Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Reelin signaling pathway	27.0	1567.0	56.0	-0.193	0.072	1000.0	-1000.0	-0.036	-1000.0
Glypican 1 network	21.0	1010.0	48.0	-0.189	0.053	1000.0	-1000.0	-0.031	-1000.0
Ephrin A  reverse signaling	20.0	144.0	7.0	-0.045	0.018	1000.0	-1000.0	-0.017	-1000.0
Signaling events regulated by Ret tyrosine kinase	20.0	1688.0	82.0	-0.134	0.034	1000.0	-1000.0	-0.051	-1000.0
IL4-mediated signaling events	18.0	1686.0	91.0	-0.675	0.465	1000.0	-1000.0	-0.162	-1000.0
PDGFR-beta signaling pathway	15.0	1457.0	97.0	-0.078	0.094	1000.0	-1000.0	-0.058	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1414.0	97.0	-0.116	0.047	1000.0	-1000.0	-0.06	-1000.0
TCGA08_retinoblastoma	14.0	117.0	8.0	-0.04	0.031	1000.0	-1000.0	-0.007	-1000.0
Angiopoietin receptor Tie2-mediated signaling	14.0	1236.0	88.0	-0.123	0.038	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by the Hedgehog family	13.0	694.0	52.0	-0.074	0.073	1000.0	-1000.0	-0.025	-1000.0
HIF-1-alpha transcription factor network	13.0	992.0	76.0	-0.448	0.034	1000.0	-1000.0	-0.143	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	13.0	1085.0	78.0	-0.183	0.04	1000.0	-1000.0	-0.051	-1000.0
Syndecan-1-mediated signaling events	12.0	414.0	34.0	-0.335	0.036	1000.0	-1000.0	-0.039	-1000.0
Visual signal transduction: Cones	12.0	486.0	38.0	-0.076	0.037	1000.0	-1000.0	-0.02	-1000.0
TCGA08_p53	12.0	89.0	7.0	-0.047	0.028	1000.0	-1000.0	-0.01	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	620.0	54.0	-0.107	0.035	1000.0	-1000.0	-0.049	-1000.0
p75(NTR)-mediated signaling	11.0	1458.0	125.0	-0.374	0.069	1000.0	-1000.0	-0.067	-1000.0
Nongenotropic Androgen signaling	11.0	581.0	52.0	-0.158	0.044	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by PRL	11.0	387.0	34.0	-0.087	0.088	1000.0	-1000.0	-0.038	-1000.0
BCR signaling pathway	10.0	1076.0	99.0	-0.108	0.031	1000.0	-1000.0	-0.046	-1000.0
Plasma membrane estrogen receptor signaling	10.0	929.0	86.0	-0.376	0.106	1000.0	-1000.0	-0.045	-1000.0
Visual signal transduction: Rods	10.0	545.0	52.0	-0.103	0.029	1000.0	-1000.0	-0.036	-1000.0
FOXA2 and FOXA3 transcription factor networks	9.0	430.0	46.0	-0.335	0.03	1000.0	-1000.0	-0.129	-1000.0
BMP receptor signaling	9.0	772.0	81.0	-0.081	0.051	1000.0	-1000.0	-0.049	-1000.0
VEGFR1 specific signals	9.0	514.0	56.0	0.0	0.098	1000.0	-1000.0	-0.041	-1000.0
Ras signaling in the CD4+ TCR pathway	9.0	155.0	17.0	-0.069	0.045	1000.0	-1000.0	-0.025	-1000.0
Endothelins	8.0	827.0	96.0	-0.367	0.092	1000.0	-1000.0	-0.059	-1000.0
Signaling mediated by p38-alpha and p38-beta	8.0	359.0	44.0	-0.035	0.027	1000.0	-1000.0	-0.033	-1000.0
Effects of Botulinum toxin	8.0	224.0	26.0	-0.076	0.047	1000.0	-1000.0	-0.011	-1000.0
Syndecan-2-mediated signaling events	7.0	519.0	69.0	-0.138	0.045	1000.0	-1000.0	-0.034	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	431.0	61.0	-0.16	0.085	1000.0	-1000.0	-0.041	-1000.0
