rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(1), RAB9A(1) 1187560 12 6 12 1 5 3 2 1 1 0 0.0706 0.238 1.000 2 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(3) 515787 3 3 3 0 1 0 0 2 0 0 0.448 0.386 1.000 3 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(1), FMOD(2), KERA(2), LUM(2) 1001919 7 4 7 1 1 0 1 4 1 0 0.478 0.397 1.000 4 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 3 RANBP1(1), RANGAP1(4) 544748 5 3 5 1 2 2 1 0 0 0 0.365 0.399 1.000 5 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 6 ADCY1(5), FSHB(1), FSHR(4), XPO1(2) 2056757 12 7 12 1 4 1 2 3 2 0 0.161 0.483 1.000 6 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(10), BMPR1A(4), BMPR2(3) 1735555 17 9 17 3 4 6 2 1 4 0 0.190 0.495 1.000 7 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 6 ADORA2A(1), ADORA3(5), P2RY2(1), P2RY6(1) 1309771 8 6 8 1 4 2 0 0 2 0 0.121 0.508 1.000 8 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(1) 1070904 3 3 3 0 1 1 1 0 0 0 0.341 0.540 1.000 9 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IL12B(1) 830479 5 5 4 2 0 2 0 0 3 0 0.927 0.553 1.000 10 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ARPC1A(2), ARPC2(1), CDC42(1), WASF1(1), WASL(6) 2248368 15 10 13 3 3 4 2 2 4 0 0.382 0.559 1.000 11 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(2) 554983 2 2 2 0 1 1 0 0 0 0 0.477 0.560 1.000 12 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(3) 454101 4 2 4 0 2 1 0 1 0 0 0.236 0.567 1.000 13 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(1), LDLR(1), LPL(4) 1469397 10 5 10 0 3 3 1 1 2 0 0.0233 0.578 1.000 14 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(3), CPS1(5), GLS(1), GOT1(3) 2162834 13 6 12 0 4 2 3 3 0 1 0.0265 0.595 1.000 15 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(4) 895970 5 4 5 1 4 0 0 0 1 0 0.411 0.610 1.000 16 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(3), BAD(1), CHRNB1(4), CHRNG(2), MUSK(7), PIK3R1(2), PTK2(3), SRC(2), TERT(6), YWHAH(1) 4042757 31 18 26 6 7 8 1 4 11 0 0.136 0.631 1.000 17 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 315467 1 1 1 0 0 0 0 0 1 0 0.842 0.669 1.000 18 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 GRIA2(1), JUND(1), PPP1R1B(1) 910935 3 3 3 0 0 0 1 1 1 0 0.649 0.688 1.000 19 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 4 AOC2(3), AOC3(3), CES1(2) 1507434 8 5 8 1 4 2 2 0 0 0 0.174 0.691 1.000 20 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 619349 3 2 3 2 0 0 0 1 2 0 0.934 0.701 1.000 21 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(2), CSF3(2), EPO(2), IL6(1), IL7(1), IL9(1) 1719135 11 5 10 1 1 1 2 4 3 0 0.291 0.703 1.000 22 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 199171 2 1 2 1 2 0 0 0 0 0 0.802 0.711 1.000 23 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ARPC1A(2), ARPC2(1), CDC42(1), PDGFRA(3), PIK3R1(2), WASL(6) 2773823 15 9 13 2 4 4 1 2 4 0 0.220 0.722 1.000 24 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 CREB1(2), HRAS(1), SHC1(2), SRC(2) 1709431 7 6 7 2 2 2 0 0 3 0 0.560 0.727 1.000 25 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 5 ABCB1(7), ABCB11(4), ABCC1(1), ABCC3(5), GSTP1(1) 3252573 18 11 15 2 5 3 3 5 2 0 0.0608 0.740 1.000 26 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(5), UBE2F(1), UBE2G2(1) 1776018 10 5 10 1 4 1 3 1 1 0 0.127 0.743 1.000 27 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 10 ADCY1(5), ADRB2(1), CFTR(5), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SLC9A3R1(1) 3066954 21 11 21 3 8 5 2 4 2 0 0.0408 0.749 1.000 28 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MAX(1), MYC(2), SP1(1), SP3(1) 1729562 5 5 5 0 1 0 1 0 3 0 0.534 0.755 1.000 29 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 5 ARNTL(1), CRY1(1), CRY2(1), CSNK1E(1), PER1(5) 1943148 9 6 8 1 2 1 0 1 5 0 0.357 0.761 1.000 30 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1R(9) 1818711 12 9 10 3 2 3 0 2 5 0 0.431 0.766 1.000 31 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 8 ADAR(5), APOBEC3B(2), APOBEC3G(1) 1820847 8 5 8 1 3 2 2 1 0 0 0.236 0.770 1.000 32 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), TAT(1) 726398 4 2 4 1 0 1 2 1 0 0 0.677 0.777 1.000 33 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 10 BCAT1(2), COASY(2), DPYD(4), ENPP3(3), PANK1(1), PANK3(1), PANK4(2), PPCS(1), UPB1(2) 3421765 18 11 17 2 4 6 2 4 2 0 0.0591 0.779 1.000 34 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), FUT2(3), FUT3(1), ST3GAL4(2) 2012061 11 8 11 2 8 0 0 2 1 0 0.256 0.783 1.000 35 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(2), ACADS(1), ACAT1(2), HADHA(1) 1510553 8 4 8 0 1 4 1 1 1 0 0.0836 0.786 1.000 36 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 6 HSD11B1(1), LPL(4), NR3C1(2), PPARG(1), RXRA(1) 1546719 9 4 9 1 3 1 2 1 2 0 0.177 0.789 1.000 37 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(2), TPI1(3) 1074702 6 3 6 1 3 2 0 1 0 0 0.295 0.792 1.000 38 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2), HLA-DRB1(1) 659834 3 2 3 1 0 0 0 1 2 0 0.905 0.813 1.000 39 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(2), BDH2(1), HMGCS2(1), OXCT1(2), OXCT2(1) 2017978 9 5 9 1 1 5 0 1 2 0 0.148 0.816 1.000 40 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 14 BCAT1(2), BCAT2(2), COASY(2), DPYD(4), ENPP3(3), ILVBL(2), PANK1(1), PANK3(1), PANK4(2), PPCDC(1), PPCS(1), UPB1(2), VNN1(1) 4363460 24 13 23 2 8 7 3 4 2 0 0.00962 0.830 1.000 41 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADH(1), HADHA(1), HADHB(2), HSD17B4(3), MECR(2), PPT1(1), PPT2(3) 2366220 13 6 13 0 3 3 1 2 4 0 0.0205 0.830 1.000 42 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(3) 1273098 4 3 4 2 2 1 1 0 0 0 0.786 0.843 1.000 43 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 9 ACTA1(4), EPHA4(4), EPHB1(2), ITGA1(7), L1CAM(6), LYN(1), RAP1B(3), SELP(3) 4020348 30 17 27 5 12 5 3 4 6 0 0.0485 0.847 1.000 44 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 5 ADCY1(5), GNB1(2), PRKAR1A(1) 1239130 8 4 8 2 3 3 0 1 1 0 0.310 0.847 1.000 45 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 CDK5R1(1), CSNK1D(1), DRD1(5), PLCB1(1), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 3629405 23 11 23 4 10 3 3 5 2 0 0.107 0.849 1.000 46 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3) 3500482 31 14 31 6 7 7 5 5 7 0 0.104 0.852 1.000 47 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATM(11), ATR(10), CHEK2(1), YWHAH(1) 3919061 23 14 23 4 3 2 6 4 8 0 0.470 0.853 1.000 48 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(1), GLS(1), OAT(2), PRODH(2) 1579580 9 4 9 1 3 1 2 1 2 0 0.224 0.854 1.000 49 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(2), GPR171(2), GPR18(2), GPR34(1), GPR39(4), GPR65(3), GPR75(1) 2740159 16 11 16 4 2 5 1 4 4 0 0.340 0.854 1.000 50 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPT(2), ENPP3(3), FLAD1(5), RFK(1), TYR(4) 2699666 16 9 13 2 5 3 2 1 5 0 0.261 0.856 1.000 51 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(1), HADHA(1) 1347131 3 3 3 1 1 0 1 0 1 0 0.656 0.858 1.000 52 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(3), NR1H4(1), RXRA(1) 1506654 6 4 6 1 2 3 1 0 0 0 0.194 0.860 1.000 53 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 12 F10(4), FGA(6), FGB(4), FGG(2), PROC(1), PROS1(2), SERPINC1(3), TFPI(2) 3300008 24 8 23 5 3 6 9 3 3 0 0.231 0.862 1.000 54 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(1), CD3E(1), CD4(2), CD58(2), CSF3(2), IL6(1) 1737423 11 4 10 1 1 1 1 3 5 0 0.264 0.867 1.000 55 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 3608520 19 12 19 3 12 1 3 1 2 0 0.0811 0.869 1.000 56 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 HLA-DRB1(1) 637989 1 1 1 0 0 0 0 0 1 0 1.000 0.882 1.000 57 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO3(1), FARS2(2), GOT1(3), PAH(1), TAT(1) 2284627 11 7 10 2 3 2 4 2 0 0 0.335 0.883 1.000 58 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(4), CAMP(2), CREB1(2), CREB5(1), SNX13(4), SRC(2), TERF2IP(1) 3154681 19 10 19 2 2 2 4 4 7 0 0.191 0.890 1.000 59 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(2), ARF3(1), CDK4(2), MDM2(2), NXT1(1), PRB1(1) 1973412 9 5 9 1 6 0 3 0 0 0 0.170 0.890 1.000 60 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), OXCT1(2) 933559 4 2 4 0 0 3 0 0 1 0 0.324 0.894 1.000 61 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ARPC1A(2), ARPC2(1), NCK1(3), NCKAP1(4), NTRK1(3), PIR(2), WASF1(1), WASF2(2), WASL(6) 3975004 28 13 26 5 9 6 3 4 6 0 0.180 0.896 1.000 62 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(3), UBE2D1(1), UBE2E1(1), UBE2E3(2), UBE2G2(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(6) 2939320 19 8 17 1 8 4 4 1 2 0 0.0121 0.897 1.000 63 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 6 ATM(11), CDC25B(2), MYT1(12), YWHAH(1) 3283477 26 13 26 5 8 4 4 5 5 0 0.198 0.907 1.000 64 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(3), IDH2(5), OGDH(5), SDHA(6), SUCLA2(1) 2602372 20 10 19 5 3 3 5 6 3 0 0.402 0.910 1.000 65 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(6) 1835786 10 6 9 2 4 0 1 3 2 0 0.436 0.912 1.000 66 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(1), FUT2(3), FUT9(1), GCNT2(1), ST8SIA1(2) 1747926 8 4 8 1 6 1 1 0 0 0 0.134 0.914 1.000 67 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(2), ACADS(1), ACSL1(2), ACSL3(4), ACSL4(3), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1), SCP2(1) 4680162 19 10 19 1 5 4 4 2 4 0 0.0188 0.916 1.000 68 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(2) 1563637 14 6 12 2 6 2 3 0 3 0 0.0911 0.917 1.000 69 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(3), ARHGAP5(6), CASP1(4), CASP10(2), CASP8(2), CASP9(1) 3269260 18 10 17 5 3 3 1 3 7 1 0.635 0.920 1.000 70 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25B(2), CDK7(1) 1721214 3 3 3 1 2 0 0 0 1 0 0.691 0.921 1.000 71 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(2), ATP6V0C(1), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(2), SHMT2(4), TYMS(1) 4968172 28 12 26 6 4 4 6 4 9 1 0.172 0.922 1.000 72 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), FH(3), IDH1(1), IDH2(5), MDH2(1), SUCLA2(1) 2458559 15 8 14 2 1 3 5 2 4 0 0.334 0.923 1.000 73 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1) 2228147 8 7 8 2 6 1 1 0 0 0 0.311 0.925 1.000 74 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1) 2228147 8 7 8 2 6 1 1 0 0 0 0.311 0.925 1.000 75 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRP9(1), SRPR(2) 2079787 12 4 12 0 3 4 3 1 1 0 0.0352 0.927 1.000 76 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(4), SPCS1(1) 859342 7 3 7 2 1 1 2 3 0 0 0.638 0.929 1.000 77 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 26 ABAT(2), ACADL(2), ACADM(2), ACADSB(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), CNDP1(2), DPYD(4), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), UPB1(2) 7832383 44 23 44 4 16 8 8 6 5 1 0.000529 0.930 1.000 78 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 14 NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV2(3) 1686987 10 6 9 3 3 5 0 2 0 0 0.499 0.931 1.000 79 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(3), CPOX(3), HMBS(1), PPOX(2) 2123550 9 7 9 2 3 2 1 1 2 0 0.547 0.931 1.000 80 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3) 4908489 46 22 44 8 11 7 9 7 12 0 0.0419 0.933 1.000 81 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(2), DHFR(1), FTCD(2), GART(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(7), SHMT1(2), SHMT2(4), TYMS(1) 5099221 29 12 27 6 5 4 5 5 9 1 0.140 0.936 1.000 82 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 CD3E(1), HLA-A(7), ICAM1(2), ITGAL(3), ITGB2(1) 2111242 14 6 13 4 4 0 2 3 5 0 0.556 0.940 1.000 83 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(2), ERBB3(6), NRG1(3), UBE2D1(1) 2852820 16 7 16 2 1 4 5 3 3 0 0.195 0.941 1.000 84 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(4), FBXW7(6), RB1(3), TFDP1(1) 2336974 16 9 16 6 2 4 3 3 4 0 0.749 0.943 1.000 85 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF3(2), EPO(2), FLT3(4), IL6(1), IL9(1), TGFB1(1), TGFB2(2) 2336734 14 8 12 3 2 2 4 2 4 0 0.518 0.944 1.000 86 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 6 AGT(1), AGTR2(1), BDKRB2(1), KNG1(2), NOS3(9) 1869733 14 6 14 3 6 0 7 0 1 0 0.327 0.945 1.000 87 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(6), HDC(1), TH(1), TPH1(2) 1705181 11 5 11 5 3 0 3 1 3 1 0.702 0.946 1.000 88 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(6), MEF2A(2), MEF2C(2), MEF2D(2), YWHAH(1) 2235400 16 7 16 2 3 3 7 1 2 0 0.126 0.948 1.000 89 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1), SQLE(2) 907943 6 4 5 3 2 2 1 0 1 0 0.727 0.949 1.000 90 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(3), FUT3(1), FUT5(1), FUT6(2) 1434162 8 5 8 2 5 2 0 0 1 0 0.284 0.950 1.000 91 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(4), LPO(6), MPO(2), TPO(7) 2349521 23 12 23 5 11 1 6 2 3 0 0.140 0.950 1.000 92 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), CD80(1), HLA-DRB1(1) 1100222 4 2 4 1 0 0 1 1 2 0 0.845 0.950 1.000 93 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFLAR(3) 1072663 5 3 5 3 1 0 1 1 2 0 0.841 0.950 1.000 94 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 ADRB2(1), AKT1(3), ANXA1(3), GNB1(2), NOS3(9), NR3C1(2), PIK3R1(2), RELA(3), SYT1(1) 3830017 26 13 25 6 6 3 8 4 5 0 0.387 0.951 1.000 95 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(2), KEAP1(2), MAFF(2), MAPK8(2), NFE2L2(1) 2522256 9 5 9 1 2 0 1 3 3 0 0.315 0.951 1.000 96 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 9 CAPN1(1), CAPNS1(3), CAPNS2(2), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(2), MAPT(3), PPP2CA(1) 2068361 15 9 15 5 6 5 0 2 2 0 0.398 0.954 1.000 97 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), TPO(7), TYR(4) 2706020 27 13 26 8 12 2 7 2 4 0 0.356 0.954 1.000 98 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(7), PRKACB(1), PRKACG(3), PRKAR2B(1) 2811189 12 7 12 4 2 3 2 2 3 0 0.702 0.954 1.000 99 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL1(1), FOSL2(3), IFNAR1(2), IFNAR2(1), MAPK8(2), RELA(3), TNFRSF11A(5), TRAF6(1) 3108588 18 9 17 5 1 3 3 5 6 0 0.638 0.955 1.000 100 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 10 ARRB1(1), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 2105512 12 4 12 2 7 3 1 1 0 0 0.121 0.956 1.000 101 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3E(1), CD4(2) 890226 3 1 3 1 0 0 0 1 2 0 0.839 0.957 1.000 102 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(3), TAT(1), TYR(4) 1296960 9 4 9 3 2 1 4 2 0 0 0.695 0.958 1.000 103 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), JUNB(1), MAF(2), MAP2K3(1), NFATC1(4), NFATC2(10), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 3489258 30 16 26 6 14 6 2 2 6 0 0.0228 0.958 1.000 104 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(3), GPI(3), HK1(3), PFKL(2), PGAM1(1), PGK1(3), PKLR(2), TPI1(3) 2596957 22 9 22 6 10 8 1 2 1 0 0.0956 0.958 1.000 105 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 7 CDC25B(2), CSK(1), PTPRA(1), SRC(2) 2022956 6 6 6 2 3 2 1 0 0 0 0.490 0.958 1.000 106 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 5 CDK5R1(1), DAB1(2), LRP8(3), RELN(14), VLDLR(3) 3377683 23 15 19 8 7 4 3 2 6 1 0.711 0.958 1.000 107 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3) 1552564 13 2 13 4 5 3 1 2 2 0 0.424 0.960 1.000 108 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), ADRB2(1), PLCE1(6), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RAP2B(2) 3582318 23 10 23 4 9 2 3 6 3 0 0.133 0.961 1.000 109 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(6), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), WBSCR17(2) 3980509 24 12 23 7 11 3 6 2 2 0 0.381 0.962 1.000 110 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 15 HLA-DRB1(1), IFNGR1(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL2RA(1), IL4R(3) 3149639 12 10 12 4 2 1 2 2 5 0 0.799 0.964 1.000 111 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), ATP6V0C(1), CAT(1), EPX(4), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), SHMT1(2), SHMT2(4), TPO(7) 3314319 33 14 32 7 11 8 8 1 5 0 0.0670 0.965 1.000 112 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 5 BAAT(1), CSAD(1), GAD1(6), GAD2(5), GGT1(1) 1504258 14 7 14 7 4 3 4 1 1 1 0.761 0.966 1.000 113 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(2), FDPS(1), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(2), NQO2(2), SQLE(2), VKORC1(3) 3149254 27 13 25 6 8 7 7 1 4 0 0.122 0.966 1.000 114 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(1), CD4(2), HLA-DRB1(1), LCK(1), PTPRC(3), ZAP70(6) 2206166 14 5 14 2 4 3 1 2 4 0 0.147 0.969 1.000 115 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CD4(2), HLA-DRB1(1), IL1B(1), IL6(1) 1275298 5 2 5 1 0 0 1 1 3 0 0.715 0.970 1.000 116 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2), PNPO(1), PSAT1(2) 1349692 5 4 5 3 1 1 3 0 0 0 0.831 0.970 1.000 117 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(3), HK2(3), HK3(4), PGM1(1), TGDS(1) 2852929 13 7 13 4 8 1 2 0 2 0 0.322 0.970 1.000 118 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 EGFR(2), ELK1(2), GNB1(2), HRAS(1), IGF1R(6), KLK2(1), MKNK2(3), MYC(2), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(4), SHC1(2), SRC(2), STAT3(2) 7960687 36 22 34 8 9 9 3 3 12 0 0.137 0.971 1.000 119 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 6 THBS1(7) 1710622 7 7 4 3 5 2 0 0 0 0 0.466 0.972 1.000 120 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA4(3), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(7), LDLR(1), LPL(4), LRP1(21), SCARB1(1), SOAT1(1) 7616519 50 27 50 9 20 10 5 3 11 1 0.00956 0.972 1.000 121 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 8 CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD3B1(2) 2064192 11 3 11 4 1 5 2 2 1 0 0.504 0.976 1.000 122 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 9 ATM(11), CDC25B(2), CDK4(2), MYT1(12), RB1(3), YWHAH(1) 4123552 31 13 31 5 9 4 7 6 5 0 0.134 0.977 1.000 123 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 594511 3 1 3 1 0 1 2 0 0 0 0.756 0.979 1.000 124 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 14 CD44(4), CSF1(2), IL1B(1), IL6R(1), SELL(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(2), TNFSF8(3) 3095681 20 8 19 9 6 1 3 4 6 0 0.790 0.979 1.000 125 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 12 AKR1A1(1), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), SIRT1(1), SIRT2(1) 3134879 9 5 9 0 4 1 1 2 1 0 0.0505 0.979 1.000 126 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), SQLE(2) 1204816 6 4 5 3 2 2 1 0 1 0 0.730 0.980 1.000 127 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), HSD3B7(3), PON1(1), PON2(1), RDH11(2) 2505610 13 5 13 2 3 2 3 4 1 0 0.207 0.980 1.000 128 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 16 ADCY1(5), GNB1(2), PPP2CA(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1) 3699849 22 7 22 4 8 6 1 3 4 0 0.0700 0.980 1.000 129 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), MIOX(1), UGDH(2) 2391158 9 7 9 3 5 1 1 2 0 0 0.480 0.981 1.000 130 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1), HSD3B7(3), RDH11(2) 1349588 6 2 6 0 1 0 2 2 1 0 0.192 0.981 1.000 131 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(1), GHR(1), HRAS(1), IGF1R(6), PIK3R1(2), SHC1(2) 3097657 16 9 15 4 6 2 2 2 4 0 0.347 0.981 1.000 132 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 7 CPN2(2), CYP11A1(2), CYP17A1(1), HSD11B1(1), HSD3B1(2) 1634850 8 4 8 4 1 2 3 2 0 0 0.714 0.982 1.000 133 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 23 ABAT(2), ACADM(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), CNDP1(2), DPYD(4), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), UPB1(2) 7058986 37 20 37 4 14 5 8 5 4 1 0.00353 0.982 1.000 134 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 5 TGDS(1), UGDH(2), UXS1(2) 1087579 5 4 5 3 0 1 1 2 1 0 0.924 0.982 1.000 135 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(2), UXS1(2) 1087579 5 4 5 3 0 