCK(1), PIK3CA(6), PIK3R1(2), STAT5A(2) 7865046 37 26 28 11 8 4 6 4 15 0 0.674 1.000 1.000 443 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(3), AKT1(3), ANGPTL2(2), CDC42(1), FLNA(10), FLNC(12), FSCN1(1), FSCN3(3), GDI1(1), GDI2(3), LIMK1(1), MYH2(4), MYLK(11), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), ROCK1(6), ROCK2(2), WASF1(1), WASL(6) 13549358 100 54 79 24 20 15 15 12 38 0 0.303 1.000 1.000 444 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(3), AKT2(2), AKT3(4), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(7), PIK3CB(3), PLD2(5), PLD3(2) 12686371 75 42 65 18 24 11 10 7 23 0 0.168 1.000 1.000 445 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(3), BLVRA(2), COX15(1), CP(5), CPOX(3), EARS2(1), EPRS(1), FTH1(5), FTMT(3), GUSB(1), HMBS(1), PPOX(2), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 11685888 58 32 48 11 8 13 6 11 20 0 0.175 1.000 1.000 446 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(3), EP300(6), IKBKB(4), NFKBIA(2), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1) 6318203 24 12 24 9 6 4 8 2 4 0 0.665 1.000 1.000 447 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(8), ASAH1(1), CAMP(2), CERK(1), CREB1(2), CREB5(1), DAG1(2), EPHB2(4), GNAQ(1), ITPKB(3), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1) 8142870 45 19 45 12 14 5 7 9 10 0 0.197 1.000 1.000 448 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ACPT(2), ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2D6(1), CYP2E1(3), CYP2F1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), CYP4B1(1), CYP51A1(1), PON1(1) 8186065 58 25 55 18 21 7 11 9 10 0 0.298 1.000 1.000 449 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(2), SOS1(14), STAT5A(2), SYK(2) 6631097 34 20 23 11 8 5 1 3 17 0 0.792 1.000 1.000 450 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(2), ARHGAP5(6), ARHGAP6(3), ARHGEF1(3), ARHGEF11(6), ARHGEF5(4), ARPC1A(2), ARPC2(1), BAIAP2(4), DIAPH1(7), GSN(6), LIMK1(1), MYLK(11), PIP5K1B(2), PPP1R12B(1), ROCK1(6), SRC(2), TLN1(11), VCL(3) 12893721 81 37 75 19 22 19 11 10 18 1 0.0299 1.000 1.000 451 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), ASPA(1), CARM1(2), CNDP1(2), DDC(1), FTCD(2), HAL(1), HDC(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), PRPS1(1), PRPS2(1), UROC1(5) 11100192 57 31 48 10 15 10 12 13 7 0 0.0159 1.000 1.000 452 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH4A1(3), AMD1(1), AOC2(3), AOC3(3), ARG1(1), ARG2(1), ASL(3), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), GOT1(3), NOS1(10), NOS3(9), OAT(2), ODC1(1), P4HA1(5), P4HA2(2), P4HA3(2), PYCR1(1), RARS(1) 12412093 74 30 73 9 32 13 17 6 5 1 0.000103 1.000 1.000 453 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(7), ACTB(2), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(3), CDC42(1), CDH1(1), CTNNB1(9), CTTN(2), FYN(9), HCLS1(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(6), ROCK2(2), TLR4(1), TLR5(3), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4), WASL(6) 14666113 100 50 87 18 29 17 11 13 30 0 0.0151 1.000 1.000 454 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(7), ACTB(2), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(3), CDC42(1), CDH1(1), CTNNB1(9), CTTN(2), FYN(9), HCLS1(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(6), ROCK2(2), TLR4(1), TLR5(3), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4), WASL(6) 14666113 100 50 87 18 29 17 11 13 30 0 0.0151 1.000 1.000 455 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 146 APC(8), APC2(2), AXIN1(4), AXIN2(1), BTRC(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(10), CREBBP(3), CSNK1A1(1), CSNK1A1L(4), CSNK1E(1), CSNK2A1(1), CTBP2(3), CTNNB1(9), CUL1(4), CXXC4(1), DAAM1(11), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(4), DVL3(2), EP300(6), FBXW11(2), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GSK3B(2), LEF1(3), LRP5(7), LRP6(5), MAP3K7(12), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(2), MYC(2), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NKD1(4), NKD2(1), NLK(2), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPARD(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP3CA(3), PPP3CC(2), PRICKLE1(3), PRICKLE2(4), PRKACB(1), PRKACG(3), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(6), ROCK2(2), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD2(1), SMAD3(1), SMAD4(41), SOX17(1), TCF7(2), TCF7L1(4), TCF7L2(1), TP53(119), VANGL1(2), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(7), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1) 46126808 480 161 391 87 129 66 53 70 162 0 3.11e-07 1.000 1.000 456 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), GALNT1(3), GALNT10(6), GALNT13(2), GALNT14(1), GALNT2(2), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT4(1), OGT(2), ST3GAL1(2), ST3GAL2(1), WBSCR17(2) 8985944 36 18 35 10 12 6 9 4 5 0 0.299 1.000 1.000 457 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRK(1), CRKL(2), DOCK1(5), ELK1(2), HGF(1), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PAK1(19), PIK3CA(6), PIK3R1(2), PTEN(2), PTK2(3), PXN(1), RAP1B(3), RASA1(4), SOS1(14), SRC(2), STAT3(2) 12550110 90 50 61 16 13 18 5 9 45 0 0.159 1.000 1.000 458 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(8), GAL3ST1(1), GALC(2), GBA(4), GLB1(2), LCT(6), NEU4(2), PPAP2B(2), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD1(1), SMPD3(1), SMPD4(3), SPHK1(1), SPHK2(1), SPTLC1(3), SPTLC2(1), UGCG(1), UGT8(1) 10145079 50 25 47 14 20 11 5 7 7 0 0.0496 1.000 1.000 459 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(2), ACADM(2), ACOX1(1), ACOX2(2), ACOX3(2), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ANGPTL4(1), APOA5(3), AQP7(14), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP27A1(3), CYP4A22(2), CYP7A1(2), CYP8B1(2), EHHADH(1), FABP4(1), FADS2(15), GK2(5), HMGCS2(1), ILK(1), LPL(4), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(5), PLTP(1), PPARA(1), PPARD(2), PPARG(1), RXRA(1), RXRB(1), RXRG(1), SCD(12), SCP2(1), SLC27A1(3), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(2), SORBS1(1), UBC(2), UCP1(1) 18226623 137 64 103 27 30 27 25 9 44 2 0.0158 1.000 1.000 460 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(4), AMOTL1(2), ASH1L(9), CDC42(1), CDK4(2), CGN(1), CLDN17(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTTN(2), EPB41(4), EPB41L1(3), EPB41L2(3), EPB41L3(4), EXOC3(1), EXOC4(8), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), IGSF5(1), INADL(1), JAM2(2), KRAS(142), LLGL1(5), LLGL2(3), MAGI1(2), MAGI2(12), MAGI3(2), MLLT4(5), MPDZ(4), MRAS(2), MYH1(6), MYH10(38), MYH11(8), MYH13(4), MYH14(7), MYH15(10), MYH2(4), MYH3(2), MYH4(10), MYH6(7), MYH7(8), MYH7B(8), MYH8(6), MYH9(4), MYL9(1), PARD3(7), PARD6A(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP2R3A(4), PPP2R3B(2), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCI(3), PRKCQ(3), PTEN(2), RAB13(1), RHOA(1), RRAS(2), SPTAN1(3), SRC(2), SYMPK(5), TJP1(6), TJP2(5), TJP3(3), YES1(1), ZAK(5) 54687721 485 166 294 87 94 111 122 51 107 0 1.86e-08 1.000 1.000 461 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADL(2), ACADM(2), ACADS(1), ACADSB(3), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), BCAT1(2), BCKDHA(4), BCKDHB(2), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2) 10018499 46 19 44 6 13 12 7 4 10 0 0.00463 1.000 1.000 462 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(2), BLNK(1), ELK1(2), HRAS(1), LYN(1), MAP3K1(3), MAPK8IP3(5), PAPPA(3), RPS6KA1(2), SHC1(2), SOS1(14), SYK(2), VAV1(6) 9046787 44 27 32 11 10 4 4 5 20 1 0.553 1.000 1.000 463 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), ELK1(2), FCER1A(1), FCER1G(1), HRAS(1), LYN(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PAK2(3), PIK3CA(6), PIK3R1(2), PLCG1(1), PPP3CA(3), PPP3CC(2), SHC1(2), SOS1(14), SYK(2), SYT1(1), VAV1(6) 12010420 83 38 68 16 17 14 7 13 31 1 0.0833 1.000 1.000 464 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(2), AKT3(4), CISH(1), IARS(4), IL4R(3), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PIK3CA(6), PPP1R13B(1), SHC1(2), SOS1(14), SOS2(1), SRC(2), STAT6(5), TYK2(2) 10361829 57 32 44 16 11 8 7 9 22 0 0.611 1.000 1.000 465 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(3), CAPNS2(2), ITGA1(7), ITGB3(1), PTK2(3), PXN(1), SPTAN1(3), SRC(2), TLN1(11) 8031855 43 11 43 6 15 13 5 4 6 0 0.00228 1.000 1.000 466 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(3), AKT2(2), AKT3(4), APC(8), AXIN1(4), AXIN2(1), CSNK1A1(1), CTNNB1(9), DACT1(4), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(2), GSK3B(2), LRP1(21), MVP(3), NKD1(4), NKD2(1), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(2), WIF1(2) 