rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(10), CDKN2A(17), E2F1(4), MDM2(8), MYC(6), PIK3CA(80), PIK3R1(12), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), RAC1(1), RB1(14), TBX2(10), TP53(200), TWIST1(3) 11920579 400 265 261 39 100 58 65 60 112 5 <1.00e-15 <1.00e-15 <1.03e-13 2 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(49), ATR(28), BRCA1(16), BRCA2(39), CHEK1(6), CHEK2(10), FANCA(12), FANCC(6), FANCD2(14), FANCE(6), FANCF(1), FANCG(4), HUS1(2), MRE11A(7), RAD1(2), RAD17(6), RAD50(12), RAD51(1), RAD9A(5), TP53(200), TREX1(4) 25906136 430 254 328 43 96 51 49 71 153 10 1.26e-12 <1.00e-15 <1.03e-13 3 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(10), ATM(49), BRCA1(16), CDKN1A(5), CHEK1(6), CHEK2(10), JUN(5), MAPK8(6), MDM2(8), MRE11A(7), NFKB1(8), NFKBIA(1), RAD50(12), RAD51(1), RBBP8(5), RELA(7), TP53(200), TP73(6) 17491262 362 248 262 38 86 42 40 60 128 6 1.31e-11 <1.00e-15 <1.03e-13 4 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(33), AKT1(3), ATM(49), BAX(1), CDKN1A(5), CPB2(10), CSNK1A1(5), CSNK1D(4), FHL2(2), HIC1(10), HIF1A(5), HSPA1A(4), IGFBP3(5), MAPK8(6), MDM2(8), NFKBIB(8), NQO1(3), TP53(200) 12175875 361 248 265 32 95 48 36 61 115 6 <1.00e-15 <1.00e-15 <1.03e-13 5 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(9), MAX(3), MYC(6), SP1(5), SP3(5), TP53(200), WT1(5) 4140585 233 206 143 11 68 28 23 35 77 2 <1.00e-15 <1.00e-15 <1.03e-13 6 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(5), DNAJC3(3), EIF2S1(2), EIF2S2(3), NFKB1(8), NFKBIA(1), RELA(7), TP53(200) 5730250 229 200 141 10 62 26 23 39 77 2 <1.00e-15 <1.00e-15 <1.03e-13 7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(5), CCND1(2), CDK2(4), CDK4(2), CDKN1A(5), CDKN1B(1), CDKN2A(17), CFL1(1), E2F1(4), E2F2(5), MDM2(8), NXT1(3), PRB1(3), TP53(200) 4941636 260 213 168 17 73 34 26 39 84 4 <1.00e-15 1.67e-15 1.47e-13 8 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(8), ATM(49), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), CASP3(2), CASP6(1), CASP7(4), CASP9(3), EIF2S1(2), PRKCA(8), PTK2(11), PXN(6), STAT1(11), TLN1(28), TP53(200) 16068160 348 244 253 28 102 47 35 53 106 5 <1.00e-15 2.22e-15 1.64e-13 9 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(49), ATR(28), CDC25C(11), CHEK1(6), CHEK2(10), TP53(200), YWHAH(3) 9392938 307 232 211 22 78 32 33 51 107 6 9.74e-12 2.44e-15 1.64e-13 10 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(5), HSPA1A(4), IFNG(2), IFNGR1(10), IFNGR2(2), IKBKB(10), JAK2(12), LIN7A(9), NFKB1(8), NFKBIA(1), RB1(14), RELA(7), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TP53(200), USH1C(8), WT1(5) 10636090 309 226 219 41 83 39 32 54 98 3 4.05e-10 2.66e-15 1.64e-13 11 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(49), CDC25A(5), CDC25B(6), CDC25C(11), CDK2(4), CDK4(2), CHEK1(6), MYT1(22), RB1(14), TP53(200), WEE1(6), YWHAH(3) 10343333 328 238 233 25 82 40 35 58 107 6 1.68e-14 3.11e-15 1.74e-13 12 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(46), DAXX(11), HRAS(1), PAX3(14), PML(16), RARA(4), RB1(14), SIRT1(8), SP100(19), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TP53(200) 11157095 345 228 252 40 105 40 43 50 105 2 1.11e-13 4.00e-15 2.05e-13 13 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(8), ATM(49), BAX(1), BCL2(4), CCND1(2), CCNE1(5), CDK2(4), CDK4(2), CDKN1A(5), E2F1(4), MDM2(8), PCNA(2), RB1(14), TIMP3(10), TP53(200) 10653159 318 237 221 24 80 40 36 52 103 7 3.22e-15 4.44e-15 2.10e-13 14 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(8), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CASP2(3), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), FADD(3), FAS(3), FASLG(5), GZMB(2), JUN(5), MAP2K4(9), MAP3K1(16), MAPK10(4), MCL1(2), MDM2(8), MYC(6), NFKB1(8), NFKBIA(1), PARP1(13), PRF1(13), RELA(7), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(9), TP53(200), TRADD(2), TRAF1(4), TRAF2(4) 21906316 407 251 305 56 106 50 41 69 136 5 7.67e-12 3.57e-14 1.57e-12 15 