E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.01 0.086 -9999.0 0.0 -0.258 48.0 48.0 KLHL20 0.014 0.043 0.16 3.0 -0.19 1.0 4.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.015 0.062 0.339 6.0 -9999.0 0.0 6.0 ENAH -0.01 0.085 -9999.0 0.0 -0.258 46.0 46.0 AP1M1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.018 0.026 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.021 -9999.0 0.0 -0.134 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.049 -9999.0 0.0 -0.158 16.0 16.0 RAPGEF1 -0.008 0.079 0.293 4.0 -9999.0 0.0 4.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.092 -9999.0 0.0 -0.26 55.0 55.0 CRK -0.008 0.076 -9999.0 0.0 -0.249 37.0 37.0 E-cadherin/gamma catenin/alpha catenin 0.046 0.021 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.028 0.048 0.144 3.0 -0.208 18.0 21.0 IQGAP1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.009 0.084 -9999.0 0.0 -0.258 45.0 45.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.015 0.015 -9999.0 0.0 -0.158 1.0 1.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.049 0.026 -9999.0 0.0 -0.162 3.0 3.0 PI3K -0.019 0.019 -9999.0 0.0 -0.201 1.0 1.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.023 0.03 -9999.0 0.0 -0.308 4.0 4.0 E-cadherin(dimer)/Ca2+ 0.052 0.026 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.008 0.027 0.105 5.0 -0.122 1.0 6.0 PIK3R1 0.022 0.031 -9999.0 0.0 -0.308 4.0 4.0 CDH1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.018 0.069 0.312 11.0 -9999.0 0.0 11.0 actin cytoskeleton organization 0.015 0.043 0.196 11.0 -0.14 1.0 12.0 CDC42/GDP 0.02 0.072 0.286 16.0 -9999.0 0.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.015 0.064 0.174 3.0 -0.308 18.0 21.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.056 0.028 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.007 0.076 0.3 16.0 -9999.0 0.0 16.0 CDC42/GTP/IQGAP1 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.021 0.062 0.377 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.037 0.182 11.0 -0.091 1.0 12.0 NME1 0.03 0.022 0.174 11.0 -9999.0 0.0 11.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.008 0.084 -9999.0 0.0 -0.258 45.0 45.0 regulation of cell-cell adhesion 0.011 0.02 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.006 0.02 0.08 3.0 -9999.0 0.0 3.0 Rap1/GTP 0.021 0.036 0.187 11.0 -9999.0 0.0 11.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.051 -9999.0 0.0 -0.153 14.0 14.0 CCND1 0.016 0.042 0.206 11.0 -0.11 1.0 12.0 VAV2 0.006 0.088 0.327 1.0 -0.55 1.0 2.0 RAP1/GDP 0.026 0.051 0.259 9.0 -9999.0 0.0 9.0 adherens junction assembly -0.008 0.082 -9999.0 0.0 -0.251 45.0 45.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.041 0.046 -9999.0 0.0 -0.155 11.0 11.0 E-cadherin/beta catenin 0.011 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.087 -9999.0 0.0 -0.257 48.0 48.0 PIK3CA 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 Rac1/GTP 0.002 0.045 -9999.0 0.0 -0.295 1.0 1.0 E-cadherin/beta catenin/alpha catenin 0.045 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.003 0.094 -9999.0 0.0 -0.265 55.0 55.0