TCR signaling in naïve CD8+ T cells	7.0	733.0	93.0	-0.038	0.041	1000.0	-1000.0	-0.043	-1000.0
Canonical Wnt signaling pathway	7.0	361.0	51.0	-0.16	0.09	1000.0	-1000.0	-0.036	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	230.0	31.0	-0.183	0.026	1000.0	-1000.0	-0.047	-1000.0
Wnt signaling	7.0	54.0	7.0	-0.057	0.023	1000.0	-1000.0	-0.016	-1000.0
LPA receptor mediated events	7.0	760.0	102.0	-0.142	0.034	1000.0	-1000.0	-0.06	-1000.0
Coregulation of Androgen receptor activity	6.0	516.0	76.0	-0.127	0.063	1000.0	-1000.0	-0.022	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	205.0	34.0	-0.021	0.056	1000.0	-1000.0	-0.032	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	117.0	17.0	-0.145	0.058	1000.0	-1000.0	-0.035	-1000.0
amb2 Integrin signaling	6.0	506.0	82.0	-0.126	0.045	1000.0	-1000.0	-0.044	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	102.0	15.0	-0.124	0.026	1000.0	-1000.0	-0.035	-1000.0
EPHB forward signaling	6.0	528.0	85.0	-0.036	0.069	1000.0	-1000.0	-0.06	-1000.0
IGF1 pathway	6.0	364.0	57.0	-0.034	0.051	1000.0	-1000.0	-0.051	-1000.0
Caspase cascade in apoptosis	5.0	440.0	74.0	-0.08	0.063	1000.0	-1000.0	-0.05	-1000.0
Osteopontin-mediated events	5.0	227.0	38.0	-0.071	0.039	1000.0	-1000.0	-0.05	-1000.0
Noncanonical Wnt signaling pathway	5.0	133.0	26.0	-0.057	0.038	1000.0	-1000.0	-0.041	-1000.0
Nectin adhesion pathway	5.0	370.0	63.0	-0.324	0.072	1000.0	-1000.0	-0.041	-1000.0
S1P5 pathway	5.0	100.0	17.0	-0.098	0.088	1000.0	-1000.0	-0.015	-1000.0
S1P1 pathway	5.0	184.0	36.0	-0.135	0.028	1000.0	-1000.0	-0.046	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	616.0	120.0	-0.072	0.073	1000.0	-1000.0	-0.042	-1000.0
S1P4 pathway	5.0	130.0	25.0	-0.097	0.044	1000.0	-1000.0	-0.025	-1000.0
Regulation of Androgen receptor activity	5.0	367.0	70.0	-0.199	0.055	1000.0	-1000.0	-0.051	-1000.0
Aurora B signaling	5.0	367.0	67.0	-0.425	0.101	1000.0	-1000.0	-0.03	-1000.0
Thromboxane A2 receptor signaling	4.0	513.0	105.0	-0.066	0.04	1000.0	-1000.0	-0.042	-1000.0
Arf6 signaling events	4.0	304.0	62.0	-0.036	0.063	1000.0	-1000.0	-0.031	-1000.0
PLK1 signaling events	4.0	389.0	85.0	-0.009	0.056	1000.0	-1000.0	-0.029	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	275.0	68.0	-0.056	0.066	1000.0	-1000.0	-0.035	-1000.0
Glucocorticoid receptor regulatory network	4.0	467.0	114.0	-0.201	0.101	1000.0	-1000.0	-0.067	-1000.0
Ceramide signaling pathway	4.0	375.0	76.0	-0.032	0.067	1000.0	-1000.0	-0.035	-1000.0
HIF-2-alpha transcription factor network	4.0	195.0	43.0	-0.177	0.082	1000.0	-1000.0	-0.07	-1000.0
EGFR-dependent Endothelin signaling events	4.0	101.0	21.0	-0.035	0.038	1000.0	-1000.0	-0.041	-1000.0
Syndecan-4-mediated signaling events	4.0	288.0	67.0	-0.134	0.046	1000.0	-1000.0	-0.034	-1000.0
S1P3 pathway	4.0	192.0	42.0	-0.092	0.043	1000.0	-1000.0	-0.028	-1000.0
FOXM1 transcription factor network	4.0	248.0	51.0	-0.289	0.026	1000.0	-1000.0	-0.165	-1000.0
