Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.059 0.121 0.436 15.0 -9999.0 0.0 15.0 IHH 0.049 0.047 0.191 15.0 -9999.0 0.0 15.0 SHH Np/Cholesterol/GAS1 -0.041 0.104 -9999.0 0.0 -0.219 40.0 40.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.104 0.218 40.0 -9999.0 0.0 40.0 SMO/beta Arrestin2 0.028 0.118 0.411 1.0 -0.517 1.0 2.0 SMO 0.015 0.113 0.297 12.0 -0.537 1.0 13.0 AKT1 0.006 0.113 -9999.0 0.0 -0.403 5.0 5.0 ARRB2 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.015 0.112 0.296 12.0 -0.529 1.0 13.0 STIL -0.009 0.116 0.243 13.0 -9999.0 0.0 13.0 DHH N/PTCH2 0.033 0.028 -9999.0 0.0 -0.272 1.0 1.0 DHH N/PTCH1 0.063 0.08 0.31 15.0 -9999.0 0.0 15.0 PIK3CA 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.065 0.147 0.524 15.0 -9999.0 0.0 15.0 determination of left/right symmetry 0.015 0.112 0.296 12.0 -0.529 1.0 13.0 PIK3R1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.064 0.147 0.523 15.0 -9999.0 0.0 15.0 IHH N/Hhip -0.169 0.166 -9999.0 0.0 -0.295 102.0 102.0 DHH N/Hhip -0.154 0.15 -9999.0 0.0 -0.272 100.0 100.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.015 0.112 0.296 12.0 -0.529 1.0 13.0 pancreas development -0.231 0.196 -9999.0 0.0 -0.381 102.0 102.0 HHAT 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.0 0.103 -9999.0 0.0 -0.381 11.0 11.0 somite specification 0.015 0.112 0.296 12.0 -0.529 1.0 13.0 SHH Np/Cholesterol/PTCH1 -0.003 0.111 0.27 12.0 -9999.0 0.0 12.0 SHH Np/Cholesterol/PTCH2 -0.032 0.092 -9999.0 0.0 -0.209 34.0 34.0 SHH Np/Cholesterol/Megalin -0.055 0.079 -9999.0 0.0 -0.21 33.0 33.0 SHH -0.067 0.104 -9999.0 0.0 -0.273 33.0 33.0 catabolic process 0.056 0.102 0.372 15.0 -9999.0 0.0 15.0 SMO/Vitamin D3 0.0 0.133 0.315 13.0 -0.312 1.0 14.0 SHH Np/Cholesterol/Hhip -0.153 0.134 -9999.0 0.0 -0.246 102.0 102.0 LRP2 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.015 0.119 0.254 12.0 -0.35 1.0 13.0 SHH Np/Cholesterol/BOC -0.03 0.091 -9999.0 0.0 -0.21 33.0 33.0 SHH Np/Cholesterol/CDO -0.029 0.092 -9999.0 0.0 -0.209 33.0 33.0 mesenchymal cell differentiation 0.152 0.134 0.244 102.0 -9999.0 0.0 102.0 mol:Vitamin D3 0.019 0.136 0.316 14.0 -9999.0 0.0 14.0 IHH N/PTCH2 0.045 0.043 -9999.0 0.0 -0.301 1.0 1.0 CDON 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.069 0.104 0.395 15.0 -9999.0 0.0 15.0 Megalin/LRPAP1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.022 0.033 -9999.0 0.0 -0.381 1.0 1.0 SHH Np/Cholesterol -0.033 0.087 -9999.0 0.0 -0.204 33.0 33.0 PTCH1 0.056 0.102 0.373 15.0 -9999.0 0.0 15.0 HHIP -0.231 0.196 -9999.0 0.0 -0.381 102.0 102.0