E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.195 0.232 -9999.0 0.0 -0.459 105.0 105.0 KLHL20 -0.055 0.091 0.166 1.0 -0.254 4.0 5.0 CYFIP2 -0.041 0.175 -9999.0 0.0 -0.549 27.0 27.0 Rac1/GDP -0.112 0.139 -9999.0 0.0 -0.311 58.0 58.0 ENAH -0.195 0.232 -9999.0 0.0 -0.457 106.0 106.0 AP1M1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.017 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.095 0.097 -9999.0 0.0 -0.258 2.0 2.0 ABI1/Sra1/Nap1 -0.063 0.064 -9999.0 0.0 -0.186 25.0 25.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.102 0.178 -9999.0 0.0 -0.325 96.0 96.0 RAPGEF1 -0.171 0.202 -9999.0 0.0 -0.405 97.0 97.0 CTNND1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.202 0.238 -9999.0 0.0 -0.467 107.0 107.0 CRK -0.184 0.213 -9999.0 0.0 -0.431 100.0 100.0 E-cadherin/gamma catenin/alpha catenin -0.118 0.186 -9999.0 0.0 -0.351 96.0 96.0 alphaE/beta7 Integrin 0.027 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.029 0.027 -9999.0 0.0 -0.32 1.0 1.0 DLG1 -0.197 0.232 -9999.0 0.0 -0.456 107.0 107.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.075 0.071 -9999.0 0.0 -0.192 3.0 3.0 MLLT4 0.016 0.036 -9999.0 0.0 -0.549 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.036 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.095 0.091 -9999.0 0.0 -0.249 2.0 2.0 ARF6 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.148 0.211 -9999.0 0.0 -0.406 100.0 100.0 TIAM1 0.024 0.036 0.254 6.0 -9999.0 0.0 6.0 E-cadherin(dimer)/Ca2+ -0.098 0.167 -9999.0 0.0 -0.306 96.0 96.0 AKT1 -0.051 0.062 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.015 0.254 1.0 -9999.0 0.0 1.0 CDH1 -0.206 0.278 0.254 2.0 -0.549 101.0 103.0 RhoA/GDP -0.118 0.146 -9999.0 0.0 -0.311 65.0 65.0 actin cytoskeleton organization -0.04 0.069 0.142 2.0 -0.184 4.0 6.0 CDC42/GDP -0.117 0.144 -9999.0 0.0 -0.312 63.0 63.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.103 0.134 -9999.0 0.0 -0.268 95.0 95.0 ITGB7 0.021 0.021 0.254 2.0 -9999.0 0.0 2.0 RAC1 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.103 0.178 -9999.0 0.0 -0.325 96.0 96.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.102 0.16 -9999.0 0.0 -0.302 97.0 97.0 mol:GDP -0.135 0.165 -9999.0 0.0 -0.357 66.0 66.0 CDC42/GTP/IQGAP1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.112 0.155 -9999.0 0.0 -0.319 65.0 65.0 RAC1/GTP/IQGAP1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.026 0.053 0.217 2.0 -0.249 1.0 3.0 NME1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.196 0.229 -9999.0 0.0 -0.457 102.0 102.0 regulation of cell-cell adhesion -0.084 0.085 -9999.0 0.0 -0.217 62.0 62.0 WASF2 -0.032 0.041 -9999.0 0.0 -0.126 2.0 2.0 Rap1/GTP -0.098 0.116 -9999.0 0.0 -0.285 3.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.089 0.172 -9999.0 0.0 -0.31 91.0 91.0 CCND1 -0.033 0.06 0.229 1.0 -0.314 1.0 2.0 VAV2 -0.188 0.233 -9999.0 0.0 -0.63 13.0 13.0 RAP1/GDP -0.1 0.129 -9999.0 0.0 -0.304 11.0 11.0 adherens junction assembly -0.189 0.222 -9999.0 0.0 -0.442 102.0 102.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.095 0.161 -9999.0 0.0 -0.302 91.0 91.0 E-cadherin/beta catenin -0.152 0.188 -9999.0 0.0 -0.369 108.0 108.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.196 0.228 -9999.0 0.0 -0.449 107.0 107.0 PIK3CA 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.102 0.126 0.298 1.0 -0.36 10.0 11.0 E-cadherin/beta catenin/alpha catenin -0.119 0.186 -9999.0 0.0 -0.352 97.0 97.0 ITGAE 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.206 0.243 -9999.0 0.0 -0.477 107.0 107.0