Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.021 0.073 0.237 11.0 -0.237 1.0 12.0 KIRREL 0.023 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.021 0.073 0.238 1.0 -0.237 11.0 12.0 PLCG1 0.015 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.041 0.077 0.229 1.0 -0.21 10.0 11.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.014 0.043 0.252 1.0 -0.22 2.0 3.0 FYN -0.01 0.064 0.218 5.0 -0.177 10.0 15.0 mol:Ca2+ 0.027 0.062 0.221 1.0 -0.234 5.0 6.0 mol:DAG 0.028 0.063 0.225 1.0 -0.235 5.0 6.0 NPHS2 -0.01 0.056 -9999.0 0.0 -0.377 3.0 3.0 mol:IP3 0.028 0.063 0.225 1.0 -0.235 5.0 6.0 regulation of endocytosis 0.03 0.061 0.209 1.0 -0.173 9.0 10.0 Nephrin/NEPH1/podocin/Cholesterol 0.03 0.067 0.212 1.0 -0.192 12.0 13.0 establishment of cell polarity 0.021 0.073 0.237 1.0 -0.237 11.0 12.0 Nephrin/NEPH1/podocin/NCK1-2 0.056 0.071 -9999.0 0.0 -0.211 6.0 6.0 Nephrin/NEPH1/beta Arrestin2 0.032 0.062 0.217 1.0 -0.175 9.0 10.0 NPHS1 0.008 0.092 0.334 2.0 -0.362 8.0 10.0 Nephrin/NEPH1/podocin 0.031 0.06 0.214 1.0 -0.174 11.0 12.0 TJP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.029 0.064 0.229 1.0 -0.236 5.0 6.0 CD2AP 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.043 0.073 0.229 1.0 -0.21 10.0 11.0 GRB2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.02 0.068 0.222 5.0 -0.199 10.0 15.0 cytoskeleton organization -0.008 0.049 0.226 2.0 -0.258 2.0 4.0 Nephrin/NEPH1 0.02 0.051 0.194 1.0 -0.158 11.0 12.0 Nephrin/NEPH1/ZO-1 0.034 0.064 0.225 1.0 -0.199 9.0 10.0