Signaling events mediated by PTP1B	3.0	295.0	76.0	-0.033	0.055	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	3.0	191.0	55.0	-0.007	0.066	1000.0	-1000.0	-0.044	-1000.0
Insulin-mediated glucose transport	3.0	97.0	32.0	-0.143	0.044	1000.0	-1000.0	-0.027	-1000.0
mTOR signaling pathway	3.0	168.0	53.0	-0.059	0.034	1000.0	-1000.0	-0.046	-1000.0
IFN-gamma pathway	3.0	247.0	68.0	-0.04	0.037	1000.0	-1000.0	-0.054	-1000.0
IL1-mediated signaling events	3.0	210.0	62.0	-0.041	0.06	1000.0	-1000.0	-0.04	-1000.0
Ephrin B reverse signaling	3.0	153.0	48.0	-0.041	0.043	1000.0	-1000.0	-0.028	-1000.0
FAS signaling pathway (CD95)	3.0	141.0	47.0	-0.019	0.046	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	3.0	231.0	58.0	-0.152	0.048	1000.0	-1000.0	-0.031	-1000.0
Syndecan-3-mediated signaling events	3.0	137.0	35.0	-0.11	0.069	1000.0	-1000.0	-0.03	-1000.0
Integrins in angiogenesis	3.0	327.0	84.0	-0.079	0.061	1000.0	-1000.0	-0.04	-1000.0
Regulation of p38-alpha and p38-beta	3.0	163.0	54.0	-0.042	0.053	1000.0	-1000.0	-0.042	-1000.0
Glypican 2 network	3.0	12.0	4.0	0.018	0.03	1000.0	-1000.0	0.01	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	242.0	76.0	-0.013	0.09	1000.0	-1000.0	-0.062	-1000.0
Class I PI3K signaling events	3.0	263.0	73.0	-0.017	0.042	1000.0	-1000.0	-0.041	-1000.0
IL23-mediated signaling events	3.0	233.0	60.0	-0.155	0.035	1000.0	-1000.0	-0.124	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	130.0	33.0	-0.039	0.063	1000.0	-1000.0	-0.021	-1000.0
ErbB2/ErbB3 signaling events	2.0	190.0	65.0	-0.034	0.038	1000.0	-1000.0	-0.06	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	317.0	136.0	-0.119	0.05	1000.0	-1000.0	-0.044	-1000.0
IL12-mediated signaling events	2.0	249.0	87.0	-0.035	0.055	1000.0	-1000.0	-0.091	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	58.0	28.0	-0.084	0.043	1000.0	-1000.0	-0.022	-1000.0
Cellular roles of Anthrax toxin	2.0	93.0	39.0	-0.014	0.032	1000.0	-1000.0	-0.02	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	200.0	85.0	-0.026	0.061	1000.0	-1000.0	-0.046	-1000.0
Arf6 downstream pathway	2.0	93.0	43.0	-0.029	0.041	1000.0	-1000.0	-0.028	-1000.0
PDGFR-alpha signaling pathway	2.0	114.0	44.0	-0.012	0.066	1000.0	-1000.0	-0.039	-1000.0
ceramide signaling pathway	2.0	112.0	49.0	-0.0	0.043	1000.0	-1000.0	-0.038	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	244.0	83.0	-0.118	0.069	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	2.0	139.0	64.0	-0.04	0.068	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	271.0	125.0	-0.015	0.094	1000.0	-1000.0	-0.051	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	2.0	191.0	68.0	-0.183	0.035	1000.0	-1000.0	-0.097	-1000.0
Arf6 trafficking events	2.0	159.0	71.0	-0.046	0.048	1000.0	-1000.0	-0.028	-1000.0
Regulation of Telomerase	2.0	249.0	102.0	-0.177	0.064	1000.0	-1000.0	-0.049	-1000.0
Insulin Pathway	2.0	155.0	74.0	-0.019	0.086	1000.0	-1000.0	-0.054	-1000.0
Arf1 pathway	2.0	150.0	54.0	-0.005	0.068	1000.0	-1000.0	-0.019	-1000.0