11489728 83 37 80 17 31 15 12 12 13 0 0.0133 1.000 1.000 467 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG10B(2), ALG11(3), ALG12(4), ALG13(2), ALG5(1), ALG9(1), B4GALT2(16), DDOST(1), DHDDS(1), DOLPP1(1), DPAGT1(8), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(5), MGAT3(3), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1) 11964724 69 39 48 13 14 12 6 7 30 0 0.244 1.000 1.000 468 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), AOX1(2), DBH(1), DCT(3), DDC(1), FAH(1), GOT1(3), HGD(2), HPD(3), TAT(1), TH(1), TPO(7), TYR(4) 8864271 55 20 55 19 23 8 10 6 7 1 0.257 1.000 1.000 469 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), ATP8A1(3), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKAR(8), CCKBR(3), CCR1(2), CCR10(2), CCR2(1), CCR3(11), CCR4(4), CCR7(1), CX3CR1(1), CXCR4(3), EDNRB(2), FPR1(2), FSHR(4), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(2), MC2R(2), MC3R(4), MC5R(3), NMBR(1), NPY1R(3), NPY2R(3), NPY5R(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(2), SSTR1(4), SSTR3(2), SSTR4(3), TACR1(3), TACR2(1), TACR3(4), TRHR(2), TSHR(3) 14645425 111 51 96 30 35 13 23 14 24 2 0.0649 1.000 1.000 470 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHB(1), PDHA1(4), PDHA2(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 13586408 73 26 71 18 35 18 8 5 7 0 0.0113 1.000 1.000 471 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHB(1), PDHA1(4), PDHA2(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 13586408 73 26 71 18 35 18 8 5 7 0 0.0113 1.000 1.000 472 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(8), AR(4), ASAH1(1), BRAF(4), CAMP(2), CCL16(1), DAG1(2), EGFR(2), GNA11(3), GNA15(4), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), MAPK10(1), PHKA2(7), PIK3CA(6), PIK3CD(2), PIK3R1(2), SRC(2) 15078744 92 47 83 20 24 12 15 12 29 0 0.0774 1.000 1.000 473 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), SYT1(1), TRAF2(1), TRAF5(1), TRAF6(1) 9699048 43 19 43 13 10 9 9 7 8 0 0.210 1.000 1.000 474 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(1), CAPN2(1), CAPNS1(3), CAPNS2(2), EGF(4), EGFR(2), HRAS(1), ITGA1(7), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTK2(3), PXN(1), TLN1(11) 9220196 60 19 60 12 24 16 8 7 5 0 0.00524 1.000 1.000 475 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNGR1(2), JAK1(1), JAK2(2), PTPRU(6), REG1A(2), STAT1(3) 3185640 17 9 16 9 8 0 5 2 2 0 0.889 1.000 1.000 476 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(2), ACAA1(1), ACADM(2), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), AUH(1), BCAT1(2), BCAT2(2), BCKDHA(4), BCKDHB(2), DBT(3), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HIBCH(10), HMGCS2(1), HSD17B4(3), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2), OXCT2(1) 12017079 63 31 52 10 17 10 10 5 21 0 0.0266 1.000 1.000 477 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(5), CSK(1), DAG1(2), DTYMK(1), EPHB2(4), FBXW7(6), GRAP2(2), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFAT5(31), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PLCG1(1), PTPRC(3), RASGRP1(2), RASGRP2(1), RASGRP3(2), SOS1(14), SOS2(1), VAV1(6), ZAP70(6) 15840294 127 70 72 22 20 16 10 9 71 1 0.385 1.000 1.000 478 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), ELK1(2), HRAS(1), LYN(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), SHC1(2), SOS1(14), SYK(2), SYT1(1), VAV1(6) 10683400 63 29 48 14 13 11 3 9 26 1 0.255 1.000 1.000 479 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CHUK(1), DAXX(6), EGF(4), EGFR(2), ETS1(3), ETS2(2), HOXA7(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK13(1), MAPK8(2), NFKBIA(2), PPP2CA(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCQ(3), RELA(3), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 13818710 79 41 68 24 15 12 14 11 27 0 0.560 1.000 1.000 480 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(4), AR(4), ESR1(1), ESR2(3), ESRRA(2), NPM1(1), NR0B1(3), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(3), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), PGR(4), PPARA(1), PPARD(2), PPARG(1), RARB(2), RARG(2), ROR1(4), RORA(1), RORC(1), RXRA(1), RXRB(1), RXRG(1), THRA(5), THRB(1) 11972866 68 28 62 19 22 15 10 6 15 0 0.0798 1.000 1.000 481 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1D(1), ADRA2A(1), ADRA2C(3), ADRB2(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), DRD1(5), DRD3(1), DRD5(5), HRH2(2), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(5), HTR7(1) 7306002 56 31 53 22 22 9 12 8 5 0 0.489 1.000 1.000 482 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(1), ELK1(2), FPR1(2), GNA15(4), GNB1(2), HRAS(1), MAP2K3(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKBIA(2), PAK1(19), PLCB1(1), PPP3CA(3), PPP3CC(2), RELA(3), SYT1(1) 10804863 74 40 52 17 15 12 10 6 31 0 0.376 1.000 1.000 483 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(1), AKT1(3), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(3), CSNK1A1(1), EDN1(4), ELSPBP1(2), FKBP1A(1), GATA4(1), GSK3B(2), HAND2(1), HRAS(1), LIF(2), MAPK8(2), MEF2C(2), MYH2(4), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NKX2-5(1), PIK3CA(6), PIK3R1(2), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1) 14215439 84 38 77 19 29 14 13 10 18 0 0.0279 1.000 1.000 484 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2RL3(1), GNAI1(1), GNB1(2), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(2), PTK2(3), SRC(2), SYK(2), TBXAS1(1) 6806211 23 4 23 9 7 8 2 4 2 0 0.640 1.000 1.000 485 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(4), MAP3K1(3), MAP3K7(12), NFKBIA(2), RELA(3), TLR4(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1) 6918258 33 19 24 11 5 3 8 4 13 0 0.913 1.000 1.000 486 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(7), ABLIM1(6), ABLIM2(2), ABLIM3(2), ARHGEF12(6), CDC42(1), CDK5(5), CXCR4(3), DCC(4), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNB2(1), EPHA1(4), EPHA2(5), EPHA3(2), EPHA4(4), EPHA5(7), EPHA6(2), EPHA7(3), EPHA8(8), EPHB1(2), EPHB2(4), EPHB3(4), EPHB4(5), EPHB6(11), FYN(9), GNAI1(1), GNAI2(1), GSK3B(2), HRAS(1), KRAS(142), L1CAM(6), LIMK1(1), LIMK2(2), LRRC4C(3), MET(4), NCK1(3), NCK2(2), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NGEF(7), NRP1(1), NTN4(1), NTNG1(3), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(9), PLXNA3(8), PLXNB1(6), PLXNB2(6), PLXNB3(6), PLXNC1(4), PPP3CA(3), PPP3CC(2), PTK2(3), RAC2(1), RASA1(4), RGS3(2), RHOA(1), RHOD(1), RND1(2), ROBO1(8), ROBO2(7), ROBO3(11), ROCK1(6), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(5), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(1), SEMA4C(5), SEMA4F(3), SEMA4G(3), SEMA5A(6), SEMA5B(4), SEMA6A(2), SEMA6C(3), SEMA6D(1), SEMA7A(1), SLIT1(8), SLIT2(7), SLIT3(7), SRGAP1(9), SRGAP2(1), SRGAP3(11), UNC5A(10), UNC5B(3), UNC5C(3), UNC5D(11) 55944235 581 175 344 119 116 126 121 57 160 1 2.82e-06 1.000 1.000 487 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(2), AKT3(4), ASAH1(1), BRAF(4), DAG1(2), EGFR(2), EPHB2(4), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), PIK3CB(3), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), SHC1(2), SOS1(14), SOS2(1), SRC(2), STAT3(2), TERF2IP(1) 16454092 95 51 77 20 23 9 11 12 40 0 0.249 1.000 1.000 488 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(4), AGPAT1(1), AGPAT3(3), AGPAT4(3), CDIPT(3), CHAT(4), CPT1B(5), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), GNPAT(1), GPD1(1), GPD2(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(2), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLCB2(5), PLCG1(1), PLCG2(7), PPAP2B(2), PPAP2C(1) 14194517 75 28 75 21 23 10 15 11 16 0 0.162 1.000 1.000 489 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CARM1(2), CREBBP(3), EP300(6), ERCC3(16), ESR1(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(6), HDAC4(4), HDAC5(2), HDAC6(1), MEF2C(2), NCOR2(5), NR0B1(3), NRIP1(1), POLR2A(6), TBP(3) 13217759 70 42 53 21 15 8 12 6 29 0 0.742 1.000 1.000 490 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A2(2), EIF4B(3), EIF4G1(8), EIF4G2(1), EIF4G3(7), FKBP1A(1), PDK2(3), PIK3CA(6), PIK3R1(2), PPP2CA(1), PTEN(2), TSC1(1), TSC2(8) 7717848 48 23 46 14 14 10 11 6 7 0 0.418 1.000 1.000 491 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLB(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLG(5), POLH(1), POLI(1), POLK(3), POLL(2), POLM(2), POLQ(3), PRIM1(1), REV1(1), REV3L(6) 11450899 42 14 40 7 8 8 9 8 9 0 0.102 