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(10), ATM(49), ATR(28), CCNA1(10), CCND1(2), CCNE1(5), CDC25A(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2A(17), CDKN2B(1), E2F1(4), GSK3B(6), HDAC1(9), RB1(14), SKP2(6), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9), TP53(200) 17737262 408 254 310 64 98 49 46 71 138 6 8.23e-08 1.52e-08 6.23e-07 16 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(49), ATR(28), BRCA1(16), CCNB1(3), CDC25A(5), CDC25B(6), CDC25C(11), CDC34(2), CDKN1A(5), CDKN2D(4), CHEK1(6), CHEK2(10), EP300(27), MDM2(8), MYT1(22), PRKDC(56), RPS6KA1(9), TP53(200), WEE1(6), YWHAH(3), YWHAQ(4) 24559677 480 261 376 69 127 56 63 83 144 7 4.81e-11 5.27e-07 2.03e-05 17 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(23), HLA-A(22), IL18(1), ITGB1(11), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), LAT(3), MAP2K1(7), MAPK3(3), PAK1(5), PIK3CA(80), PIK3R1(12), PTK2B(16), PTPN6(6), RAC1(1), SYK(9), VAV1(13) 10927188 230 123 164 22 39 46 43 39 56 7 1.10e-10 3.34e-06 0.000121 18 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(14) 424734 14 14 12 1 5 1 2 1 5 0 0.0724 9.52e-05 0.00326 19 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(10), CDKN1B(1), GRB2(4), ILK(9), ITGB1(11), MAPK1(3), MAPK3(3), PDK2(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PTEN(36), PTK2(11), SHC1(7), SOS1(9) 11291315 201 118 142 20 38 36 40 36 47 4 1.90e-09 0.000338 0.0104 20 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(4), CDC42(3), DLD(10), DUSP10(8), DUSP4(2), DUSP8(2), GAB1(4), GCK(9), IL1R1(4), JUN(5), MAP2K4(9), MAP2K5(1), MAP2K7(38), MAP3K1(16), MAP3K10(13), MAP3K11(9), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K7(11), MAP3K9(5), MAPK10(4), MAPK7(8), MAPK8(6), MAPK9(5), MYEF2(8), NFATC3(5), NR2C2(6), PAPPA(29), SHC1(7), TP53(200), TRAF6(6), ZAK(8) 29514100 526 258 427 83 158 71 59 82 151 5 3.38e-12 0.000339 0.0104 21 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(80), PIK3R1(12), PLCB1(21), PLCG1(22), PRKCA(8), VAV1(13) 7542730 159 100 109 17 38 36 37 23 24 1 5.73e-09 0.000580 0.0170 22 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(8), BAD(4), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BCL2L11(4), BID(2), BIRC2(7), BIRC3(10), BIRC5(3), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CHUK(5), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), GZMB(2), HELLS(7), IKBKB(10), IRF1(5), IRF2(24), IRF3(3), IRF4(8), IRF5(6), IRF6(8), IRF7(4), JUN(5), LTA(4), MAP2K4(9), MAP3K1(16), MAPK10(4), MDM2(8), MYC(6), NFKB1(8), NFKBIA(1), NFKBIB(8), NFKBIE(1), PLEKHG5(9), PRF1(13), RELA(7), RIPK1(3), TNF(3), TNFRSF10B(2), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(4), TNFRSF25(5), TNFSF10(9), TP53(200), TP73(6), TRADD(2), TRAF1(4), TRAF2(4), TRAF3(7) 33599531 554 272 447 91 149 68 62 94 176 5 1.69e-11 0.00404 0.113 23 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3E(2), CD80(5), CD86(7), CTLA4(4), GRB2(4), HLA-DRA(7), HLA-DRB1(1), ICOS(4), ITK(5), LCK(4), PIK3CA(80), PIK3R1(12), PTPN11(8) 7523533 144 97 95 16 30 32 38 24 19 1 1.24e-07 0.00423 0.113 24 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(8), AKT1(3), ANXA1(6), CALM1(2), CALM2(3), CALM3(1), GNAS(38), GNB1(2), GNGT1(3), NFKB1(8), NOS3(15), NPPA(2), NR3C1(9), PIK3CA(80), PIK3R1(12), RELA(7), SYT1(5) 10506382 204 123 149 26 58 36 39 39 31 1 1.03e-07 0.0199 0.512 25 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(4), CASP9(3), CHUK(5), GH1(2), GHR(9), NFKB1(8), NFKBIA(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PPP2CA(4), RELA(7), YWHAH(3) 8259425 142 94 96 18 24 37 38 25 17 1 3.11e-07 0.0235 0.580 26 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), BCL2(4), EGFR(19), IGF1R(20), MYC(6), POLR2A(24), PPP2CA(4), PRKCA(8), RB1(14), TEP1(37), TERF1(8), TERT(9), TNKS(21), TP53(200), XRCC5(10) 16541878 387 235 293 77 109 51 53 60 112 2 4.77e-07 0.0286 0.678 27 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(4), BCL2L1(1), CASP9(3), CDC42(3), CHUK(5), ELK1(4), HRAS(1), MAP2K1(7), MAPK3(3), NFKB1(8), PIK3CA(80), PIK3R1(12), RAC1(1), RAF1(9), RALBP1(10), RALGDS(14), RELA(7), RHOA(20) 