E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.015 0.026 -9999.0 0.0 -9999.0 0.0 0.0 KLHL20 0.047 0.061 0.191 9.0 -0.219 1.0 10.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.067 0.076 0.244 2.0 -9999.0 0.0 2.0 ENAH 0.015 0.027 -9999.0 0.0 -9999.0 0.0 0.0 AP1M1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.052 0.056 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.003 0.016 -9999.0 0.0 -0.152 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.029 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.067 0.084 0.273 4.0 -9999.0 0.0 4.0 CTNND1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.027 0.023 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.067 0.08 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin 0.051 0.013 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.032 0.021 -9999.0 0.0 -0.162 1.0 1.0 IQGAP1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.018 -9999.0 0.0 -0.122 1.0 1.0 DLG1 0.015 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.032 0.048 -9999.0 0.0 -0.133 11.0 11.0 PI3K -0.013 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.058 0.017 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.021 0.048 0.114 4.0 -9999.0 0.0 4.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.08 0.081 0.295 4.0 -9999.0 0.0 4.0 actin cytoskeleton organization 0.04 0.05 0.155 10.0 -0.16 1.0 11.0 CDC42/GDP 0.08 0.081 0.213 12.0 -9999.0 0.0 12.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.063 0.019 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.045 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.072 0.088 0.303 4.0 -9999.0 0.0 4.0 CDC42/GTP/IQGAP1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.09 0.079 0.297 4.0 -9999.0 0.0 4.0 RAC1/GTP/IQGAP1 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.038 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.035 0.04 0.126 14.0 -0.113 1.0 15.0 NME1 0.019 0.052 -9999.0 0.0 -0.359 3.0 3.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.015 0.027 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.006 0.018 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.019 0.026 0.09 7.0 -9999.0 0.0 7.0 Rap1/GTP 0.075 0.075 0.162 65.0 -9999.0 0.0 65.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.064 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.04 0.046 0.144 14.0 -0.137 1.0 15.0 VAV2 0.086 0.091 0.318 1.0 -0.408 1.0 2.0 RAP1/GDP 0.082 0.08 0.174 65.0 -9999.0 0.0 65.0 adherens junction assembly 0.015 0.026 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.049 0.029 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.011 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.008 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.001 0.036 -9999.0 0.0 -0.348 1.0 1.0 E-cadherin/beta catenin/alpha catenin 0.051 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.023 -9999.0 0.0 -9999.0 0.0 0.0