1.000 1.000 492 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), CLOCK(23), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(1), ETV6(3), GFRA1(3), GSTP1(1), HERPUD1(2), HSPA8(3), IDI1(1), MYF6(1), NCKAP1(4), NCOA4(1), NR1D2(1), PER1(5), PER2(5), PPP1R3C(2), PURA(1), TOB1(8), TUBB3(3), UCP3(1), UGP2(6), ZFR(3) 10305653 84 51 53 26 12 8 6 14 43 1 0.972 1.000 1.000 493 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(2), ACACA(4), ACACB(8), ACADM(2), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), HIBCH(10), LDHAL6B(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3) 11016800 50 25 41 10 14 8 6 5 17 0 0.196 1.000 1.000 494 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(1), PTPRU(6), REG1A(2), STAT1(3), STAT2(2), TYK2(2) 3485751 18 9 17 9 10 0 5 2 1 0 0.818 1.000 1.000 495 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(2), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHAL6B(2), LDHB(1), PDHA1(4), PDHA2(2), PFKL(2), PFKM(3), PFKP(1), PGAM1(1), PGAM4(2), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 16213255 86 31 84 23 39 22 10 5 10 0 0.0172 1.000 1.000 496 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(3), ANGPTL2(2), DAG1(2), DGKA(2), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NR1I3(1), PAK1(19), PDE3A(14), PDE3B(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), RIPK3(2), SGCB(1) 13750940 92 54 64 19 20 8 12 6 46 0 0.372 1.000 1.000 497 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), AOX1(2), CARM1(2), DBH(1), DCT(3), DDC(1), ESCO1(3), ESCO2(12), FAH(1), GOT1(3), HEMK1(1), HGD(2), HPD(3), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), SH3GLB1(1), TAT(1), TH(1), TPO(7), TYR(4), TYRP1(1) 16603983 100 44 81 25 27 15 18 18 21 1 0.116 1.000 1.000 498 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1C1(1), AKR1C3(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), CYP1A1(2), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2F1(3), CYP2S1(2), CYP3A5(1), CYP3A7(3), EPHX1(7), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 16031713 104 41 89 26 24 20 18 14 28 0 0.137 1.000 1.000 499 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(3), APC(8), ASAH1(1), CAMP(2), DAG1(2), DLG4(3), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), RYR1(24) 12948450 82 39 76 24 32 7 14 9 20 0 0.245 1.000 1.000 500 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(1), CAD(6), CANT1(4), CTPS2(1), DCK(1), DPYD(4), DPYS(21), DTYMK(1), DUT(1), ITPA(1), NME1(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3), RRM1(2), TYMS(1), UMPS(2), UPB1(2) 16190318 92 44 72 21 24 17 12 10 29 0 0.0910 1.000 1.000 501 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADL(2), ACADM(2), ACADS(1), ACADSB(3), ACAT1(2), ACOX1(1), ACOX3(2), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP4A22(2), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3) 13608163 69 21 69 14 25 17 9 7 11 0 0.00705 1.000 1.000 502 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), CITED2(1), CPT1B(5), CREBBP(3), DUT(1), EHHADH(1), EP300(6), HSD17B4(3), HSPA1A(1), LPL(4), ME1(2), MYC(2), NCOR1(9), NCOR2(5), NFKBIA(2), NR1H3(3), NR2F1(2), NRIP1(1), PIK3CA(6), PIK3R1(2), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTGS2(1), RB1(3), RELA(3), RXRA(1), SP1(1), STAT5A(2) 17770601 81 35 81 22 25 17 14 10 15 0 0.0920 1.000 1.000 503 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CAMK2D(1), CDK5(5), FYN(9), GNA11(3), GNAI1(1), GNB1(2), HRAS(1), JAK2(2), MAPK8(2), MAPT(3), MYLK(11), PLCG1(1), SHC1(2), SOS1(14), STAT1(3), STAT3(2), STAT5A(2), SYT1(1) 11679425 67 39 44 21 14 8 6 6 33 0 0.890 1.000 1.000 504 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(3), CD14(3), CD19(1), CD1A(2), CD1B(5), CD1C(2), CD1D(9), CD1E(1), CD2(2), CD22(2), CD33(3), CD34(1), CD38(2), CD3E(1), CD4(2), CD44(4), CD5(2), CD55(1), CD59(2), CD8B(2), CR1(5), CR2(10), CSF1(2), CSF1R(5), CSF2RA(1), CSF3(2), CSF3R(3), DNTT(4), EPO(2), EPOR(2), FCGR1A(1), FLT3(4), FLT3LG(1), GP5(2), GP9(2), HLA-DRB1(1), IL1B(1), IL1R2(9), IL2RA(1), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL7(1), IL7R(3), IL9R(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGAM(1), ITGB3(1), KIT(4), MME(2), MS4A1(4), THPO(1), TPO(7) 22817212 158 66 136 34 31 24 26 28 49 0 0.0318 1.000 1.000 505 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(1), ACTN2(4), BCAR1(2), BCR(2), CAPN1(1), CAPNS1(3), CAPNS2(2), CRKL(2), CSK(1), FYN(9), HRAS(1), ITGA1(7), MAPK8(2), PPP1R12B(1), PTK2(3), PXN(1), ROCK1(6), SHC1(2), SOS1(14), SRC(2), TLN1(11), VCL(3), ZYX(1) 13373182 85 40 66 12 22 19 6 7 31 0 0.00584 1.000 1.000 506 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), ERCC3(16), GTF2E1(1), GTF2E2(4), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3B(8), POLR3E(5), TAF5(1), TAF6(2), TAF9(2), TBP(3) 9712053 67 40 48 20 17 6 9 6 29 0 0.850 1.000 1.000 507 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2A(3), ENPP3(3), GAA(2), GANAB(4), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(3), HK2(3), HK3(4), MGAM(1), PGM1(1), PYGB(2), PYGL(2), PYGM(2), SI(5), UGDH(2), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1), UXS1(2) 15916563 79 41 73 22 26 16 10 10 17 0 0.246 1.000 1.000 508 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(4), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(3), CHAT(4), CHPT1(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), ESCO1(3), ESCO2(12), ETNK2(2), GNPAT(1), GPAM(4), GPD1(1), GPD2(1), LYPLA2(1), PCYT1A(2), PCYT1B(1), PHOSPHO1(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLD2(5), PPAP2B(2), PPAP2C(1), PTDSS1(3), PTDSS2(1), SH3GLB1(1) 18589272 94 47 81 27 24 12 15 13 30 0 0.322 1.000 1.000 509 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ADAM17(4), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(7), IGSF5(1), IKBKB(4), JAM2(2), LYN(1), MAP2K4(5), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NOD1(3), PAK1(19), PLCG1(1), PLCG2(7), PTPRZ1(4), RELA(3), SRC(2), TCIRG1(1), TJP1(6) 19697576 115 54 90 18 16 20 20 14 45 0 0.0259 1.000 1.000 510 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAD(1), BCL2L1(7), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(6), DFFB(1), FAS(3), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(3), PTPN13(8), TFG(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TRAF6(1) 12335638 68 28 56 20 14 13 12 6 23 0 0.649 1.000 1.000 511 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(17), CARS2(2), DARS(1), DARS2(2), EARS2(1), EPRS(1), FARS2(2), FARSA(2), FARSB(1), GARS(7), IARS(4), KARS(2), LARS2(2), MARS2(2), MTFMT(4), NARS2(2), PARS2(2), QARS(2), RARS(1), RARS2(4), SARS2(4), TARS(2), VARS(4), VARS2(3), WARS(2) 15067054 77 45 57 20 21 13 10 7 26 0 0.419 1.000 1.000 512 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), FUK(1), GMDS(1), GMPPA(5), HK1(3), HK2(3), HK3(4), HSD3B7(3), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(3), PFKL(2), PFKM(3), PFKP(1), PGM2(1), PHPT1(1), PMM2(2), RDH11(2), TPI1(3), TSTA3(1) 10476671 51 21 51 17 22 8 14 5 2 0 0.256 1.000 1.000 513 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(2), AKT3(4), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(2), CR2(10), CSK(1), DAG1(2), FLOT2(1), GSK3A(2), GSK3B(2), INPP5D(1), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), MAP4K1(3), NFATC1(4), NFATC2(10), PDK1(1), PIK3CA(6), PIK3CD(2), PIK3R1(2), PLCG2(7), PPP1R13B(1), PPP3CA(3), PPP3CC(2), PTPRC(3), SHC1(2), SOS1(14), SOS2(1), SYK(2), VAV1(6) 20769047 140 61 114 25 38 21 12 19 49 1 0.00539 1.000 1.000 514 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AANAT(1), ACAT1(2), AFMID(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), AOX1(2), ASMT(2), CARM1(2), CAT(1), CYP1A1(2), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), INMT(1), KMO(2), KYNU(1), LCMT1(1), LCMT2(2), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(5), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), TDO2(1), TPH1(2), TPH2(2), WARS(2) 16901506 85 33 77 20 26 12 21 17 9 0 0.0485 1.000 1.000 515 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(3), BIRC2(2), CASP2(3), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CRADD(2), DAXX(6), DFFB(1), GSN(6), LMNB1(1), LMNB2(1), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK8(2), MDM2(2), NFKBIA(2), NUMA1(3), PAK2(3), PRKCD(11), PRKDC(9), PSEN1(1), PSEN2(1), PTK2(3), RASA1(4), RB1(3), RELA(3), SPTAN1(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 19615051 97 38 85 26 16 12 23 12 34 0 0.440 1.000 1.000 516 