1 1 2 1 0 0.924 0.982 1.000 136 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1), COQ7(1) 1160684 2 2 2 2 0 1 0 0 1 0 0.953 0.982 1.000 137 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACPT(2), ENPP3(3), FLAD1(5), MTMR2(1), MTMR6(2), PHPT1(1), RFK(1), TYR(4) 4191351 20 10 17 5 7 4 3 1 5 0 0.526 0.982 1.000 138 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(3), SP1(1), SP3(1) 1851811 6 2 6 0 1 0 3 1 1 0 0.354 0.982 1.000 139 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 20 ACTA1(4), ADCY1(5), GNAI1(1), GNB1(2), HRAS(1), MYT1(12), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RPS6KA1(2), SRC(2) 4892747 38 14 37 8 14 10 4 6 4 0 0.0400 0.983 1.000 140 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3), MASP1(2) 5814449 48 22 46 9 11 7 9 8 13 0 0.0531 0.984 1.000 141 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(7), ATM(11), BRCA1(6), CHEK2(1), MAPK8(2), MDM2(2), MRE11A(4), NFKBIA(2), RAD50(1), RELA(3), TP73(1) 7574891 40 23 35 4 7 4 9 5 15 0 0.0843 0.986 1.000 142 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), FBP2(1), GOT1(3), GPT(2), GPT2(3), MDH2(1), ME1(2), ME2(4), ME3(2), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TPI1(3) 5038960 32 13 32 3 6 10 10 3 3 0 0.00276 0.987 1.000 143 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), FDFT1(2), FDPS(1), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NSDHL(2), SQLE(2) 3727666 23 12 22 7 7 6 5 0 5 0 0.407 0.987 1.000 144 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(4), GGT1(1), SHMT1(2), SHMT2(4) 1580415 12 8 12 6 3 4 2 1 2 0 0.698 0.988 1.000 145 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(2), KARS(2) 1305213 4 2 4 3 1 0 1 1 1 0 0.952 0.988 1.000 146 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 17 AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 4562475 22 13 19 4 3 3 5 5 6 0 0.362 0.989 1.000 147 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT2A1(1), SUOX(1) 1680152 11 3 11 4 1 2 1 4 3 0 0.685 0.989 1.000 148 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(1), ABAT(2), ADSL(2), ADSS(3), AGXT(2), AGXT2(2), ASL(3), ASNS(3), ASPA(1), CAD(6), DARS(1), DDO(2), GAD1(6), GAD2(5), GOT1(3), GPT(2), GPT2(3), PC(3) 6934256 50 24 48 11 15 9 13 6 6 1 0.0848 0.989 1.000 149 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(1), FUT2(3), FUT9(1), GBGT1(1), HEXA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2) 2825903 17 7 17 2 10 3 3 0 1 0 0.0346 0.989 1.000 150 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 20 ADCY1(5), AKT1(3), BAD(1), CSF2RB(2), IGF1R(6), IL3RA(3), KIT(4), PIK3R1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), YWHAH(1) 5384035 36 15 35 8 15 6 4 6 5 0 0.0535 0.990 1.000 151 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ASPH(2), CREB1(2), EP300(6), EPO(2), HIF1A(1), NOS3(9) 4639782 22 9 22 2 7 2 7 2 4 0 0.0580 0.990 1.000 152 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(4), LARS2(2), PDHA1(4), PDHA2(2) 2770266 14 8 12 3 4 5 2 3 0 0 0.282 0.991 1.000 153 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(1), EPX(4), LPO(6), MPO(2), MTHFR(1), SHMT1(2), SHMT2(4), TPO(7) 3242080 29 11 29 7 11 7 6 2 3 0 0.101 0.991 1.000 154 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(4), ACSS1(1), ACSS2(2), FH(3), IDH1(1), IDH2(5), MDH2(1), SUCLA2(1) 3670897 21 11 20 6 6 3 5 2 5 0 0.562 0.992 1.000 155 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), PC(3), PCK1(3), SDHA(6), SUCLA2(1), SUCLG1(3) 5728549 34 15 32 7 5 6 11 7 5 0 0.237 0.992 1.000 156 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 10 ARNTL(1), CRY1(1), CRY2(1), CSNK1D(1), CSNK1E(1), NPAS2(4), PER1(5), PER2(5), PER3(2) 4332505 21 11 19 4 3 6 3 3 6 0 0.156 0.992 1.000 157 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 13 CD3E(1), IL2RA(1), TGFB1(1), TGFB2(2) 2173470 5 4 4 5 2 0 0 0 3 0 0.993 0.992 1.000 158 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(1), SHMT1(2), SHMT2(4) 1199303 8 4 8 6 2 3 2 0 1 0 0.888 0.992 1.000 159 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), DNAJC3(2), NFKBIA(2), RELA(3) 2573970 8 4 8 2 1 1 2 2 2 0 0.687 0.993 1.000 160 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), E2F4(3), PRB1(1) 2377911 14 3 14 3 3 3 5 3 0 0 0.295 0.993 1.000 161 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(2), ACADS(1), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH5A1(1), EHHADH(1), GAD1(6), GAD2(5), HADHA(1), L2HGDH(2), OXCT1(2), PDHA1(4), PDHA2(2) 7184162 38 20 36 7 11 11 7 4 4 1 0.0300 0.993 1.000 162 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 6 CHRM1(1), GNAQ(1), GNB1(2), PLCB1(1), TUB(2) 1726260 7 3 7 3 1 3 0 2 1 0 0.645 0.993 1.000 163 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 16 CBL(5), EGF(4), EGFR(2), HRAS(1), PTPRB(10), RASA1(4), SHC1(2), SRC(2) 6018370 30 16 30 4 2 8 5 5 9 1 0.0885 0.993 1.000 164 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(2), ESR1(1), GREB1(8), MTA1(1), PDZK1(1), TUBA8(4) 3131290 17 9 17 4 4 9 1 1 2 0 0.0759 0.994 1.000 165 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 17 CSNK2A1(1), ELK1(2), HRAS(1), IGF1R(6), MAPK8(2), PIK3R1(2), RASA1(4), SHC1(2), SRF(1) 4873997 21 13 21 5 6 2 1 3 9 0 0.312 0.994 1.000 166 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(2), PGAP1(1), PIGB(3), PIGG(2), PIGL(2), PIGM(1), PIGO(9), PIGP(2), PIGQ(6), PIGS(3), PIGW(2) 6750883 33 14 32 3 9 6 6 5 7 0 0.00658 0.994 1.000 167 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(4), CHAT(4), PCYT1A(2), PDHA1(4), PDHA2(2), SLC18A3(3) 1985491 19 13 17 9 6 5 5 1 2 0 0.609 0.994 1.000 168 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 18 CSNK2A1(1), ELK1(2), HRAS(1), INSR(4), MAPK8(2), PIK3R1(2), RASA1(4), SHC1(2), SRF(1) 5083541 19 11 19 4 6 2 0 3 8 0 0.272 0.994 1.000 169 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 15 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB10(1), PSMB5(2), PSMB6(1) 2129948 9 5 9 4 2 0 2 1 4 0 0.843 0.994 1.000 170 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(2), CSF3(2), HLA-DRB1(1), IL12B(1), IL6(1), IL7(1), TGFB1(1), TGFB2(2) 3750033 13 7 11 5 1 2 1 3 6 0 0.893 0.995 1.000 171 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(2), IL10RB(2), IL6(1), JAK1(1), STAT1(3), STAT3(2), STAT5A(2) 3385568 15 7 15 5 7 2 2 1 3 0 0.589 0.995 1.000 172 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(2) 1893310 21 7 20 4 7 7 0 3 4 0 0.0524 0.995 1.000 173 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 7 CDC25B(2), CDK7(1), XPO1(2) 1894486 5 4 5 2 3 0 0 0 2 0 0.673 0.995 1.000 174 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), PRKCE(1) 2212858 14 4 13 4 6 3 1 1 2 1 0.282 0.995 1.000 175 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), MUT(2) 1381953 4 2 4 2 0 1 0 1 2 0 0.814 0.995 1.000 176 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(3), CREB1(2), HRAS(1), MAPK7(4), MEF2A(2), MEF2C(2), MEF2D(2), NTRK1(3), PIK3R1(2), PLCG1(1), RPS6KA1(2), SHC1(2) 4738692 26 14 24 4 7 6 4 1 8 0 0.131 0.995 1.000 177 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 18 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB5(2), PSMB6(1), UBE3A(6) 3303138 14 7 13 3 4 1 2 2 5 0 0.444 0.995 1.000 178 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 19 ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2) 3371418 14 6 14 4 3 4 4 1 2 0 0.426 0.995 1.000 179 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 19 ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2) 3371418 14 6 14 4 3 4 4 1 2 0 0.426 0.995 1.000 180 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 19 ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2) 3371418 14 6 14 4 3 4 4 1 2 0 0.426 0.995 1.000 181 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(3), PIK3R1(2), PLCB1(1), PLCG1(1), VAV1(6) 2954919 13 5 12 5 3 3 0 3 3 1 0.713 0.995 1.000 182 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 15 ABCC1(1), ABCG2(1), BCHE(6), CES1(2), CYP3A5(1), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1) 5112647 24 18 20 7 2 4 5 5 7 1 0.645 0.996 1.000 183 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 12 AKT1(3), BAD(1), HRAS(1), IGF1R(6), PIK3R1(2), SHC1(2), YWHAH(1) 3205178 16 9 15 5 6 2 1 2 5 0 0.556 0.996 1.000 184 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CD80(1), CR1(5), FCGR2B(2), HLA-DRB1(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3) 3601277 18 10 17 6 6 3 1 2 6 0 0.457 0.996 1.000 185 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 19 F10(4), F11(1), F12(3), F13B(2), F8(9), FGA(6), FGB(4), FGG(2), LPA(8), PLAT(2), PLG(1), SERPINE1(2), SERPINF2(1), VWF(5) 8557048 50 25 46 11 14 10 12 4 9 1 0.104 0.996 1.000 186 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(7), MDM2(2), MYC(2), PIK3R1(2), POLR1A(6), POLR1B(3), RB1(3), TBX2(2) 4709654 27 12 26 4 7 5 6 2 7 0 0.0886 0.996 1.000 187 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(3), DHFR(1), IMPDH1(3), MTHFD2(1), POLB(1), POLD1(2), POLG(5), PRPS2(1), RRM1(2) 3606928 21 9 20 4 5 7 1 1 7 0 0.0954 0.996 1.000 188 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), ME1(2), PC(3), PDHA1(4), SLC25A1(1) 2584347 13 7 11 5 4 7 1 1 0 0 0.386 0.996 1.000 189 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), AFMID(2), HAO1(1), HAO2(1), MDH2(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1) 3520582 12 6 11 1 3 3 1 0 5 0 0.131 0.996 1.000 190 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(5), DYRK1B(3), GLI2(5), GLI3(14), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SMO(2), SUFU(1) 4721277 41 21 40 13 18 7 7 5 4 0 0.220 0.996 1.000 191 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELL(1) 2929624 14 6 14 4 4 2 1 3 4 0 0.326 0.996 1.000 192 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 31 AARS(1), ABAT(2), ADSL(2), ADSS(3), ADSSL1(1), AGXT(2), AGXT2(2), ASL(3), ASNS(3), ASPA(1), ASRGL1(1), ASS1(4), CAD(6), DARS(1), DARS2(2), DDO(2), DLAT(4), GAD1(6), GAD2(5), GOT1(3), GPT(2), GPT2(3), NARS2(2), PC(3), PDHA1(4), PDHA2(2) 9691752 70 36 64 16 21 15 14 8 11 1 0.0347 0.997 1.000 193 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ACPT(2), ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), CYP3A5(1), CYP3A7(3), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), PON1(1), PON2(1) 5058800 29 13 28 8 10 5 2 6 6 0 0.324 0.997 1.000 194 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(6), CAPN2(1), CAPNS1(3), CAPNS2(2), EP300(6), MEF2D(2), NFATC1(4), NFATC2(10), PPP3CA(3), PPP3CC(2), SYT1(1) 6774478 40 24 36 8 12 9 1 5 13 0 0.0731 0.997 1.000 195 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), EHHADH(1), GCDH(2), HADHA(1) 2167501 6 2 6 1 1 2 2 0 1 0 0.344 0.997 1.000 196 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP7(2), DFFB(1), HMGB2(1), TOP2A(2), TOP2B(6) 2559831 12 8 12 3 3 3 2 3 1 0 0.508 0.997 1.000 197 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 20 DLG4(3), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), NOS1(10), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1) 6749256 55 24 54 14 23 8 7 9 8 0 0.0766 0.997 1.000 198 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), FBP2(1), GOT1(3), GPT(2), GPT2(3), MDH2(1), ME1(2), ME3(2), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TKTL1(1), TPI1(3) 5622414 29 13 29 3 6 8 10 2 3 0 0.00976 0.997 1.000 199 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 10 ACE2(4), AGT(1), AGTR2(1), CMA1(1), COL4A1(5), COL4A2(6), COL4A3(2), COL4A5(5), COL4A6(6) 5884864 31 16 28 5 5 6 12 1 7 0 0.252 0.997 1.000 200 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), MTMR6(2), NFS1(2), PHPT1(1), TPK1(1) 1778486 7 4 7 4 3 2 1 0 1 0 0.917 0.997 1.000 201 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(5), CSF1R(5), EGF(4), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SH3KBP1(2), SRC(2) 5383141 28 13 25 4 4 7 5 3 9 0 0.158 0.998 1.000 202 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 14 ACOX1(1), ACOX3(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4) 2606090 10 5 10 7 2 2 3 1 2 0 0.972 0.998 1.000 203 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 AKT1(3), EGFR(2), IGF1R(6), MYC(2), POLR2A(6), PPP2CA(1), RB1(3), TERT(6), TNKS(4), XRCC5(2) 5934755 35 18 34 10 14 3 5 7 6 0 0.315 0.998 1.000 204 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAT1(2), EHHADH(1), HADHA(1), HADHB(2) 2317983 7 2 7 1 0 3 1 0 3 0 0.287 0.998 1.000 205 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT1(3), AKT2(2), AKT3(4), ELK1(2), HRAS(1), NGFR(1), NTRK1(3), PIK3CD(2), SHC1(2) 3267625 20 13 18 9 10 1 1 2 6 0 0.731 0.998 1.000 206 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), FGA(6), FGB(4), FGG(2), PLAT(2), PLG(1), SERPINE1(2) 3713527 20 8 19 7 3 4 5 5 3 0 0.605 0.998 1.000 207 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKBIA(2), PLCB1(1), RELA(3) 2303338 7 4 7 5 1 1 2 1 2 0 0.971 0.998 1.000 208 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 23 AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), XYLB(2) 6926702 33 17 29 6 4 7 7 8 7 0 0.207 0.998 1.000 209 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT2(2), B3GNT7(1), CHST1(1), CHST2(2), CHST4(1), CHST6(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 3321200 16 7 16 2 6 2 5 2 1 0 0.0558 0.998 1.000 210 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(5), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNB1(2), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTPRC(3), ZAP70(6) 5873012 34 13 34 6 14 7 4 4 5 0 0.0250 0.998 1.000 211 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(5), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNB1(2), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTPRC(3), ZAP70(6) 5873012 34 13 34 6 14 7 4 4 5 0 0.0250 0.998 1.000 212 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 11 ACO1(4), HAO1(1), HAO2(1), MDH2(1), MTHFD1(1), MTHFD1L(1), MTHFD2(1) 3351290 10 5 9 0 2 3 1 0 4 0 0.0681 0.998 1.000 213 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 9 AKR1D1(1), CYP11A1(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2) 2109017 8 5 8 4 2 2 2 2 0 0 0.736 0.998 1.000 214 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 9 AKR1D1(1), CYP11A1(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2) 2109017 8 5 8 4 2 2 2 2 0 0 0.736 0.998 1.000 215 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(1), LEPR(7), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2) 4006041 17 6 17 3 2 6 1 2 6 0 0.186 0.998 1.000 216 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 HRAS(1), MMP2(2), MMP9(4), RECK(3) 1787037 10 4 9 4 5 2 1 0 2 0 0.518 0.998 1.000 217 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GCK(1), GFPT1(2), GNE(2), GNPDA1(2), GNPDA2(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(4), RENBP(1) 4735333 25 12 25 7 13 4 4 1 3 0 0.241 0.998 1.000 218 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ICAM1(2), ITGA4(1), ITGAL(3), ITGB2(1), SELE(2), SELL(1) 3371748 14 7 14 6 4 1 2 3 4 0 0.649 0.998 1.000 219 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GPHN(2), SRC(2), UBQLN1(3) 3369458 22 7 21 5 8 4 5 2 2 1 0.176 0.998 1.000 220 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(3), CHST12(1), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT2A1(1), SULT2B1(1), SUOX(1) 2614353 16 8 16 5 5 2 2 4 3 0 0.477 0.998 1.000 221 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 10 EPO(2), EPOR(2), HIF1A(1), JAK2(2), NFKBIA(2), RELA(3) 3108374 12 5 12 4 4 1 5 0 2 0 0.757 0.998 1.000 222 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2) 3955394 21 8 21 4 3 7 8 2 1 0 0.132 0.999 1.000 223 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(4), APAF1(3), CASP9(1), DAXX(6), FASLG(1), MAPKAPK3(1) 2972485 16 6 14 7 3 5 3 2 3 0 0.729 0.999 1.000 224 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(2), FARSB(1), GOT1(3), PAH(1), TAT(1) 2417060 10 7 9 3 3 2 4 1 0 0 0.559 0.999 1.000 225 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(3), HRAS(1), KLK2(1), NTRK1(3), PIK3R1(2), PLCG1(1), SHC1(2) 2991989 13 9 12 5 6 2 1 1 3 0 0.714 0.999 1.000 226 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3) 1731493 9 2 9 3 3 0 1 2 3 0 0.580 0.999 1.000 227 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), EHHADH(1), HADHA(1) 3389833 10 8 10 3 6 1 2 0 1 0 0.363 0.999 1.000 228 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), CREB1(2), SYT1(1) 3259789 9 5 9 2 3 0 2 0 4 0 0.467 0.999 1.000 229 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ARG2(1), ASL(3), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), OAT(2), ODC1(1), PYCR1(1) 4978972 23 7 22 2 8 3 7 3 1 1 0.0216 0.999 1.000 230 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1) 3702314 21 6 21 7 10 5 2 2 2 0 0.330 0.999 1.000 231 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(3), BAD(1), CASP9(1), CHUK(1), GHR(1), NFKBIA(2), PIK3R1(2), PPP2CA(1), RELA(3), YWHAH(1) 3356803 16 8 15 5 2 3 4 2 5 0 0.700 0.999 1.000 232 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3) 3822350 18 11 18 6 11 3 1 2 1 0 0.365 0.999 1.000 233 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 20 COL4A1(5), COL4A2(6), COL4A3(2), COL4A5(5), COL4A6(6), F10(4), F11(1), F12(3), F8(9), FGA(6), FGB(4), FGG(2), KLKB1(2), PROC(1), PROS1(2), SERPINC1(3), SERPING1(1) 10218919 62 27 55 10 11 13 19 3 15 1 0.0913 0.999 1.000 234 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 CYP27B1(1), CYP51A1(1), DHCR7(1), FDFT1(2), FDPS(1), GGCX(2), HMGCR(7), IDI1(1), LSS(3), MVD(2), MVK(1), NQO1(2), NSDHL(2), SQLE(2), VKORC1(3) 5243493 31 17 29 8 11 6 8 1 5 0 0.216 0.999 1.000 235 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 11 CASR(5), GPRC5A(2), GPRC5B(5), GPRC5C(6), GRM2(5), GRM3(3), GRM4(4), GRM5(7), GRM7(5), GRM8(5) 4620970 47 21 44 13 16 13 6 5 7 0 0.0989 0.999 1.000 236 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(4), EGFR(2), HGS(2) 3566725 11 3 11 1 0 5 3 2 1 0 0.138 0.999 1.000 237 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(2), IARS(4), ILVBL(2), LARS2(2), PDHA1(4), PDHA2(2), VARS(4), VARS2(3) 5171584 25 13 23 6 10 7 3 3 2 0 0.200 0.999 1.000 238 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 16 CHUK(1), IKBKB(4), MAP3K1(3), MAP3K5(2), MAP4K5(1), MAPK8(2), NFKBIA(2), RELA(3), TRAF2(1) 5236184 19 8 19 5 2 3 5 4 5 0 0.572 0.999 1.000 239 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(3), APC(8), AXIN1(4), CD14(3), CTNNB1(9), DVL1(4), FZD1(5), GJA1(1), GNAI1(1), GSK3B(2), LBP(1), LEF1(3), LY96(1), PIK3R1(2), PPP2CA(1), RELA(3), TLR4(1), WNT1(1) 8068079 53 22 50 8 15 9 7 13 9 0 0.0221 0.999 1.000 240 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 15 CARM1(2), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2) 3714755 19 7 19 5 2 8 7 1 1 0 0.290 0.999 1.000 241 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), NAT1(2), NAT2(1), XDH(5) 2197664 18 8 18 8 8 2 1 4 3 0 0.735 0.999 1.000 242 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(3), BAD(1), BAK1(1), CASP9(1), CES1(2) 3018823 8 2 8 3 2 3 3 0 0 0 0.700 0.999 1.000 243 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(3), ATM(11), CCNE1(1), CDK4(2), MDM2(2), PCNA(1), RB1(3) 4841970 23 10 23 4 5 4 7 4 3 0 0.238 0.999 1.000 244 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), SP1(1), SP3(1), SYT1(1) 5867296 31 14 27 7 8 7 2 4 10 0 0.194 0.999 1.000 245 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(4), FURIN(2), NOTCH1(10), PSEN1(1) 2727017 17 6 17 8 8 7 1 1 0 0 0.337 0.999 1.000 246 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(3), BCAR1(2), ILK(1), PDK2(3), PIK3R1(2), PTEN(2), PTK2(3), SHC1(2) 4088883 18 9 17 4 6 4 3 1 4 0 0.251 0.999 1.000 247 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), DDC(1), EPX(4), GOT1(3), HPD(3), LPO(6), MPO(2), PRDX1(1), PRDX2(1), PRDX5(2), TAT(1), TPO(7) 6156453 44 20 43 8 19 7 10 3 5 0 0.0152 1.000 1.000 248 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(3), ASRGL1(1), CA5A(3), CA5B(2), CA6(1), CA8(1), CA9(1), CPS1(5), GLS(1), GLUD2(3), HAL(1) 5914428 22 11 21 5 4 8 3 2 4 1 0.312 1.000 1.000 249 