11177540 195 119 140 28 43 44 44 35 28 1 4.95e-08 0.0311 0.710 28 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), GRB2(4), HRAS(1), KLK2(1), NTRK1(9), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), SHC1(7), SOS1(9) 9147566 156 101 108 20 38 35 37 25 20 1 1.54e-07 0.0364 0.800 29 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(8), ATM(49), ATR(28), BAI1(20), BAX(1), BID(2), CASP3(2), CASP8(18), CASP9(3), CCNB1(3), CCNB3(21), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNG2(1), CD82(3), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN2A(17), CHEK1(6), CHEK2(10), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(5), IGF1(2), IGFBP3(5), MDM2(8), MDM4(4), PERP(3), PPM1D(9), PTEN(36), RCHY1(1), RFWD2(8), RPRM(6), RRM2(3), RRM2B(4), SERPINB5(3), SERPINE1(3), SESN1(2), SESN2(2), SESN3(5), SFN(1), SIAH1(3), STEAP3(9), THBS1(17), TNFRSF10B(2), TP53(200), TP53I3(1), TP73(6), TSC2(14), ZMAT3(4) 38258894 593 290 478 104 157 70 64 109 183 10 2.00e-09 0.0677 1.000 30 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(3), AKT1(3), AKT2(10), AKT3(8), APAF1(8), ATM(49), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CAPN1(7), CAPN2(10), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CFLAR(1), CHUK(5), CSF2RB(12), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(5), IRAK1(7), IRAK2(11), IRAK3(9), IRAK4(3), MYD88(4), NFKB1(8), NFKB2(9), NFKBIA(1), NTRK1(9), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RELA(7), RIPK1(3), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(9), TP53(200), TRADD(2), TRAF2(4) 48899408 787 298 623 123 206 114 99 134 225 9 <1.00e-15 0.110 1.000 31 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(5), CDC34(2), CDK2(4), CUL1(24), E2F1(4), FBXW7(32), RB1(14), TFDP1(5) 4857435 90 64 78 11 29 9 14 10 28 0 7.65e-05 0.133 1.000 32 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), KLK2(1), MAP2K1(7), MAPK3(3), MAPK8(6), NGFR(7), PIK3CA(80), PIK3R1(12), PLCG1(22), RAF1(9), SHC1(7), SOS1(9) 11214607 183 107 132 25 46 38 39 33 26 1 4.74e-08 0.142 1.000 33 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(10), FMOD(12), KERA(5), LUM(8) 2129598 36 29 36 4 14 2 4 12 4 0 0.0127 0.160 1.000 34 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(9), ERBB4(59), NRG2(9), NRG3(24), PRKCA(8), PSEN1(5) 5281109 114 80 103 22 27 13 22 31 21 0 0.0173 0.193 1.000 35 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(7), GRIA2(26), JUND(2), PPP1R1B(3) 2191409 41 34 41 7 8 9 6 11 7 0 0.0317 0.209 1.000 36 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(4), LIPT1(5) 895003 9 9 8 1 2 3 1 0 2 1 0.207 0.416 1.000 37 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(10), AOC3(13), CES1(16), ESD(1) 3537071 40 35 38 4 11 3 3 9 14 0 0.0597 0.522 1.000 38 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(7), GSTZ1(2), HGD(6) 1306926 15 15 13 3 4 0 3 4 4 0 0.398 0.529 1.000 39 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(6), GH1(2), GHR(9), HRAS(1), IGF1(2), IGF1R(20), PIK3CA(80), PIK3R1(12), SHC1(7), SOD2(2), SOD3(1) 7807677 145 93 99 29 26 38 39 24 17 1 0.000181 0.672 1.000 40 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(4), EIF4G1(25), EIF4G3(22), GHR(9), IRS1(27), MAPK1(3), MAPK14(2), MAPK3(3), MKNK1(5), PABPC1(10), PDK2(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PRKCA(8), PTEN(36), RPS6KB1(6) 16509284 268 136 204 34 48 51 50 42 71 6 2.26e-08 0.674 1.000 41 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(3), SEC61A2(4), SRP19(3), SRP54(6), SRP68(6), SRP72(14), SRP9(2), SRPR(16) 4424708 54 42 52 5 15 7 10 5 17 0 0.00309 0.675 1.000 42 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(3), TGDS(5), UGDH(8), UXS1(8) 2256701 25 22 25 3 9 2 6 4 4 0 0.0333 0.688 1.000 43 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(6), TPI1(3) 965217 9 9 9 2 4 2 1 1 1 0 0.360 0.704 1.000 44 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(53), CDH1(33), CREBBP(46), EP300(27), MAP2K1(7), MAP3K7(11), MAPK3(3), SKIL(7), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17) 