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(3), AKT2(2), AKT3(4), ANGPTL2(2), ARHGAP4(2), ARHGEF11(6), BTK(1), CDC42(1), GDI1(1), GDI2(3), INPPL1(5), ITPR1(10), ITPR2(12), ITPR3(10), LIMK1(1), MYLK(11), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDK1(1), PIK3CA(6), PIK3CD(2), PIK3CG(5), PIK3R1(2), PPP1R13B(1), PTEN(2), RACGAP1(3), ROCK1(6), ROCK2(2), SAG(1), WASF1(1), WASL(6) 19738833 142 71 113 35 35 20 18 15 54 0 0.254 1.000 1.000 517 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), AOX1(2), ASMT(2), CAT(1), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2D6(1), CYP2E1(3), CYP2F1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), CYP4B1(1), CYP51A1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2) 15316734 76 30 74 23 27 10 20 10 9 0 0.235 1.000 1.000 518 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(9), ASH2L(3), CARM1(2), CTCFL(1), DOT1L(1), EED(3), EHMT1(5), EHMT2(6), EZH1(1), EZH2(3), FBXO11(2), HCFC1(5), HSF4(1), KDM6A(8), MEN1(5), NSD1(7), OGT(2), PAXIP1(1), PPP1CA(1), PRDM2(8), PRDM9(5), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(11), RBBP5(1), SATB1(10), SETD1A(30), SETD2(9), SETD8(1), SETDB1(3), SETMAR(1), SMYD3(1), STK38(2), SUV39H2(3), SUV420H1(4), SUV420H2(2), SUZ12(2), WHSC1(4), WHSC1L1(8) 33760713 175 93 124 30 24 19 22 30 80 0 0.121 1.000 1.000 519 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(7), ACTN1(1), AKT1(3), AKT2(2), AKT3(4), ANGPTL2(2), ARHGEF6(2), ARHGEF7(9), BCAR1(2), BRAF(4), CDC42(1), CDKN2A(43), CRK(1), CSE1L(3), DOCK1(5), EPHB2(4), FYN(9), GRB7(3), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGB3BP(1), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MRAS(2), MYLK(11), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PIK3CA(6), PIK3CB(3), PKLR(2), PLCG1(1), PLCG2(7), PTEN(2), PTK2(3), ROCK1(6), ROCK2(2), SHC1(2), SOS1(14), SOS2(1), SRC(2), TERF2IP(1), TLN1(11), TLN2(6), ZYX(1) 34641760 267 107 202 49 60 40 26 30 111 0 0.00280 1.000 1.000 520 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), BAD(1), CABIN1(6), CAMK4(2), CD3E(1), CD69(1), CREBBP(3), CSNK2A1(1), EGR2(3), EGR3(2), EP300(6), FCER1A(1), FOSL1(1), GATA3(3), GATA4(1), GSK3A(2), GSK3B(2), HRAS(1), IL1B(1), IL2RA(1), IL6(1), ITK(1), JUNB(1), KPNA5(1), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(2), MYF5(2), NCK2(2), NFAT5(31), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(6), OPRD1(2), P2RX7(2), PAK1(19), PPP3CC(2), PTPRC(3), RELA(3), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(6), VAV1(6), XPO5(2) 25599712 170 79 119 37 41 25 15 13 75 1 0.161 1.000 1.000 521 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(2), AKT1(3), AKT2(2), AKT3(4), ARRB1(1), ARRB2(3), ATF4(1), BDNF(1), BRAF(4), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1D(35), CACNA1E(10), CACNA1F(2), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(6), CACNA2D2(2), CACNA2D3(3), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(3), CACNG3(3), CACNG4(1), CACNG5(2), CD14(3), CDC25B(2), CDC42(1), CHUK(1), CRK(1), CRKL(2), DAXX(6), DUSP10(1), DUSP14(1), DUSP16(2), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(1), ECSIT(7), EGF(4), EGFR(2), ELK1(2), ELK4(1), FAS(3), FASLG(1), FGF10(18), FGF12(1), FGF13(2), FGF14(2), FGF17(1), FGF18(1), FGF23(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(4), FLNA(10), FLNB(4), FLNC(12), HRAS(1), IKBKB(4), IL1B(1), IL1R2(9), JUND(1), KRAS(142), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP3K7(12), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(3), MAX(1), MEF2C(2), MKNK2(3), MOS(3), MRAS(2), MYC(2), NF1(6), NFATC2(10), NFATC4(5), NFKB2(1), NLK(2), NR4A1(3), NTF3(8), NTRK1(3), NTRK2(3), PAK1(19), PAK2(3), PDGFRA(3), PDGFRB(7), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), PTPN5(1), RAC2(1), RAP1B(3), RAPGEF2(6), RASA1(4), RASA2(2), RASGRF1(1), RASGRF2(7), RASGRP1(2), RASGRP2(1), RASGRP3(2), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS(2), SOS1(14), SOS2(1), SRF(1), STK3(1), STK4(3), STMN1(1), TAOK1(4), TAOK2(26), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), TNFRSF1A(2), TP53(119), TRAF2(1), TRAF6(1), ZAK(5) 82248269 852 178 542 133 183 146 155 88 275 5 9.66e-15 1.000 1.000 522 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(1), ACTN2(4), ACTN4(1), APC(8), APC2(2), ARAF(2), ARHGEF1(3), ARHGEF12(6), ARHGEF6(2), ARHGEF7(9), ARPC1A(2), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(4), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(4), CD14(3), CDC42(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CRK(1), CRKL(2), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH1(7), DIAPH2(1), DIAPH3(18), DOCK1(5), EGF(4), EGFR(2), FGD1(1), FGF10(18), FGF12(1), FGF13(2), FGF14(2), FGF17(1), FGF18(1), FGF23(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(4), FN1(9), GIT1(7), GSN(6), HRAS(1), IQGAP1(3), IQGAP2(1), IQGAP3(3), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(7), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), KRAS(142), LIMK1(1), LIMK2(2), MOS(3), MRAS(2), MYH10(38), MYH14(7), MYH9(4), MYL9(1), MYLK(11), MYLK2(4), NCKAP1(4), NCKAP1L(5), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(7), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PPP1R12B(1), PTK2(3), PXN(1), RAC2(1), RDX(4), RHOA(1), ROCK1(6), ROCK2(2), RRAS(2), SCIN(1), SOS1(14), SOS2(1), SSH1(4), SSH2(3), SSH3(1), TIAM1(10), TIAM2(5), VAV1(6), VCL(3), WASF1(1), WASF2(2), WASL(6) 78463302 628 172 374 124 118 129 136 55 188 2 3.60e-06 1.000 1.000 523 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(4), ARHGAP5(6), BAD(1), BCAR1(2), BIRC2(2), BRAF(4), CAPN2(1), CCND2(3), CCND3(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(5), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A4(13), COL4A6(6), COL5A1(25), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), COMP(4), CRK(1), CRKL(2), CTNNB1(9), DIAPH1(7), DOCK1(5), EGF(4), EGFR(2), ELK1(2), ERBB2(6), FARP2(3), FLNA(10), FLNB(4), FLNC(12), FLT1(4), FN1(9), FYN(9), GSK3B(2), HGF(1), HRAS(1), IBSP(3), IGF1R(6), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), KDR(1), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), MAPK10(1), MAPK8(2), MAPK9(1), MET(4), MYL9(1), MYLK(11), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PARVB(3), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(7), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTEN(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RELN(14), RHOA(1), ROCK1(6), ROCK2(2), SHC1(2), SHC2(2), SHC4(2), SOS1(14), SOS2(1), SRC(2), THBS1(7), THBS2(4), THBS3(1), THBS4(34), TLN1(11), TLN2(6), TNC(14), TNN(5), TNR(14), TNXB(13), VAV1(6), VCL(3), VEGFC(1), VTN(2), VWF(5), ZYX(1) 104580098 675 158 575 166 176 123 95 84 191 6 0.000673 1.000 1.000 524 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 ACTB(2), CHAD(1), COL11A1(7), COL11A2(5), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A4(13), COL4A6(6), COL5A1(25), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), COMP(4), DES(1), DSC1(5), DSC2(6), DSC3(6), DSG1(2), DSG2(3), DSG3(1), DSG4(5), FN1(9), GJA1(1), GJA10(1), GJA3(1), GJA4(2), GJA5(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJC3(2), GJD4(2), IBSP(3), INA(3), ITGA6(5), ITGB4(8), KRT1(2), KRT10(2), KRT12(3), KRT13(2), KRT14(2), KRT15(4), KRT16(1), KRT17(3), KRT19(1), KRT2(3), KRT20(3), KRT24(2), KRT25(1), KRT27(1), KRT28(2), KRT3(2), KRT31(2), KRT33A(2), KRT33B(1), KRT34(3), KRT37(1), KRT38(2), KRT39(2), KRT4(2), KRT40(1), KRT5(1), KRT6A(4), KRT6B(1), KRT7(3), KRT72(1), KRT73(14), KRT74(3), KRT75(1), KRT76(7), KRT77(2), KRT78(2), KRT79(2), KRT82(2), KRT83(4), KRT85(1), KRT86(2), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), LMNB1(1), LMNB2(1), NES(7), PRPH(1), RELN(14), THBS1(7), THBS2(4), THBS3(1), THBS4(34), TNC(14), TNN(5), TNR(14), TNXB(13), VTN(2), VWF(5) 70230241 509 143 438 137 151 78 82 59 135 4 0.0176 1.000 1.000 525 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 169 