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(8), AXIN1(4), BTRC(2), CREBBP(3), CSNK1A1(1), CSNK1D(1), CSNK2A1(1), CTNNB1(9), DVL1(4), FZD1(5), GSK3B(2), MYC(2), NLK(2), PPARD(2), PPP2CA(1), TLE1(3), WIF1(2), WNT1(1) 8030887 53 23 53 9 13 11 10 10 9 0 0.0252 1.000 1.000 250 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), FUT1(1), FUT2(3), FUT9(1), GBGT1(1), HEXA(1), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2) 2995892 15 7 15 3 8 3 3 0 1 0 0.121 1.000 1.000 251 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(3), EP300(6), ESR1(1), SRC(2) 4210565 12 7 12 3 3 3 4 1 1 0 0.321 1.000 1.000 252 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3), THY1(1) 2968478 13 5 13 3 7 1 0 2 3 0 0.215 1.000 1.000 253 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(1), CDC34(1), CUL1(4), RB1(3), SKP2(3), TFDP1(1) 2406145 16 8 16 8 3 5 4 3 1 0 0.829 1.000 1.000 254 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ICAM1(2), ITGA4(1), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2), SELL(1), SELP(3) 4461888 18 8 18 7 5 3 2 3 5 0 0.485 1.000 1.000 255 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(4), RB1(3), SKP2(3), TFDP1(1) 2396592 12 7 12 6 2 3 3 3 1 0 0.865 1.000 1.000 256 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH18A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AMD1(1), AOC2(3), AOC3(3), ARG1(1), ARG2(1), ASL(3), ASS1(4), CPS1(5), ODC1(1), SAT2(1) 8279665 30 16 28 3 17 4 4 2 2 1 0.00407 1.000 1.000 257 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(2), CREBBP(3), EP300(6), NCOA3(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RXRA(1) 5765837 26 13 26 8 9 4 6 3 3 1 0.351 1.000 1.000 258 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(3), JAK1(1), JAK2(2), TYK2(2) 2909471 8 5 8 4 2 0 3 1 2 0 0.897 1.000 1.000 259 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(3), JAK1(1), JAK2(2), TYK2(2) 2909471 8 5 8 4 2 0 3 1 2 0 0.897 1.000 1.000 260 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(4), BAIAP2(4), CASP1(4), CASP7(2), CASP8(2), INSR(4), ITCH(3), MAGI1(2), MAGI2(12), WWP1(2), WWP2(6) 5939029 45 25 40 13 15 7 4 7 12 0 0.340 1.000 1.000 261 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(1), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SRF(1), STAT1(3), STAT3(2), STAT5A(2) 8386078 35 17 35 8 9 5 4 6 11 0 0.307 1.000 1.000 262 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 2411659 7 3 7 5 3 0 2 0 2 0 0.901 1.000 1.000 263 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(1), CD4(2), ICAM1(2), ITGAL(3), ITGB2(1), PTPRC(3), THY1(1) 3117056 15 5 15 4 7 1 0 3 4 0 0.317 1.000 1.000 264 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(2), CD3E(1), CD4(2), IL12B(1), IL12RB1(1), IL12RB2(2), JAK2(2), STAT4(1), TYK2(2) 4135444 14 6 14 6 2 1 3 2 6 0 0.902 1.000 1.000 265 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), ESCO1(3), SH3GLB1(1) 4262085 10 5 10 2 2 2 1 3 2 0 0.398 1.000 1.000 266 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 15 CD3E(1), CD80(1), HLA-DRB1(1), ITK(1), LCK(1), PIK3R1(2) 2739290 7 3 7 4 2 1 1 1 2 0 0.901 1.000 1.000 267 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 10 COL4A1(5), COL4A2(6), COL4A3(2), COL4A5(5), COL4A6(6), SLC2A1(3) 6109634 27 12 24 8 5 5 9 1 7 0 0.684 1.000 1.000 268 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(1), ELK1(2), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3R1(2), PLCG1(1), SHC1(2) 4003737 13 7 13 3 4 3 1 1 4 0 0.282 1.000 1.000 269 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(3), CCND2(3), CCND3(1), CCNE1(1), CDK4(2), CDK6(2), CDK7(1), RB1(3), RBL1(1), TFDP1(1) 4090298 18 6 18 6 2 5 5 4 2 0 0.505 1.000 1.000 270 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 11 ARF1(2), ARFGAP1(2), ARFGEF2(3), CLTB(1), COPA(6), GBF1(3), GPLD1(2), KDELR2(1) 4214443 20 9 18 7 5 3 3 4 4 1 0.593 1.000 1.000 271 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(2), GSK3B(2), PPP1CA(1) 3225117 11 3 11 4 2 3 4 0 2 0 0.702 1.000 1.000 272 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), GSS(1), NOX1(4), RELA(3), XDH(5) 2786464 14 7 14 7 5 3 3 2 1 0 0.849 1.000 1.000 273 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(7), AKT1(3), ATM(11), CSNK1A1(1), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), HSPA1A(1), MAPK8(2), MDM2(2), NFKBIB(1), NQO1(2) 5621445 35 20 33 10 6 4 8 9 8 0 0.477 1.000 1.000 274 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 BLVRA(2), CP(5), CPOX(3), EPRS(1), GUSB(1), HMBS(1), PPOX(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 7265463 31 17 28 5 4 5 4 7 11 0 0.267 1.000 1.000 275 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(4), FH(3), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), OGDH(5), PC(3), PDHA1(4), PDHA2(2), PDK1(1), PDK2(3), PDK4(1), SDHA(6), SUCLA2(1), SUCLG1(3) 7938626 46 19 43 10 9 10 13 8 6 0 0.112 1.000 1.000 276 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(3), HK2(3), HK3(4), ISYNA1(1), PGM1(1), TGDS(1) 3276862 14 7 14 5 9 1 2 0 2 0 0.350 1.000 1.000 277 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(3), FBL(1), GPT(2), LDHB(1), NCL(2) 2528350 12 3 11 6 3 1 5 1 2 0 0.885 1.000 1.000 278 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), MBTPS1(3), SCAP(3), SREBF2(5) 3485307 12 8 10 8 4 2 0 2 4 0 0.944 1.000 1.000 279 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), HRAS(1), MYC(2), NFKBIA(2), PLCB1(1), RELA(3) 4325454 11 6 11 5 2 2 3 1 3 0 0.935 1.000 1.000 280 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(3), BAD(1), CASP9(1), CDC42(1), CHUK(1), ELK1(2), HRAS(1), PIK3R1(2), RALBP1(2), RALGDS(2), RELA(3), RHOA(1) 4679415 20 11 19 8 5 4 3 3 5 0 0.771 1.000 1.000 281 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 HLA-A(7), KLRC3(2), KLRC4(1), PIK3R1(2), PTPN6(4), SYK(2), VAV1(6) 4254260 24 11 23 9 7 3 4 6 3 1 0.675 1.000 1.000 282 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(7), NT5E(1), NT5M(1) 4055340 20 7 20 6 7 3 5 3 2 0 0.374 1.000 1.000 283 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(1), EGF(4), EGFR(2), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), SRF(1), STAT1(3), STAT3(2), STAT5A(2) 9090550 38 19 38 9 7 7 5 7 12 0 0.326 1.000 1.000 284 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 23 ADCY1(5), AKT1(3), CAMK2D(1), CREB1(2), HRAS(1), PIK3R1(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RPS6KA1(2), RPS6KA5(4) 6195070 29 15 26 9 10 4 2 3 10 0 0.587 1.000 1.000 285 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(3), ANXA6(3), CYP11A1(2), EDNRB(2), HSD11B1(1), PRL(4), PTGDR(2), PTGDS(2), PTGFR(2), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1) 5716991 27 12 27 9 12 2 6 6 1 0 0.458 1.000 1.000 286 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(2), RELA(3), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(2), TRAF2(1), TRAF5(1), TRAF6(1) 4098821 13 4 13 4 2 1 5 1 4 0 0.718 1.000 1.000 287 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(1), C1R(1), C1S(6), C2(6), C3(11), C5(2), C6(6), C7(4), C8A(5), C9(3), MASP1(2) 5970004 48 22 46 11 11 7 9 8 13 0 0.119 1.000 1.000 288 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), ASPA(1), CNDP1(2), DDC(1), HAL(1), HDC(1), PRPS1(1), PRPS2(1) 6815696 26 18 26 5 12 5 4 2 3 0 0.0577 1.000 1.000 289 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(3), BIRC2(2), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1), LMNB1(1), LMNB2(1) 5086465 24 10 23 4 5 5 5 2 7 0 0.235 1.000 1.000 290 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 B3GNT2(2), B3GNT3(2), B3GNT4(1), B3GNT5(1), FUT1(1), FUT2(3), FUT3(1), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GCNT2(1), ST8SIA1(2) 4386976 19 9 19 3 10 4 3 0 2 0 0.0561 1.000 1.000 291 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(1), ETV5(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), JAK2(2), MAP2K6(3), MAPK8(2), STAT4(1), TYK2(2) 5232124 18 9 18 6 4 1 4 1 8 0 0.672 1.000 1.000 292 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(6), CTNNB1(9), PTK2(3), PXN(1), SRC(2), VCL(3) 5463774 36 12 36 4 16 10 1 8 1 0 0.00144 1.000 1.000 293 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(1), ELK1(2), EPO(2), EPOR(2), HRAS(1), JAK2(2), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(2), STAT5A(2) 5304323 21 7 21 6 7 2 4 2 6 0 0.413 1.000 1.000 294 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(2), ATG7(3), BECN1(3), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(1), ULK1(3), ULK3(1) 5960733 25 11 24 6 6 6 1 7 5 0 0.305 1.000 1.000 295 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 20 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB5(2), PSMB6(1), PSMD1(4), PSMD11(2), PSMD12(2), PSMD2(1) 4134660 17 8 17 7 4 2 4 3 4 0 0.804 1.000 1.000 296 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(3), AKT2(2), AKT3(4), BPNT1(2), ILK(1), PDK1(1), PIK3CD(2), PTEN(2), RBL2(2), SHC1(2) 4337790 21 11 19 9 7 2 3 4 5 0 0.795 1.000 1.000 297 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(3), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(2), PIK3R1(2), RB1(3), RELA(3), TFDP1(1) 4743369 20 9 19 9 4 3 6 3 4 0 0.912 1.000 1.000 298 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(4), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), MDH2(1), OGDH(5), OGDHL(2), PC(3), PCK1(3), PCK2(5), SDHA(6), SUCLA2(1), SUCLG1(3) 8286680 49 22 45 13 12 7 12 8 9 1 0.307 1.000 1.000 299 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 15 CARS2(2), GOT1(3), LDHAL6B(2), LDHB(1), SULT1C4(1), SULT4A1(1) 3234666 10 4 10 5 1 2 3 2 2 0 0.862 1.000 1.000 300 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(2), KARS(2) 1921201 6 2 6 3 1 0 3 1 1 0 0.905 1.000 1.000 301 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(3), APAF1(3), ATM(11), BAD(1), CASP7(2), CASP9(1), PTK2(3), PXN(1), STAT1(3), TLN1(11) 7301258 39 15 38 8 11 9 6 7 6 0 0.127 1.000 1.000 302 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(2), HDAC5(2), MEF2A(2), MEF2C(2), MEF2D(2), PPARA(1), PPP3CA(3), PPP3CC(2), SYT1(1), YWHAH(1) 5710031 24 11 24 6 5 5 5 3 6 0 0.261 1.000 1.000 303 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(2), HRAS(1), IL3RA(3), JAK2(2), PTPN6(4), SHC1(2), STAT5A(2) 4186652 16 8 16 7 7 1 3 2 3 0 0.769 1.000 1.000 304 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CHUK(1), EGR3(2), GNAQ(1), MAP3K1(3), MYC(2), NFATC1(4), NFATC2(10), NFKBIA(2), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RELA(3), SYT1(1), VIPR2(1) 7565767 45 21 41 12 14 7 5 6 13 0 0.270 1.000 1.000 305 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 20 ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), SHMT1(2) 3639005 14 6 14 6 3 4 4 1 2 0 0.666 1.000 1.000 306 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(11), CCND2(3), CDK4(2), ESR2(3), FSHR(4), GJA4(2), LHCGR(2), MLH1(1), NCOR1(9), NRIP1(1), PGR(4), PRLR(2), SMPD1(1), ZP2(1) 9495867 46 21 46 9 13 6 12 8 7 0 0.0731 1.000 1.000 307 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(3), ANAPC2(4), ANAPC4(3), ANAPC5(6), ANAPC7(1), BTRC(2), CDC16(1), CDC20(1), CDC23(2), CUL1(4), CUL2(2), CUL3(1), FBXW11(2), FBXW7(6), ITCH(3), SKP1(1), SKP2(3), SMURF2(1), TCEB1(2), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(2), WWP1(2), WWP2(6) 10837481 61 30 59 15 18 11 12 8 12 0 0.225 1.000 1.000 308 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 26 ACTA1(4), AKT1(3), BDKRB2(1), CHRM1(1), CHRNA1(4), FLT1(4), FLT4(11), KDR(1), NOS3(9), PDE2A(1), PDE3B(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKG1(1), PRKG2(2), SLC7A1(1), SYT1(1), TNNI1(1) 8354474 55 25 54 10 25 7 10 3 10 0 0.00380 1.000 1.000 309 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(2), JAK3(3), STAT3(2), TYK2(2) 3330983 10 4 10 9 3 2 3 0 2 0 0.981 1.000 1.000 310 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(3), CA5A(3), CA5B(2), CA6(1), CA8(1), CA9(1), CPS1(5), GLS(1), HAL(1) 5286534 18 8 17 4 3 6 2 2 4 1 0.396 1.000 1.000 311 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKM(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RBKS(1), RPE(2), RPIA(1), TALDO1(1), TKT(1) 5708618 30 13 30 9 12 4 8 3 3 0 0.223 1.000 1.000 312 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAK1(1), BIK(1), BIRC2(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1) 3664484 13 4 13 4 2 3 3 2 3 0 0.591 1.000 1.000 313 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 19 CHUK(1), CREBBP(3), EP300(6), IKBKB(4), IL1B(1), MAP2K3(1), MAP2K6(3), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(3), TLR2(2) 7408097 29 13 29 8 7 5 8 2 7 0 0.314 1.000 1.000 314 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 11 ACAA1(1), ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL6(1), FADS1(1), FASN(7), HADHA(1), HSD17B12(1) 3714310 16 6 16 5 5 4 4 0 2 1 0.246 1.000 1.000 315 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 19 ATM(11), ATR(10), BRCA1(6), CDC25B(2), CDC34(1), CHEK2(1), EP300(6), MDM2(2), MYT1(12), PRKDC(9), RPS6KA1(2), YWHAH(1) 11055038 63 33 60 12 13 9 11 13 17 0 0.140 1.000 1.000 316 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(3), BIRC2(2), CASP10(2), CASP7(2), CASP8(2), CASP9(1), DFFB(1), SCAP(3), SREBF2(5) 4934676 21 10 19 6 5 5 2 2 7 0 0.438 1.000 1.000 317 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(6), CPS1(5), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(2), GLS(1), GOT1(3), GPT(2), GPT2(3), GSS(1), NADSYN1(4), PPAT(2), QARS(2) 9262877 51 20 51 12 10 11 15 6 7 2 0.154 1.000 1.000 318 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(3), LDHB(1) 1906164 4 2 4 2 1 0 2 1 0 0 0.898 1.000 1.000 319 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 5 IFNGR1(2), JAK1(1), JAK2(2), STAT1(3) 2089635 8 5 8 4 2 0 3 2 1 0 0.870 1.000 1.000 320 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 ATM(11), ATR(10), BRCA1(6), BRCA2(14), CHEK2(1), FANCA(5), FANCC(2), FANCD2(8), FANCG(1), HUS1(1), MRE11A(4), RAD50(1), TREX1(2) 11574751 66 34 57 12 8 11 11 9 27 0 0.307 1.000 1.000 321 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(2), AKT3(4), ARHGEF11(6), CDC42(1), DLG4(3), LPA(8), MAP2K4(5), MAP3K1(3), MAP3K5(2), MAPK8(2), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(7), PIK3CB(3), PLD2(5), PLD3(2), PTK2(3), RDX(4), ROCK1(6), ROCK2(2), SRF(1), TBXA2R(1) 13790702 79 40 74 19 17 13 15 14 20 0 0.163 1.000 1.000 322 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(1), ARG2(1), ASL(3), ASS1(4), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), EPRS(1), GLUD2(3), GOT1(3), LAP3(2), NOS1(10), NOS3(9), OAT(2), P4HA1(5), P4HA2(2), P4HA3(2), PARS2(2), PRODH(2), PYCR1(1), RARS(1), RARS2(4) 10102622 76 34 74 13 28 12 19 8 8 1 0.00643 1.000 1.000 323 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1), SYT1(1) 3848791 8 3 8 7 0 2 1 2 3 0 0.942 1.000 1.000 324 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 15 ACE2(4), AGT(1), AGTR2(1), ANPEP(3), CMA1(1), CPA3(1), CTSG(2), ENPEP(3), LNPEP(2), MME(2), NLN(1), THOP1(1) 4960489 22 8 22 6 3 7 7 4 1 0 0.266 1.000 1.000 325 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), ESCO1(3), SH3GLB1(1) 6600642 27 7 27 7 8 8 2 5 4 0 0.219 1.000 1.000 326 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(1), HRAS(1), JAK2(2), PIK3R1(2), PLCG1(1), RASA1(4), SHC1(2), STAT1(3), STAT3(2), STAT5A(2), THPO(1) 6983448 21 11 21 6 5 4 2 2 8 0 0.628 1.000 1.000 327 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(4), ACAT1(2), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), HAGH(2), LDHB(1), MDH2(1), ME1(2), ME2(4), ME3(2), PC(3), PCK1(3), PDHA1(4), PDHA2(2), PKLR(2) 10102048 49 21 47 9 13 22 5 3 6 0 0.00856 1.000 1.000 328 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(2), ALDH4A1(3), ALDH5A1(1), CAD(6), CPS1(5), EARS2(1), EPRS(1), GAD1(6), GAD2(5), GCLC(1), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLUD2(3), GOT1(3), GPT(2), GPT2(3), GSR(1), GSS(1), NADSYN1(4), NAGK(1), PPAT(2), QARS(2) 11030353 59 23 59 14 11 13 19 7 7 2 0.122 1.000 1.000 329 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TNFAIP3(2), TRAF6(1) 5092817 19 7 19 7 2 5 7 2 3 0 0.727 1.000 1.000 330 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(5), AKT1(3), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(4), ITGB3(1), PDGFRA(3), PIK3R1(2), PLCB1(1), PTK2(3), SMPD1(1), SPHK1(1), SRC(2) 7026905 30 10 29 6 8 10 2 4 6 0 0.0907 1.000 1.000 331 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), GCK(1), GMDS(1), GMPPA(5), HK1(3), HK2(3), HK3(4), PFKFB1(2), PFKFB3(1), PFKFB4(3), PFKM(3), PFKP(1), PMM2(2), TPI1(3) 6703874 37 17 37 11 18 6 9 2 2 0 0.148 1.000 1.000 332 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(2), AGT(1), AGTR2(1), EDNRB(2), EGF(4), EGFR(2), HRAS(1), MYC(2), PLCG1(1), RELA(3) 5598666 19 8 19 6 3 4 5 1 6 0 0.639 1.000 1.000 333 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 17 AOC2(3), AOC3(3), CES1(2), DDHD1(3), ESCO1(3), LIPA(1), PLA1A(2), SH3GLB1(1) 6717608 18 9 18 3 6 3 5 3 1 0 0.146 1.000 1.000 334 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(4), EXTL1(3), EXTL2(2), EXTL3(6), GLCE(2), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), NDST1(3), NDST3(3), NDST4(3) 5896020 36 12 36 9 13 7 10 3 3 0 0.122 1.000 1.000 335 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CYP2C9(2), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), EHHADH(1), ESCO1(3), HADHA(1), SH3GLB1(1) 8269781 21 12 21 6 9 3 3 3 3 0 0.336 1.000 1.000 336 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(2), ACADS(1), ACAT1(2), ACSM1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH5A1(1), BDH1(2), BDH2(1), DDHD1(3), EHHADH(1), GAD1(6), GAD2(5), HADH(1), HADHA(1), HMGCS2(1), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(2), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(2), PLA1A(2), RDH11(2) 11371578 58 26 56 11 15 15 13 9 5 1 0.0120 1.000 1.000 337 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 10 APC(8), CDH1(1), CREBBP(3), EP300(6), SKIL(1), TGFB1(1), TGFB2(2) 6190356 22 13 21 8 6 2 6 3 5 0 0.760 1.000 1.000 338 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKL(2), PFKM(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RBKS(1), RPE(2), RPIA(1), TALDO1(1), TKT(1), TKTL1(1) 6814642 33 14 33 8 13 5 8 3 4 0 0.106 1.000 1.000 339 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(7), NT5C1B(3), NT5E(1), NT5M(1), NUDT12(1) 5695242 24 8 24 8 8 3 7 3 3 0 0.478 1.000 1.000 340 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), MANBA(2), NEU4(2) 4699040 20 11 20 7 7 3 4 0 6 0 0.526 1.000 1.000 341 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(4), APC(8), AXIN1(4), BTRC(2), CTNNB1(9), DVL1(4), FZD1(5), GSK3B(2), NOTCH1(10), PSEN1(1), WNT1(1) 6166393 50 17 50 10 17 15 6 9 3 0 0.0109 1.000 1.000 342 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 19 ARHGAP5(6), DIAPH1(7), HRAS(1), ITGA1(7), MYLK(11), PIK3R1(2), PTK2(3), PXN(1), ROCK1(6), SHC1(2), SRC(2), TLN1(11) 9071892 59 23 59 12 18 17 8 7 8 1 0.0307 1.000 1.000 343 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(8), AXIN1(4), CREBBP(3), CTNNB1(9), DVL1(4), EP300(6), FZD1(5), GSK3B(2), LDB1(2), LEF1(3), TRRAP(11), WNT1(1) 9286604 58 21 57 12 20 10 9 13 6 0 0.0276 1.000 1.000 344 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 9 B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 2016705 7 2 7 2 3 0 3 1 0 0 0.560 1.000 1.000 345 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(1), ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1D1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), BAAT(1), CYP27A1(3), CYP7A1(2), HADHB(2) 6165623 31 12 31 10 12 7 5 3 4 0 0.324 1.000 1.000 346 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(3), CPO(2), HBB(1), HMBS(1) 2254333 7 5 7 4 4 1 1 0 1 0 0.788 1.000 1.000 347 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3) 4694728 22 6 22 3 7 6 5 1 3 0 0.0509 1.000 1.000 348 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(2), ACOT11(1), DHRS1(1), DHRS2(2), DHRS3(2), DHRS7(1), EHHADH(1), ESCO1(3), GCDH(2), HADHA(1), SH3GLB1(1) 6883212 17 7 17 3 4 4 3 3 3 0 0.174 1.000 1.000 349 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(2), RELA(3), TANK(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 6882445 38 14 38 10 10 