15063845 233 137 212 42 49 25 36 45 74 4 0.000507 0.779 1.000 45 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(6), ALDOA(1), ALDOB(9), ALDOC(7), TPI1(3) 2295817 26 25 26 4 6 7 3 6 4 0 0.0607 0.784 1.000 46 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(3), FDPS(12), IDI1(2), SQLE(9) 1868455 26 19 25 3 7 3 3 4 9 0 0.0499 0.785 1.000 47 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(3), TGDS(5), UGDH(8), UGP2(9), UXS1(8) 2875221 34 27 33 4 11 2 6 6 9 0 0.0275 0.785 1.000 48 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(4), CASP3(2), CASP8(18), CFL1(1), CFLAR(1), PDE6D(1) 2273778 27 23 24 5 3 5 4 3 12 0 0.329 0.842 1.000 49 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), PAK1(5), PDGFRA(13), PIK3CA(80), PIK3R1(12), RAC1(1), WASL(5) 7868033 134 89 88 25 18 34 38 20 23 1 0.000697 0.861 1.000 50 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(5), CDK2(4), CDKN1B(1), CKS1B(2), CUL1(24), E2F1(4), RB1(14), RBX1(1), SKP2(6), TFDP1(5), UBE2M(1) 5045457 67 49 67 10 10 9 14 11 23 0 0.00671 0.867 1.000 51 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(3), FDPS(12), GGPS1(4), IDI1(2), IDI2(3), SQLE(9) 2503359 33 22 32 4 8 4 3 6 12 0 0.0438 0.892 1.000 52 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(10), AKT3(8), BPNT1(6), GRB2(4), ILK(9), MAPK1(3), MAPK3(3), PDK1(3), PIK3CA(80), PIK3CD(15), PTEN(36), PTK2B(16), RBL2(7), SHC1(7), SOS1(9) 11979562 219 121 161 33 52 43 37 38 46 3 4.70e-06 0.894 1.000 53 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(4), CALM1(2), CALM2(3), CALM3(1), ELK1(4), FCER1A(5), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP2K1(7), MAP2K4(9), MAP2K7(38), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PAK2(12), PIK3CA(80), PIK3R1(12), PLA2G4A(7), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), RAF1(9), SHC1(7), SOS1(9), SYK(9), SYT1(5), VAV1(13) 25251022 392 164 332 56 124 65 61 57 80 5 4.82e-14 0.915 1.000 54 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(6), CCL2(1), CSF1(5), LDLR(12), LPL(9) 3127094 33 30 31 6 10 4 3 4 12 0 0.0688 0.925 1.000 55 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(8), ARHGAP5(26), ARHGDIB(1), CASP1(3), CASP10(8), CASP3(2), CASP8(18), CASP9(3), GZMB(2), JUN(5), PRF1(13) 7569058 89 61 82 10 19 11 8 17 31 3 0.00490 0.941 1.000 56 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(10), CRK(1), GNAI1(3), GNAQ(3), GNB1(2), GNGT1(3), HRAS(1), MAP2K1(7), MAPK1(3), MAPK3(3), NFKB1(8), PIK3C2G(14), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), PTK2(11), PTK2B(16), PXN(6), RAF1(9), RELA(7) 16166225 229 129 176 31 61 43 44 32 48 1 1.40e-09 0.966 1.000 57 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(11), HLA-DRA(7), HLA-DRB1(1) 1393636 20 20 15 8 5 2 2 3 8 0 0.914 0.972 1.000 58 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2) 668133 2 2 2 1 0 0 2 0 0 0 0.759 0.972 1.000 59 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(4), LPL(9), NR3C1(9), PPARG(4), RETN(1), RXRA(13), TNF(3) 3397366 43 39 41 10 11 4 6 12 10 0 0.214 0.978 1.000 60 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(23), CD3E(2), GZMB(2), HLA-A(22), ICAM1(4), ITGAL(22), ITGB2(12), PRF1(13) 5115651 100 63 85 21 21 9 10 14 40 6 0.105 0.978 1.000 61 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(53), AXIN1(15), CCND1(2), CD14(1), CTNNB1(27), DVL1(8), FZD1(11), GJA1(13), GNAI1(3), GSK3B(6), IRAK1(7), LBP(3), LEF1(5), LY96(5), MYD88(4), NFKB1(8), PDPK1(1), PIK3CA(80), PIK3R1(12), PPP2CA(4), RELA(7), TIRAP(1), TLR4(27), TOLLIP(6), WNT1(10) 18003085 322 166 255 60 56 53 59 69 79 6 2.90e-06 0.980 1.000 62 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(33), ABCB11(11), ABCB4(29), ABCC1(14), ABCC3(14), GSTP1(1) 8412303 102 73 96 16 26 11 12 18 35 0 0.00259 0.984 1.000 63 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(3), CCR3(12), HLA-DRA(7), HLA-DRB1(1), IL3(1) 1784846 25 20 24 6 9 4 3 6 3 0 0.186 0.984 1.000 64 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(6), SLPI(2) 