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY7(2), ADCY8(4), ADCY9(5), ADORA2A(1), ADRA1A(4), ADRA1D(1), ADRB2(1), ATP2A1(6), ATP2A2(3), ATP2B1(7), ATP2B2(7), ATP2B3(7), ATP2B4(2), AVPR1A(1), AVPR1B(1), BDKRB1(1), BDKRB2(1), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1D(35), CACNA1E(10), CACNA1F(2), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(6), CALML3(1), CALML6(2), CAMK2D(1), CAMK4(2), CCKAR(8), CCKBR(3), CD38(2), CHRM1(1), CHRM2(3), CHRM3(2), CHRM5(3), CHRNA7(1), CYSLTR2(1), DRD1(5), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(6), ERBB4(6), GNA11(3), GNA14(1), GNA15(4), GNAL(3), GNAQ(1), GNAS(16), GRIN1(8), GRIN2A(7), GRIN2C(6), GRIN2D(5), GRM1(17), GRM5(7), GRPR(1), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(5), HTR7(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), LHCGR(2), LTB4R2(1), MYLK(11), MYLK2(4), NOS1(10), NOS3(9), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(2), PDE1B(2), PDE1C(1), PDGFRA(3), PDGFRB(7), PHKA2(7), PHKB(4), PHKG1(2), PHKG2(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PLCZ1(5), PPID(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), PTGER3(1), PTGFR(2), RYR1(24), RYR2(26), RYR3(23), SLC25A4(1), SLC25A5(1), SLC25A6(3), SLC8A1(2), SLC8A2(4), SLC8A3(5), SPHK1(1), SPHK2(1), TACR1(3), TACR2(1), TACR3(4), TBXA2R(1), TNNC1(2), TNNC2(1), TRHR(2), TRPC1(3), VDAC1(7), VDAC2(1) 77255500 601 143 516 159 215 75 102 72 133 4 0.000279 1.000 1.000 526 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1B(2), ACVR2A(9), AMH(2), AMHR2(5), BMP2(3), BMP7(2), BMPR1A(4), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(2), CCL26(1), CCL27(1), CCL3(1), CCL7(1), CCL8(1), CCR1(2), CCR2(1), CCR3(11), CCR4(4), CCR7(1), CCR9(1), CD40(1), CRLF2(1), CSF1(2), CSF1R(5), CSF2RA(1), CSF2RB(2), CSF3(2), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCR4(3), EDA(1), EDA2R(2), EDAR(2), EGF(4), EGFR(2), EPO(2), EPOR(2), FAS(3), FASLG(1), FLT1(4), FLT3(4), FLT3LG(1), FLT4(11), GDF5(2), GHR(1), HGF(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNGR2(17), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL17RA(3), IL18R1(1), IL18RAP(3), IL1B(1), IL1R2(9), IL1RAP(2), IL20RA(2), IL21(2), IL21R(1), IL22RA1(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL6ST(4), IL7(1), IL7R(3), IL9(1), IL9R(1), INHBA(2), INHBB(2), INHBC(1), KDR(1), KIT(4), LEPR(7), LIF(2), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(3), PDGFC(2), PDGFRA(3), PDGFRB(7), PF4V1(1), PLEKHO2(1), PRL(4), PRLR(2), RELT(1), TGFB1(1), TGFB2(2), TGFBR1(8), TGFBR2(10), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(5), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF8(2), TNFRSF9(7), TNFSF12(2), TNFSF13(2), TNFSF14(1), TNFSF18(1), TNFSF8(3), TNFSF9(28), TPO(7), TSLP(1), VEGFC(1), XCR1(3) 49861461 366 127 287 71 83 58 44 43 137 1 0.000631 1.000 1.000 527 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(2), CD44(4), CHAD(1), COL11A1(7), COL11A2(5), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A4(13), COL4A6(6), COL5A1(25), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), DAG1(2), FN1(9), FNDC1(9), FNDC3A(3), GP5(2), GP6(1), GP9(2), HMMR(11), HSPG2(3), IBSP(3), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), RELN(14), SDC3(1), SDC4(2), SV2A(5), SV2C(1), THBS1(7), THBS2(4), THBS3(1), THBS4(34), TNC(14), TNN(5), TNR(14), TNXB(13), VTN(2), VWF(5) 63436959 423 127 358 108 105 75 71 50 118 4 0.0241 1.000 1.000 528 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADRA1A(4), ADRA1D(1), ADRB2(1), ANXA6(3), ARRB1(1), ARRB2(3), ATP1A4(4), ATP1B3(1), ATP2A2(3), ATP2B1(7), ATP2B2(7), ATP2B3(7), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1D(35), CACNA1E(10), CACNA1S(6), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), GJA1(1), GJA4(2), GJA5(1), GJB1(1), GJB4(1), GJB6(2), GNA11(3), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK4(2), GRK5(4), GRK6(1), ITPR1(10), ITPR2(12), ITPR3(10), KCNB1(9), KCNJ5(1), MIB1(3), NME7(1), PLCB3(4), PRKACB(1), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCQ(3), PRKD1(1), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(2), RGS7(2), RGS9(4), RYR1(24), RYR2(26), RYR3(23), SLC8A1(2), SLC8A3(5), USP5(2), YWHAH(1) 53360125 382 124 321 117 128 57 57 36 100 4 0.0998 1.000 1.000 529 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 238 ADORA2A(1), ADORA3(5), ADRA1A(4), ADRA2A(1), ADRA2B(4), ADRA2C(3), ADRB2(1), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), C5AR1(1), CALCR(2), CCKAR(8), CCKBR(3), CGA(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CRHR1(2), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(5), DRD3(1), DRD5(5), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHB(1), FSHR(4), GABBR1(18), GABBR2(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GABRB1(3), GABRB2(2), GABRB3(5), GABRD(7), GABRE(3), GABRG1(1), GABRG2(1), GABRG3(2), GABRP(1), GABRQ(2), GABRR2(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GIPR(2), GLP2R(3), GLRA1(3), GLRA2(3), GLRB(1), GNRHR(1), GPR156(2), GPR35(1), GPR50(2), GPR83(1), GRIA1(3), GRIA2(1), GRIA4(2), GRID1(7), GRID2(10), GRIK1(1), GRIK2(9), GRIK3(4), GRIK4(2), GRIK5(2), GRIN1(8), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRIN3A(4), GRIN3B(5), GRM1(17), GRM2(5), GRM3(3), GRM4(4), GRM5(7), GRM6(7), GRM7(5), GRM8(5), GRPR(1), HCRTR1(2), HCRTR2(5), HRH2(2), HRH3(1), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(5), HTR7(1), LEPR(7), LHB(2), LHCGR(2), LTB4R(7), LTB4R2(1), MC2R(2), MC3R(4), MC5R(3), MCHR1(3), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(3), NMBR(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR1(1), NPFFR2(1), NPY1R(3), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(2), P2RY1(7), P2RY13(2), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(7), PRL(4), PRLR(2), PRSS1(7), PRSS3(1), PTGDR(2), PTGER3(1), PTGFR(2), RXFP1(1), SSTR1(4), SSTR3(2), SSTR4(3), SSTR5(5), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(2), TAAR8(3), TACR1(3), TACR2(1), TACR3(4), TBXA2R(1), THRA(5), THRB(1), TRHR(2), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1) 62644830 502 120 451 138 171 77 91 68 94 1 0.000107 1.000 1.000 530 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(2), ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADM(1), ARRB1(1), ARRB2(3), ATF1(1), ATF3(1), ATF4(1), ATF5(1), ATP2A2(3), CALCA(2), CAMK2D(1), CNN2(1), CORIN(3), CRHR1(2), DGKZ(3), ETS2(2), GABPA(2), GABPB2(1), GBA2(3), GJA1(1), GNAQ(1), GNB1(2), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK4(2), GRK5(4), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(2), IL1B(1), IL6(1), ITPR1(10), ITPR2(12), ITPR3(10), MAFF(2), MIB1(3), MYLK2(4), NOS1(10), NOS3(9), OXTR(2), PDE4D(2), PLCB3(4), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCD(11), PRKCE(1), PRKCH(6), PRKCQ(3), PRKD1(1), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(2), RGS7(2), RGS9(4), RYR1(24), RYR2(26), RYR3(23), SLC8A1(2), SP1(1), TNXB(13), USP5(2), YWHAH(1) 49169188 305 113 276 104 107 44 50 35 67 2 0.281 1.000 1.000 531 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(3), CADM3(3), CD2(2), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(2), CD6(1), CD80(1), CD86(5), CD8B(2), CDH1(1), CDH15(4), CDH2(5), CDH3(14), CDH4(5), CDH5(2), CLDN17(1), CLDN3(2), CLDN9(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(8), ESAM(1), F11R(1), GLG1(2), HLA-A(7), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(3), ICAM1(2), ICAM3(2), ICOSLG(1), ITGA4(1), ITGA6(5), ITGA8(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGB2(1), ITGB8(3), JAM2(2), L1CAM(6), MPZL1(1), NCAM1(3), NCAM2(5), NEGR1(2), NEO1(3), NFASC(5), NLGN1(5), NLGN2(3), NLGN3(5), NRCAM(2), NRXN1(4), NRXN2(7), NRXN3(4), PDCD1(1), PTPRC(3), PTPRF(28), PTPRM(6), PVRL1(19), PVRL2(1), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELL(1), SELP(3), SIGLEC1(12), VCAN(10) 41565916 273 103 217 88 76 36 39 35 87 0 0.355 1.000 1.000 532 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(2), AKT3(4), BCL2L1(7), CBL(5), CBLB(2), CBLC(1), CCND2(3), CCND3(1), CISH(1), CREBBP(3), CRLF2(1), CSF2RA(1), CSF2RB(2), CSF3(2), CSF3R(3), EP300(6), EPO(2), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNGR2(17), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL20RA(2), IL21(2), IL21R(1), IL22RA1(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL6ST(4), IL7(1), IL7R(3), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(7), LIF(2), LIFR(5), MYC(2), OSMR(3), PIAS1(2), PIAS2(3), PIAS3(2), PIAS4(3), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PRL(4), PRLR(2), PTPN6(4), SOCS4(3), SOCS5(4), SOCS7(1), SOS1(14), SOS2(1), SPRED1(1), SPRED2(1), SPRY4(5), STAM(6), STAM2(1), STAT1(3), STAT2(2), STAT3(2), STAT4(1), STAT5A(2), STAT6(5), TPO(7), TSLP(1), TYK2(2) 40624239 250 100 205 69 61 33 33 35 88 0 0.373 1.000 1.000 533 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2A(3), ASCC3(5), ATP13A2(2), DDX18(1), DDX23(1), DDX4(6), DDX41(2), DDX47(5), DDX50(7), DDX51(1), DDX54(2), DDX55(1), DDX56(2), DHX58(4), ENPP3(3), EP400(8), ERCC2(2), ERCC3(16), G6PC2(1), GAA(2), GANC(1), GBA(4), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(3), HK2(3), HK3(4), IFIH1(7), MGAM(1), MOV10L1(6), NUDT8(1), PGM1(1), PYGB(2), PYGL(2), PYGM(2), RAD54L(5), RUVBL2(4), SETX(6), SI(5), SKIV2L2(1), SMARCA2(10), SMARCA5(1), UGDH(2), UGP2(6), UGT1A1(5), UGT1A10(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), UXS1(2) 