6 9 5 8 0 0.265 1.000 1.000 350 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), CASP8(2), MAP2K4(5), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(3), SMPD1(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 5793492 22 9 22 8 6 1 5 4 6 0 0.768 1.000 1.000 351 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(5), DDX20(1), E2F4(3), ETS1(3), ETS2(2), HDAC5(2), HRAS(1), NCOR2(5), RBL1(1), RBL2(2), SIN3A(6) 7447741 33 15 30 10 6 7 7 5 8 0 0.424 1.000 1.000 352 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(2), CASP10(2), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), DFFB(1), GAS2(4), NFKBIA(2), RELA(3), SPTAN1(3), TNFRSF10A(2), TNFRSF10B(2), TNFSF12(2), TRADD(1), TRAF2(1) 9463044 37 15 37 8 12 7 6 3 9 0 0.133 1.000 1.000 353 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(7), ATM(11), ATR(10), CCNA1(3), CCNE1(1), CDK4(2), CDK6(2), DHFR(1), GSK3B(2), RB1(3), SKP2(3), TFDP1(1), TGFB1(1), TGFB2(2) 7769480 49 22 47 14 7 9 12 7 14 0 0.555 1.000 1.000 354 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(5), CREB1(2), ELK1(2), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1) 9223638 51 22 47 11 17 12 2 7 13 0 0.0444 1.000 1.000 355 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), MAN2B1(2), MAN2B2(2), MANBA(2), NEU4(2) 5782790 24 13 24 9 9 3 5 0 7 0 0.511 1.000 1.000 356 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2M1(1), ARF1(2), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(2), GSK3B(2), LYN(1), PFKL(2), PFKM(3), PFKP(1), PLCG1(1), PRKCE(1) 7157597 25 10 23 7 7 8 3 2 5 0 0.246 1.000 1.000 357 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(9), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAR2B(1), PRKCE(1) 5042466 21 8 21 9 6 4 4 5 2 0 0.820 1.000 1.000 358 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 22 GHR(1), HRAS(1), INSR(4), JAK2(2), PIK3R1(2), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(2), SRF(1), STAT5A(2) 7192159 22 10 21 7 8 2 4 2 6 0 0.652 1.000 1.000 359 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(4), F2RL1(2), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(2), PLD2(5), PLD3(2), PTK2(3), RASAL1(6), SRC(2), TEC(2), VAV1(6) 7752533 47 15 44 12 15 12 7 4 8 1 0.0855 1.000 1.000 360 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(2), ACACA(4), ACADL(2), ACADM(2), ACADSB(3), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3) 9192870 34 14 34 6 9 8 5 6 6 0 0.0831 1.000 1.000 361 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(4), ERBB4(6), PSEN1(1) 2533711 11 3 11 5 1 5 1 3 1 0 0.778 1.000 1.000 362 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(5), ARHGEF1(3), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(2), PIK3R1(2), PLCB1(1), PPP1R12B(1), ROCK1(6) 6318013 23 11 23 9 4 8 3 3 5 0 0.615 1.000 1.000 363 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 37 APAF1(3), BAK1(1), BIRC2(2), CASP2(3), CASP7(2), CASP8(2), CASP9(1), FASLG(1), MAP2K4(5), MAP3K1(3), MAPK10(1), MDM2(2), MYC(2), NFKBIA(2), PARP1(8), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 9686217 46 22 43 14 9 4 13 6 13 1 0.719 1.000 1.000 364 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(2), AKT1(3), AKT2(2), AKT3(4), BAD(1), BTK(1), DAPP1(2), GSK3A(2), GSK3B(2), IARS(4), INPP5D(1), PDK1(1), PPP1R13B(1), PTEN(2), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS2(1), TEC(2), YWHAE(3), YWHAH(1) 8601872 41 20 37 12 13 8 2 7 11 0 0.334 1.000 1.000 365 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 26 CCL3(1), CCR1(2), CCR2(1), CCR4(4), CCR7(1), CD4(2), CXCR4(3), IFNGR1(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL4R(3), TGFB1(1), TGFB2(2) 5220583 27 15 26 10 5 4 4 4 10 0 0.805 1.000 1.000 366 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 9 CREBBP(3), DFFB(1), HMGB2(1), NME1(1), SET(1) 2490051 7 4 7 4 2 1 2 1 1 0 0.805 1.000 1.000 367 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), ASPA(1), CARM1(2), CNDP1(2), DDC(1), FTCD(2), HAL(1), HDC(1), HEMK1(1), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRPS1(1), PRPS2(1), UROC1(5) 10875696 46 21 45 9 14 10 12 4 6 0 0.0277 1.000 1.000 368 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 18 ALG5(1), B4GALT5(2), DDOST(1), MAN1A1(2), MAN1B1(2), MGAT1(1), MGAT3(3), MGAT4B(1), MGAT5(2), ST6GAL1(1) 4923225 16 8 15 9 8 1 1 4 2 0 0.880 1.000 1.000 369 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(4), ACACB(8), ACAT1(2), ACOT12(3), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), HAGH(2), LDHAL6B(2), LDHB(1), MDH2(1), ME1(2), ME2(4), ME3(2), PC(3), PCK1(3), PCK2(5), PDHA1(4), PDHA2(2), PKLR(2) 12818187 66 29 62 15 21 22 6 4 12 1 0.0219 1.000 1.000 370 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(3), GPI(3), HK1(3), HK2(3), HK3(4), LDHAL6B(2), LDHB(1), MDH2(1), PC(3), PCK1(3), PDHA1(4), PDHA2(2), PFKL(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PKLR(2), TPI1(3) 11801608 61 25 59 13 25 17 10 4 5 0 0.00700 1.000 1.000 371 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(3), AKT2(2), AKT3(4), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(7), PIK3CB(3), PLD2(5), PLD3(2) 12686371 75 42 65 18 24 11 10 7 23 0 0.168 1.000 1.000 372 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MIOX(1), OCRL(1), PIK3C2A(5), PIK3C2B(12), PIK3CB(3), PIK3CG(5), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7) 12008972 60 24 58 14 22 8 6 10 14 0 0.100 1.000 1.000 373 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(3), CABIN1(6), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1R(6), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(2), MEF2C(2), MEF2D(2), NFATC1(4), NFATC2(10), PIK3R1(2), PPP3CA(3), PPP3CC(2), SYT1(1), YWHAH(1) 9175343 60 26 55 14 18 11 8 6 17 0 0.0543 1.000 1.000 374 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 35 ANKHD1(4), EEF1A2(1), EEF1D(1), EEF1G(3), EEF2(6), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B2(3), EIF2B3(2), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(8), EIF4G3(7), EIF5(2), ETF1(1), GSPT2(1), PABPC3(5), SLC35A4(2) 11360660 57 23 55 12 12 14 14 7 10 0 0.125 1.000 1.000 375 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG2(3), AKT1(3), ANGPTL2(2), CDC42(1), FLNA(10), FLNC(12), FSCN1(1), FSCN3(3), GDI1(1), GDI2(3), LIMK1(1), MYH2(4), MYLK(11), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PAK7(1), ROCK1(6), ROCK2(2), WASF1(1), WASL(6) 13230122 81 39 78 24 20 15 15 12 19 0 0.297 1.000 1.000 376 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 49 AKR1D1(1), ARSE(1), CARM1(2), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD3B1(2), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), STS(4), SULT2A1(1), SULT2B1(1), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 12686761 58 27 53 14 9 17 15 10 7 0 0.122 1.000 1.000 377 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 45 ADCY4(2), ADCY6(3), ADCY8(4), CACNA1A(9), CACNA1B(12), GNB1(2), GNB3(2), GNG13(1), GRM4(4), ITPR3(10), PLCB2(5), PRKACB(1), PRKACG(3), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R2(3), TAS1R3(2), TAS2R1(4), TAS2R10(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R4(4), TAS2R41(1), TAS2R42(1), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(1) 14827491 92 38 90 23 36 14 15 13 14 0 0.00698 1.000 1.000 378 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1) 5840646 22 13 22 8 11 4 2 2 3 0 0.518 1.000 1.000 379 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), DDC(1), EPX(4), ESCO1(3), GOT1(3), HPD(3), LPO(6), MPO(2), SH3GLB1(1), TAT(1), TPO(7) 9215147 44 17 44 7 20 6 9 5 4 0 0.00972 1.000 1.000 380 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(3), EP300(6), IKBKB(4), NFKBIA(2), RELA(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1) 6318203 24 12 24 9 6 4 8 2 4 0 0.665 1.000 1.000 381 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 5 ACACA(4), ACACB(8), FASN(7), MCAT(1), OXSM(1) 4414873 21 5 21 5 8 6 4 1 1 1 0.0890 1.000 1.000 382 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(8), ASAH1(1), CAMP(2), CERK(1), CREB1(2), CREB5(1), DAG1(2), EPHB2(4), GNAQ(1), ITPKB(3), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1) 8142870 45 19 45 12 14 5 7 9 10 0 0.197 1.000 1.000 383 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ACPT(2), ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2D6(1), CYP2E1(3), CYP2F1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), CYP4B1(1), CYP51A1(1), PON1(1) 8186065 58 25 55 18 21 7 11 9 10 0 0.298 1.000 1.000 384 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 29 ARHGAP4(2), ARHGAP5(6), ARHGAP6(3), ARHGEF1(3), ARHGEF11(6), ARHGEF5(4), ARPC1A(2), ARPC2(1), BAIAP2(4), DIAPH1(7), LIMK1(1), MYLK(11), PIP5K1B(2), PPP1R12B(1), ROCK1(6), SRC(2), TLN1(11), VCL(3) 12484829 75 32 73 18 21 19 11 10 13 1 0.0386 1.000 1.000 385 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(7), ACTB(2), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(3), CDC42(1), CDH1(1), CTNNB1(9), CTTN(2), HCLS1(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(6), ROCK2(2), TLR4(1), TLR5(3), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4), WASL(6) 14331615 91 42 86 18 29 17 11 13 21 0 0.0146 1.000 1.000 386 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(7), ACTB(2), ARHGEF2(1), ARPC5(1), ARPC5L(1), CD14(3), CDC42(1), CDH1(1), CTNNB1(9), CTTN(2), HCLS1(1), LY96(1), NCK1(3), NCK2(2), NCL(2), RHOA(1), ROCK1(6), ROCK2(2), TLR4(1), TLR5(3), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4), WASL(6) 14331615 91 42 86 18 29 17 11 13 21 0 0.0146 1.000 1.000 387 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(1), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(3), WDR1(2) 2764672 13 3 13 5 4 2 1 5 1 0 0.566 1.000 1.000 388 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 64 AGTR2(1), ATP8A1(3), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKBR(3), CCR1(2), CCR10(2), CCR2(1), CCR4(4), CCR7(1), CX3CR1(1), CXCR4(3), EDNRB(2), FPR1(2), FSHR(4), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(2), MC2R(2), MC3R(4), MC5R(3), NMBR(1), NPY1R(3), NPY2R(3), NPY5R(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(2), SSTR1(4), SSTR3(2), SSTR4(3), TACR1(3), TACR2(1), TACR3(4), TRHR(2), TSHR(3) 14205821 92 37 90 29 34 13 22 12 10 1 0.0707 1.000 1.000 389 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH4A1(3), AMD1(1), AOC2(3), AOC3(3), ARG1(1), ARG2(1), ASL(3), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(5), DAO(2), GOT1(3), NOS1(10), NOS3(9), OAT(2), ODC1(1), P4HA1(5), P4HA2(2), P4HA3(2), PYCR1(1), RARS(1) 12412093 74 30 73 9 32 13 17 6 5 1 0.000103 1.000 1.000 390 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), GALNT1(3), GALNT10(6), GALNT13(2), GALNT14(1), GALNT2(2), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT4(1), OGT(2), ST3GAL1(2), ST3GAL2(1), WBSCR17(2) 8985944 36 18 35 10 12 6 9 4 5 0 0.299 1.000 1.000 391 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(3), BCR(2), CRKL(2), HRAS(1), JAK2(2), MAP2K4(5), MAP3K1(3), MAPK8(2), MYC(2), PIK3R1(2), STAT1(3), STAT5A(2) 6482323 29 16 28 10 8 1 5 6 9 0 0.816 1.000 1.000 392 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(8), GAL3ST1(1), GALC(2), GBA(4), GLB1(2), LCT(6), NEU4(2), PPAP2B(2), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD1(1), SMPD3(1), SMPD4(3), SPHK1(1), SPHK2(1), SPTLC1(3), SPTLC2(1), UGCG(1), UGT8(1) 10145079 50 25 47 14 20 11 5 7 7 0 0.0496 1.000 1.000 393 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADL(2), ACADM(2), ACADS(1), ACADSB(3), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), BCAT1(2), BCKDHA(4), BCKDHB(2), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2) 10018499 46 19 44 6 13 12 7 4 10 0 0.00463 1.000 1.000 394 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 29 APC(8), AXIN1(4), BMP2(3), BMP4(2), BMP5(3), BMP7(2), BMPR1A(4), BMPR2(3), CHRD(2), CTNNB1(9), DVL1(4), FZD1(5), GATA4(1), GSK3B(2), MEF2C(2), NKX2-5(1), RFC1(4), TGFB1(1), TGFB2(2), WNT1(1) 9333488 63 25 62 10 23 13 8 12 7 0 0.00534 1.000 1.000 395 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 39 CD3E(1), ELK1(2), HRAS(1), LCK(1), MAP2K4(5), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKBIA(2), PIK3R1(2), PLCG1(1), PPP3CA(3), PPP3CC(2), RASA1(4), RELA(3), SHC1(2), SYT1(1), VAV1(6), ZAP70(6) 11709711 68 28 64 14 18 13 7 10 19 1 0.0474 1.000 1.000 396 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(3), CAPNS2(2), ITGA1(7), ITGB3(1), PTK2(3), PXN(1), SPTAN1(3), SRC(2), TLN1(11) 8031855 43 11 43 6 15 13 5 4 6 0 0.00228 1.000 1.000 397 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 71 CANX(2), CD4(2), CD8B(2), CREB1(2), CTSB(2), CTSS(2), HLA-A(7), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(3), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL3(2), KIR3DL1(3), KLRC3(2), KLRC4(1), LGMN(1), NFYC(1), PDIA3(2), RFX5(1), TAP1(4), TAP2(1), TAPBP(1) 12187438 56 30 55 16 8 15 8 12 13 0 0.277 1.000 1.000 398 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(3), AKT2(2), AKT3(4), APC(8), AXIN1(4), AXIN2(1), CSNK1A1(1), CTNNB1(9), DACT1(4), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(2), GSK3B(2), LRP1(21), MVP(3), NKD1(4), NKD2(1), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(2), WIF1(2) 11489728 83 37 80 17 31 15 12 12 13 0 0.0133 1.000 1.000 399 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 EIF2B1(1), EIF2B2(3), EIF2B3(2), EIF2B5(1), ELAVL1(1), FLT1(4), FLT4(11), HIF1A(1), HRAS(1), KDR(1), NOS3(9), PIK3R1(2), PLCG1(1), PTK2(3), PXN(1), SHC1(2) 8940529 44 20 44 12 14 11 10 1 8 0 0.207 1.000 1.000 400 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), AOX1(2), DBH(1), DCT(3), DDC(1), FAH(1), GOT1(3), HGD(2), HPD(3), TAT(1), TH(1), TPO(7), TYR(4) 8864271 55 20 55 19 23 8 10 6 7 1 0.257 1.000 1.000 401 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DGAT1(3), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), GLB1(2), LCT(6), LIPF(2), LIPG(4), LPL(4), PNLIP(2), PPAP2B(2), PPAP2C(1) 13296369 76 27 76 24 33 11 8 8 16 0 0.118 1.000 1.000 402 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(1), ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1D1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), BAAT(1), CYP27A1(3), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(3), SOAT1(1) 8576630 43 13 43 12 16 9 9 5 4 0 0.153 1.000 1.000 403 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHB(1), PDHA1(4), PDHA2(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 13586408 73 26 71 18 35 18 8 5 7 0 0.0113 1.000 1.000 404 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHB(1), PDHA1(4), PDHA2(2), PFKM(3), PFKP(1), PGAM1(1), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 13586408 73 26 71 18 35 18 8 5 7 0 0.0113 1.000 1.000 405 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(3), CHUK(1), ELK1(2), IKBKB(4), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAPK8(2), NFKBIA(2), PPARA(1), RELA(3), TLR10(1), TLR2(2), TLR3(3), TLR4(1), TLR6(4), TLR9(5), TRAF6(1) 9901117 48 22 47 14 12 6 8 9 13 0 0.386 1.000 1.000 406 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 31 AGT(1), EGFR(2), ELK1(2), GNAQ(1), HRAS(1), MAP2K4(5), MAP3K1(3), MAPK8(2), MEF2A(2), MEF2C(2), MEF2D(2), PTK2(3), SHC1(2), SRC(2), SYT1(1) 8330096 31 12 31 10 5 6 6 5 9 0 0.458 1.000 1.000 407 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(1), CAPN2(1), CAPNS1(3), CAPNS2(2), EGF(4), EGFR(2), HRAS(1), ITGA1(7), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTK2(3), PXN(1), TLN1(11) 9220196 60 19 60 12 24 16 8 7 5 0 0.00524 1.000 1.000 408 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNGR1(2), JAK1(1), JAK2(2), PTPRU(6), REG1A(2), STAT1(3) 3185640 17 9 16 9 8 0 5 2 2 0 0.889 1.000 1.000 409 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 26 CASP2(3), CASP8(2), CRADD(2), DFFB(1), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(5), MAP3K1(3), MAPK8(2), PAK2(3), PRKDC(9), RB1(3), SPTAN1(3), TNFRSF1A(2), TRADD(1), TRAF2(1) 10399527 45 14 45 10 12 3 11 8 11 0 0.227 1.000 1.000 410 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(3), AKT2(2), AKT3(4), BCR(2), BTK(1), CD19(1), DAPP1(2), FLOT2(1), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), PDK1(1), PHF11(1), PLCG2(7), PPP1R13B(1), PREX1(9), PTEN(2), PTPRC(3), RPS6KA1(2), RPS6KA2(2), SAG(1), SYK(2), TEC(2), VAV1(6) 14801447 88 40 80 23 31 8 9 15 24 1 0.189 1.000 1.000 411 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2RL3(1), GNAI1(1), GNB1(2), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(2), PTK2(3), SRC(2), SYK(2), TBXAS1(1) 6806211 23 4 23 9 7 8 2 4 2 0 0.640 1.000 1.000 412 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ABAT(2), ACAA1(1), ACADM(2), ACADS(1), ACAT1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), AUH(1), BCAT1(2), BCAT2(2), BCKDHA(4), BCKDHB(2), DBT(3), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HMGCS2(1), HSD17B4(3), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2), OXCT2(1) 11794249 53 21 51 10 17 10 10 5 11 0 0.0258 1.000 1.000 413 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 39 ALAS2(3), BLVRA(2), COX15(1), CP(5), CPOX(3), EARS2(1), EPRS(1), FTMT(3), GUSB(1), HMBS(1), PPOX(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 11285707 48 23 44 11 8 12 6 10 12 0 0.225 1.000 1.000 414 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(4), AGPAT1(1), AGPAT3(3), AGPAT4(3), CDIPT(3), CHAT(4), CPT1B(5), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), GNPAT(1), GPD1(1), GPD2(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(2), PCYT1B(1), PLA2G3(2), PLA2G6(4), PLCB2(5), PLCG1(1), PLCG2(7), PPAP2B(2), PPAP2C(1) 14194517 75 28 75 21 23 10 15 11 16 0 0.162 1.000 1.000 415 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 19 GNAQ(1), GNB1(2), HRAS(1), LIMK1(1), NOX1(4), PLCB1(1), PPP1R12B(1), PTK2(3), ROCK2(2) 6261415 16 6 16 9 5 5 1 2 3 0 0.882 1.000 1.000 416 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(4), AR(4), ESR1(1), ESR2(3), ESRRA(2), NPM1(1), NR0B1(3), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(3), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), PGR(4), PPARA(1), PPARD(2), PPARG(1), RARB(2), RARG(2), ROR1(4), RORA(1), RORC(1), RXRA(1), RXRB(1), RXRG(1), THRB(1) 11672631 63 25 60 19 17 15 10 6 15 0 0.149 1.000 1.000 417 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(1), ELK1(2), FCER1A(1), FCER1G(1), HRAS(1), LYN(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PAK2(3), PIK3R1(2), PLCG1(1), PPP3CA(3), PPP3CC(2), SHC1(2), SYK(2), SYT1(1), VAV1(6) 10655616 63 24 59 16 17 12 6 10 17 1 0.163 1.000 1.000 418 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), AKR1A1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DGAT1(3), DGAT2(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), GK2(5), GLB1(2), GPAM(4), LCT(6), LIPA(1), LIPF(2), LIPG(4), LPL(4), MGLL(2), PNLIP(2), PPAP2B(2), PPAP2C(1) 16220556 95 33 95 28 36 17 12 11 19 0 0.0592 1.000 1.000 419 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLB(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLG(5), POLH(1), POLI(1), POLK(3), POLL(2), POLM(2), POLQ(3), PRIM1(1), REV1(1), REV3L(6) 11450899 42 14 40 7 8 8 9 8 9 0 0.102 1.000 1.000 420 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(3), AKT2(2), AKT3(4), ASAH1(1), BRAF(4), DAG1(2), EGFR(2), EPHB2(4), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), PIK3CB(3), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), SHC1(2), SOS2(1), SRC(2), STAT3(2), TERF2IP(1) 15703704 81 41 74 20 23 8 11 11 28 0 0.280 1.000 1.000 421 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 18 CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), PDE6B(3), PDE6C(1), PDE6G(1), SLC6A13(1) 9225920 44 20 39 13 14 5 9 3 13 0 0.511 1.000 1.000 422 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(3), APC(8), AR(4), ASAH1(1), BRAF(4), CAMP(2), CCL16(1), DAG1(2), EGFR(2), GNA11(3), GNA15(4), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), MAPK10(1), PHKA2(7), PIK3CD(2), PIK3R1(2), SRC(2) 14474328 86 43 77 20 24 11 14 10 27 0 0.128 1.000 1.000 423 