1005759 8 7 8 3 4 1 0 1 2 0 0.652 0.986 1.000 65 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), IFNG(2), IL2RA(2), IL4(4), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), TGFBR3(9), TOB1(1), TOB2(6) 6207476 73 61 69 16 16 5 16 12 24 0 0.155 0.986 1.000 66 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(8), SUCLA2(3) 1240358 11 11 11 3 6 0 1 1 3 0 0.534 0.991 1.000 67 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(6), ACAT2(5), OXCT1(10) 1985949 21 20 20 7 3 6 2 3 7 0 0.780 0.993 1.000 68 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(5), FOS(1), FYN(9), JUN(5), MAPK14(2), THBS1(17) 4344725 41 34 39 8 10 5 9 9 8 0 0.0845 0.994 1.000 69 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), INSR(17), IRS1(27), JUN(5), MAP2K1(7), MAPK3(3), MAPK8(6), PIK3CA(80), PIK3R1(12), PTPN11(8), RAF1(9), RASA1(19), SHC1(7), SLC2A4(5), SOS1(9), SRF(5) 14938999 234 122 178 37 49 49 42 37 53 4 1.94e-07 0.996 1.000 70 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(3), IFNG(2), IL12A(3), IL12B(2), IL18(1) 1747883 11 10 11 4 2 3 1 4 1 0 0.734 0.996 1.000 71 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), CREB1(4), GRB2(4), HRAS(1), MAPK1(3), MAPK3(3), MAPK7(8), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), NTRK1(9), PIK3CA(80), PIK3R1(12), PLCG1(22), RPS6KA1(9), SHC1(7) 11095191 186 106 138 30 46 44 42 25 28 1 3.69e-07 0.997 1.000 72 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(4), CREBBP(46), EP300(27), FYN(9), IL2RG(9), IL7(2), IL7R(15), JAK1(19), JAK3(12), LCK(4), NMI(2), PIK3CA(80), PIK3R1(12), PTK2B(16), STAT5A(10), STAT5B(13) 16376636 280 126 218 44 63 51 52 47 64 3 1.88e-07 0.997 1.000 73 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(7), CBS(9), CTH(3), MUT(7) 2864191 29 27 28 6 6 3 3 2 15 0 0.316 0.998 1.000 74 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(6), PAPSS1(6), PAPSS2(6), SULT1A2(8), SULT1E1(3), SULT2A1(4), SUOX(7) 3588654 40 32 40 7 12 9 4 8 7 0 0.0587 0.998 1.000 75 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(12), CD4(11), HLA-DRA(7), HLA-DRB1(1), IL1B(4), IL4(4), IL5RA(8) 3135061 48 38 42 12 11 4 7 10 16 0 0.307 0.998 1.000 76 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(12), CFL1(1), GNAQ(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), LIMK1(6), MAP2K1(7), MAPK1(3), MAPK3(3), MYL2(9), NOX1(7), PIK3C2G(14), PLCB1(21), PPP1R12B(16), PRKCA(8), PTK2(11), RAF1(9), ROCK2(16) 14764064 191 103 180 28 66 21 18 40 46 0 5.37e-05 0.998 1.000 77 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(4), CD28(1), CD3E(2), CD4(11) 1887793 18 18 13 8 2 1 4 3 8 0 0.966 0.998 1.000 78 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(4), HLCS(6), SPCS1(2), SPCS3(3) 1799998 15 13 15 5 4 1 0 9 1 0 0.617 0.999 1.000 79 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(11), CD80(5), HLA-DRA(7), HLA-DRB1(1), IL10(2), IL4(4) 2331569 31 30 25 9 11 2 2 6 10 0 0.614 0.999 1.000 80 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(4), GBA(12), GGT1(9), SHMT1(2), SHMT2(11) 3200743 38 31 36 9 12 3 6 5 12 0 0.177 0.999 1.000 81 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(10), CCNE1(5), CDC34(2), CDK2(4), CUL1(24), E2F1(4), RB1(14), SKP2(6), TFDP1(5) 5022983 74 57 74 17 12 11 16 14 21 0 0.0497 0.999 1.000 82 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(7), ACADS(4), ACAT1(6), ECHS1(2), HADHA(5) 3169892 27 22 25 5 6 5 4 4 8 0 0.129 0.999 1.000 83 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), MIOX(6), UGDH(8) 4975235 71 47 62 15 15 8 11 12 25 0 0.109 0.999 1.000 84 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(5), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAP2K1(7), MAPK3(3), MPL(5), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), STAT1(11), STAT3(7), STAT5A(10), STAT5B(13), THPO(6) 17605329 256 128 203 36 60 49 46 47 51 3 1.30e-08 0.999 1.000 85 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(5), BIRC3(10), CASP8(18), FADD(3), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4) 4894710 57 