34622393 202 90 168 73 47 34 28 27 65 1 0.951 1.000 1.000 534 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 164 ADORA2A(1), ADORA3(5), ADRA1A(4), ADRA1D(1), ADRA2A(1), ADRA2C(3), ADRB2(1), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKAR(8), CCKBR(3), CCR1(2), CCR10(2), CCR2(1), CCR3(11), CCR4(4), CCR7(1), CCR9(1), CCRL2(2), CHML(5), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CMKLR1(1), CX3CR1(1), CXCR4(3), DRD1(5), DRD3(1), DRD5(5), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHR(4), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR35(1), GPR4(2), GPR50(2), GPR6(1), GPR83(1), GPR87(1), GRPR(1), HCRTR1(2), HCRTR2(5), HRH2(2), HRH3(1), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(5), HTR7(1), LHCGR(2), LTB4R(7), MC3R(4), MC5R(3), MLNR(1), MTNR1A(1), MTNR1B(3), NMBR(1), NMUR1(1), NMUR2(3), NPY1R(3), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OR10A5(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(2), P2RY1(7), P2RY12(1), P2RY13(2), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(2), RGR(1), RRH(1), SSTR1(4), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(2) 34332494 238 89 215 70 74 35 59 34 35 1 0.0143 1.000 1.000 535 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADSL(2), ADSS(3), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(4), AMPD2(2), AMPD3(4), APRT(1), ATIC(2), CANT1(4), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GART(1), GMPR(3), GMPR2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IMPDH1(3), ITPA(1), NME1(1), NME4(1), NME7(1), NPR1(5), NPR2(1), NT5C1B(3), NT5C2(6), NT5E(1), NT5M(1), NUDT2(1), NUDT9(4), PAICS(2), PAPSS1(2), PAPSS2(4), PDE10A(9), PDE11A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4C(2), PDE4D(2), PDE5A(3), PDE6G(1), PDE7B(1), PDE8A(2), PDE8B(3), PDE9A(1), PFAS(7), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), POLR3B(8), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RRM1(2), RRM2B(1), XDH(5) 45976311 240 88 223 69 81 40 34 40 43 2 0.0549 1.000 1.000 536 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(4), BCAR1(2), CAPN1(1), CAPN11(1), CAPN2(1), CAPN3(4), CAPN5(3), CAPN6(6), CAPN9(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(5), FYN(9), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(7), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), MAP2K3(1), MAP2K6(3), MAPK10(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(4), PAK1(19), PAK2(3), PAK4(2), PAK6(1), PIK3R2(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), ROCK1(6), ROCK2(2), SDCCAG8(2), SEPP1(1), SHC1(2), SORBS1(1), SOS1(14), SRC(2), TLN1(11), TNS1(4), VCL(3), ZYX(1) 37978960 210 81 166 48 47 36 31 18 78 0 0.0527 1.000 1.000 537 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(4), CHUK(1), CREB1(2), DAXX(6), ELK1(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP3K7(12), MAP3K9(4), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK4(1), MAPK6(2), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(2), MEF2C(2), MEF2D(2), MKNK2(3), MYC(2), NFKBIA(2), PAK1(19), PAK2(3), RELA(3), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), RPS6KA5(4), RPS6KB2(4), SHC1(2), SP1(1), STAT1(3), TGFB1(1), TGFB2(2), TGFBR1(8), TRADD(1), TRAF2(1) 27300625 169 80 135 44 33 27 25 12 72 0 0.498 1.000 1.000 538 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(3), ABCA12(14), ABCA13(13), ABCA2(6), ABCA3(7), ABCA4(8), ABCA5(8), ABCA6(6), ABCA7(7), ABCA8(6), ABCA9(10), ABCB1(7), ABCB10(2), ABCB11(4), ABCB4(9), ABCB5(7), ABCB6(4), ABCB8(1), ABCC1(1), ABCC10(5), ABCC11(3), ABCC12(5), ABCC2(20), ABCC3(5), ABCC4(5), ABCC5(4), ABCC6(6), ABCC8(1), ABCC9(3), ABCD1(1), ABCD2(2), ABCD3(1), ABCG1(3), ABCG2(1), ABCG4(4), ABCG5(3), ABCG8(2), CFTR(5), TAP1(4), TAP2(1) 33256320 213 78 185 52 55 39 24 37 55 3 0.0160 1.000 1.000 539 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALML3(1), CALML6(2), CDIPT(3), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(1), INPP5E(2), INPPL1(5), ITPK1(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), OCRL(1), PI4KA(4), PI4KB(2), PIK3C2A(5), PIK3C2B(12), PIK3C3(2), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PLCZ1(5), PRKCG(2), PTEN(2), SYNJ1(2), SYNJ2(3) 35337932 185 74 171 48 56 25 24 25 55 0 0.0414 1.000 1.000 540 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(2), ACTN2(4), ACTN4(1), DES(1), DMD(11), MYBPC1(4), MYBPC2(1), MYBPC3(3), MYH3(2), MYH6(7), MYH7(8), MYH8(6), MYL1(1), MYL3(3), MYL9(1), MYOM1(4), NEB(21), TMOD1(1), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(4), TNNT2(3), TNNT3(1), TPM1(1), TPM3(1), TTN(116) 38480061 214 74 211 64 59 46 48 26 33 2 0.294 1.000 1.000 541 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK2(1), CLK3(3), CLK4(2), COL2A1(5), CPSF1(4), CPSF2(4), CPSF3(5), CPSF4(2), CSTF1(1), CSTF2(1), CSTF2T(1), CSTF3(4), DDX20(1), DHX15(4), DHX16(4), DHX38(2), DHX8(3), DHX9(14), DICER1(10), FUS(2), LSM2(1), METTL3(2), NCBP2(2), NONO(1), NUDT21(1), PABPN1(2), PAPOLA(2), PHF5A(2), POLR2A(6), PPM1G(2), PRPF3(3), PRPF4(3), PRPF4B(1), PRPF8(9), PTBP1(3), PTBP2(1), RBM17(1), RBM5(1), RNGTT(4), SF3A2(1), SF3B1(4), SF3B2(3), SF3B5(1), SNRPA(1), SNRPB(1), SNRPE(3), SNRPN(2), SPOP(1), SRPK1(2), SRRM1(4), SUPT5H(2), U2AF1(3), U2AF2(3), XRN2(4) 29558180 155 73 132 33 47 23 19 23 42 1 0.0666 1.000 1.000 542 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 109 A4GNT(1), ALG10(1), ALG10B(2), ALG11(3), ALG12(4), ALG13(2), ALG9(1), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT2(16), B4GALT5(2), CHPF(2), CHST1(1), CHST11(3), CHST12(1), CHST14(3), CHST2(2), CHST4(1), CHST6(4), CHSY1(2), DDOST(1), DPAGT1(8), EXT1(2), EXT2(4), EXTL1(3), EXTL2(2), EXTL3(6), GALNT1(3), GALNT10(6), GALNT13(2), GALNT14(1), GALNT2(2), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GANAB(4), GCNT4(1), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT2(5), MGAT3(3), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(3), NDST3(3), NDST4(3), OGT(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), WBSCR17(2), XYLT1(5), XYLT2(7) 31343199 173 68 148 42 51 28 32 16 46 0 0.0456 1.000 1.000 543 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(1), BDKRB1(1), BDKRB2(1), C1QA(1), C1QB(1), C1QC(1), C1R(1), C1S(6), C2(6), C3(11), C3AR1(2), C5(2), C5AR1(1), C6(6), C7(4), C8A(5), C9(3), CD46(1), CD55(1), CD59(2), CFB(3), CFD(1), CFH(6), CFI(3), CR1(5), CR2(10), F10(4), F11(1), F12(3), F13A1(3), F13B(2), F5(14), F8(9), FGA(6), FGB(4), FGG(2), KLKB1(2), KNG1(2), MASP1(2), PLAT(2), PLAUR(10), PLG(1), PROC(1), PROS1(2), SERPINA1(2), SERPINA5(2), SERPINC1(3), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(2), THBD(3), VWF(5) 25265476 177 68 154 45 38 27 32 32 47 1 0.0990 1.000 1.000 544 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(2), ACVRL1(1), AKT1(3), BMPR1A(4), BMPR2(3), BUB1(2), CDIPT(3), CDKL1(1), CLK1(3), CLK2(1), CLK4(2), COL4A3BP(1), CSNK2A1(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MAP3K10(4), MOS(3), OCRL(1), PAK4(2), PIK3C2A(5), PIK3C2B(12), PIK3CA(6), PIK3CB(3), PIK3CG(5), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCQ(3), PRKD1(1), PRKG1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), STK11(4), TGFBR1(8), VRK1(1) 32080599 174 68 160 45 53 25 22 25 49 0 0.0983 1.000 1.000 545 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADSL(2), ADSS(3), AK2(1), ALLC(2), AMPD1(4), AMPD2(2), AMPD3(4), APRT(1), ATIC(2), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), CANT1(4), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), FHIT(1), GART(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IMPDH1(3), ITPA(1), NME1(1), NPR1(5), NPR2(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(2), PAPSS2(4), PDE4A(2), PDE4C(2), PDE4D(2), PDE5A(3), PDE6B(3), PDE6C(1), PDE6G(1), PDE7B(1), PDE8A(2), PDE9A(1), PFAS(7), PKLR(2), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(3), PRPS2(1), RRM1(2) 36160083 186 68 180 47 69 38 28 19 30 2 0.00429 1.000 1.000 546 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(3), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMP8A(1), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(1), CSNK1G3(11), DHH(2), FBXW11(2), GLI1(6), GLI2(5), GLI3(14), GSK3B(2), HHIP(5), LRP2(10), PRKACB(1), PRKACG(3), PTCH1(6), PTCH2(8), SMO(2), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(7), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1), ZIC2(5) 17335283 137 67 122 40 52 