Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
BCR signaling pathway	125.0	12407.0	99.0	-0.714	0.043	1000.0	-1000.0	-0.049	-1000.0
IL4-mediated signaling events	120.0	10991.0	91.0	-1.251	1.002	1000.0	-1000.0	-0.062	-1000.0
TCR signaling in naïve CD8+ T cells	105.0	9767.0	93.0	-0.559	0.123	1000.0	-1000.0	-0.034	-1000.0
IL23-mediated signaling events	105.0	6315.0	60.0	-0.762	0.034	1000.0	-1000.0	-0.011	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	81.0	2783.0	34.0	-0.148	0.035	1000.0	-1000.0	-0.024	-1000.0
IL12-mediated signaling events	76.0	6689.0	87.0	-0.674	0.113	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	61.0	4214.0	68.0	-0.575	0.12	1000.0	-1000.0	-0.037	-1000.0
Caspase cascade in apoptosis	59.0	4407.0	74.0	-0.161	0.124	1000.0	-1000.0	-0.022	-1000.0
Calcium signaling in the CD4+ TCR pathway	56.0	1761.0	31.0	-0.347	0.035	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling events	56.0	282.0	5.0	-0.082	0.035	1000.0	-1000.0	0.017	-1000.0
IL27-mediated signaling events	55.0	2841.0	51.0	-0.262	0.173	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	54.0	934.0	17.0	-0.22	0.033	1000.0	-1000.0	-0.02	-1000.0
Ras signaling in the CD4+ TCR pathway	51.0	876.0	17.0	-0.139	0.063	1000.0	-1000.0	-0.008	-1000.0
FAS signaling pathway (CD95)	50.0	2395.0	47.0	-0.094	0.076	1000.0	-1000.0	-0.025	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	47.0	3484.0	74.0	-0.082	0.08	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling in the nascent adherens junction	46.0	3531.0	76.0	-0.095	0.051	1000.0	-1000.0	-0.034	-1000.0
a4b1 and a4b7 Integrin signaling	42.0	210.0	5.0	-0.031	0.01	1000.0	-1000.0	0.016	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	40.0	1825.0	45.0	-0.171	0.072	1000.0	-1000.0	-0.017	-1000.0
Thromboxane A2 receptor signaling	39.0	4147.0	105.0	-0.121	0.057	1000.0	-1000.0	-0.025	-1000.0
IL2 signaling events mediated by PI3K	39.0	2303.0	58.0	-0.15	0.06	1000.0	-1000.0	-0.028	-1000.0
amb2 Integrin signaling	38.0	3163.0	82.0	-0.183	0.044	1000.0	-1000.0	-0.013	-1000.0
Glucocorticoid receptor regulatory network	38.0	4378.0	114.0	-0.42	0.234	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	38.0	3187.0	82.0	-0.068	0.035	1000.0	-1000.0	-0.027	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	37.0	1375.0	37.0	-0.219	0.049	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events	37.0	2736.0	73.0	-0.376	0.069	1000.0	-1000.0	-0.021	-1000.0
Angiopoietin receptor Tie2-mediated signaling	37.0	3280.0	88.0	-0.209	0.046	1000.0	-1000.0	-0.052	-1000.0
IL2 signaling events mediated by STAT5	36.0	799.0	22.0	-0.164	0.036	1000.0	-1000.0	-0.018	-1000.0
S1P4 pathway	35.0	892.0	25.0	-0.111	0.045	1000.0	-1000.0	-0.009	-1000.0
IFN-gamma pathway	34.0	2379.0	68.0	-0.121	0.045	1000.0	-1000.0	-0.033	-1000.0
Endothelins	33.0	3185.0	96.0	-0.146	0.036	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling in keratinocytes	33.0	1454.0	43.0	-0.082	0.037	1000.0	-1000.0	-0.012	-1000.0