46 53 13 9 8 6 8 25 1 0.333 1.000 1.000 86 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(4), FOS(1), JUN(5), KEAP1(11), MAFF(1), MAPK1(3), MAPK14(2), MAPK8(6), NFE2L2(2), PRKCA(8) 5186728 43 35 42 9 11 11 5 6 10 0 0.0369 1.000 1.000 87 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCL2(4), BCR(14), CRKL(2), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), MYC(6), PIK3CA(80), PIK3R1(12), RAF1(9), SOS1(9), STAT1(11), STAT5A(10), STAT5B(13) 16477058 237 126 183 40 50 48 43 39 54 3 4.55e-07 1.000 1.000 88 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(8), AASDHPPT(1), AASS(10), KARS(7) 2770822 26 20 26 6 6 5 5 6 4 0 0.258 1.000 1.000 89 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(5), CDC25B(6), CDC25C(11), CSK(8), GRB2(4), PRKCA(8), PTPRA(15), SRC(5) 5410644 65 46 62 12 20 5 9 11 19 1 0.0426 1.000 1.000 90 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(9), SHMT1(2), SHMT2(11) 2413569 23 20 21 8 7 3 2 1 10 0 0.502 1.000 1.000 91 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(6), ACAT2(5), ACYP1(1), ACYP2(3), ECHS1(2), EHHADH(4), GCDH(7), HADHA(5), SDHB(4), SDS(4) 4575240 41 30 37 8 7 8 8 3 15 0 0.111 1.000 1.000 92 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(11), CD8A(4), CSF1(5), CSF3(1), EPO(3), IL11(3), IL3(1), IL4(4), IL7(2) 3565277 34 30 28 9 9 4 4 6 11 0 0.487 1.000 1.000 93 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYB(1), NFYC(3), RB1(14), SP1(5), SP3(5) 3917350 28 24 28 5 6 4 6 4 8 0 0.110 1.000 1.000 94 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8) 3311151 25 20 24 5 4 0 6 9 6 0 0.200 1.000 1.000 95 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(3), GORASP1(4), MAP2K4(9), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MAPKAPK5(4), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PIK3CA(80), PIK3CD(15), PIK3R1(12), SYT1(5), TRAF2(4), TRAF3(7), TRAF5(4), TRAF6(6) 19660821 276 141 226 44 86 50 45 39 50 6 2.65e-09 1.000 1.000 96 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(28), CPT1A(14), LEP(3), LEPR(14), PRKAA1(7), PRKAA2(10), PRKAB1(11), PRKAB2(4), PRKAG1(5), PRKAG2(7) 8497428 103 64 99 18 30 10 10 24 28 1 0.0266 1.000 1.000 97 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(10), F13A1(19), F2(11), F2R(6), FGA(12), FGB(6), FGG(5), PLAT(7), PLG(18), SERPINB2(9), SERPINE1(3) 7868198 106 73 102 24 33 10 14 29 20 0 0.0415 1.000 1.000 98 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAA2(9), ACAT1(6), ACAT2(5), ECHS1(2), EHHADH(4), HADHA(5), HADHB(6), SDS(4) 4902371 44 30 42 9 6 9 11 3 15 0 0.0712 1.000 1.000 99 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(11), GLS2(8), GLUD1(4), GLUD2(13) 2669437 36 27 35 9 8 3 5 12 8 0 0.312 1.000 1.000 100 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(8), BAD(4), BAK1(4), BAX(1), BCL10(2), BCL2(4), BCL2L1(1), BCL2L11(4), BID(2), CASP9(3), CES1(16) 6389112 49 34 49 8 18 11 3 11 6 0 0.0242 1.000 1.000 101 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(5), DAB1(13), FYN(9), LRP8(5), RELN(52), VLDLR(7) 8227346 94 62 93 19 23 18 15 23 15 0 0.00432 1.000 1.000 102 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(8), BAK1(4), BAX(1), BCL2(4), BCL2L1(1), BID(2), BIRC2(7), BIRC3(10), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), DFFA(4), DFFB(3), DIABLO(1) 7882657 73 50 68 10 13 12 10 16 22 0 0.0159 1.000 1.000 103 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(4), DFFA(4), DFFB(3), GZMB(2), HMGB1(3), HMGB2(3), TOP2A(15), TOP2B(11) 5217700 47 35 38 8 6 6 5 14 16 0 0.333 1.000 1.000 104 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JAK1(19), JUN(5), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), PDGFA(2), PDGFRA(13), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5), STAT1(11), STAT3(7), STAT5A(10) 20498960 294 137 235 48 65 55 49 48 72 5 9.70e-08 1.000 1.000 105 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(8), CYP2C9(1) 1190402 9 7 9 5 5 1 0 2 1 0 0.935 1.000 1.000 106 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(6), CHRNA1(7), SNAP25(2), STX1A(4), VAMP2(1) 