25 17 11 32 0 0.133 1.000 1.000 547 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 59 APC(8), AXIN1(4), CCND2(3), CCND3(1), CSNK1E(1), CTNNB1(9), DVL1(4), DVL2(4), DVL3(2), FBXW2(2), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GSK3B(2), LDLR(1), MAPK10(1), MAPK9(1), MYC(2), PAFAH1B1(1), PPP2R5C(6), PPP2R5E(1), PRKCD(11), PRKCE(1), PRKCG(2), PRKCH(6), PRKCI(3), PRKCQ(3), PRKD1(1), RHOA(1), SFRP4(1), TCF7(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(7), WNT2B(3), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2) 17099740 132 67 114 36 49 25 11 17 30 0 0.0409 1.000 1.000 548 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(8), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADIPOR1(2), AKT1(3), AKT2(2), AKT3(4), CHUK(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(4), IRS1(30), IRS2(4), IRS4(4), JAK1(1), JAK2(2), JAK3(3), LEPR(7), MAPK10(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NPY(2), PCK1(3), PCK2(5), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(4), PRKCQ(3), RELA(3), RXRA(1), RXRB(1), RXRG(1), SLC2A1(3), STAT3(2), STK11(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2) 23494551 155 66 128 49 38 27 19 16 54 1 0.505 1.000 1.000 549 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(2), AKT3(4), CASP8(2), CCL3(1), CD14(3), CD40(1), CD80(1), CD86(5), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IKBKB(4), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(1), IRF5(1), IRF7(2), LBP(1), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K7(12), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), RELA(3), STAT1(3), TBK1(1), TICAM1(2), TLR1(5), TLR2(2), TLR3(3), TLR4(1), TLR5(3), TLR6(4), TLR8(2), TLR9(5), TRAF6(1) 25163917 140 63 123 35 35 19 22 20 44 0 0.0953 1.000 1.000 550 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AK3(1), CAD(6), CANT1(4), CTPS2(1), DCK(1), DPYD(4), DPYS(21), DTYMK(1), DUT(1), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME7(1), NT5C1B(3), NT5C2(6), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), POLR3B(8), PRIM1(1), RRM1(2), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(2) 22769591 126 60 98 31 27 18 19 24 38 0 0.203 1.000 1.000 551 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), ASCC3(5), ATP13A2(2), DDX18(1), DDX23(1), DDX4(6), DDX41(2), DDX47(5), DDX50(7), DDX51(1), DDX54(2), DDX55(1), DDX56(2), DHFR(1), DHX58(4), EP400(8), ERCC2(2), ERCC3(16), FPGS(3), GCH1(1), GGH(2), IFIH1(7), MOV10L1(6), NUDT8(1), QDPR(2), RAD54L(5), RUVBL2(4), SETX(6), SKIV2L2(1), SMARCA2(10), SMARCA5(1) 17653995 129 60 103 53 25 23 16 15 49 1 0.988 1.000 1.000 552 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(6), BCAR1(2), CDC42(1), CDH5(2), CLDN17(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTNND1(3), CXCR4(3), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(2), ITGA4(1), ITGAL(3), ITGAM(1), ITGB2(1), ITK(1), JAM2(2), MAPK11(1), MAPK12(1), MAPK13(1), MLLT4(5), MMP2(2), MMP9(4), MYL9(1), NCF2(1), NCF4(1), NOX1(4), NOX3(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RAPGEF3(4), RAPGEF4(3), RHOA(1), RHOH(2), ROCK1(6), ROCK2(2), SIPA1(3), THY1(1), TXK(1), VAV1(6), VCL(3) 35143000 166 58 163 61 54 33 19 26 31 3 0.414 1.000 1.000 553 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(1), ATF1(1), BRAF(4), CAMP(2), CREB1(2), CREB5(1), CREBBP(3), CRKL(2), DAG1(2), EGR1(23), EGR2(3), EGR3(2), ELK1(2), FRS2(1), GNAQ(1), MAP1B(7), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), NTRK1(3), OPN1LW(2), PIK3CA(6), PIK3CD(2), PIK3R1(2), SHC1(2), SRC(2), TERF2IP(1), TH(1) 14731938 101 57 82 31 23 11 14 11 42 0 0.660 1.000 1.000 554 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(8), ATP4A(24), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(6), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7A2(1), COX7B2(2), COX7C(1), COX8C(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(3), NDUFV2(3), SDHA(6), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1), UQCRH(2) 15677355 110 55 86 31 21 19 14 15 40 1 0.639 1.000 1.000 555 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(5), CCKBR(3), CCR2(1), CCR3(11), CELSR1(5), CELSR2(11), CELSR3(12), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(3), EMR3(1), FSHR(4), GHRHR(1), GNRHR(1), GPR116(3), GPR132(1), GPR133(9), GPR135(1), GPR143(1), GPR18(2), GPR56(1), GPR61(1), GPR84(1), GRM1(17), GRPR(1), LGR6(3), LPHN2(10), LPHN3(1), LTB4R2(1), OR2M4(3), P2RY13(2), PTGFR(2), SMO(2), TAAR5(2), TSHR(3) 18818404 131 53 115 41 44 20 21 16 29 1 0.122 1.000 1.000 556 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(2), INPPL1(5), ISYNA1(1), ITPK1(1), ITPKB(3), MINPP1(1), MIOX(1), OCRL(1), PI4KA(4), PI4KB(2), PIK3C3(2), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PLCZ1(5), PTEN(2), SYNJ1(2), SYNJ2(3) 20987328 95 44 89 31 25 14 14 15 27 0 0.397 1.000 1.000 557 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1A1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CEL(14), DGAT1(3), DGAT2(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), GK2(5), GLB1(2), GPAM(4), LCT(6), LIPA(1), LIPF(2), LIPG(4), LPL(4), MGLL(2), PNLIP(2), PPAP2B(2), PPAP2C(1) 16553271 109 43 99 31 36 18 12 11 32 0 0.111 1.000 1.000 558 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(10), B3GALT4(2), CDR1(2), DGKI(5), IL6ST(4), RPL10(3), RPL11(1), RPL12(1), RPL14(1), RPL15(2), RPL18(2), RPL18A(1), RPL19(1), RPL24(1), RPL28(3), RPL32(2), RPL34(1), RPL35(1), RPL36(1), RPL3L(2), RPL4(3), RPL7A(2), RPLP0(1), RPLP2(1), RPS11(2), RPS25(2), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5), RPS6KB2(4), RPSA(1), SLC36A2(1), TBC1D10C(3), TSPAN9(1), UBB(1), UBC(2) 14730832 82 43 77 56 15 11 17 8 30 1 1.000 1.000 1.000 559 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(2), AKT3(4), BRAF(4), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CA(6), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIK3R5(5), PRKAA1(1), PRKAA2(1), RICTOR(6), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5), RPS6KB2(4), STK11(4), TSC1(1), TSC2(8), ULK1(3), ULK3(1), VEGFC(1) 15088870 84 41 78 26 22 16 11 7 28 0 0.563 1.000 1.000 560 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(4), APH1A(3), CREBBP(3), CTBP2(3), DLL4(2), DTX1(3), DTX2(5), DVL1(4), DVL2(4), DVL3(2), EP300(6), JAG1(2), JAG2(3), LFNG(1), MAML1(5), MAML2(3), MAML3(17), NCOR2(5), NOTCH1(10), NOTCH2(4), NOTCH3(7), NOTCH4(5), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RBPJL(1), SNW1(1) 20114108 109 40 94 69 31 26 18 10 24 0 0.999 1.000 1.000 561 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(3), CDC7(1), CDT1(1), DIAPH2(1), MCM10(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), NACA(13), PCNA(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), PRIM1(1), RFC1(4), RFC2(2), RFC3(1), RPA1(1), RPA2(3), RPA3(2), RPS27A(1), UBB(1), UBC(2) 14211732 76 34 73 42 25 11 15 12 11 2 0.993 1.000 1.000 562 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BAD(1), BRAF(4), CREB1(2), CREB5(1), DUSP6(2), DUSP9(1), MKNK2(3), MOS(3), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS1(14), SOS2(1) 8322265 39 34 27 14 7 4 4 2 22 0 0.973 1.000 1.000 563 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(1), CBR3(5), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2J2(4), CYP2U1(1), CYP4A22(2), CYP4F2(2), CYP4F3(4), DHRS4(4), EPHX2(1), GGT1(1), GPX5(4), GPX6(1), LTA4H(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1) 10953036 64 32 54 29 19 9 13 3 19 1 0.910 1.000 1.000 564 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(16), GTF2A1(1), GTF2E1(1), GTF2F1(6), NCOA2(3), NCOA3(3), NCOR2(5), POLR2A(6), RXRA(1), TBP(3) 7062938 45 31 30 25 8 3 6 2 25 1 1.000 1.000 1.000 565 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CBR3(5), CYP4F2(2), CYP4F3(4), EPX(4), GGT1(1), LPO(6), LTA4H(2), MPO(2), PLA2G3(2), PLA2G6(4), PRDX1(1), PRDX2(1), PRDX5(2), PTGDS(2), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1), TPO(7) 7829592 56 28 48 22 20 5 11 3 16 1 0.822 1.000 1.000 566 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ARRB2(3), CALML3(1), CALML6(2), CAMK2D(1), CLCA1(2), CLCA2(2), CLCA4(2), CNGA3(4), CNGA4(2), CNGB1(11), GNAL(3), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDC(1), PDE1C(1), PRKACB(1), PRKACG(3), PRKG1(1), PRKG2(2) 8538815 52 27 44 19 15 9 12 5 11 0 0.648 1.000 1.000 567 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(2), ALAS2(3), AOC2(3), AOC3(3), CHDH(2), DAO(2), DMGDH(4), GARS(7), GLDC(1), HSD3B7(3), PHGDH(2), PSAT1(2), RDH11(2), SARDH(3), SARS2(4), SHMT1(2), SHMT2(4), TARS(2) 12057914 53 25 48 20 29 12 5 5 2 0 