Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.033 0.081 -9999.0 0.0 -0.647 1.0 1.0 IHH 0.019 0.017 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.148 0.224 -9999.0 0.0 -0.519 42.0 42.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.146 0.222 0.515 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 0.013 0.064 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.007 0.066 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.02 0.042 -9999.0 0.0 -0.297 1.0 1.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.007 0.065 -9999.0 0.0 -9999.0 0.0 0.0 STIL -0.076 0.192 -9999.0 0.0 -0.4 42.0 42.0 DHH N/PTCH2 0.014 0.048 -9999.0 0.0 -0.598 1.0 1.0 DHH N/PTCH1 0.034 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.012 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.03 0.108 -9999.0 0.0 -0.652 4.0 4.0 determination of left/right symmetry 0.007 0.065 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.03 0.107 -9999.0 0.0 -0.646 4.0 4.0 IHH N/Hhip 0.004 0.058 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.002 0.05 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.007 0.065 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development 0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.013 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.008 0.006 -9999.0 0.0 -9999.0 0.0 0.0 somite specification 0.007 0.065 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 -0.083 0.202 -9999.0 0.0 -0.424 42.0 42.0 SHH Np/Cholesterol/PTCH2 -0.11 0.217 -9999.0 0.0 -0.477 43.0 43.0 SHH Np/Cholesterol/Megalin -0.157 0.256 -9999.0 0.0 -0.512 54.0 54.0 SHH -0.139 0.268 -9999.0 0.0 -0.599 42.0 42.0 catabolic process 0.031 0.047 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 -0.07 0.189 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip -0.118 0.215 -9999.0 0.0 -0.482 42.0 42.0 LRP2 -0.07 0.232 -9999.0 0.0 -0.781 16.0 16.0 receptor-mediated endocytosis -0.087 0.196 -9999.0 0.0 -0.558 6.0 6.0 SHH Np/Cholesterol/BOC -0.115 0.215 -9999.0 0.0 -0.48 42.0 42.0 SHH Np/Cholesterol/CDO -0.112 0.219 -9999.0 0.0 -0.485 42.0 42.0 mesenchymal cell differentiation 0.118 0.213 0.479 42.0 -9999.0 0.0 42.0 mol:Vitamin D3 -0.081 0.202 -9999.0 0.0 -0.421 42.0 42.0 IHH N/PTCH2 0.019 0.053 -9999.0 0.0 -0.647 1.0 1.0 CDON 0.012 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.034 0.048 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 -0.045 0.181 -9999.0 0.0 -0.598 16.0 16.0 PTCH2 0.008 0.061 -9999.0 0.0 -0.781 1.0 1.0 SHH Np/Cholesterol -0.113 0.215 -9999.0 0.0 -0.482 42.0 42.0 PTCH1 0.031 0.047 -9999.0 0.0 -9999.0 0.0 0.0 HHIP 0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0