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CAMK1(2), CAMK1G(1), ELK1(2), FPR1(2), GNA15(4), GNB1(2), HRAS(1), MAP2K3(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKBIA(2), PLCB1(1), PPP3CA(3), PPP3CC(2), RELA(3), SYT1(1) 10485627 55 23 51 17 15 12 10 6 12 0 0.369 1.000 1.000 424 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 CHUK(1), IKBKB(4), IL1B(1), IL1RAP(2), IL1RN(2), IL6(1), IRAK3(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), MAPK8(2), NFKBIA(2), RELA(3), TGFB1(1), TGFB2(2), TRAF6(1) 8000664 31 14 30 10 5 5 6 5 10 0 0.604 1.000 1.000 425 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(1), PTPRU(6), REG1A(2), STAT1(3), STAT2(2), TYK2(2) 3485751 18 9 17 9 10 0 5 2 1 0 0.818 1.000 1.000 426 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(4), AGT(1), AKT1(3), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(3), CSNK1A1(1), ELSPBP1(2), FKBP1A(1), GATA4(1), GSK3B(2), HAND2(1), HRAS(1), LIF(2), MAPK8(2), MEF2C(2), MYH2(4), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NKX2-5(1), PIK3R1(2), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), SYT1(1) 13489785 74 31 69 19 29 13 12 8 12 0 0.0588 1.000 1.000 427 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(2), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(2), GCK(1), GPI(3), HK1(3), HK2(3), HK3(4), LDHAL6B(2), LDHB(1), PDHA1(4), PDHA2(2), PFKL(2), PFKM(3), PFKP(1), PGAM1(1), PGAM4(2), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 16213255 86 31 84 23 39 22 10 5 10 0 0.0172 1.000 1.000 428 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(4), CRK(1), CRKL(2), DOCK1(5), ELK1(2), HGF(1), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PIK3R1(2), PTEN(2), PTK2(3), PXN(1), RAP1B(3), RASA1(4), SRC(2), STAT3(2) 10876070 51 20 51 16 13 16 4 6 12 0 0.279 1.000 1.000 429 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(1), BTK(1), ELK1(2), HRAS(1), LYN(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(3), PPP3CC(2), SHC1(2), SYK(2), SYT1(1), VAV1(6) 9933012 49 19 45 14 13 10 3 8 14 1 0.289 1.000 1.000 430 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 36 AKT1(3), CDC42(1), DUSP10(1), DUSP8(1), GCK(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K9(4), MAPK10(1), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(2), TRAF6(1), ZAK(5) 13609306 62 29 58 17 18 8 11 8 17 0 0.396 1.000 1.000 431 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 A4GALT(1), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GNT2(2), B3GNT3(2), B3GNT4(1), B3GNT5(1), B4GALNT1(1), FUT1(1), FUT2(3), FUT3(1), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GBGT1(1), GCNT2(1), PIGB(3), PIGG(2), PIGL(2), PIGM(1), PIGO(9), PIGP(2), PIGQ(6), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(2), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3), UGCG(1) 13358685 72 33 69 12 26 13 14 7 12 0 0.00151 1.000 1.000 432 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 32 ABAT(2), ACACA(4), ACACB(8), ACADM(2), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), LDHAL6B(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3) 10793970 40 15 40 10 14 8 6 5 7 0 0.192 1.000 1.000 433 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(3), APC(8), ASAH1(1), CAMP(2), DAG1(2), DLG4(3), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), RYR1(24) 12948450 82 39 76 24 32 7 14 9 20 0 0.245 1.000 1.000 434 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADL(2), ACADM(2), ACADS(1), ACADSB(3), ACAT1(2), ACOX1(1), ACOX3(2), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP4A22(2), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3) 13608163 69 21 69 14 25 17 9 7 11 0 0.00705 1.000 1.000 435 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 38 ACTG2(3), ADCY3(7), ADCY9(5), ARF1(2), ARF3(1), ARF4(1), ARL4D(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0C(1), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), ERO1L(1), PDIA4(2), PLCG1(1), PLCG2(7), SEC61A1(1), SEC61A2(2), SEC61B(1), SEC61G(1), TRIM23(1) 8882279 48 18 48 16 16 10 8 5 9 0 0.343 1.000 1.000 436 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 29 GTF2A1(1), GTF2E1(1), GTF2H1(1), GTF2H4(1), GTF2IRD1(2), STON1(2), TAF1(10), TAF1L(7), TAF2(2), TAF4(4), TAF4B(2), TAF5(1), TAF5L(4), TAF6(2), TAF6L(3), TAF7L(1), TAF9(2) 9218858 46 26 40 14 9 5 9 6 17 0 0.863 1.000 1.000 437 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 64 ACAA1(1), ACADL(2), ACADM(2), ACOX1(1), ACOX2(2), ACOX3(2), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ANGPTL4(1), APOA5(3), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP27A1(3), CYP4A22(2), CYP7A1(2), CYP8B1(2), EHHADH(1), FABP4(1), GK2(5), HMGCS2(1), ILK(1), LPL(4), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(5), PLTP(1), PPARA(1), PPARD(2), PPARG(1), RXRA(1), RXRB(1), RXRG(1), SCP2(1), SLC27A1(3), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(2), SORBS1(1), UBC(2), UCP1(1) 17596316 96 37 94 27 30 22 18 8 16 2 0.0759 1.000 1.000 438 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 38 ALG10(1), ALG10B(2), ALG11(3), ALG12(4), ALG13(2), ALG5(1), ALG9(1), DDOST(1), DHDDS(1), DOLPP1(1), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT3(3), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1) 11274179 40 16 39 12 13 10 5 7 5 0 0.289 1.000 1.000 439 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 67 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), AKR1C1(1), AKR1C3(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), CYP1A1(2), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2F1(3), CYP2S1(2), CYP3A5(1), CYP3A7(3), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 15351285 87 28 82 26 23 19 17 13 15 0 0.196 1.000 1.000 440 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 76 AIFM1(2), AKT1(3), AKT2(2), AKT3(4), APAF1(3), ATM(11), BAD(1), BIRC2(2), CAPN1(1), CAPN2(1), CASP10(2), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CSF2RB(2), DFFB(1), FASLG(1), IKBKB(4), IL1B(1), IL1RAP(2), IL3RA(3), IRAK3(2), IRAK4(1), NFKB2(1), NFKBIA(2), NTRK1(3), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), RELA(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 21986010 105 46 103 25 38 20 13 14 20 0 0.0272 1.000 1.000 441 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), FUK(1), GMDS(1), GMPPA(5), HK1(3), HK2(3), HK3(4), HSD3B7(3), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(3), PFKL(2), PFKM(3), PFKP(1), PGM2(1), PHPT1(1), PMM2(2), RDH11(2), TPI1(3), TSTA3(1) 10476671 51 21 51 17 22 8 14 5 2 0 0.256 1.000 1.000 442 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 33 ACTA1(4), ACTN1(1), ACTN2(4), BCAR1(2), BCR(2), CAPN1(1), CAPNS1(3), CAPNS2(2), CRKL(2), CSK(1), HRAS(1), ITGA1(7), MAPK8(2), PPP1R12B(1), PTK2(3), PXN(1), ROCK1(6), SHC1(2), SRC(2), TLN1(11), VCL(3), ZYX(1) 12288296 62 24 62 12 22 18 6 6 10 0 0.00690 1.000 1.000 443 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 BCR(2), BLNK(1), ELK1(2), HRAS(1), LYN(1), MAP3K1(3), MAPK8IP3(5), PAPPA(3), RPS6KA1(2), SHC1(2), SYK(2), VAV1(6) 8296399 30 15 29 11 10 3 4 4 8 1 0.614 1.000 1.000 444 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(1), CITED2(1), CPT1B(5), CREBBP(3), DUT(1), EHHADH(1), EP300(6), HSD17B4(3), HSPA1A(1), LPL(4), ME1(2), MYC(2), NCOR1(9), NCOR2(5), NFKBIA(2), NR1H3(3), NR2F1(2), NRIP1(1), PIK3R1(2), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PTGS2(1), RB1(3), RELA(3), RXRA(1), SP1(1), STAT5A(2) 17166185 75 30 75 22 25 16 13 8 13 0 0.149 1.000 1.000 445 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 62 APAF1(3), BAD(1), BAK1(1), BIRC2(2), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FASLG(1), HELLS(1), IKBKB(4), IRF1(2), IRF2(1), IRF3(1), IRF5(1), IRF6(4), IRF7(2), MAP2K4(5), MAP3K1(3), MAPK10(1), MDM2(2), MYC(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), RELA(3), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TP73(1), TRADD(1), TRAF2(1) 15409578 71 30 70 20 16 12 16 9 17 1 0.316 1.000 1.000 446 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 57 ATP12A(8), ATP6AP1(1), ATP6V0A1(3), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), ATP7A(4), ATP7B(1), COX4I1(1), COX6A1(1), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV2(3), SDHA(6), SHMT1(2), UQCRB(1), UQCRFS1(1), UQCRH(2) 9570060 51 24 48 17 12 11 8 12 7 1 0.538 1.000 1.000 447 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 61 ADAM10(1), ADAM17(4), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), IGSF5(1), IKBKB(4), JAM2(2), LYN(1), MAP2K4(5), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NOD1(3), PLCG1(1), PLCG2(7), PTPRZ1(4), RELA(3), SRC(2), TCIRG1(1), TJP1(6) 18130218 79 27 79 18 14 19 18 13 15 0 0.0566 1.000 1.000 448 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 34 AKT1(3), ATF1(1), CDC42(1), CREB1(2), CREB5(1), DUSP10(1), ELK1(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K10(4), MAP3K4(2), MAP3K5(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), MKNK2(3), MYEF2(2), NR2C2(1), SRF(1), TRAF6(1) 9157579 40 25 39 14 8 5 9 4 14 0 0.684 1.000 1.000 449 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(3), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(2), AOC2(3), AOC3(3), AOX1(2), CARM1(2), DBH(1), DCT(3), DDC(1), ESCO1(3), FAH(1), GOT1(3), HEMK1(1), HGD(2), HPD(3), LCMT1(1), LCMT2(2), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), SH3GLB1(1), TAT(1), TH(1), TPO(7), TYR(4), TYRP1(1) 16041052 77 23 77 22 26 15 18 9 8 1 0.103 1.000 1.000 450 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 CDC42(1), CREB1(2), DAXX(6), ELK1(2), HRAS(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K5(2), MAP3K9(4), MAPKAPK5(1), MAX(1), MEF2A(2), MEF2C(2), MEF2D(2), MYC(2), RPS6KA5(4), SHC1(2), STAT1(3), TGFB1(1), TGFB2(2), TRADD(1), TRAF2(1) 9723575 53 27 49 18 12 5 10 6 20 0 0.796 1.000 1.000 451 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 AANAT(1), ACAT1(2), AFMID(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), AOX1(2), ASMT(2), CARM1(2), CAT(1), CYP1A1(2), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), INMT(1), KMO(2), KYNU(1), LCMT1(1), LCMT2(2), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(5), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), TDO2(1), TPH1(2), TPH2(2), WARS(2) 16677010 74 23 74 19 25 12 21 8 8 0 0.0788 1.000 1.000 452 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 43 AKT1(3), AKT2(2), AKT3(4), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(2), CSK(1), DAG1(2), FLOT2(1), GSK3A(2), GSK3B(2), INPP5D(1), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), MAP4K1(3), NFATC1(4), NFATC2(10), PDK1(1), PIK3CD(2), PIK3R1(2), PLCG2(7), PPP1R13B(1), PPP3CA(3), PPP3CC(2), PTPRC(3), SHC1(2), SOS2(1), SYK(2), VAV1(6) 18800097 110 45 98 24 38 16 11 13 31 1 0.0165 1.000 1.000 453 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), AOC2(3), AOC3(3), AOX1(2), ASMT(2), CAT(1), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2D6(1), CYP2E1(3), CYP2F1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), CYP4B1(1), CYP51A1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2) 15316734 76 30 74 23 27 10 20 10 9 0 0.235 1.000 1.000 454 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 80 ANPEP(3), CD14(3), CD19(1), CD1A(2), CD1B(5), CD1C(2), CD1E(1), CD2(2), CD22(2), CD33(3), CD34(1), CD38(2), CD3E(1), CD4(2), CD44(4), CD5(2), CD55(1), CD59(2), CD8B(2), CR1(5), CSF1(2), CSF1R(5), CSF2RA(1), CSF3(2), CSF3R(3), DNTT(4), EPO(2), EPOR(2), FCGR1A(1), FLT3(4), FLT3LG(1), GP5(2), GP9(2), HLA-DRB1(1), IL1B(1), IL2RA(1), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL7(1), IL7R(3), IL9R(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGAM(1), ITGB3(1), KIT(4), MME(2), MS4A1(4), THPO(1), TPO(7) 21798433 130 53 123 33 30 19 26 25 30 0 0.0698 1.000 1.000 455 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(4), AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CDIPT(3), CHAT(4), CHPT1(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), ESCO1(3), ETNK2(2), GNPAT(1), GPAM(4), GPD1(1), GPD2(1), LYPLA2(1), PCYT1A(2), PCYT1B(1), PHOSPHO1(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLD2(5), PPAP2B(2), PPAP2C(1), PTDSS1(3), PTDSS2(1), SH3GLB1(1) 18250837 82 36 80 25 24 12 15 13 18 0 0.224 1.000 1.000 456 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 53 AK3(1), CAD(6), CTPS2(1), DCK(1), DPYD(4), DTYMK(1), DUT(1), ITPA(1), NME1(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3), RRM1(2), TYMS(1), UMPS(2), UPB1(2) 15726936 67 23 67 20 24 16 11 9 7 0 0.109 1.000 1.000 457 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 66 ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), ACVR1B(2), ACVR1C(2), BAIAP2(4), CDC42(1), CDH1(1), CREBBP(3), CSNK2A1(1), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTNND1(3), EGFR(2), EP300(6), ERBB2(6), FARP2(3), FER(6), FGFR1(1), IGF1R(6), INSR(4), IQGAP1(3), LEF1(3), LMO7(7), MET(4), MLLT4(5), NLK(2), PARD3(7), PTPN6(4), PTPRB(10), PTPRJ(3), PTPRM(6), PVRL2(1), PVRL3(1), RAC2(1), RHOA(1), SMAD2(1), SMAD3(1), SORBS1(1), SRC(2), SSX2IP(2), TCF7(2), TCF7L1(4), TCF7L2(1), TJP1(6), VCL(3), WASF1(1), WASF2(2), WASL(6), YES1(1) 29939071 174 60 166 30 47 33 29 28 36 1 0.000237 1.000 1.000 458 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 29 AKT1(3), ANGPTL2(2), DAG1(2), DGKA(2), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), NR1I3(1), PDE3B(1), PIK3CD(2), PIK3R1(2), RIPK3(2), SGCB(1) 12236331 53 25 47 18 15 5 10 4 19 0 0.730 1.000 1.000 459 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 184 ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(4), ARHGAP5(6), BAD(1), BCAR1(2), BIRC2(2), BRAF(4), CAPN2(1), CCND2(3), CCND3(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(5), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A6(6), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), COMP(4), CRK(1), CRKL(2), CTNNB1(9), DIAPH1(7), DOCK1(5), EGF(4), EGFR(2), ELK1(2), ERBB2(6), FARP2(3), FLNA(10), FLNB(4), FLNC(12), FLT1(4), FN1(9), GSK3B(2), HGF(1), HRAS(1), IBSP(3), IGF1R(6), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), KDR(1), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), MAPK10(1), MAPK8(2), MAPK9(1), MET(4), MYL9(1), MYLK(11), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PARVB(3), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(7), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTEN(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RELN(14), RHOA(1), ROCK1(6), ROCK2(2), SHC1(2), SHC2(2), SHC4(2), SOS2(1), SRC(2), THBS1(7), THBS2(4), THBS3(1), TLN1(11), TLN2(6), TNC(14), TNN(5), TNR(14), TNXB(13), VAV1(6), VCL(3), VEGFC(1), VTN(2), VWF(5), ZYX(1) 99632225 550 137 529 162 165 114 87 79 100 5 0.00385 1.000 1.000 460 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 232 ACVR1B(2), ACVR1C(2), AKT1(3), AKT2(2), AKT3(4), ARRB1(1), ARRB2(3), ATF4(1), BDNF(1), BRAF(4), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1E(10), CACNA1F(2), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(6), CACNA2D2(2), CACNA2D3(3), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(3), CACNG3(3), CACNG4(1), CACNG5(2), CD14(3), CDC25B(2), CDC42(1), CHUK(1), CRK(1), CRKL(2), DAXX(6), DUSP10(1), DUSP14(1), DUSP16(2), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(1), EGF(4), EGFR(2), ELK1(2), ELK4(1), FASLG(1), FGF12(1), FGF13(2), FGF14(2), FGF17(1), FGF18(1), FGF23(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(4), FLNA(10), FLNB(4), FLNC(12), HRAS(1), IKBKB(4), IL1B(1), JUND(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(3), MAX(1), MEF2C(2), MKNK2(3), MOS(3), MRAS(2), MYC(2), NF1(6), NFATC2(10), NFATC4(5), NFKB2(1), NLK(2), NR4A1(3), NTRK1(3), NTRK2(3), PAK2(3), PDGFRA(3), PDGFRB(7), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), PTPN5(1), RAC2(1), RAP1B(3), RAPGEF2(6), RASA1(4), RASA2(2), RASGRF1(1), RASGRP1(2), RASGRP2(1), RASGRP3(2), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS(2), SOS2(1), SRF(1), STK3(1), STK4(3), STMN1(1), TAOK1(4), TGFB1(1), TGFB2(2), TNFRSF1A(2), TRAF2(1), TRAF6(1), ZAK(5) 76204957 415 125 395 130 138 63 65 51 94 4 0.0829 1.000 1.000 461 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 132 ACTB(2), CHAD(1), COL11A1(7), COL11A2(5), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A6(6), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), COMP(4), DES(1), DSC1(5), DSC2(6), DSC3(6), DSG1(2), DSG2(3), DSG3(1), DSG4(5), FN1(9), GJA1(1), GJA10(1), GJA3(1), GJA4(2), GJA5(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJC3(2), GJD4(2), IBSP(3), INA(3), ITGA6(5), ITGB4(8), KRT1(2), KRT10(2), KRT12(3), KRT13(2), KRT14(2), KRT15(4), KRT16(1), KRT17(3), KRT19(1), KRT2(3), KRT20(3), KRT24(2), KRT25(1), KRT27(1), KRT28(2), KRT3(2), KRT31(2), KRT33A(2), KRT33B(1), KRT34(3), KRT37(1), KRT38(2), KRT39(2), KRT4(2), KRT40(1), KRT5(1), KRT6A(4), KRT6B(1), KRT7(3), KRT72(1), KRT74(3), KRT75(1), KRT77(2), KRT78(2), KRT79(2), KRT82(2), KRT83(4), KRT85(1), KRT86(2), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), LMNB1(1), LMNB2(1), NES(7), PRPH(1), RELN(14), THBS1(7), THBS2(4), THBS3(1), TNC(14), TNN(5), TNR(14), TNXB(13), VTN(2), VWF(5) 67137030 416 122 398 133 135 72 76 57 73 3 0.0738 1.000 1.000 462 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 159 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY7(2), ADCY8(4), ADCY9(5), ADORA2A(1), ADRA1A(4), ADRA1D(1), ADRB2(1), ATP2A1(6), ATP2A2(3), ATP2B1(7), ATP2B2(7), ATP2B4(2), AVPR1A(1), AVPR1B(1), BDKRB1(1), BDKRB2(1), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1E(10), CACNA1F(2), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(6), CALML3(1), CALML6(2), CAMK2D(1), CAMK4(2), CCKBR(3), CD38(2), CHRM1(1), CHRM2(3), CHRM3(2), CHRM5(3), CHRNA7(1), CYSLTR2(1), DRD1(5), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(6), ERBB4(6), GNA11(3), GNA14(1), GNA15(4), GNAL(3), GNAQ(1), GRIN2A(7), GRIN2C(6), GRIN2D(5), GRM5(7), GRPR(1), HRH2(2), HTR2A(3), HTR2B(1), HTR4(1), HTR5A(5), HTR7(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), LHCGR(2), LTB4R2(1), MYLK(11), MYLK2(4), NOS1(10), NOS3(9), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(2), PDE1B(2), PDE1C(1), PDGFRA(3), PDGFRB(7), PHKA2(7), PHKB(4), PHKG1(2), PHKG2(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PPID(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), PTGER3(1), PTGFR(2), RYR1(24), RYR3(23), SLC25A4(1), SLC25A5(1), SLC25A6(3), SLC8A1(2), SLC8A2(4), SLC8A3(5), SPHK1(1), SPHK2(1), TACR1(3), TACR2(1), TACR3(4), TBXA2R(1), TNNC1(2), TNNC2(1), TRHR(2), TRPC1(3), VDAC2(1) 69976639 467 122 451 147 185 67 92 60 60 3 0.00266 1.000 1.000 463 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 81 AGRN(2), CD44(4), CHAD(1), COL11A1(7), COL11A2(5), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(6), COL4A1(5), COL4A2(6), COL4A6(6), COL5A2(8), COL5A3(6), COL6A1(1), COL6A2(8), COL6A3(9), COL6A6(6), DAG1(2), FN1(9), FNDC1(9), FNDC3A(3), GP5(2), GP6(1), GP9(2), HSPG2(3), IBSP(3), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAV(4), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), LAMA1(16), LAMA2(11), LAMA3(6), LAMA4(6), LAMA5(7), LAMB1(6), LAMB2(6), LAMB3(4), LAMB4(3), LAMC1(3), LAMC2(1), LAMC3(3), RELN(14), SDC3(1), SDC4(2), SV2A(5), SV2C(1), THBS1(7), THBS2(4), THBS3(1), TNC(14), TNN(5), TNR(14), TNXB(13), VTN(2), VWF(5) 60573678 340 104 324 103 94 69 65 47 62 3 0.0594 1.000 1.000 464 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 227 