0.352 1.000 1.000 568 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), ALAS2(3), AOC2(3), AOC3(3), ATP6V0C(1), CHDH(2), CPT1B(5), DAO(2), DMGDH(4), GARS(7), GLDC(1), PLCB2(5), PLCG1(1), PLCG2(7), SARDH(3), SHMT1(2), SHMT2(4), TARS(2) 11867513 59 24 57 21 26 14 8 5 6 0 0.314 1.000 1.000 569 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(3), B3GAT3(2), CHPF(2), CHST11(3), CHST12(1), CHST14(3), CHSY1(2), DSE(4), XYLT1(5), XYLT2(7) 4206947 32 23 29 13 13 4 7 2 6 0 0.577 1.000 1.000 570 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(4), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(2), LCT(6), MAN2B1(2), MAN2B2(2), MANBA(2), NAGLU(2), NEU4(2) 9841351 43 22 42 19 12 7 8 3 13 0 0.782 1.000 1.000 571 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), HRAS(1), IL6(1), IL6R(1), IL6ST(4), JAK1(1), JAK2(2), JAK3(3), SHC1(2), SOS1(14), SRF(1), STAT3(2) 6752518 35 21 24 16 5 4 3 3 20 0 0.987 1.000 1.000 572 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(2), CD97(2), CRHR1(2), CRHR2(1), ELTD1(5), EMR1(3), EMR2(3), GHRHR(1), GIPR(2), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(10), LPHN3(1), VIPR1(1), VIPR2(1) 7558705 41 19 41 17 9 9 5 11 7 0 0.542 1.000 1.000 573 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), DNMT3A(8), DNMT3B(5), MARS2(2), MTFMT(4), MTR(7), TAT(1) 5793794 30 19 24 16 7 5 5 2 10 1 0.936 1.000 1.000 574 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), POLR3B(8) 6485860 30 19 27 11 12 4 4 6 4 0 0.562 1.000 1.000 575 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(1), GSK3B(2), IGF1R(6), INPPL1(5), PDK2(3), PIK3CA(6), PIK3R1(2), PPP2CA(1), PTEN(2) 5508889 31 19 28 10 6 5 4 6 10 0 0.643 1.000 1.000 576 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(2), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ATP6V0C(1), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(6), GCDH(2), HADHA(1), PLOD1(2), SHMT1(2), SHMT2(4), TMLHE(1) 10380977 40 18 36 18 13 9 11 0 7 0 0.715 1.000 1.000 577 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL10L(2), RPL11(1), RPL12(1), RPL14(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL24(1), RPL28(3), RPL32(2), RPL34(1), RPL35(1), RPL36A(2), RPL36AL(1), RPL3L(2), RPS11(2), RPS25(2), RPS27(1), RPS28(1), RPSA(1) 6369092 32 17 31 11 9 3 9 0 11 0 0.796 1.000 1.000 578 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(4), CHAT(4), DBH(1), DDC(1), GAD1(6), GAD2(5), HDC(1), PAH(1), SLC18A3(3), TH(1), TPH1(2) 4094886 30 16 30 13 11 2 9 2 5 1 0.596 1.000 1.000 579 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(4), GLB1(2), LCT(6), NEU4(2), PPAP2B(2), PPAP2C(1), SMPD1(1), SPTLC1(3), SPTLC2(1), UGCG(1) 6862460 32 16 32 12 11 9 3 2 7 0 0.283 1.000 1.000 580 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), CREB1(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), PIK3CA(6), PIK3R1(2), RB1(3), RELA(3), SP1(1) 5437899 27 16 26 10 4 2 7 5 9 0 0.872 1.000 1.000 581 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(3), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(2), GNPDA1(2), GNPDA2(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(4), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PHPT1(1), RENBP(1) 8020922 37 16 37 15 17 4 8 4 4 0 0.674 1.000 1.000 582 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(4), GPX6(1), GSR(1), GSS(1), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), OPLAH(3) 6374895 38 15 34 16 8 9 7 3 11 0 0.649 1.000 1.000 583 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(11), C5(2), C6(6), C7(4), ICAM1(2), IL6(1), ITGA4(1), ITGAL(3), ITGB2(1), SELP(3) 6874289 34 15 34 14 10 8 5 2 9 0 0.533 1.000 1.000 584 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), DNMT3A(8), DNMT3B(5), MARS2(2), MTR(7) 4854061 24 15 21 14 7 4 5 2 5 1 0.901 1.000 1.000 585 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(3), GNAQ(1), GNB1(2), MYLK(11), PLCB1(1), PPP1R12B(1), ROCK1(6) 5762081 31 15 31 12 6 9 4 5 6 1 0.653 1.000 1.000 586 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), EPRS(1), FARS2(2), GARS(7), IARS(4), KARS(2), LARS2(2), MARS2(2), QARS(2), RARS(1), TARS(2), WARS(2) 8839491 29 14 27 10 9 7 6 5 2 0 0.542 1.000 1.000 587 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(4), GSS(1), GSTA1(5), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), PGD(1) 5149499 32 14 28 13 6 7 4 4 11 0 0.691 1.000 1.000 588 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(2), LCT(6), NAGLU(2) 5827840 26 14 25 16 5 7 3 2 9 0 0.957 1.000 1.000 589 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), HSD3B7(3), PLA2G12B(1), PLA2G3(2), PLA2G6(4), RDH11(2) 6660072 36 13 35 13 9 5 11 7 4 0 0.690 1.000 1.000 590 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST2(3), HS3ST3B1(1), XYLT1(5), XYLT2(7) 1926000 18 12 16 13 6 6 2 1 3 0 0.887 1.000 1.000 591 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), PIK3CA(6), PIK3R1(2), PLCG1(1), PTK2(3), PXN(1), RELA(3) 7861261 27 12 27 15 7 8 3 4 5 0 0.895 1.000 1.000 592 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(2), MAP3K1(3), NCOR2(5), RXRA(1), THRA(5), THRB(1) 4901856 21 12 18 10 6 5 5 2 3 0 0.814 1.000 1.000 593 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST2(3), HS3ST3B1(1), XYLT1(5), XYLT2(7) 1926000 18 12 16 13 6 6 2 1 3 0 0.887 1.000 1.000 594 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(3), PPP3CC(2), SYNJ1(2), SYNJ2(3), SYT1(1) 6244918 25 12 25 11 4 6 3 4 8 0 0.768 1.000 1.000 595 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(6), PGM1(1), PYGL(2), PYGM(2), TPI1(3) 3782512 17 11 17 11 7 4 1 1 4 0 0.844 1.000 1.000 596 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), LCT(6), NAGLU(2) 4109106 19 11 19 12 4 5 2 2 6 0 0.913 1.000 1.000 597 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(3), EP300(6), LPL(4), NCOA2(3), PPARG(1), RXRA(1) 5129266 18 11 18 10 6 2 4 2 4 0 0.894 1.000 1.000 598 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), PDE1B(2), PLCB1(1), PLCB2(5), PRL(4), TRH(3) 3137803 19 11 19 11 9 1 4 2 3 0 0.874 1.000 1.000 599 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(2), PLA2G6(4), PTGDS(2), PTGES(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1) 4265803 21 10 21 11 10 2 4 2 3 0 0.826 1.000 1.000 600 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(2), CD33(3), CD5(2), IL12B(1), ITGAX(3), TLR2(2), TLR4(1), TLR9(5) 5172921 22 9 22 10 9 5 2 5 1 0 0.655 1.000 1.000 601 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLD2(5), PPAP2B(2), PPAP2C(1) 6493807 31 9 29 16 11 4 6 4 6 0 0.904 1.000 1.000 602 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(1), JAK2(2), JAK3(3), PIAS1(2), PIAS3(2), PTPRU(6), REG1A(2), SOAT1(1) 3895037 20 9 19 15 9 2 5 0 4 0 0.989 1.000 1.000 603 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PIAS3(2), PTPRU(6), REG1A(2), SRC(2), STAT3(2) 4304090 23 9 22 16 9 5 5 0 4 0 0.970 1.000 1.000 604 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SNAP23(2), SNAP29(3), STX11(2), STX12(1), STX2(1), STX3(1), STX4(2), STX7(1), TSNARE1(1), VAMP4(1), VAMP7(1), VTI1A(2) 4703952 18 8 18 13 8 0 2 2 6 0 0.991 1.000 1.000 605 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22RA1(1), JAK1(1), JAK2(2), JAK3(3), STAT1(3), STAT3(2), STAT5A(2), TYK2(2) 5208374 18 8 18 12 7 2 4 2 3 0 0.962 1.000 1.000 606 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1) 6291158 21 8 21 10 3 5 7 2 4 0 0.889 1.000 1.000 607 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(3), NR1I3(1), PTGS1(2), PTGS2(1) 1464698 11 7 10 5 8 1 0 2 0 0 0.749 1.000 1.000 608 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(1), JAK1(1), STAT1(3), STAT2(2), TYK2(2) 3025980 11 6 11 5 4 0 4 3 0 0 0.775 1.000 1.000 609 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), GGT1(1), MARS2(2), PAPSS1(2), PAPSS2(4), SCLY(2) 3464119 13 6 13 11 4 4 2 1 2 0 0.951 1.000 1.000 610 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 MTNR1A(1), MTNR1B(3), PTGDR(2), PTGFR(2), TBXA2R(1) 3240491 9 5 9 10 2 1 5 0 1 0 0.971 1.000 1.000 611 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL16(1), IL6(1), IL9(1) 2753138 4 2 4 3 0 2 1 1 0 0 0.838 1.000 1.000 612 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1), TGM2(1) 1385991 2 2 2 2 2 0 0 0 0 0 0.893 1.000 1.000 613 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1) 1876503 2 1 2 4 1 1 0 0 0 0 0.984 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 470342 1 1 1 2 0 0 1 0 0 0 0.995 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 139470 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 420745 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000