ceramide signaling pathway	32.0	1590.0	49.0	-0.102	0.05	1000.0	-1000.0	-0.023	-1000.0
Syndecan-1-mediated signaling events	31.0	1083.0	34.0	-0.095	0.035	1000.0	-1000.0	-0.014	-1000.0
Fc-epsilon receptor I signaling in mast cells	31.0	3050.0	97.0	-0.104	0.06	1000.0	-1000.0	-0.032	-1000.0
HIF-1-alpha transcription factor network	28.0	2190.0	76.0	-0.082	0.107	1000.0	-1000.0	-0.001	-1000.0
LPA receptor mediated events	28.0	2916.0	102.0	-0.072	0.045	1000.0	-1000.0	-0.06	-1000.0
Syndecan-4-mediated signaling events	28.0	1922.0	67.0	-0.172	0.046	1000.0	-1000.0	-0.026	-1000.0
Visual signal transduction: Cones	26.0	988.0	38.0	-0.145	0.043	1000.0	-1000.0	-0.007	-1000.0
FOXA2 and FOXA3 transcription factor networks	25.0	1189.0	46.0	-0.419	0.04	1000.0	-1000.0	-0.032	-1000.0
Atypical NF-kappaB pathway	25.0	801.0	31.0	-0.135	0.049	1000.0	-1000.0	-0.007	-1000.0
Glypican 1 network	24.0	1175.0	48.0	-0.215	0.038	1000.0	-1000.0	-0.023	-1000.0
Osteopontin-mediated events	23.0	892.0	38.0	-0.036	0.049	1000.0	-1000.0	-0.013	-1000.0
TRAIL signaling pathway	23.0	1116.0	48.0	-0.031	0.052	1000.0	-1000.0	-0.015	-1000.0
Regulation of p38-alpha and p38-beta	23.0	1265.0	54.0	-0.234	0.072	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Rods	23.0	1227.0	52.0	-0.145	0.047	1000.0	-1000.0	-0.012	-1000.0
Aurora C signaling	21.0	149.0	7.0	-0.056	0.032	1000.0	-1000.0	-0.005	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	21.0	1105.0	52.0	-0.176	0.079	1000.0	-1000.0	-0.016	-1000.0
Ephrin A  reverse signaling	20.0	141.0	7.0	-0.0	0.025	1000.0	-1000.0	-0.0	-1000.0
Ceramide signaling pathway	20.0	1525.0	76.0	-0.102	0.079	1000.0	-1000.0	-0.028	-1000.0
Paxillin-dependent events mediated by a4b1	20.0	732.0	36.0	-0.04	0.059	1000.0	-1000.0	-0.026	-1000.0
Arf6 signaling events	19.0	1194.0	62.0	-0.104	0.073	1000.0	-1000.0	-0.037	-1000.0
EPO signaling pathway	18.0	1018.0	55.0	-0.038	0.053	1000.0	-1000.0	-0.014	-1000.0
IL6-mediated signaling events	18.0	1424.0	75.0	-0.187	0.056	1000.0	-1000.0	-0.027	-1000.0
Plasma membrane estrogen receptor signaling	18.0	1602.0	86.0	-0.055	0.062	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PTP1B	17.0	1316.0	76.0	-0.24	0.063	1000.0	-1000.0	-0.036	-1000.0
Nectin adhesion pathway	17.0	1096.0	63.0	-0.174	0.072	1000.0	-1000.0	-0.025	-1000.0
EPHB forward signaling	17.0	1522.0	85.0	-0.053	0.067	1000.0	-1000.0	-0.038	-1000.0
Integrins in angiogenesis	16.0	1409.0	84.0	-0.136	0.076	1000.0	-1000.0	-0.025	-1000.0
PDGFR-beta signaling pathway	15.0	1483.0	97.0	-0.298	0.087	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	14.0	1098.0	78.0	-0.074	0.09	1000.0	-1000.0	-0.032	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	376.0	28.0	-0.111	0.065	1000.0	-1000.0	-0.009	-1000.0
Signaling events mediated by the Hedgehog family	13.0	709.0	52.0	-0.204	0.058	1000.0	-1000.0	-0.018	-1000.0
Cellular roles of Anthrax toxin	13.0	544.0	39.0	-0.122	0.041	1000.0	-1000.0	-0.015	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	13.0	1179.0	85.0	-0.037	0.073	1000.0	-1000.0	-0.042	-1000.0
