Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.103 0.131 -9999.0 0.0 -0.264 93.0 93.0 epithelial cell differentiation -0.099 0.163 -9999.0 0.0 -0.303 96.0 96.0 CYFIP2 -0.041 0.175 -9999.0 0.0 -0.549 27.0 27.0 ENAH -0.094 0.099 0.243 1.0 -9999.0 0.0 1.0 EGFR 0.016 0.039 0.254 1.0 -0.549 1.0 2.0 EPHA2 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.123 0.137 -9999.0 0.0 -0.295 96.0 96.0 CTNNB1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.118 -9999.0 0.0 -0.352 26.0 26.0 AQP5 -0.115 0.151 -9999.0 0.0 -0.528 11.0 11.0 CTNND1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.122 0.133 -9999.0 0.0 -0.291 94.0 94.0 regulation of calcium-dependent cell-cell adhesion -0.129 0.14 -9999.0 0.0 -0.296 100.0 100.0 EGF -0.21 0.275 -9999.0 0.0 -0.549 101.0 101.0 NCKAP1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.218 0.234 -9999.0 0.0 -0.573 62.0 62.0 cortical microtubule organization -0.099 0.163 -9999.0 0.0 -0.303 96.0 96.0 GO:0000145 -0.117 0.127 -9999.0 0.0 -0.278 94.0 94.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.098 0.166 -9999.0 0.0 -0.306 96.0 96.0 MLLT4 0.016 0.036 -9999.0 0.0 -0.549 1.0 1.0 ARF6/GDP -0.12 0.114 -9999.0 0.0 -0.276 86.0 86.0 ARF6 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.11 0.13 -9999.0 0.0 -0.277 88.0 88.0 PVRL2 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.122 0.135 -9999.0 0.0 -0.295 92.0 92.0 ARF6/GTP 0.046 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.207 0.278 0.254 2.0 -0.549 101.0 103.0 EGFR/EGFR/EGF/EGF -0.202 0.215 -9999.0 0.0 -0.381 136.0 136.0 RhoA/GDP -0.094 0.158 -9999.0 0.0 -0.292 96.0 96.0 actin cytoskeleton organization -0.12 0.134 -9999.0 0.0 -0.291 95.0 95.0 IGF-1R heterotetramer 0.014 0.05 -9999.0 0.0 -0.548 2.0 2.0 GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.014 0.05 -9999.0 0.0 -0.549 2.0 2.0 IGF1 0.019 0.075 0.254 8.0 -0.549 3.0 11.0 DIAPH1 -0.077 0.245 -9999.0 0.0 -0.662 33.0 33.0 Wnt receptor signaling pathway 0.099 0.163 0.303 96.0 -9999.0 0.0 96.0 RHOA 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.123 0.115 -9999.0 0.0 -0.278 88.0 88.0 CTNNA1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.123 0.137 -9999.0 0.0 -0.297 95.0 95.0 EFNA1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.118 0.132 -9999.0 0.0 -0.286 93.0 93.0 Ephrin A1/EPHA2 -0.094 0.15 -9999.0 0.0 -0.29 89.0 89.0 SEC6/SEC8 -0.109 0.115 -9999.0 0.0 -0.283 73.0 73.0 MGAT3 -0.13 0.142 -9999.0 0.0 -0.301 100.0 100.0 HGF/MET -0.104 0.159 -9999.0 0.0 -0.299 96.0 96.0 HGF -0.004 0.11 -9999.0 0.0 -0.549 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.103 0.132 -9999.0 0.0 -0.266 93.0 93.0 actin cable formation -0.089 0.108 -9999.0 0.0 -0.294 20.0 20.0 KIAA1543 -0.122 0.135 -9999.0 0.0 -0.288 96.0 96.0 KIFC3 -0.123 0.14 -9999.0 0.0 -0.298 96.0 96.0 NCK1 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.123 0.136 -9999.0 0.0 -0.295 95.0 95.0 NCK1/GIT1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.099 0.163 -9999.0 0.0 -0.303 96.0 96.0 EXOC4 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.124 0.136 -9999.0 0.0 -0.295 96.0 96.0 PIP5K1C -0.124 0.135 -9999.0 0.0 -0.295 94.0 94.0 LIMA1 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.103 0.116 0.263 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.126 0.14 -9999.0 0.0 -0.517 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.094 0.152 -9999.0 0.0 -0.293 85.0 85.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.024 0.028 -9999.0 0.0 -0.407 1.0 1.0 MET 0.012 0.061 -9999.0 0.0 -0.549 3.0 3.0 PLEKHA7 -0.128 0.141 -9999.0 0.0 -0.302 96.0 96.0 mol:GTP 0.043 0.016 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.089 0.142 0.301 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization -0.103 0.131 -9999.0 0.0 -0.264 93.0 93.0 regulation of cell-cell adhesion -0.12 0.134 -9999.0 0.0 -0.291 95.0 95.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.103 0.132 -9999.0 0.0 -0.266 93.0 93.0