Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.03 0.105 -9999.0 0.0 -0.206 94.0 94.0 epithelial cell differentiation -0.004 0.123 -9999.0 0.0 -0.211 93.0 93.0 CYFIP2 0.015 0.09 -9999.0 0.0 -0.417 15.0 15.0 ENAH -0.033 0.075 0.316 2.0 -0.261 1.0 3.0 EGFR 0.027 0.035 -9999.0 0.0 -0.417 2.0 2.0 EPHA2 0.03 0.047 -9999.0 0.0 -0.417 4.0 4.0 MYO6 -0.034 0.102 0.213 7.0 -0.202 93.0 100.0 CTNNB1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.065 -9999.0 0.0 -0.244 15.0 15.0 AQP5 -0.03 0.088 -9999.0 0.0 -0.352 2.0 2.0 CTNND1 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.032 0.101 0.214 6.0 -0.201 91.0 97.0 regulation of calcium-dependent cell-cell adhesion -0.038 0.106 0.214 6.0 -0.204 98.0 104.0 EGF 0.001 0.114 -9999.0 0.0 -0.417 25.0 25.0 NCKAP1 0.035 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.08 0.16 0.395 1.0 -0.42 47.0 48.0 cortical microtubule organization -0.004 0.123 -9999.0 0.0 -0.211 93.0 93.0 GO:0000145 -0.048 0.088 0.194 7.0 -0.192 91.0 98.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.127 -9999.0 0.0 -0.212 93.0 93.0 MLLT4 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.051 0.074 -9999.0 0.0 -0.188 79.0 79.0 ARF6 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.073 0.044 -9999.0 0.0 -0.227 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.032 0.088 0.227 4.0 -0.24 3.0 7.0 PVRL2 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.029 0.098 0.223 5.0 -0.203 82.0 87.0 ARF6/GTP 0.08 0.047 -9999.0 0.0 -0.212 3.0 3.0 CDH1 -0.082 0.197 -9999.0 0.0 -0.417 94.0 94.0 EGFR/EGFR/EGF/EGF -0.026 0.124 -9999.0 0.0 -0.213 104.0 104.0 RhoA/GDP -0.001 0.12 -9999.0 0.0 -0.201 93.0 93.0 actin cytoskeleton organization -0.04 0.098 0.198 7.0 -0.2 93.0 100.0 IGF-1R heterotetramer 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.03 0.041 -9999.0 0.0 -0.417 3.0 3.0 DIAPH1 -0.017 0.218 -9999.0 0.0 -0.569 36.0 36.0 Wnt receptor signaling pathway 0.004 0.123 0.211 93.0 -9999.0 0.0 93.0 RHOA 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.075 -9999.0 0.0 -0.19 79.0 79.0 CTNNA1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.041 0.099 0.199 7.0 -0.204 93.0 100.0 EFNA1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.051 0.09 0.209 6.0 -0.196 89.0 95.0 Ephrin A1/EPHA2 -0.006 0.11 -9999.0 0.0 -0.201 83.0 83.0 SEC6/SEC8 -0.032 0.083 -9999.0 0.0 -0.19 78.0 78.0 MGAT3 -0.039 0.107 0.216 6.0 -0.207 98.0 104.0 HGF/MET -0.019 0.127 -9999.0 0.0 -0.222 94.0 94.0 HGF 0.024 0.058 -9999.0 0.0 -0.417 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.03 0.106 -9999.0 0.0 -0.207 94.0 94.0 actin cable formation 0.003 0.108 0.28 17.0 -0.26 7.0 24.0 KIAA1543 -0.056 0.095 0.187 9.0 -0.197 104.0 113.0 KIFC3 -0.035 0.102 0.216 6.0 -0.203 93.0 99.0 NCK1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.034 0.104 0.235 4.0 -0.203 94.0 98.0 NCK1/GIT1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.004 0.123 -9999.0 0.0 -0.211 93.0 93.0 EXOC4 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.033 0.104 0.213 7.0 -0.203 93.0 100.0 PIP5K1C -0.032 0.103 0.216 6.0 -0.203 91.0 97.0 LIMA1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.026 0.104 0.517 3.0 -0.302 1.0 4.0 adherens junction assembly -0.042 0.102 0.301 3.0 -0.366 6.0 9.0 IGF-1R heterotetramer/IGF1 -0.008 0.114 -9999.0 0.0 -0.198 94.0 94.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.006 0.102 -9999.0 0.0 -0.417 20.0 20.0 PLEKHA7 -0.042 0.109 0.216 6.0 -0.207 104.0 110.0 mol:GTP 0.071 0.043 -9999.0 0.0 -0.226 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.013 0.12 0.324 11.0 -9999.0 0.0 11.0 cortical actin cytoskeleton stabilization -0.03 0.105 -9999.0 0.0 -0.206 94.0 94.0 regulation of cell-cell adhesion -0.04 0.098 0.198 7.0 -0.2 93.0 100.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.03 0.106 -9999.0 0.0 -0.207 94.0 94.0