p75(NTR)-mediated signaling	13.0	1673.0	125.0	-0.102	0.088	1000.0	-1000.0	-0.031	-1000.0
BMP receptor signaling	13.0	1128.0	81.0	-0.138	0.074	1000.0	-1000.0	-0.02	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1089.0	83.0	-0.097	0.066	1000.0	-1000.0	-0.011	-1000.0
LPA4-mediated signaling events	12.0	144.0	12.0	-0.048	0.01	1000.0	-1000.0	-0.011	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1480.0	120.0	-0.074	0.084	1000.0	-1000.0	-0.031	-1000.0
Syndecan-2-mediated signaling events	11.0	821.0	69.0	-0.172	0.058	1000.0	-1000.0	-0.028	-1000.0
Ephrin B reverse signaling	11.0	549.0	48.0	-0.101	0.048	1000.0	-1000.0	-0.029	-1000.0
Noncanonical Wnt signaling pathway	10.0	277.0	26.0	-0.001	0.052	1000.0	-1000.0	-0.025	-1000.0
IL1-mediated signaling events	10.0	673.0	62.0	-0.032	0.089	1000.0	-1000.0	-0.021	-1000.0
Canonical Wnt signaling pathway	10.0	518.0	51.0	-0.027	0.073	1000.0	-1000.0	-0.022	-1000.0
EGFR-dependent Endothelin signaling events	10.0	225.0	21.0	-0.02	0.055	1000.0	-1000.0	-0.029	-1000.0
ErbB2/ErbB3 signaling events	9.0	640.0	65.0	-0.023	0.06	1000.0	-1000.0	-0.043	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	606.0	61.0	-0.067	0.088	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class I	8.0	836.0	104.0	-0.064	0.081	1000.0	-1000.0	-0.036	-1000.0
TCGA08_retinoblastoma	8.0	68.0	8.0	-0.002	0.027	1000.0	-1000.0	-0.001	-1000.0
Aurora B signaling	8.0	544.0	67.0	-0.097	0.089	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	7.0	300.0	39.0	-0.054	0.073	1000.0	-1000.0	-0.009	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	392.0	54.0	-0.078	0.065	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-gamma and p38-delta	7.0	114.0	15.0	-0.004	0.034	1000.0	-1000.0	-0.019	-1000.0
Effects of Botulinum toxin	7.0	187.0	26.0	-0.026	0.045	1000.0	-1000.0	-0.001	-1000.0
mTOR signaling pathway	6.0	326.0	53.0	-0.022	0.057	1000.0	-1000.0	-0.025	-1000.0
HIF-2-alpha transcription factor network	6.0	276.0	43.0	-0.165	0.169	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	6.0	27.0	4.0	0.025	0.036	1000.0	-1000.0	0.017	-1000.0
TCGA08_rtk_signaling	6.0	172.0	26.0	-0.039	0.082	1000.0	-1000.0	-0.02	-1000.0
Insulin Pathway	6.0	458.0	74.0	-0.06	0.083	1000.0	-1000.0	-0.021	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	207.0	33.0	-0.009	0.077	1000.0	-1000.0	-0.026	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.027	0.027	1000.0	-1000.0	-0.02	-1000.0
PLK1 signaling events	5.0	466.0	85.0	-0.007	0.068	1000.0	-1000.0	-0.025	-1000.0
S1P1 pathway	5.0	180.0	36.0	-0.0	0.051	1000.0	-1000.0	-0.011	-1000.0
FoxO family signaling	5.0	351.0	64.0	-0.409	0.095	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	232.0	44.0	-0.006	0.061	1000.0	-1000.0	-0.013	-1000.0
Wnt signaling	5.0	41.0	7.0	0.007	0.033	1000.0	-1000.0	-0.001	-1000.0
Regulation of Telomerase	5.0	585.0	102.0	-0.112	0.077	1000.0	-1000.0	-0.024	-1000.0
VEGFR1 specific signals	5.0	289.0	56.0	-0.047	0.083	1000.0	-1000.0	-0.023	-1000.0
