Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.041 0.002 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.152 0.125 -9999.0 0.0 -0.24 46.0 46.0 LRPAP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.152 0.124 0.239 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 0.047 0.053 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.03 0.037 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.004 0.111 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.007 0.13 -9999.0 0.0 -0.428 6.0 6.0 ADRBK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.03 0.037 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.001 0.076 0.355 1.0 -9999.0 0.0 1.0 DHH N/PTCH2 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.052 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.031 0.015 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.03 0.037 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.031 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.033 0.161 -9999.0 0.0 -0.338 15.0 15.0 DHH N/Hhip -0.031 0.146 -9999.0 0.0 -0.308 15.0 15.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.03 0.037 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.068 0.19 -9999.0 0.0 -0.428 15.0 15.0 HHAT 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.301 0.206 -9999.0 0.0 -0.428 50.0 50.0 somite specification 0.03 0.037 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.032 0.021 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.026 0.021 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.024 0.025 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.015 0.017 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.038 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.03 0.034 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip -0.031 0.114 -9999.0 0.0 -0.246 15.0 15.0 LRP2 0.03 0.023 -9999.0 0.0 -0.161 1.0 1.0 receptor-mediated endocytosis 0.025 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.008 0.077 -9999.0 0.0 -0.263 5.0 5.0 SHH Np/Cholesterol/CDO 0.017 0.05 -9999.0 0.0 -0.238 2.0 2.0 mesenchymal cell differentiation 0.031 0.113 0.245 15.0 -9999.0 0.0 15.0 mol:Vitamin D3 0.044 0.059 0.376 1.0 -9999.0 0.0 1.0 IHH N/PTCH2 0.053 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.019 0.077 -9999.0 0.0 -0.428 2.0 2.0 IHH N/PTCH1 0.049 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.046 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.038 0.008 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.068 0.19 -9999.0 0.0 -0.428 15.0 15.0