E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.09 0.196 -9999.0 0.0 -0.398 102.0 102.0 KLHL20 -0.014 0.096 0.207 7.0 -0.212 25.0 32.0 CYFIP2 0.015 0.09 -9999.0 0.0 -0.417 15.0 15.0 Rac1/GDP -0.033 0.126 0.255 1.0 -0.246 77.0 78.0 ENAH -0.086 0.191 -9999.0 0.0 -0.389 99.0 99.0 AP1M1 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.012 0.092 -9999.0 0.0 -0.176 69.0 69.0 ABI1/Sra1/Nap1 -0.037 0.052 -9999.0 0.0 -0.149 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.033 0.163 -9999.0 0.0 -0.25 125.0 125.0 RAPGEF1 -0.069 0.173 0.239 3.0 -0.355 91.0 94.0 CTNND1 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.087 0.207 -9999.0 0.0 -0.409 104.0 104.0 CRK -0.078 0.185 -9999.0 0.0 -0.381 93.0 93.0 E-cadherin/gamma catenin/alpha catenin -0.018 0.137 -9999.0 0.0 -0.249 93.0 93.0 alphaE/beta7 Integrin 0.004 0.115 -9999.0 0.0 -0.291 48.0 48.0 IQGAP1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.035 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.051 0.03 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.089 0.198 -9999.0 0.0 -0.403 101.0 101.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.025 0.059 -9999.0 0.0 -0.134 71.0 71.0 MLLT4 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.047 0.069 -9999.0 0.0 -0.224 21.0 21.0 PI3K -0.027 0.077 -9999.0 0.0 -0.169 70.0 70.0 ARF6 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.041 0.15 -9999.0 0.0 -0.295 94.0 94.0 TIAM1 0.008 0.105 -9999.0 0.0 -0.417 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.0 0.127 -9999.0 0.0 -0.212 93.0 93.0 AKT1 -0.008 0.057 0.156 4.0 -9999.0 0.0 4.0 PIK3R1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.082 0.197 -9999.0 0.0 -0.417 94.0 94.0 RhoA/GDP -0.029 0.135 0.282 4.0 -0.247 81.0 85.0 actin cytoskeleton organization -0.008 0.075 0.176 8.0 -0.157 24.0 32.0 CDC42/GDP -0.03 0.135 0.282 4.0 -0.246 82.0 86.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.037 0.105 -9999.0 0.0 -0.212 96.0 96.0 ITGB7 -0.026 0.154 -9999.0 0.0 -0.417 49.0 49.0 RAC1 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.001 0.136 -9999.0 0.0 -0.227 93.0 93.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.013 0.117 -9999.0 0.0 -0.211 93.0 93.0 mol:GDP -0.05 0.143 0.283 4.0 -0.28 83.0 87.0 CDC42/GTP/IQGAP1 0.045 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.022 0.141 0.272 3.0 -0.253 79.0 82.0 RAC1/GTP/IQGAP1 0.041 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.051 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.001 0.056 0.144 11.0 -0.108 18.0 29.0 NME1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.09 0.198 -9999.0 0.0 -0.403 101.0 101.0 regulation of cell-cell adhesion -0.019 0.076 -9999.0 0.0 -0.156 76.0 76.0 WASF2 -0.005 0.043 0.102 5.0 -0.093 10.0 15.0 Rap1/GTP -0.014 0.102 -9999.0 0.0 -0.193 71.0 71.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.022 0.161 -9999.0 0.0 -0.234 126.0 126.0 CCND1 -0.0 0.066 0.164 11.0 -0.13 18.0 29.0 VAV2 -0.095 0.244 0.366 1.0 -0.446 101.0 102.0 RAP1/GDP -0.013 0.118 0.298 3.0 -0.207 79.0 82.0 adherens junction assembly -0.086 0.193 -9999.0 0.0 -0.391 101.0 101.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.03 0.148 -9999.0 0.0 -0.227 123.0 123.0 E-cadherin/beta catenin -0.07 0.145 -9999.0 0.0 -0.311 97.0 97.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.087 0.193 -9999.0 0.0 -0.393 100.0 100.0 PIK3CA 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.059 0.123 -9999.0 0.0 -0.343 28.0 28.0 E-cadherin/beta catenin/alpha catenin -0.017 0.137 -9999.0 0.0 -0.249 93.0 93.0 ITGAE 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.088 0.21 -9999.0 0.0 -0.419 103.0 103.0