ADORA2A(1), ADORA3(5), ADRA1A(4), ADRA2A(1), ADRA2B(4), ADRA2C(3), ADRB2(1), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), C5AR1(1), CALCR(2), CCKBR(3), CGA(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CRHR1(2), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(5), DRD3(1), DRD5(5), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHB(1), FSHR(4), GABBR2(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GABRB1(3), GABRB2(2), GABRB3(5), GABRE(3), GABRG1(1), GABRG2(1), GABRG3(2), GABRP(1), GABRQ(2), GABRR2(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GIPR(2), GLP2R(3), GLRA1(3), GLRA2(3), GLRB(1), GNRHR(1), GPR156(2), GPR35(1), GPR50(2), GPR83(1), GRIA1(3), GRIA2(1), GRIA4(2), GRID1(7), GRID2(10), GRIK1(1), GRIK2(9), GRIK3(4), GRIK4(2), GRIK5(2), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRIN3A(4), GRIN3B(5), GRM2(5), GRM3(3), GRM4(4), GRM5(7), GRM6(7), GRM7(5), GRM8(5), GRPR(1), HCRTR1(2), HRH2(2), HRH3(1), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR4(1), HTR5A(5), HTR7(1), LEPR(7), LHB(2), LHCGR(2), LTB4R2(1), MC2R(2), MC3R(4), MC5R(3), MCHR1(3), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(3), NMBR(1), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR1(1), NPFFR2(1), NPY1R(3), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(2), P2RY13(2), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(7), PRL(4), PRLR(2), PRSS3(1), PTGDR(2), PTGER3(1), PTGFR(2), RXFP1(1), SSTR1(4), SSTR3(2), SSTR4(3), SSTR5(5), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(2), TAAR8(3), TACR1(3), TACR2(1), TACR3(4), TBXA2R(1), THRB(1), TRHR(2), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1) 59211677 408 103 397 133 150 69 85 58 45 1 0.00277 1.000 1.000 465 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 117 ABL1(7), ABLIM1(6), ABLIM2(2), ABLIM3(2), ARHGEF12(6), CDC42(1), CXCR4(3), DCC(4), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNB2(1), EPHA1(4), EPHA2(5), EPHA3(2), EPHA4(4), EPHA5(7), EPHA6(2), EPHA7(3), EPHA8(8), EPHB1(2), EPHB2(4), EPHB3(4), EPHB4(5), GNAI1(1), GNAI2(1), GSK3B(2), HRAS(1), L1CAM(6), LIMK1(1), LIMK2(2), LRRC4C(3), MET(4), NCK1(3), NCK2(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NRP1(1), NTN4(1), NTNG1(3), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(9), PLXNA3(8), PLXNB1(6), PLXNB2(6), PLXNB3(6), PLXNC1(4), PPP3CA(3), PPP3CC(2), PTK2(3), RAC2(1), RASA1(4), RGS3(2), RHOA(1), RHOD(1), RND1(2), ROBO1(8), ROBO2(7), ROBO3(11), ROCK1(6), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(5), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(1), SEMA4C(5), SEMA4F(3), SEMA4G(3), SEMA5A(6), SEMA5B(4), SEMA6A(2), SEMA6C(3), SEMA6D(1), SEMA7A(1), SLIT1(8), SLIT2(7), SLIT3(7), SRGAP1(9), SRGAP2(1), UNC5B(3), UNC5C(3) 51575949 325 103 312 112 111 57 47 47 62 1 0.238 1.000 1.000 466 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 192 ABI2(2), ACTN1(1), ACTN2(4), ACTN4(1), APC(8), APC2(2), ARAF(2), ARHGEF1(3), ARHGEF12(6), ARHGEF6(2), ARPC1A(2), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(4), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(4), CD14(3), CDC42(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CRK(1), CRKL(2), CSK(1), CYFIP1(1), CYFIP2(2), DIAPH1(7), DIAPH2(1), DOCK1(5), EGF(4), EGFR(2), FGD1(1), FGF12(1), FGF13(2), FGF14(2), FGF17(1), FGF18(1), FGF23(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(4), FN1(9), HRAS(1), IQGAP1(3), IQGAP2(1), IQGAP3(3), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(7), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), LIMK1(1), LIMK2(2), MOS(3), MRAS(2), MYH14(7), MYH9(4), MYL9(1), MYLK(11), MYLK2(4), NCKAP1(4), NCKAP1L(5), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDGFRA(3), PDGFRB(7), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PPP1R12B(1), PTK2(3), PXN(1), RAC2(1), RDX(4), RHOA(1), ROCK1(6), ROCK2(2), RRAS(2), SCIN(1), SOS2(1), SSH1(4), SSH2(3), SSH3(1), TIAM1(10), TIAM2(5), VAV1(6), VCL(3), WASF1(1), WASF2(2), WASL(6) 72960312 346 101 336 118 105 63 60 42 74 2 0.347 1.000 1.000 467 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 132 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADRA1A(4), ADRA1D(1), ADRB2(1), ANXA6(3), ARRB1(1), ARRB2(3), ATP1A4(4), ATP1B3(1), ATP2A2(3), ATP2B1(7), ATP2B2(7), CACNA1A(9), CACNA1B(12), CACNA1C(9), CACNA1E(10), CACNA1S(6), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(2), CASQ1(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), GJA1(1), GJA4(2), GJA5(1), GJB1(1), GJB4(1), GJB6(2), GNA11(3), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK4(2), GRK5(4), GRK6(1), ITPR1(10), ITPR2(12), ITPR3(10), KCNJ5(1), MIB1(3), NME7(1), PLCB3(4), PRKACB(1), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCQ(3), PRKD1(1), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(2), RGS7(2), RYR1(24), RYR3(23), SLC8A1(2), SLC8A3(5), USP5(2), YWHAH(1) 47281845 284 96 273 108 111 52 49 29 40 3 0.204 1.000 1.000 468 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 140 APC(8), APC2(2), AXIN1(4), AXIN2(1), BTRC(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(10), CREBBP(3), CSNK1A1(1), CSNK1A1L(4), CSNK1E(1), CSNK2A1(1), CTBP2(3), CTNNB1(9), CUL1(4), CXXC4(1), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(4), DVL3(2), EP300(6), FBXW11(2), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GSK3B(2), LEF1(3), LRP5(7), LRP6(5), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(2), MYC(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NKD1(4), NKD2(1), NLK(2), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPARD(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP3CA(3), PPP3CC(2), PRICKLE1(3), PRICKLE2(4), PRKACB(1), PRKACG(3), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(6), ROCK2(2), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD2(1), SMAD3(1), SOX17(1), TCF7(2), TCF7L1(4), TCF7L2(1), VANGL1(2), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1) 43562374 259 94 250 84 89 51 33 41 45 0 0.0773 1.000 1.000 469 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 134 ACTA1(4), ACTA2(2), ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADM(1), ARRB1(1), ARRB2(3), ATF1(1), ATF3(1), ATF4(1), ATF5(1), ATP2A2(3), CALCA(2), CAMK2D(1), CNN2(1), CORIN(3), CRHR1(2), DGKZ(3), ETS2(2), GABPA(2), GABPB2(1), GBA2(3), GJA1(1), GNAQ(1), GNB1(2), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG13(1), GRK4(2), GRK5(4), GRK6(1), GUCA2B(1), GUCY1A3(1), IGFBP4(2), IL1B(1), IL6(1), ITPR1(10), ITPR2(12), ITPR3(10), MAFF(2), MIB1(3), MYLK2(4), NOS1(10), NOS3(9), OXTR(2), PDE4D(2), PLCB3(4), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCE(1), PRKCQ(3), PRKD1(1), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(2), RGS7(2), RYR1(24), RYR3(23), SLC8A1(2), SP1(1), TNXB(13), USP5(2), YWHAH(1) 45446754 258 91 249 99 98 41 43 30 44 2 0.398 1.000 1.000 470 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 242 ACVR1B(2), AMH(2), AMHR2(5), BMP2(3), BMP7(2), BMPR1A(4), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(2), CCL26(1), CCL27(1), CCL3(1), CCL7(1), CCL8(1), CCR1(2), CCR2(1), CCR4(4), CCR7(1), CCR9(1), CD40(1), CRLF2(1), CSF1(2), CSF1R(5), CSF2RA(1), CSF2RB(2), CSF3(2), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCR4(3), EDA(1), EDA2R(2), EDAR(2), EGF(4), EGFR(2), EPO(2), EPOR(2), FASLG(1), FLT1(4), FLT3(4), FLT3LG(1), FLT4(11), GDF5(2), GHR(1), HGF(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL17RA(3), IL18R1(1), IL18RAP(3), IL1B(1), IL1RAP(2), IL20RA(2), IL21(2), IL21R(1), IL22RA1(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL6ST(4), IL7(1), IL7R(3), IL9(1), IL9R(1), INHBA(2), INHBB(2), INHBC(1), KDR(1), KIT(4), LEPR(7), LIF(2), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(3), PDGFC(2), PDGFRA(3), PDGFRB(7), PF4V1(1), PLEKHO2(1), PRL(4), PRLR(2), RELT(1), TGFB1(1), TGFB2(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(5), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(1), TNFRSF8(2), TNFSF12(2), TNFSF13(2), TNFSF14(1), TNFSF18(1), TNFSF8(3), TPO(7), TSLP(1), VEGFC(1), XCR1(3) 47918407 264 88 255 68 77 53 41 40 53 0 0.00263 1.000 1.000 471 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 126 ACTB(2), ACTN1(1), ACTN2(4), ACTN4(1), AKT1(3), AKT2(2), AKT3(4), AMOTL1(2), ASH1L(9), CDC42(1), CDK4(2), CGN(1), CLDN17(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTTN(2), EPB41(4), EPB41L1(3), EPB41L2(3), EPB41L3(4), EXOC3(1), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), IGSF5(1), INADL(1), JAM2(2), LLGL1(5), LLGL2(3), MAGI1(2), MAGI2(12), MAGI3(2), MLLT4(5), MPDZ(4), MRAS(2), MYH1(6), MYH11(8), MYH13(4), MYH14(7), MYH15(10), MYH2(4), MYH3(2), MYH4(10), MYH6(7), MYH7(8), MYH7B(8), MYH8(6), MYH9(4), MYL9(1), PARD3(7), PARD6A(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP2R3A(4), PPP2R3B(2), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(3), PTEN(2), RAB13(1), RHOA(1), RRAS(2), SPTAN1(3), SRC(2), SYMPK(5), TJP1(6), TJP2(5), TJP3(3), YES1(1), ZAK(5) 52116323 280 88 271 83 88 48 46 42 56 0 0.0655 1.000 1.000 472 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 71 ARAF(2), BRAF(4), CACNA1A(9), CRHR1(2), GNA11(3), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GRIA1(3), GRIA2(1), GRID2(10), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HRAS(1), IGF1R(6), ITPR1(10), ITPR2(12), ITPR3(10), LYN(1), NOS1(10), NOS3(9), NPR1(5), NPR2(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PRKCG(2), PRKG1(1), PRKG2(2), RYR1(24) 29752342 185 77 177 48 74 16 38 25 32 0 0.0433 1.000 1.000 473 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 124 ACACA(4), ACACB(8), AKT1(3), AKT2(2), AKT3(4), ARAF(2), BAD(1), BRAF(4), CALML3(1), CALML6(2), CBL(5), CBLB(2), CBLC(1), CRK(1), CRKL(2), ELK1(2), EXOC7(1), FASN(7), FBP2(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(2), GYS1(3), GYS2(2), HRAS(1), IKBKB(4), INPP5D(1), INSR(4), IRS2(4), IRS4(4), LIPE(2), MAPK10(1), MAPK8(2), MAPK9(1), MKNK2(3), PCK1(3), PCK2(5), PDE3B(1), PFKL(2), PFKM(3), PFKP(1), PHKA2(7), PHKB(4), PHKG1(2), PHKG2(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(4), PPP1R3C(2), PPP1R3D(1), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAG3(4), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCI(3), PYGB(2), PYGL(2), PYGM(2), RPS6KB2(4), SHC1(2), SHC2(2), SHC4(2), SOCS4(3), SORBS1(1), SOS2(1), TRIP10(1), TSC1(1), TSC2(8) 41301526 198 76 190 75 66 41 23 20 46 2 0.370 1.000 1.000 474 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 138 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ADSL(2), ADSS(3), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(4), AMPD2(2), AMPD3(4), APRT(1), ATIC(2), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GART(1), GMPR(3), GMPR2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IMPDH1(3), ITPA(1), NME1(1), NME4(1), NME7(1), NPR1(5), NPR2(1), NT5C1B(3), NT5E(1), NT5M(1), NUDT2(1), NUDT9(4), PAICS(2), PAPSS1(2), PAPSS2(4), PDE11A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4C(2), PDE4D(2), PDE5A(3), PDE6G(1), PDE7B(1), PDE8A(2), PDE8B(3), PDE9A(1), PFAS(7), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(3), PRPS2(1), RRM1(2), RRM2B(1), XDH(5) 44348294 213 74 207 66 77 37 31 33 33 2 0.0975 1.000 1.000 475 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(2), ACTN2(4), ACTN4(1), DES(1), DMD(11), MYBPC1(4), MYBPC2(1), MYBPC3(3), MYH3(2), MYH6(7), MYH7(8), MYH8(6), MYL1(1), MYL3(3), MYL9(1), MYOM1(4), NEB(21), TMOD1(1), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(4), TNNT2(3), TNNT3(1), TPM1(1), TPM3(1), TTN(116) 38480061 214 74 211 64 59 46 48 26 33 2 0.294 1.000 1.000 476 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 126 ALCAM(1), CADM1(3), CADM3(3), CD2(2), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(2), CD6(1), CD80(1), CD8B(2), CDH1(1), CDH15(4), CDH2(5), CDH4(5), CDH5(2), CLDN17(1), CLDN3(2), CLDN9(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(8), ESAM(1), F11R(1), GLG1(2), HLA-A(7), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(2), HLA-DRB1(1), HLA-F(1), HLA-G(3), ICAM1(2), ICAM3(2), ICOSLG(1), ITGA4(1), ITGA6(5), ITGA8(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGB2(1), ITGB8(3), JAM2(2), L1CAM(6), MPZL1(1), NCAM1(3), NCAM2(5), NEGR1(2), NEO1(3), NFASC(5), NLGN1(5), NLGN2(3), NLGN3(5), NRCAM(2), NRXN1(4), NRXN2(7), NRXN3(4), PDCD1(1), PTPRC(3), PTPRM(6), PVRL2(1), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELL(1), SELP(3), SIGLEC1(12), VCAN(10) 39550289 207 70 203 81 68 35 39 33 32 0 0.336 1.000 1.000 477 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 144 AKT1(3), AKT2(2), AKT3(4), CBL(5), CBLB(2), CBLC(1), CCND2(3), CCND3(1), CISH(1), CREBBP(3), CRLF2(1), CSF2RA(1), CSF2RB(2), CSF3(2), CSF3R(3), EP300(6), EPO(2), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), IFNK(1), IL10RA(2), IL10RB(2), IL12B(1), IL12RB1(1), IL12RB2(2), IL20RA(2), IL21(2), IL21R(1), IL22RA1(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(2), IL3RA(3), IL4R(3), IL6(1), IL6R(1), IL6ST(4), IL7(1), IL7R(3), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(2), JAK3(3), LEPR(7), LIF(2), LIFR(5), MYC(2), OSMR(3), PIAS1(2), PIAS2(3), PIAS3(2), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PRL(4), PRLR(2), PTPN6(4), SOCS4(3), SOCS5(4), SOCS7(1), SOS2(1), SPRED1(1), SPRED2(1), STAM(6), STAM2(1), STAT1(3), STAT2(2), STAT3(2), STAT4(1), STAT5A(2), STAT6(5), TPO(7), TSLP(1), TYK2(2) 38033623 193 70 187 67 61 30 31 31 40 0 0.461 1.000 1.000 478 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CALML3(1), CALML6(2), CDIPT(3), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKI(5), DGKQ(4), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(1), INPP5E(2), INPPL1(5), ITPK1(1), ITPKB(3), ITPR1(10), ITPR2(12), ITPR3(10), OCRL(1), PI4KA(4), PI4KB(2), PIK3C2A(5), PIK3C2B(12), PIK3C3(2), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PRKCG(2), PTEN(2), SYNJ1(2), SYNJ2(3) 33906158 169 69 161 48 56 23 22 23 45 0 0.0718 1.000 1.000 479 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 75 AGL(5), ASCC3(5), ATP13A2(2), DDX18(1), DDX23(1), DDX4(6), DDX41(2), DDX47(5), DDX50(7), DDX51(1), DDX54(2), DDX55(1), DDX56(2), DHX58(4), ENPP3(3), EP400(8), ERCC2(2), G6PC2(1), GAA(2), GANC(1), GBA(4), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(3), HK2(3), HK3(4), IFIH1(7), MGAM(1), MOV10L1(6), NUDT8(1), PGM1(1), PYGB(2), PYGL(2), PYGM(2), RAD54L(5), RUVBL2(4), SETX(6), SI(5), SKIV2L2(1), SMARCA5(1), UGDH(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2A3(1), UGT2B10(3), UGT2B11(1), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), UXS1(2) 32566432 162 68 151 66 46 30 26 23 36 1 0.927 1.000 1.000 480 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 104 ABL1(7), ANAPC1(3), ANAPC2(4), ANAPC4(3), ANAPC5(6), ANAPC7(1), ATM(11), ATR(10), BUB1(2), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(4), CDC14B(1), CDC16(1), CDC20(1), CDC23(2), CDC25B(2), CDC6(3), CDC7(1), CDK4(2), CDK6(2), CDK7(1), CHEK2(1), CREBBP(3), CUL1(4), E2F3(3), EP300(6), ESPL1(8), GSK3B(2), MAD1L1(1), MAD2L1(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), PCNA(1), PKMYT1(2), PRKDC(9), RB1(3), RBL1(1), RBL2(2), SKP1(1), SKP2(3), SMAD2(1), SMAD3(1), SMC1A(1), SMC1B(5), TFDP1(1), TGFB1(1), TGFB2(2), YWHAE(3), YWHAH(1) 36545733 175 68 172 38 47 34 38 21 34 1 0.00885 1.000 1.000 481 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 87 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), CSNK1D(1), DRD1(5), EGF(4), EGFR(2), GJA1(1), GNA11(3), GNAI1(1), GNAI2(1), GNAQ(1), GRM5(7), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HRAS(1), HTR2A(3), HTR2B(1), ITPR1(10), ITPR2(12), ITPR3(10), MAP3K2(2), MAPK7(4), NPR1(5), NPR2(1), PDGFC(2), PDGFRA(3), PDGFRB(7), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PRKACB(1), PRKACG(3), PRKCG(2), PRKG1(1), PRKG2(2), SOS2(1), SRC(2), TJP1(6), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(4), TUBA3D(3), TUBA3E(5), TUBA8(4), TUBAL3(1), TUBB1(4), TUBB2B(2), TUBB3(3), TUBB6(1), TUBB8(4) 34810439 198 68 189 58 76 36 31 22 33 0 0.0226 1.000 1.000 482 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 158 ADORA2A(1), ADORA3(5), ADRA1A(4), ADRA1D(1), ADRA2A(1), ADRA2C(3), ADRB2(1), AGTR2(1), AVPR1A(1), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(1), C3AR1(2), CCKBR(3), CCR1(2), CCR10(2), CCR2(1), CCR4(4), CCR7(1), CCR9(1), CCRL2(2), CHML(5), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), CMKLR1(1), CX3CR1(1), CXCR4(3), DRD1(5), DRD3(1), DRD5(5), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHR(4), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR35(1), GPR4(2), GPR50(2), GPR6(1), GPR83(1), GPR87(1), GRPR(1), HCRTR1(2), HRH2(2), HRH3(1), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR4(1), HTR5A(5), HTR7(1), LHCGR(2), MC3R(4), MC5R(3), MLNR(1), MTNR1A(1), MTNR1B(3), NMBR(1), NMUR1(1), NMUR2(3), NPY1R(3), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(1), OR10A5(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR7C1(1), OR8B8(2), OXTR(2), P2RY12(1), P2RY13(2), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(2), RGR(1), RRH(1), SSTR1(4), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(2) 33032127 195 67 191 68 67 30 55 27 16 0 0.0648 1.000 1.000 483 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(5), ADCY8(4), ARAF(2), ATF4(1), BRAF(4), CACNA1C(9), CALML3(1), CALML6(2), CAMK2D(1), CAMK4(2), CREBBP(3), EP300(6), GNAQ(1), GRIA1(3), GRIA2(1), GRIN2A(7), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRM5(7), HRAS(1), ITPR1(10), ITPR2(12), ITPR3(10), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKCG(2), RAP1B(3), RAPGEF3(4), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5) 27032743 152 66 144 47 48 21 25 19 37 2 0.257 1.000 1.000 484 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 42 ABCA1(6), ABCA10(3), ABCA12(14), ABCA13(13), ABCA2(6), ABCA3(7), ABCA4(8), ABCA5(8), ABCA6(6), ABCA7(7), ABCA8(6), ABCA9(10), ABCB1(7), ABCB10(2), ABCB11(4), ABCB5(7), ABCB6(4), ABCB8(1), ABCC1(1), ABCC10(5), ABCC11(3), ABCC12(5), ABCC3(5), ABCC4(5), ABCC5(4), ABCC6(6), ABCC8(1), ABCC9(3), ABCD1(1), ABCD2(2), ABCD3(1), ABCG1(3), ABCG2(1), ABCG4(4), ABCG5(3), ABCG8(2), CFTR(5), TAP1(4), TAP2(1) 31650608 184 65 176 47 53 38 24 36 31 2 0.00499 1.000 1.000 485 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADSL(2), ADSS(3), AK2(1), ALLC(2), AMPD1(4), AMPD2(2), AMPD3(4), APRT(1), ATIC(2), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), FHIT(1), GART(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IMPDH1(3), ITPA(1), NME1(1), NPR1(5), NPR2(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(2), PAPSS2(4), PDE4A(2), PDE4C(2), PDE4D(2), PDE5A(3), PDE6B(3), PDE6C(1), PDE6G(1), PDE7B(1), PDE8A(2), PDE9A(1), PFAS(7), PKLR(2), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(5), POLL(2), POLQ(3), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(3), PRPS2(1), RRM1(2) 35941112 182 65 179 47 69 38 28 18 27 2 0.00495 1.000 1.000 486 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 89 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), AKAP1(2), AKAP10(2), AKAP11(6), AKAP12(5), AKAP2(9), AKAP3(2), AKAP4(1), AKAP5(1), AKAP6(6), AKAP7(2), AKAP9(9), ARHGEF1(3), GNA11(3), GNA14(1), GNA15(4), GNAI2(1), GNAL(3), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(2), GNB2(1), GNB3(2), GNB5(1), GNG13(1), HRAS(1), ITPR1(10), PALM2(1), PDE1B(2), PDE1C(1), PDE4A(2), PDE4C(2), PDE4D(2), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(3), PPP3CC(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(3), PRKD1(1), PRKD3(4), RHOA(1), RRAS(2), USP5(2) 31969506 169 63 163 68 58 34 30 21 24 2 0.587 1.000 1.000 487 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 88 CLK2(1), CLK3(3), CLK4(2), COL2A1(5), CPSF1(4), CPSF2(4), CPSF4(2), CSTF1(1), CSTF2(1), CSTF2T(1), CSTF3(4), DDX20(1), DHX15(4), DHX16(4), DHX38(2), DHX8(3), DICER1(10), FUS(2), LSM2(1), METTL3(2), NCBP2(2), NONO(1), NUDT21(1), PABPN1(2), PAPOLA(2), PHF5A(2), POLR2A(6), PPM1G(2), PRPF3(3), PRPF4B(1), PRPF8(9), PTBP1(3), PTBP2(1), RBM17(1), RBM5(1), RNGTT(4), SF3A2(1), SF3B1(4), SF3B2(3), SF3B5(1), SNRPA(1), SNRPB(1), SNRPE(3), SNRPN(2), SPOP(1), SRPK1(2), SRRM1(4), SUPT5H(2), U2AF2(3), XRN2(4) 27996168 130 59 125 31 43 19 19 23 26 0 0.0926 1.000 1.000 488 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 72 ABL1(7), ACTN1(1), AKT1(3), AKT2(2), AKT3(4), ANGPTL2(2), ARHGEF6(2), BCAR1(2), BRAF(4), CDC42(1), CRK(1), CSE1L(3), DOCK1(5), EPHB2(4), GRB7(3), ILK(1), ITGA1(7), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGB3BP(1), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MRAS(2), MYLK(11), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PIK3CB(3), PKLR(2), PLCG1(1), PLCG2(7), PTEN(2), PTK2(3), ROCK1(6), ROCK2(2), SHC1(2), SOS2(1), SRC(2), TERF2IP(1), TLN1(11), TLN2(6), ZYX(1) 