S1P3 pathway	5.0	235.0	42.0	-0.036	0.054	1000.0	-1000.0	-0.009	-1000.0
Regulation of Androgen receptor activity	5.0	416.0	70.0	-0.058	0.056	1000.0	-1000.0	-0.03	-1000.0
Arf6 downstream pathway	4.0	173.0	43.0	-0.051	0.063	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PRL	4.0	141.0	34.0	-0.054	0.077	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	4.0	185.0	44.0	-0.011	0.057	1000.0	-1000.0	-0.009	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	528.0	136.0	-0.112	0.128	1000.0	-1000.0	-0.028	-1000.0
ErbB4 signaling events	3.0	275.0	69.0	-0.031	0.055	1000.0	-1000.0	-0.022	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	200.0	65.0	0.0	0.081	1000.0	-1000.0	-0.032	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	218.0	68.0	-0.054	0.065	1000.0	-1000.0	-0.023	-1000.0
Reelin signaling pathway	3.0	176.0	56.0	-0.002	0.078	1000.0	-1000.0	-0.014	-1000.0
Retinoic acid receptors-mediated signaling	3.0	209.0	58.0	-0.033	0.067	1000.0	-1000.0	-0.021	-1000.0
Syndecan-3-mediated signaling events	3.0	134.0	35.0	-0.017	0.088	1000.0	-1000.0	-0.011	-1000.0
Nongenotropic Androgen signaling	3.0	161.0	52.0	-0.041	0.056	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	497.0	125.0	-0.074	0.087	1000.0	-1000.0	-0.015	-1000.0
Arf6 trafficking events	3.0	218.0	71.0	-0.052	0.064	1000.0	-1000.0	-0.034	-1000.0
IGF1 pathway	3.0	180.0	57.0	-0.024	0.085	1000.0	-1000.0	-0.02	-1000.0
Arf1 pathway	3.0	204.0	54.0	-0.008	0.05	1000.0	-1000.0	-0.012	-1000.0
Coregulation of Androgen receptor activity	2.0	176.0	76.0	-0.015	0.06	1000.0	-1000.0	-0.009	-1000.0
Signaling events mediated by HDAC Class II	2.0	173.0	75.0	-0.039	0.089	1000.0	-1000.0	-0.017	-1000.0
PDGFR-alpha signaling pathway	2.0	118.0	44.0	-0.019	0.071	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class III	2.0	91.0	40.0	-0.056	0.057	1000.0	-1000.0	-0.028	-1000.0
FOXM1 transcription factor network	2.0	121.0	51.0	0.008	0.263	1000.0	-1000.0	-0.023	-1000.0
Aurora A signaling	1.0	95.0	60.0	-0.0	0.074	1000.0	-1000.0	-0.007	-1000.0
Insulin-mediated glucose transport	1.0	48.0	32.0	-0.0	0.064	1000.0	-1000.0	-0.017	-1000.0
S1P5 pathway	1.0	17.0	17.0	-0.039	0.041	1000.0	-1000.0	-0.009	-1000.0
Rapid glucocorticoid signaling	1.0	36.0	20.0	-0.009	0.041	1000.0	-1000.0	-0.002	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	5.0	23.0	0.007	0.069	1000.0	-1000.0	-0.012	-1000.0
BARD1 signaling events	0.0	56.0	57.0	-0.077	0.089	1000.0	-1000.0	-0.042	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.018	-1000.0	1000.0	-1000.0	-0.003	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.012	0.08	1000.0	-1000.0	-0.017	-1000.0
TCGA08_p53	0.0	1.0	7.0	-0.0	0.031	1000.0	-1000.0	-0.002	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	5.0	27.0	0.0	0.082	1000.0	-1000.0	-0.019	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.089	1000.0	-1000.0	-0.0	-1000.0
Total	2740	171008	7203	-15.927319379	-990.376170274	131000	-131000	-2.80922833418	-131000