Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.019 0.068 -9999.0 0.0 -0.4 4.0 4.0 IHH 0.031 0.022 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.074 0.109 -9999.0 0.0 -0.177 78.0 78.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.073 0.108 0.176 78.0 -9999.0 0.0 78.0 SMO/beta Arrestin2 0.022 0.058 -9999.0 0.0 -0.265 3.0 3.0 SMO 0.007 0.046 -9999.0 0.0 -0.274 3.0 3.0 AKT1 -0.001 0.1 -9999.0 0.0 -0.349 9.0 9.0 ARRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.008 0.046 -9999.0 0.0 -0.271 3.0 3.0 STIL -0.02 0.098 0.204 10.0 -0.213 3.0 13.0 DHH N/PTCH2 0.036 0.023 -9999.0 0.0 -0.253 1.0 1.0 DHH N/PTCH1 0.037 0.042 -9999.0 0.0 -0.247 3.0 3.0 PIK3CA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.011 0.103 -9999.0 0.0 -0.73 3.0 3.0 determination of left/right symmetry 0.008 0.046 -9999.0 0.0 -0.271 3.0 3.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.011 0.102 -9999.0 0.0 -0.723 3.0 3.0 IHH N/Hhip 0.019 0.066 -9999.0 0.0 -0.184 15.0 15.0 DHH N/Hhip 0.018 0.058 -9999.0 0.0 -0.163 15.0 15.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.008 0.046 -9999.0 0.0 -0.271 3.0 3.0 pancreas development 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.036 0.018 -9999.0 0.0 -0.162 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.017 0.013 -9999.0 0.0 -9999.0 0.0 0.0 somite specification 0.008 0.046 -9999.0 0.0 -0.271 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.022 0.09 0.193 2.0 -0.219 3.0 5.0 SHH Np/Cholesterol/PTCH2 -0.029 0.096 0.19 2.0 -0.191 41.0 43.0 SHH Np/Cholesterol/Megalin -0.045 0.112 0.164 4.0 -0.207 50.0 54.0 SHH -0.062 0.12 0.375 3.0 -0.254 39.0 42.0 catabolic process 0.024 0.043 -9999.0 0.0 -0.275 3.0 3.0 SMO/Vitamin D3 -0.02 0.083 0.19 2.0 -0.25 3.0 5.0 SHH Np/Cholesterol/Hhip -0.041 0.099 0.19 2.0 -0.179 52.0 54.0 LRP2 -0.032 0.11 -9999.0 0.0 -0.359 16.0 16.0 receptor-mediated endocytosis -0.026 0.09 0.232 2.0 -0.274 5.0 7.0 SHH Np/Cholesterol/BOC -0.037 0.099 0.19 2.0 -0.184 48.0 50.0 SHH Np/Cholesterol/CDO -0.031 0.097 0.19 2.0 -0.192 42.0 44.0 mesenchymal cell differentiation 0.041 0.098 0.178 52.0 -0.188 2.0 54.0 mol:Vitamin D3 -0.015 0.101 0.209 9.0 -0.22 3.0 12.0 IHH N/PTCH2 0.038 0.03 -9999.0 0.0 -0.279 1.0 1.0 CDON 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.034 0.045 -9999.0 0.0 -0.276 3.0 3.0 Megalin/LRPAP1 0.007 0.086 -9999.0 0.0 -0.253 16.0 16.0 PTCH2 0.024 0.03 -9999.0 0.0 -0.359 1.0 1.0 SHH Np/Cholesterol -0.036 0.086 -9999.0 0.0 -0.187 40.0 40.0 PTCH1 0.024 0.043 -9999.0 0.0 -0.275 3.0 3.0 HHIP 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0