31977133 167 59 163 47 53 32 23 24 35 0 0.0657 1.000 1.000 489 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 84 ACVR1B(2), ACVR1C(2), ACVRL1(1), AMH(2), AMHR2(5), BMP2(3), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMP8A(1), BMP8B(1), BMPR1A(4), BMPR2(3), CHRD(2), COMP(4), CREBBP(3), CUL1(4), DCN(1), E2F4(3), E2F5(3), EP300(6), GDF5(2), GDF6(1), GDF7(2), INHBA(2), INHBB(2), INHBC(1), LEFTY2(1), LTBP1(2), MYC(2), NODAL(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), RBL1(1), RBL2(2), RHOA(1), ROCK1(6), ROCK2(2), RPS6KB2(4), SKP1(1), SMAD2(1), SMAD3(1), SMAD7(1), SMAD9(3), SMURF2(1), SP1(1), TFDP1(1), TGFB1(1), TGFB2(2), THBS1(7), THBS2(4), THBS3(1), ZFYVE16(5), ZFYVE9(4) 26251699 137 58 132 39 40 26 24 19 28 0 0.132 1.000 1.000 490 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 89 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(9), CACNA1F(2), CACNA1S(6), CALML3(1), CALML6(2), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), ELK1(2), FSHB(1), GNA11(3), GNAQ(1), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(10), ITPR2(12), ITPR3(10), LHB(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP2(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLD2(5), PRKACB(1), PRKACG(3), SOS2(1), SRC(2) 32763117 168 58 160 61 56 28 27 20 35 2 0.335 1.000 1.000 491 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP2(3), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMP8A(1), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(1), DHH(2), FBXW11(2), GLI1(6), GLI2(5), GLI3(14), GSK3B(2), HHIP(5), LRP2(10), PRKACB(1), PRKACG(3), PTCH1(6), PTCH2(8), SMO(2), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1), ZIC2(5) 16872290 119 57 115 39 50 24 16 11 18 0 0.149 1.000 1.000 492 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 95 ADCY1(5), ADCY2(1), ADCY3(7), ADCY4(2), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(5), CALML3(1), CALML6(2), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(3), CTNNB1(9), DCT(3), DVL1(4), DVL2(4), DVL3(2), EDNRB(2), EP300(6), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GSK3B(2), HRAS(1), KIT(4), LEF1(3), MITF(3), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), POMC(1), PRKACB(1), PRKACG(3), PRKCG(2), TCF7(2), TCF7L1(4), TCF7L2(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2B(3), WNT3A(4), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9B(1) 30011060 173 56 168 68 73 31 22 23 23 1 0.215 1.000 1.000 493 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 BRAF(4), CHUK(1), CREB1(2), DAXX(6), ELK1(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K4(2), MAP3K5(2), MAP3K6(1), MAP3K9(4), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK4(1), MAPK6(2), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(2), MEF2C(2), MEF2D(2), MKNK2(3), MYC(2), NFKBIA(2), PAK2(3), RELA(3), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), RPS6KA5(4), RPS6KB2(4), SHC1(2), SP1(1), STAT1(3), TGFB1(1), TGFB2(2), TRADD(1), TRAF2(1) 26370247 130 56 124 44 29 24 24 11 42 0 0.690 1.000 1.000 494 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 80 ABL1(7), ABL2(2), AKT1(3), AKT2(2), AKT3(4), ARAF(2), BAD(1), BRAF(4), BTC(1), CAMK2D(1), CBL(5), CBLB(2), CBLC(1), CRK(1), CRKL(2), EGF(4), EGFR(2), ELK1(2), ERBB2(6), ERBB3(6), ERBB4(6), GSK3B(2), HRAS(1), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK9(1), MYC(2), NCK1(3), NCK2(2), NRG1(3), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), RPS6KB2(4), SHC1(2), SHC2(2), SHC4(2), SOS2(1), SRC(2), STAT5A(2) 26749205 139 55 134 39 39 25 18 14 43 0 0.184 1.000 1.000 495 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 AKT1(3), AKT2(2), AKT3(4), ANGPTL2(2), ARHGAP4(2), ARHGEF11(6), BTK(1), CDC42(1), GDI1(1), GDI2(3), INPPL1(5), ITPR1(10), ITPR2(12), ITPR3(10), LIMK1(1), MYLK(11), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDK1(1), PIK3CD(2), PIK3CG(5), PIK3R1(2), PPP1R13B(1), PTEN(2), RACGAP1(3), ROCK1(6), ROCK2(2), SAG(1), WASF1(1), WASL(6) 18815181 117 55 106 35 35 19 17 13 33 0 0.331 1.000 1.000 496 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(1), ACTN2(4), ACTN4(1), ARHGAP5(6), BCAR1(2), CDC42(1), CDH5(2), CLDN17(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(6), CTNNA3(5), CTNNB1(9), CTNND1(3), CXCR4(3), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(2), ITGA4(1), ITGAL(3), ITGAM(1), ITGB2(1), ITK(1), JAM2(2), MAPK11(1), MAPK12(1), MAPK13(1), MLLT4(5), MMP2(2), MMP9(4), MYL9(1), NCF2(1), NCF4(1), NOX1(4), NOX3(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RAPGEF3(4), RAPGEF4(3), RHOA(1), RHOH(2), ROCK1(6), ROCK2(2), SIPA1(3), THY1(1), TXK(1), VAV1(6), VCL(3) 34052626 155 54 154 61 54 31 17 24 26 3 0.531 1.000 1.000 497 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 51 ASH1L(9), ASH2L(3), CARM1(2), CTCFL(1), DOT1L(1), EED(3), EHMT1(5), EHMT2(6), EZH1(1), EZH2(3), FBXO11(2), HCFC1(5), HSF4(1), KDM6A(8), MEN1(5), NSD1(7), OGT(2), PAXIP1(1), PPP1CA(1), PRDM2(8), PRDM9(5), PRMT5(1), PRMT6(1), PRMT7(2), RBBP5(1), SETD2(9), SETD8(1), SETDB1(3), SETMAR(1), SMYD3(1), STK38(2), SUV39H2(3), SUV420H1(4), SUV420H2(2), SUZ12(2), WHSC1(4) 31395507 116 53 107 27 21 18 19 19 39 0 0.221 1.000 1.000 498 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 106 A4GNT(1), ALG10(1), ALG10B(2), ALG11(3), ALG12(4), ALG13(2), ALG9(1), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT5(2), CHPF(2), CHST1(1), CHST11(3), CHST12(1), CHST14(3), CHST2(2), CHST4(1), CHST6(4), CHSY1(2), DDOST(1), EXT1(2), EXT2(4), EXTL1(3), EXTL2(2), EXTL3(6), GALNT1(3), GALNT10(6), GALNT13(2), GALNT14(1), GALNT2(2), GALNT5(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GANAB(4), GCNT4(1), HS2ST1(1), HS3ST2(3), HS3ST3B1(1), HS6ST1(2), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(1), MAN2A1(4), MGAT1(1), MGAT3(3), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(3), NDST3(3), NDST4(3), OGT(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), WBSCR17(2), XYLT1(5), XYLT2(7) 30652654 144 53 139 41 50 26 31 16 21 0 0.0534 1.000 1.000 499 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 86 AKT1(3), AKT3(4), BCAR1(2), CAPN1(1), CAPN11(1), CAPN2(1), CAPN3(4), CAPN5(3), CAPN9(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(5), GIT2(1), ILK(1), ITGA10(1), ITGA11(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(5), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(7), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(8), ITGB5(3), ITGB6(5), ITGB8(3), MAP2K3(1), MAP2K6(3), MAPK10(1), MAPK12(1), MAPK4(1), MAPK6(2), MAPK7(4), MYLK2(4), PAK2(3), PAK4(2), PAK6(1), PIK3R2(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), ROCK1(6), ROCK2(2), SDCCAG8(2), SEPP1(1), SHC1(2), SORBS1(1), SRC(2), TLN1(11), TNS1(4), VCL(3), ZYX(1) 36212078 162 53 158 47 46 35 30 17 34 0 0.0483 1.000 1.000 500 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 77 ABL1(7), ATM(11), BUB1(2), BUB1B(1), BUB3(1), CCNA1(3), CCNA2(3), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(4), CDC14B(1), CDC20(1), CDC25B(2), CDC6(3), CDC7(1), CDH1(1), CDK4(2), CHEK2(1), E2F3(3), E2F4(3), E2F5(3), EP300(6), ESPL1(8), GSK3B(2), HDAC4(4), HDAC5(2), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), MPEG1(2), PCNA(1), PRKDC(9), PTPRA(1), RB1(3), RBL1(1), SKP2(3), TBC1D8(3), TFDP1(1), TGFB1(1) 29744578 140 52 138 26 41 24 29 24 21 1 0.00139 1.000 1.000 501 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 78 ACVR1B(2), ACVRL1(1), AKT1(3), BMPR1A(4), BMPR2(3), BUB1(2), CDIPT(3), CDKL1(1), CLK1(3), CLK2(1), CLK4(2), COL4A3BP(1), CSNK2A1(1), DGKA(2), DGKB(4), DGKD(3), DGKG(1), DGKH(3), DGKQ(4), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(5), ITPKB(3), MAP3K10(4), MOS(3), OCRL(1), PAK4(2), PIK3C2A(5), PIK3C2B(12), PIK3CB(3), PIK3CG(5), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(3), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCQ(3), PRKD1(1), PRKG1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(2), STK11(4), VRK1(1) 30441305 143 51 139 44 49 20 17 22 35 0 0.282 1.000 1.000 502 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(11), CCNA1(3), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CDK7(1), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(3), E2F5(3), GBA2(3), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), MDM2(2), MYC(2), MYT1(12), NACA(13), PCNA(1), POLA2(1), POLE(8), POLE2(1), PRIM1(1), RB1(3), RBL1(1), RPA1(1), RPA2(3), RPA3(2), TFDP1(1), TNXB(13) 20946383 126 49 124 34 39 20 26 24 16 1 0.0585 1.000 1.000 503 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 64 A2M(1), BDKRB1(1), BDKRB2(1), C1QA(1), C1QB(1), C1QC(1), C1R(1), C1S(6), C2(6), C3(11), C3AR1(2), C5(2), C5AR1(1), C6(6), C7(4), C8A(5), C9(3), CD46(1), CD55(1), CD59(2), CFB(3), CFD(1), CFH(6), CFI(3), CR1(5), F10(4), F11(1), F12(3), F13A1(3), F13B(2), F8(9), FGA(6), FGB(4), FGG(2), KLKB1(2), KNG1(2), MASP1(2), PLAT(2), PLG(1), PROC(1), PROS1(2), SERPINA1(2), SERPINA5(2), SERPINC1(3), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(2), THBD(3), VWF(5) 23215215 143 49 136 40 38 23 26 22 33 1 0.112 1.000 1.000 504 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 85 AKT1(3), AKT2(2), AKT3(4), CARD11(3), CBL(5), CBLB(2), CBLC(1), CD3E(1), CD4(2), CD8B(2), CDC42(1), CDK4(2), CHUK(1), GRAP2(2), HRAS(1), IKBKB(4), ITK(1), LCK(1), MALT1(3), NCK1(3), NCK2(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PPP3CA(3), PPP3CC(2), PRKCQ(3), PTPN6(4), PTPRC(3), RASGRP1(2), RHOA(1), SOS2(1), TEC(2), VAV1(6), ZAP70(6) 25012384 130 48 124 43 42 29 13 17 28 1 0.246 1.000 1.000 505 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 55 APC(8), AXIN1(4), CCND2(3), CCND3(1), CSNK1E(1), CTNNB1(9), DVL1(4), DVL2(4), DVL3(2), FBXW2(2), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD6(1), FZD7(4), FZD8(1), FZD9(2), GSK3B(2), LDLR(1), MAPK10(1), MAPK9(1), MYC(2), PAFAH1B1(1), PPP2R5E(1), PRKCE(1), PRKCG(2), PRKCI(3), PRKCQ(3), PRKD1(1), RHOA(1), SFRP4(1), TCF7(2), WNT1(1), WNT10A(1), WNT11(1), WNT2B(3), WNT5A(5), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2) 15807685 102 48 98 34 43 23 7 16 13 0 0.0920 1.000 1.000 506 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 116 ARAF(2), BRAF(4), FASLG(1), FCER1G(1), HLA-A(7), HLA-G(3), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IFNGR1(2), ITGAL(3), ITGB2(1), KIR2DL3(2), KIR3DL1(3), KLRC3(2), LCK(1), NCR1(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG1(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PRKCG(2), PTPN6(4), RAC2(1), SHC1(2), SHC2(2), SHC4(2), SOS2(1), SYK(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(6), ZAP70(6) 27768019 125 47 120 45 41 22 14 20 27 1 0.417 1.000 1.000 507 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 89 ACTB(2), BAD(1), CABIN1(6), CAMK4(2), CD3E(1), CD69(1), CREBBP(3), CSNK2A1(1), EGR3(2), EP300(6), FCER1A(1), FOSL1(1), GATA3(3), GATA4(1), GSK3A(2), GSK3B(2), HRAS(1), IL1B(1), IL2RA(1), IL6(1), ITK(1), JUNB(1), KPNA5(1), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2D(2), MYF5(2), NCK2(2), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(6), OPRD1(2), P2RX7(2), PPP3CC(2), PTPRC(3), RELA(3), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(6), VAV1(6), XPO5(2) 24157333 117 46 112 33 41 23 14 13 25 1 0.0812 1.000 1.000 508 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 56 AKT1(3), AKT2(2), AKT3(4), BAD(1), CDC42(1), CREB1(2), CREB5(1), ERBB4(6), F2RL2(2), GSK3A(2), GSK3B(2), IFI27(1), INPPL1(5), IRS2(4), IRS4(4), MET(4), MYC(2), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PARD3(7), PARD6A(1), PDK1(1), PIK3CD(2), PPP1R13B(1), PREX1(9), PTEN(2), PTK2(3), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS2(1), TSC1(1), TSC2(8), YWHAE(3), YWHAH(1) 18689326 99 45 92 39 27 14 13 15 30 0 0.811 1.000 1.000 509 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 94 AKT1(3), AKT2(2), AKT3(4), CASP8(2), CCL3(1), CD14(3), CD40(1), CD80(1), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(1), IKBKB(4), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(1), IRF5(1), IRF7(2), LBP(1), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), RELA(3), STAT1(3), TBK1(1), TICAM1(2), TLR1(5), TLR2(2), TLR3(3), TLR4(1), TLR5(3), TLR6(4), TLR8(2), TLR9(5), TRAF6(1) 23541289 112 44 108 35 31 17 20 17 27 0 0.272 1.000 1.000 510 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(8), ACSL1(2), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADIPOR1(2), AKT1(3), AKT2(2), AKT3(4), CHUK(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(4), IRS2(4), IRS4(4), JAK1(1), JAK2(2), JAK3(3), LEPR(7), MAPK10(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NPY(2), PCK1(3), PCK2(5), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(4), PRKCQ(3), RELA(3), RXRA(1), RXRB(1), RXRG(1), SLC2A1(3), STAT3(2), STK11(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2) 22807762 125 44 121 45 36 26 18 15 29 1 0.391 1.000 1.000 511 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 39 ALPI(4), ALPL(2), ALPP(4), ALPPL2(4), ASCC3(5), ATP13A2(2), DDX18(1), DDX23(1), DDX4(6), DDX41(2), DDX47(5), DDX50(7), DDX51(1), DDX54(2), DDX55(1), DDX56(2), DHFR(1), DHX58(4), EP400(8), ERCC2(2), FPGS(3), GCH1(1), GGH(2), IFIH1(7), MOV10L1(6), NUDT8(1), QDPR(2), RAD54L(5), RUVBL2(4), SETX(6), SKIV2L2(1), SMARCA5(1) 16349756 103 43 96 46 24 22 15 15 26 1 0.950 1.000 1.000 512 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ADORA3(5), CCKBR(3), CCR2(1), CELSR1(5), CELSR2(11), CELSR3(12), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(3), EMR3(1), FSHR(4), GHRHR(1), GNRHR(1), GPR116(3), GPR132(1), GPR133(9), GPR135(1), GPR143(1), GPR18(2), GPR56(1), GPR61(1), GPR84(1), GRPR(1), LGR6(3), LPHN2(10), LPHN3(1), LTB4R2(1), OR2M4(3), P2RY13(2), PTGFR(2), SMO(2), TAAR5(2), TSHR(3) 17942239 103 41 103 38 40 18 19 15 11 0 0.157 1.000 1.000 513 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(3), ATM(11), ATR(10), BAI1(5), CASP8(2), CASP9(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(1), CCNG2(2), CDK4(2), CDK6(2), CHEK2(1), DDB2(1), EI24(1), GTSE1(2), MDM2(2), PERP(1), PTEN(2), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN1(1), SESN2(3), SESN3(2), STEAP3(3), THBS1(7), TNFRSF10B(2), TP73(1), TSC2(8), ZMAT3(2) 17862123 93 40 90 29 34 20 16 9 14 0 0.188 1.000 1.000 514 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 56 AKT1(3), AKT2(2), AKT3(4), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD72(2), CD81(2), CHUK(1), FCGR2B(2), GSK3B(2), HRAS(1), IFITM1(1), IKBKB(4), INPP5D(1), LYN(1), MALT1(3), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PTPN6(4), RAC2(1), RASGRP3(2), SYK(2), VAV1(6) 17922906 105 40 99 32 33 23 11 13 24 1 0.122 1.000 1.000 515 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 91 ANK2(10), B3GALT4(2), CDR1(2), DGKI(5), IL6ST(4), RPL11(1), RPL12(1), RPL14(1), RPL15(2), RPL18(2), RPL18A(1), RPL19(1), RPL24(1), RPL28(3), RPL32(2), RPL34(1), RPL35(1), RPL36(1), RPL3L(2), RPL4(3), RPL7A(2), RPLP0(1), RPLP2(1), RPS11(2), RPS25(2), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5), RPS6KB2(4), RPSA(1), SLC36A2(1), TSPAN9(1), UBB(1), UBC(2) 14430663 76 39 74 55 15 11 17 8 24 1 1.000 1.000 1.000 516 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(2), INPPL1(5), ISYNA1(1), ITPK1(1), ITPKB(3), MINPP1(1), MIOX(1), OCRL(1), PI4KA(4), PI4KB(2), PIK3C3(2), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(5), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(1), PLCG2(7), PTEN(2), SYNJ1(2), SYNJ2(3) 20041512 84 38 82 31 25 13 13 13 20 0 0.503 1.000 1.000 517 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(3), AKT2(2), AKT3(4), BRD4(6), CBL(5), CDC42(1), F2RL2(2), FLOT2(1), GSK3A(2), GSK3B(2), INPPL1(5), IRS2(4), IRS4(4), LNPEP(2), PARD3(7), PARD6A(1), PDK1(1), PIK3CD(2), PIK3R1(2), PTEN(2), RPS6KA1(2), RPS6KA2(2), SHC1(2), SORBS1(1), SOS2(1), YWHAE(3), YWHAH(1) 14537210 70 36 63 26 19 12 7 10 22 0 0.738 1.000 1.000 518 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 39 AGL(5), ENPP3(3), GAA(2), GANAB(4), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(3), HK2(3), HK3(4), MGAM(1), PGM1(1), PYGB(2), PYGL(2), PYGM(2), SI(5), UGDH(2), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1), UXS1(2) 15453146 71 35 67 22 26 14 9 8 14 0 0.348 1.000 1.000 519 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(3), CDC7(1), CDT1(1), DIAPH2(1), MCM10(1), MCM2(7), MCM3(5), MCM4(1), MCM5(2), MCM6(6), MCM7(1), NACA(13), PCNA(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), PRIM1(1), RFC1(4), RFC2(2), RFC3(1), RPA1(1), RPA2(3), RPA3(2), RPS27A(1), UBB(1), UBC(2) 14211732 76 34 73 42 25 11 15 12 11 2 0.993 1.000 1.000 520 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(3), AKT2(2), AKT3(4), BRAF(4), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PRKAA1(1), PRKAA2(1), RICTOR(6), RPS6KA1(2), RPS6KA2(2), RPS6KA6(5), RPS6KB2(4), STK11(4), TSC1(1), TSC2(8), ULK1(3), ULK3(1), VEGFC(1) 13998496 73 34 69 26 22 14 9 5 23 0 0.738 1.000 1.000 521 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 64 AKT1(3), AKT2(2), AKT3(4), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFATC1(4), NFATC2(10), NFATC3(2), NFATC4(5), NOS3(9), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(7), PPP3CA(3), PPP3CC(2), PRKCG(2), PTGS2(1), PTK2(3), PXN(1), RAC2(1), SHC2(2), SPHK1(1), SPHK2(1), SRC(2) 18163500 97 34 91 34 32 20 15 10 20 0 0.404 1.000 1.000 522 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 39 AKT1(3), ASAH1(1), ATF1(1), BRAF(4), CAMP(2), CREB1(2), CREB5(1), CREBBP(3), CRKL(2), DAG1(2), EGR3(2), ELK1(2), FRS2(1), GNAQ(1), MAP1B(7), MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), NTRK1(3), OPN1LW(2), PIK3CD(2), PIK3R1(2), SHC1(2), SRC(2), TERF2IP(1), TH(1) 13561813 69 34 68 28 23 10 11 7 18 0 0.661 1.000 1.000 523 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 82 AK3(1), CAD(6), CTPS2(1), DCK(1), DPYD(4), DTYMK(1), DUT(1), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME7(1), NT5C1B(3), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLD3(2), POLE(8), POLE2(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3A(1), PRIM1(1), RRM1(2), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(2) 21343720 87 33 86 27 26 16 16 19 10 0 0.221 1.000 1.000 524 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(4), CPEB1(2), EGFR(2), ERBB2(6), ERBB4(6), ETS1(3), ETS2(2), ETV6(3), ETV7(1), FMN2(14), NOTCH1(10), NOTCH2(4), NOTCH3(7), NOTCH4(5), PIWIL1(1), PIWIL2(3), PIWIL3(3), PIWIL4(1), SOS2(1) 13957199 78 33 73 41 24 10 17 11 16 0 0.994 1.000 1.000 525 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAK1(1), BFAR(2), BTK(1), CAD(6), CASP10(2), CASP8(2), CSNK1A1(1), DAXX(6), DEDD(2), EGFR(2), EPHB2(4), FAF1(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MET(4), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PTPN13(8), RALBP1(2), ROCK1(6), SMPD1(1), TPX2(2), TRAF2(1) 19703168 84 33 81 30 20 18 17 13 16 0 0.596 1.000 1.000 526 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 109 ATP12A(8), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(2), ATP6V1F(1), ATP6V1H(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7A2(1), COX7B2(2), COX7C(1), COX8C(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV2(3), SDHA(6), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1), UQCRH(2) 14022199 73 30 70 25 19 15 11 15 12 1 0.600 1.000 1.000 527 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 ADAM17(4), APH1A(3), CREBBP(3), CTBP2(3), DLL4(2), DTX1(3), DTX2(5), DVL1(4), DVL2(4), DVL3(2), EP300(6), JAG1(2), JAG2(3), LFNG(1), MAML1(5), MAML2(3), NCOR2(5), NOTCH1(10), NOTCH2(4), NOTCH3(7), NOTCH4(5), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RBPJL(1), SNW1(1) 19529015 92 29 92 49 31 26 17 10 8 0 0.892 1.000 1.000 528 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AASS(2), ACAT1(2), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(6), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(7), OGDH(5), OGDHL(2), PLOD1(2), RDH11(2), SETDB1(3), SHMT1(2), SHMT2(4), SPCS1(1), SUV39H2(3), TMLHE(1) 