1912567 20 19 20 6 7 1 2 5 5 0 0.569 1.000 1.000 107 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(2), CCNE1(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), E2F1(4), HRAS(1), MAPK1(3), MAPK3(3), NFKB1(8), NFKBIA(1), PAK1(5), PIK3CA(80), PIK3R1(12), RAC1(1), RAF1(9), RB1(14), RELA(7), TFDP1(5) 11871229 179 107 132 30 32 43 44 26 33 1 5.78e-06 1.000 1.000 108 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(6), COASY(4), DPYD(20), DPYS(8), ENPP1(7), ENPP3(12), PANK1(11), PANK2(6), PANK3(2), PANK4(5), PPCS(2), UPB1(6) 8177249 89 57 85 15 17 9 16 23 24 0 0.00379 1.000 1.000 109 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CCNH(3), CDC25A(5), CDC25B(6), CDC25C(11), MNAT1(3), SHH(6), XPO1(13) 5072964 50 36 46 11 12 10 4 11 12 1 0.165 1.000 1.000 110 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(6), COQ5(1), COQ6(4), COQ7(4), NDUFA12(2), NDUFA13(2), NDUFB11(2) 2338753 21 19 21 8 6 2 3 3 7 0 0.754 1.000 1.000 111 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(49), CDC25A(5), CDC25B(6), CDC25C(11), CHEK1(6), MYT1(22), WEE1(6), YWHAH(3) 8091041 108 68 101 22 25 14 10 24 31 4 0.0944 1.000 1.000 112 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(5), IL1B(4), MST1R(13), TNF(3) 3835744 26 22 25 4 3 4 0 7 12 0 0.153 1.000 1.000 113 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(38), GNB1(2), GNGT1(3), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8) 5665591 93 65 86 20 43 8 4 16 22 0 0.0843 1.000 1.000 114 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2) 8821947 119 73 104 23 26 16 16 21 39 1 0.0354 1.000 1.000 115 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2) 8821947 119 73 104 23 26 16 16 21 39 1 0.0354 1.000 1.000 116 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), SHMT1(2) 8821947 119 73 104 23 26 16 16 21 39 1 0.0354 1.000 1.000 117 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(49), CCNA1(10), CCNB1(3), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(5), CDK2(4), CDK4(2), CDKN1A(5), CDKN1B(1), CDKN2A(17), CDKN2B(1), CDKN2C(1), CDKN2D(4), CREB3L1(5), CREB3L3(6), CREB3L4(3), E2F1(4), E2F2(5), E2F3(3), E2F4(2), E2F5(4), GBA2(6), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), MNAT1(3), MYC(6), MYT1(22), NACA(19), PCNA(2), POLA2(4), POLE(34), POLE2(5), PRIM1(2), RB1(14), RBL1(12), RPA1(3), RPA2(4), RPA3(1), TFDP1(5), TFDP2(4), TNXB(68), TP53(200), WEE1(6) 45279709 641 280 534 124 190 81 71 109 183 7 2.12e-09 1.000 1.000 118 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(26), DIAPH1(14), FYN(9), GSN(12), HRAS(1), ITGA1(7), ITGB1(11), MAP2K1(7), MAPK1(3), MAPK3(3), MYL2(9), MYLK(25), PFN1(1), PIK3CA(80), PIK3R1(12), PTK2(11), PXN(6), RAF1(9), ROCK1(20), SHC1(7), SRC(5), TLN1(28) 21913223 306 139 247 48 80 55 53 54 57 7 1.17e-08 1.000 1.000 119 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(4), FOS(1), HRAS(1), JUN(5), MAP2K1(7), MAPK1(3), MAPK3(3), MYC(6), NFKB1(8), NFKBIA(1), PLCB1(21), PRKCA(8), RAF1(9), RELA(7), TNF(3) 9116715 87 62 81 16 23 12 8 22 22 0 0.0106 1.000 1.000 120 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(33), GNA12(1), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAR2A(3), PRKAR2B(9) 5922815 66 51 62 14 13 8 10 11 22 2 0.170 1.000 1.000 121 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6) 4671816 67 43 58 20 15 6 8 12 26 0 0.558 1.000 1.000 122 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6) 4671816 67 43 58 20 15 6 8 12 26 0 0.558 1.000 1.000 123 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8) 7370870 83 54 78 20 23 12 13 19 16 0 0.0802 1.000 1.000 124 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(3), EIF4A2(6), EIF4B(5), EIF4E(2), EIF4EBP1(4), EIF4G1(25), EIF4G3(22), FKBP1A(2), MKNK1(5), PDK2(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PPP2CA(4), PTEN(36), RPS6(1), RPS6KB1(6), TSC1(10), TSC2(14) 16184727 242 122 182 39 50 42 51 39 55 5 7.13e-06 1.000 1.000 125 