LPA4-mediated signaling events	1.0	14.0	12.0	-0.018	0.0	1000.0	-1000.0	-0.02	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.026	0.035	1000.0	-1000.0	0.007	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	88.0	65.0	-0.09	0.047	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class III	1.0	62.0	40.0	-0.048	0.05	1000.0	-1000.0	-0.023	-1000.0
TRAIL signaling pathway	1.0	64.0	48.0	-0.012	0.052	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	89.0	52.0	-0.102	0.061	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by HDAC Class I	1.0	105.0	104.0	-0.052	0.063	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by PI3K	1.0	96.0	58.0	-0.012	0.042	1000.0	-1000.0	-0.048	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	71.0	45.0	0.001	0.068	1000.0	-1000.0	-0.045	-1000.0
IL27-mediated signaling events	1.0	97.0	51.0	-0.062	0.057	1000.0	-1000.0	-0.04	-1000.0
TCGA08_rtk_signaling	1.0	51.0	26.0	-0.023	0.062	1000.0	-1000.0	-0.016	-1000.0
IL6-mediated signaling events	1.0	138.0	75.0	-0.018	0.061	1000.0	-1000.0	-0.078	-1000.0
Rapid glucocorticoid signaling	1.0	21.0	20.0	-0.016	0.028	1000.0	-1000.0	-0.011	-1000.0
p38 MAPK signaling pathway	1.0	57.0	44.0	-0.005	0.052	1000.0	-1000.0	-0.023	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	0.011	0.035	1000.0	-1000.0	-0.032	-1000.0
Canonical NF-kappaB pathway	0.0	21.0	39.0	-0.008	0.054	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class II	0.0	51.0	75.0	-0.015	0.07	1000.0	-1000.0	-0.03	-1000.0
ErbB4 signaling events	0.0	67.0	69.0	-0.047	0.087	1000.0	-1000.0	-0.045	-1000.0
BARD1 signaling events	0.0	18.0	57.0	-0.056	0.072	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.014	0.025	1000.0	-1000.0	-0.024	-1000.0
Circadian rhythm pathway	0.0	10.0	22.0	-0.01	0.058	1000.0	-1000.0	-0.044	-1000.0
Aurora A signaling	0.0	33.0	60.0	-0.01	0.073	1000.0	-1000.0	-0.021	-1000.0
Aurora C signaling	0.0	1.0	7.0	-0.0	0.042	1000.0	-1000.0	-0.011	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	35.0	37.0	-0.013	0.065	1000.0	-1000.0	-0.03	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.05	0.053	1000.0	-1000.0	-0.037	-1000.0
Atypical NF-kappaB pathway	0.0	4.0	31.0	-0.011	0.06	1000.0	-1000.0	-0.021	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	60.0	74.0	-0.053	0.066	1000.0	-1000.0	-0.059	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.015	0.048	1000.0	-1000.0	-0.036	-1000.0
IL2 signaling events mediated by STAT5	0.0	9.0	22.0	-0.005	0.036	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	0.0	25.0	43.0	-0.043	0.081	1000.0	-1000.0	-0.035	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.026	0.026	1000.0	-1000.0	-0.012	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.026	0.052	1000.0	-1000.0	0.01	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.072	1000.0	-1000.0	0.0	-1000.0
Total	656	42211	7203	-11.9027766101	7.42640056047	131000	-131000	-5.43114757233	-131000