15386706 65 28 61 23 20 12 14 7 12 0 0.467 1.000 1.000 529 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 68 AKT1(3), AKT2(2), AKT3(4), BTK(1), FCER1A(1), FCER1G(1), GAB2(2), HRAS(1), INPP5D(1), LYN(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CB(3), PIK3CD(2), PIK3CG(5), PIK3R1(2), PIK3R2(2), PIK3R3(1), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLCG1(1), PLCG2(7), PRKCE(1), RAC2(1), SOS2(1), SYK(2), VAV1(6) 17584719 81 28 79 34 24 16 9 10 21 1 0.728 1.000 1.000 530 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 35 AARS(1), CARS2(2), DARS(1), DARS2(2), EARS2(1), EPRS(1), FARS2(2), FARSA(2), FARSB(1), GARS(7), IARS(4), KARS(2), LARS2(2), MARS2(2), NARS2(2), PARS2(2), QARS(2), RARS(1), RARS2(4), TARS(2), VARS(4), VARS2(3), WARS(2) 14049765 52 26 49 18 16 12 8 7 9 0 0.495 1.000 1.000 531 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 CHUK(1), DAXX(6), EGF(4), EGFR(2), ETS1(3), ETS2(2), HOXA7(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK13(1), MAPK8(2), NFKBIA(2), PPP2CA(1), PRKCE(1), PRKCG(2), PRKCQ(3), RELA(3), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 13049852 62 26 60 23 14 11 11 10 16 0 0.632 1.000 1.000 532 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(4), ADRA1D(1), ADRA2A(1), ADRA2C(3), ADRB2(1), CHRM1(1), CHRM2(3), CHRM3(2), CHRM4(1), CHRM5(3), DRD1(5), DRD3(1), DRD5(5), HRH2(2), HTR1A(3), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR4(1), HTR5A(5), HTR7(1) 7050764 51 26 48 21 19 9 12 6 5 0 0.553 1.000 1.000 533 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 23 BRCA1(6), CARM1(2), CREBBP(3), EP300(6), ESR1(1), GRIP1(1), GTF2A1(1), GTF2E1(1), HDAC4(4), HDAC5(2), HDAC6(1), MEF2C(2), NCOR2(5), NR0B1(3), NRIP1(1), POLR2A(6), TBP(3) 12489054 48 25 45 21 14 7 11 6 10 0 0.820 1.000 1.000 534 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 APAF1(3), BIRC2(2), CASP2(3), CASP7(2), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CRADD(2), DAXX(6), DFFB(1), LMNB1(1), LMNB2(1), MAP2K7(3), MAP3K1(3), MAP3K5(2), MAPK8(2), MDM2(2), NFKBIA(2), NUMA1(3), PAK2(3), PRKDC(9), PSEN1(1), PSEN2(1), PTK2(3), RASA1(4), RB1(3), RELA(3), SPTAN1(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 18822670 80 25 78 25 15 12 20 11 22 0 0.575 1.000 1.000 535 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 37 ARNTL(1), AZIN1(1), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(1), ETV6(3), GFRA1(3), GSTP1(1), HERPUD1(2), HSPA8(3), IDI1(1), MYF6(1), NCKAP1(4), NCOA4(1), NR1D2(1), PER1(5), PER2(5), PPP1R3C(2), PURA(1), TUBB3(3), UCP3(1), ZFR(3) 9346469 47 24 44 26 12 7 6 10 12 0 0.991 1.000 1.000 536 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), ALAS2(3), AOC2(3), AOC3(3), ATP6V0C(1), CHDH(2), CPT1B(5), DAO(2), DMGDH(4), GARS(7), GLDC(1), PLCB2(5), PLCG1(1), PLCG2(7), SARDH(3), SHMT1(2), SHMT2(4), TARS(2) 11867513 59 24 57 21 26 14 8 5 6 0 0.314 1.000 1.000 537 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(3), B3GAT3(2), CHPF(2), CHST11(3), CHST12(1), CHST14(3), CHSY1(2), DSE(4), XYLT1(5), XYLT2(7) 4206947 32 23 29 13 13 4 7 2 6 0 0.577 1.000 1.000 538 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 41 CBL(5), CSK(1), DAG1(2), DTYMK(1), EPHB2(4), FBXW7(6), GRAP2(2), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK2(3), PAK4(2), PAK6(1), PAK7(1), PLCG1(1), PTPRC(3), RASGRP1(2), RASGRP2(1), RASGRP3(2), SOS2(1), VAV1(6), ZAP70(6) 13912299 63 23 63 21 20 13 9 8 12 1 0.451 1.000 1.000 539 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 45 APAF1(3), BAD(1), CASP1(4), CASP10(2), CASP2(3), CASP4(2), CASP7(2), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(6), DFFB(1), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(3), PTPN13(8), TFG(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TRAF6(1) 12012910 58 22 54 20 14 13 12 6 13 0 0.647 1.000 1.000 540 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 25 CASP10(2), CASP7(2), CASP8(2), CFLAR(3), DAXX(6), DFFB(1), FAF1(1), LMNB1(1), LMNB2(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PAK2(3), PRKDC(9), PTPN13(8), RB1(3), SPTAN1(3) 10989203 55 22 52 17 8 7 11 13 16 0 0.675 1.000 1.000 541 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 AGXT(2), AGXT2(2), ALAS2(3), AOC2(3), AOC3(3), CHDH(2), DAO(2), DMGDH(4), GARS(7), GLDC(1), HSD3B7(3), PHGDH(2), PSAT1(2), RDH11(2), SARDH(3), SHMT1(2), SHMT2(4), TARS(2) 11776822 49 22 47 20 25 12 5 5 2 0 0.470 1.000 1.000 542 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(4), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(2), LCT(6), MAN2B1(2), MAN2B2(2), MANBA(2), NAGLU(2), NEU4(2) 9841351 43 22 42 19 12 7 8 3 13 0 0.782 1.000 1.000 543 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 36 AKT1(3), AKT2(2), AKT3(4), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(4), ITPKB(3), LYN(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CD(2), PIK3R1(2), PLCG2(7), PPP1R13B(1), SHC1(2), SOS2(1), SYK(2), VAV1(6) 12597183 54 22 52 24 21 8 4 9 11 1 0.772 1.000 1.000 544 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(1), BAD(1), BRAF(4), CREB1(2), CREB5(1), DUSP6(2), DUSP9(1), MKNK2(3), MOS(3), RPS6KA1(2), RPS6KA2(2), SHC1(2), SOS2(1) 7571877 25 22 24 14 7 3 4 1 10 0 0.984 1.000 1.000 545 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 48 AKR1C3(1), ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(1), CYP2B6(1), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2J2(4), CYP2U1(1), CYP4A22(2), CYP4F2(2), EPHX2(1), GGT1(1), GPX5(4), GPX6(1), LTA4H(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1) 10354536 51 20 50 29 19 9 12 3 7 1 0.952 1.000 1.000 546 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 29 ADCY3(7), ARRB2(3), CALML3(1), CALML6(2), CAMK2D(1), CLCA1(2), CLCA2(2), CLCA4(2), CNGA3(4), CNGA4(2), GNAL(3), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDC(1), PDE1C(1), PRKACB(1), PRKACG(3), PRKG1(1), PRKG2(2) 7855564 41 20 39 18 15 8 10 4 4 0 0.696 1.000 1.000 547 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 30 AKT1(3), BAD(1), CBL(5), CFLAR(3), CRKL(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), MYC(2), PIK3R1(2), PTPN6(4), SHC1(2), STAT5A(2), SYK(2) 8005974 36 20 35 19 11 5 6 5 9 0 0.964 1.000 1.000 548 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 29 AKR1C3(1), ALOX12(1), ALOX15(1), ALOX5(1), CYP4F2(2), EPX(4), GGT1(1), LPO(6), LTA4H(2), MPO(2), PLA2G3(2), PLA2G6(4), PRDX1(1), PRDX2(1), PRDX5(2), PTGDS(2), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1), TPO(7) 7387893 47 20 46 22 20 5 11 3 7 1 0.823 1.000 1.000 549 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 24 AKT1(3), AKT2(2), AKT3(4), BAD(1), GSK3A(2), GSK3B(2), IL4R(3), IRS2(4), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CD(2), PIK3R1(2), PPP1R13B(1), SHC1(2), SOS2(1), STAT6(5) 8379007 42 20 39 18 16 10 3 6 7 0 0.635 1.000 1.000 550 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(2), CD97(2), CRHR1(2), CRHR2(1), ELTD1(5), EMR1(3), EMR2(3), GHRHR(1), GIPR(2), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(10), LPHN3(1), VIPR1(1), VIPR2(1) 7558705 41 19 41 17 9 9 5 11 7 0 0.542 1.000 1.000 551 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 33 CDK7(1), GTF2E1(1), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(6), POLR1B(3), POLR2A(6), POLR2B(3), POLR2E(1), POLR2G(2), POLR3E(5), TAF5(1), TAF6(2), TAF9(2), TBP(3) 8457759 39 19 37 17 16 5 6 2 10 0 0.889 1.000 1.000 552 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(2), ACAT1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3A2(1), ATP6V0C(1), DOT1L(1), EHHADH(1), EHMT1(5), EHMT2(6), GCDH(2), HADHA(1), PLOD1(2), SHMT1(2), SHMT2(4), TMLHE(1) 10380977 40 18 36 18 13 9 11 0 7 0 0.715 1.000 1.000 553 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 27 AKR1D1(1), ARSB(2), ARSE(1), HSD11B1(1), HSD17B2(2), HSD3B1(2), STS(4), SULT2A1(1), UGT1A1(5), UGT1A3(2), UGT1A4(4), UGT1A7(1), UGT1A9(1), UGT2B15(2), UGT2B4(1) 6746995 30 17 27 12 6 7 6 4 7 0 0.746 1.000 1.000 554 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 23 AKR1B1(1), FBP2(1), GAA(2), GANAB(4), GCK(1), GLB1(2), HK1(3), HK2(3), HK3(4), LCT(6), MGAM(1), PFKM(3), PFKP(1), PGM1(1) 8931060 33 17 33 13 16 5 5 1 6 0 0.470 1.000 1.000 555 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 15 B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(2), LCT(6), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(2), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3) 4406013 30 17 28 11 10 5 6 1 8 0 0.392 1.000 1.000 556 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL10L(2), RPL11(1), RPL12(1), RPL14(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL24(1), RPL28(3), RPL32(2), RPL34(1), RPL35(1), RPL36A(2), RPL36AL(1), RPL3L(2), RPS11(2), RPS25(2), RPS27(1), RPS28(1), RPSA(1) 6369092 32 17 31 11 9 3 9 0 11 0 0.796 1.000 1.000 557 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(3), EIF4A2(2), EIF4B(3), EIF4G1(8), EIF4G2(1), EIF4G3(7), FKBP1A(1), PDK2(3), PIK3R1(2), PPP2CA(1), PTEN(2), TSC1(1), TSC2(8) 7113432 42 17 40 14 14 9 10 4 5 0 0.577 1.000 1.000 558 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(4), CHAT(4), DBH(1), DDC(1), GAD1(6), GAD2(5), HDC(1), PAH(1), SLC18A3(3), TH(1), TPH1(2) 4094886 30 16 30 13 11 2 9 2 5 1 0.596 1.000 1.000 559 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 34 AGT(1), AGTR2(1), CAMK2D(1), GNA11(3), GNAI1(1), GNB1(2), HRAS(1), JAK2(2), MAPK8(2), MAPT(3), MYLK(11), PLCG1(1), SHC1(2), STAT1(3), STAT3(2), STAT5A(2), SYT1(1) 10427356 39 16 39 21 14 7 6 5 7 0 0.911 1.000 1.000 560 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(4), GLB1(2), LCT(6), NEU4(2), PPAP2B(2), PPAP2C(1), SMPD1(1), SPTLC1(3), SPTLC2(1), UGCG(1) 6862460 32 16 32 12 11 9 3 2 7 0 0.283 1.000 1.000 561 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 30 AKR1B1(1), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(2), HK1(3), HK2(3), HK3(4), HSD3B7(3), LCT(6), MGAM(1), PFKL(2), PFKM(3), PFKP(1), PGM1(1), RDH11(2) 10363589 37 16 37 15 19 6 5 2 5 0 0.442 1.000 1.000 562 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(3), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(2), GNPDA1(2), GNPDA2(1), HEXA(1), HEXB(2), HK1(3), HK2(3), HK3(4), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PHPT1(1), RENBP(1) 8020922 37 16 37 15 17 4 8 4 4 0 0.674 1.000 1.000 563 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 24 AKT1(3), AKT2(2), AKT3(4), CISH(1), IARS(4), IL4R(3), INPP5D(1), JAK1(1), JAK2(2), JAK3(3), PPP1R13B(1), SHC1(2), SOS2(1), SRC(2), STAT6(5), TYK2(2) 9007025 37 16 35 16 11 6 6 6 8 0 0.802 1.000 1.000 564 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 16 AHCY(2), AMD1(1), DNMT3A(8), DNMT3B(5), MARS2(2), MTR(7), TAT(1) 5611264 26 15 23 15 7 5 5 2 6 1 0.909 1.000 1.000 565 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(11), C5(2), C6(6), C7(4), ICAM1(2), IL6(1), ITGA4(1), ITGAL(3), ITGB2(1), SELP(3) 6874289 34 15 34 14 10 8 5 2 9 0 0.533 1.000 1.000 566 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), DNMT3A(8), DNMT3B(5), MARS2(2), MTR(7) 4854061 24 15 21 14 7 4 5 2 5 1 0.901 1.000 1.000 567 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(3), GNAQ(1), GNB1(2), MYLK(11), PLCB1(1), PPP1R12B(1), ROCK1(6) 5762081 31 15 31 12 6 9 4 5 6 1 0.653 1.000 1.000 568 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), EPRS(1), FARS2(2), GARS(7), IARS(4), KARS(2), LARS2(2), MARS2(2), QARS(2), RARS(1), TARS(2), WARS(2) 8839491 29 14 27 10 9 7 6 5 2 0 0.542 1.000 1.000 569 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 25 AHCY(2), CARM1(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(2), MARS2(2), METTL2B(2), METTL6(1), PAPSS1(2), PAPSS2(4), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), SCLY(2), SEPHS2(5) 6745978 33 14 32 13 10 9 10 2 2 0 0.456 1.000 1.000 570 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), HGSNAT(1), HPSE(2), HPSE2(2), HYAL1(2), LCT(6), NAGLU(2) 5827840 26 14 25 16 5 7 3 2 9 0 0.957 1.000 1.000 571 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(3), EIF2B5(1), GSK3B(2), IGF1R(6), INPPL1(5), PDK2(3), PIK3R1(2), PPP2CA(1), PTEN(2) 4904473 25 14 22 10 6 4 3 4 8 0 0.827 1.000 1.000 572 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 12 GTF2A1(1), GTF2E1(1), NCOA2(3), NCOA3(3), NCOR2(5), POLR2A(6), RXRA(1), TBP(3) 6334233 23 14 22 25 7 2 5 2 6 1 1.000 1.000 1.000 573 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 MAP2K4(5), MAP2K7(3), MAPK10(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(5), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CD(2), PIK3R1(2), SYT1(1), TRAF2(1), TRAF5(1), TRAF6(1) 9094632 37 14 37 13 10 8 8 5 6 0 0.343 1.000 1.000 574 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(3), EIF4A2(2), EIF4G1(8), EIF4G2(1), EIF4G3(7), GHR(1), PDK2(3), PIK3R1(2), PTEN(2) 6168273 29 13 27 10 7 7 7 3 5 0 0.702 1.000 1.000 575 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(4), CYP2C8(1), CYP2C9(2), CYP2E1(3), CYP2J2(4), CYP3A5(1), CYP3A7(3), HSD3B7(3), PLA2G12B(1), PLA2G3(2), PLA2G6(4), RDH11(2) 6660072 36 13 35 13 9 5 11 7 4 0 0.690 1.000 1.000 576 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST2(3), HS3ST3B1(1), XYLT1(5), XYLT2(7) 1926000 18 12 16 13 6 6 2 1 3 0 0.887 1.000 1.000 577 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST2(3), HS3ST3B1(1), XYLT1(5), XYLT2(7) 1926000 18 12 16 13 6 6 2 1 3 0 0.887 1.000 1.000 578 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(3), PPP3CC(2), SYNJ1(2), SYNJ2(3), SYT1(1) 6244918 25 12 25 11 4 6 3 4 8 0 0.768 1.000 1.000 579 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(2), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(11), NCF2(1), PDGFRA(3), PIK3R1(2), PPP1R12B(1), RALBP1(2), TRIO(9), VAV1(6), WASF1(1) 8654864 43 12 41 16 14 9 5 7 6 2 0.575 1.000 1.000 580 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(6), PGM1(1), PYGL(2), PYGM(2), TPI1(3) 3782512 17 11 17 11 7 4 1 1 4 0 0.844 1.000 1.000 581 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(2), GNS(2), GUSB(1), HEXA(1), HEXB(2), LCT(6), NAGLU(2) 4109106 19 11 19 12 4 5 2 2 6 0 0.913 1.000 1.000 582 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(3), EP300(6), IL7(1), IL7R(3), JAK1(1), JAK3(3), LCK(1), PIK3R1(2), STAT5A(2) 6926132 22 11 21 11 8 3 5 2 4 0 0.842 1.000 1.000 583 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(3), EP300(6), LPL(4), NCOA2(3), PPARG(1), RXRA(1) 5129266 18 11 18 10 6 2 4 2 4 0 0.894 1.000 1.000 584 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 BCAR1(2), CRKL(2), GNAQ(1), HRAS(1), MAP2K3(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PLCG1(1), SHC1(2), SRC(2), SYT1(1) 6945660 23 11 23 14 6 4 3 4 6 0 0.955 1.000 1.000 585 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), PDE1B(2), PLCB1(1), PLCB2(5), PRL(4), TRH(3) 3137803 19 11 19 11 9 1 4 2 3 0 0.874 1.000 1.000 586 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BIRC2(2), CASP8(2), CFLAR(3), MAP2K4(5), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 7391833 27 11 27 12 8 3 7 5 4 0 0.778 1.000 1.000 587 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(1), ALOX15B(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(2), PLA2G6(4), PTGDS(2), PTGES(1), PTGIS(2), PTGS1(2), PTGS2(1), TBXAS1(1) 4265803 21 10 21 11 10 2 4 2 3 0 0.826 1.000 1.000 588 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(3), CREB1(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), PIK3R1(2), RB1(3), RELA(3), SP1(1) 4833483 21 10 20 10 4 1 6 3 7 0 0.965 1.000 1.000 589 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(4), GPX6(1), GSR(1), GSS(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), OPLAH(3) 6247383 33 10 33 16 8 9 7 3 6 0 0.646 1.000 1.000 590 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(2), CD33(3), CD5(2), IL12B(1), ITGAX(3), TLR2(2), TLR4(1), TLR9(5) 5172921 22 9 22 10 9 5 2 5 1 0 0.655 1.000 1.000 591 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(4), GSS(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), PGD(1) 5021987 27 9 27 13 6 7 4 4 6 0 0.688 1.000 1.000 592 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(3), AGPAT4(3), AGPAT6(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G3(2), PLA2G6(4), PLD2(5), PPAP2B(2), PPAP2C(1) 6493807 31 9 29 16 11 4 6 4 6 0 0.904 1.000 1.000 593 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 10 AKT1(3), IL4R(3), JAK1(1), JAK3(3), SHC1(2), STAT6(5) 3483486 17 9 16 11 5 4 2 2 4 0 0.956 1.000 1.000 594 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(1), ELK1(2), HRAS(1), IL6(1), IL6R(1), IL6ST(4), JAK1(1), JAK2(2), JAK3(3), SHC1(2), SRF(1), STAT3(2) 6002130 21 9 21 16 5 3 3 2 8 0 0.992 1.000 1.000 595 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(1), JAK2(2), JAK3(3), PIAS1(2), PIAS3(2), PTPRU(6), REG1A(2), SOAT1(1) 3895037 20 9 19 15 9 2 5 0 4 0 0.989 1.000 1.000 596 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(2), JAK3(3), PIAS3(2), PTPRU(6), REG1A(2), SRC(2), STAT3(2) 4304090 23 9 22 16 9 5 5 0 4 0 0.970 1.000 1.000 597 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(1), HSPA1A(1), IFNGR1(2), IKBKB(4), JAK2(2), LIN7A(1), NFKBIA(2), RB1(3), RELA(3), TNFRSF1A(2), TNFRSF1B(1), USH1C(1) 4771075 23 9 23 11 5 3 8 3 4 0 0.900 1.000 1.000 598 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SNAP23(2), SNAP29(3), STX11(2), STX12(1), STX2(1), STX3(1), STX4(2), STX7(1), TSNARE1(1), VAMP4(1), VAMP7(1), VTI1A(2) 4703952 18 8 18 13 8 0 2 2 6 0 0.991 1.000 1.000 599 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22RA1(1), JAK1(1), JAK2(2), JAK3(3), STAT1(3), STAT3(2), STAT5A(2), TYK2(2) 5208374 18 8 18 12 7 2 4 2 3 0 0.962 1.000 1.000 600 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(1), ELK1(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(2), STAT5A(2), SYK(2) 5880709 20 8 20 11 8 4 1 2 5 0 0.836 1.000 1.000 601 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 CHUK(1), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TLR4(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1) 6573136 21 8 21 11 4 3 8 3 3 0 0.943 1.000 1.000 602 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(3), DAXX(6), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(5), TNFRSF1A(2), TNFRSF1B(1) 5148539 24 8 22 10 6 3 6 4 5 0 0.812 1.000 1.000 603 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(2), RELA(3), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1) 6291158 21 8 21 10 3 5 7 2 4 0 0.889 1.000 1.000 604 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(3), NR1I3(1), PTGS1(2), PTGS2(1) 1464698 11 7 10 5 8 1 0 2 0 0 0.749 1.000 1.000 605 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(4), EGFR(2), MAP3K1(3), NCOR2(5), RXRA(1), THRB(1) 4601621 16 7 16 10 1 5 5 2 3 0 0.955 1.000 1.000 606 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(2), HRAS(1), PIK3R1(2), PLCG1(1), PTK2(3), PXN(1), RELA(3) 7256845 21 6 21 15 7 7 2 2 3 0 0.965 1.000 1.000 607 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(1), JAK1(1), STAT1(3), STAT2(2), TYK2(2) 3025980 11 6 11 5 4 0 4 3 0 0 0.775 1.000 1.000 608 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), GGT1(1), MARS2(2), PAPSS1(2), PAPSS2(4), SCLY(2) 3464119 13 6 13 11 4 4 2 1 2 0 0.951 1.000 1.000 609 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 MTNR1A(1), MTNR1B(3), PTGDR(2), PTGFR(2), TBXA2R(1) 3240491 9 5 9 10 2 1 5 0 1 0 0.971 1.000 1.000 610 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 10 CDK5R1(1), HRAS(1), KLK2(1), NGFR(1) 1866640 4 2 4 4 3 0 1 0 0 0 0.944 1.000 1.000 611 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL16(1), IL6(1), IL9(1) 2753138 4 2 4 3 0 2 1 1 0 0 0.838 1.000 1.000 612 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1), TGM2(1) 1385991 2 2 2 2 2 0 0 0 0 0 0.893 1.000 1.000 613 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1) 1876503 2 1 2 4 1 1 0 0 0 0 0.984 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 470342 1 1 1 2 0 0 1 0 0 0 0.995 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 139470 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 420745 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000