Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.047 0.023 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.009 0.088 0.377 15.0 -9999.0 0.0 15.0 EGFR -0.002 0.09 -9999.0 0.0 -0.308 39.0 39.0 EPHA2 -0.002 0.096 0.174 3.0 -0.308 43.0 46.0 MYO6 0.007 0.055 0.189 24.0 -9999.0 0.0 24.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.051 0.015 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.142 0.194 -9999.0 0.0 -0.392 181.0 181.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.052 0.194 29.0 -9999.0 0.0 29.0 regulation of calcium-dependent cell-cell adhesion -0.004 0.058 0.195 29.0 -9999.0 0.0 29.0 EGF 0.023 0.084 0.174 40.0 -0.308 23.0 63.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.002 0.071 0.345 2.0 -0.367 14.0 16.0 cortical microtubule organization 0.047 0.023 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.002 0.049 0.183 29.0 -9999.0 0.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.052 0.026 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.032 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.066 -9999.0 0.0 -0.166 39.0 39.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.035 0.169 11.0 -9999.0 0.0 11.0 PVRL2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.005 0.043 0.196 18.0 -9999.0 0.0 18.0 ARF6/GTP 0.048 0.067 -9999.0 0.0 -0.157 39.0 39.0 CDH1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.022 0.068 -9999.0 0.0 -0.153 54.0 54.0 RhoA/GDP 0.048 0.024 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.013 0.041 0.162 19.0 -9999.0 0.0 19.0 IGF-1R heterotetramer 0.026 0.017 0.173 1.0 -0.307 1.0 2.0 GIT1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.017 0.174 1.0 -0.308 1.0 2.0 IGF1 0.008 0.089 0.174 17.0 -0.308 33.0 50.0 DIAPH1 0.025 0.118 -9999.0 0.0 -0.491 16.0 16.0 Wnt receptor signaling pathway -0.047 0.023 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.032 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.013 0.042 0.164 19.0 -0.162 1.0 20.0 EFNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.014 0.047 0.183 16.0 -9999.0 0.0 16.0 Ephrin A1/EPHA2 0.027 0.056 -9999.0 0.0 -0.15 30.0 30.0 SEC6/SEC8 -0.02 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.004 0.058 0.196 29.0 -9999.0 0.0 29.0 HGF/MET 0.02 0.07 -9999.0 0.0 -0.179 45.0 45.0 HGF 0.011 0.075 0.174 9.0 -0.308 24.0 33.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.016 0.112 0.307 42.0 -0.236 5.0 47.0 KIAA1543 -0.005 0.044 0.183 22.0 -9999.0 0.0 22.0 KIFC3 -0.006 0.044 0.19 21.0 -9999.0 0.0 21.0 NCK1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.048 0.194 23.0 -9999.0 0.0 23.0 NCK1/GIT1 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.047 0.023 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.002 0.051 0.198 26.0 -9999.0 0.0 26.0 PIP5K1C -0.001 0.053 0.196 29.0 -9999.0 0.0 29.0 LIMA1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.006 0.096 0.401 15.0 -9999.0 0.0 15.0 adherens junction assembly -0.009 0.098 0.288 15.0 -0.471 9.0 24.0 IGF-1R heterotetramer/IGF1 0.032 0.048 0.164 1.0 -0.146 24.0 25.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.004 0.093 -9999.0 0.0 -0.308 42.0 42.0 PLEKHA7 -0.004 0.047 0.195 22.0 -9999.0 0.0 22.0 mol:GTP 0.041 0.065 -9999.0 0.0 -0.165 39.0 39.0 establishment of epithelial cell apical/basal polarity 0.005 0.091 0.32 26.0 -9999.0 0.0 26.0 cortical actin cytoskeleton stabilization 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.013 0.041 0.162 19.0 -9999.0 0.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0