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(19), AP2A1(14), AP2M1(8), BIN1(7), CALM1(2), CALM2(3), CALM3(1), DNM1(6), EPN1(8), EPS15(2), NME2(3), PICALM(4), PPP3CA(13), PPP3CB(6), PPP3CC(6), SYNJ1(11), SYNJ2(20), SYT1(5) 12712095 138 76 129 20 40 16 15 28 39 0 2.66e-05 1.000 1.000 126 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP1(1), RANBP2(36), RANGAP1(14) 4949325 53 41 52 15 8 9 12 11 11 2 0.251 1.000 1.000 127 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(21), ARHGEF1(12), F2(11), F2R(6), F2RL3(4), GNA12(1), GNA13(7), GNAI1(3), GNAQ(3), GNB1(2), GNGT1(3), MAP3K7(11), PIK3CA(80), PIK3R1(12), PLCB1(21), PPP1R12B(16), PRKCA(8), PTK2B(16), ROCK1(20) 15161315 257 134 207 46 65 48 51 43 46 4 8.97e-07 1.000 1.000 128 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(9), ECHS1(2), HADH(2), HADHA(5), HADHB(6), HSD17B4(7), MECR(4), PPT1(5), PPT2(3) 4964482 43 27 42 8 8 8 12 3 12 0 0.0162 1.000 1.000 129 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(3), BAK1(4), BAX(1), BFAR(5), BTK(4), CAD(20), CASP10(8), CASP3(2), CASP8(18), CD7(5), CDK2AP1(1), CSNK1A1(5), DAXX(11), DEDD(3), DEDD2(3), DFFA(4), DIABLO(1), EGFR(19), EPHB2(15), FADD(3), FAF1(10), FAIM2(1), HSPB1(2), IL1A(2), MAP2K4(9), MAP2K7(38), MAP3K1(16), MAP3K5(10), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MET(10), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR0B2(3), PFN1(1), PFN2(1), PTPN13(34), RALBP1(10), RIPK1(3), ROCK1(20), SMPD1(6), TP53(200), TPX2(7), TRAF2(4) 42616830 609 268 502 119 177 71 71 96 185 9 2.56e-08 1.000 1.000 130 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), FDXR(10), SHMT1(2) 9380013 129 75 114 25 30 18 19 21 40 1 0.0205 1.000 1.000 131 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(16), GBA(12), LPO(11), MPO(9), PRDX6(2), TPO(27) 4887943 77 63 74 19 29 9 8 20 10 1 0.118 1.000 1.000 132 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(11), CD44(8), CSF1(5), FCGR3A(5), IL1B(4), IL6R(3), SELL(6), SPN(4), TGFB1(3), TGFB2(9), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(7), TNFSF8(4) 7689174 81 57 78 22 22 7 8 19 24 1 0.183 1.000 1.000 133 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(7), HLA-DRA(7), HLA-DRB1(1), IFNG(2), IFNGR1(10), IFNGR2(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18(1), IL18R1(6), IL2RA(2), IL4(4), IL4R(7) 7425987 74 51 74 19 18 10 12 15 19 0 0.127 1.000 1.000 134 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), CREB1(4), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), NFKB1(8), PIK3CA(80), PIK3R1(12), RB1(14), RELA(7), SP1(5) 11376961 179 111 128 32 32 38 45 26 37 1 3.37e-05 1.000 1.000 135 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(6), BCAT2(9), COASY(4), DPYD(20), DPYS(8), ENPP1(7), ENPP3(12), ILVBL(8), PANK1(11), PANK2(6), PANK3(2), PANK4(5), PPCDC(1), PPCS(2), UPB1(6), VNN1(4) 10155213 111 67 107 20 28 10 18 29 26 0 0.00241 1.000 1.000 136 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(9), ACP2(5), ACP5(3), ACPP(5), ACPT(6), ENPP1(7), ENPP3(12), FLAD1(5), RFK(2), TYR(15) 5693618 69 50 61 14 11 10 14 15 19 0 0.0859 1.000 1.000 137 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(53), AXIN1(15), CREBBP(46), CTNNB1(27), DVL1(8), EP300(27), FZD1(11), GSK3B(6), HDAC1(9), LDB1(4), LEF1(5), PITX2(5), TRRAP(62), WNT1(10) 19433883 288 139 262 58 89 25 34 52 83 5 0.000194 1.000 1.000 138 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2), TAT(5) 1539314 10 10 10 9 4 2 1 2 1 0 0.972 1.000 1.000 139 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(8), CYSLTR2(1), GPR161(12), GPR171(2), GPR18(3), GPR39(10), GPR45(17), GPR65(1), GPR68(4), GPR75(5) 5775854 63 48 56 17 26 4 8 9 16 0 0.204 1.000 1.000 140 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(28), ACACB(40), FASN(27), MCAT(3), OLAH(1), OXSM(6) 9197344 105 64 100 22 31 14 15 24 20 1 0.0107 1.000 1.000 141 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(14), APOBEC1(6), APOBEC2(3), APOBEC3B(5), APOBEC3C(1), APOBEC3F(2), APOBEC3G(3), APOBEC4(2) 4299379 36 25 36 7 11 7 5 6 7 0 0.119 1.000 1.000 142 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(5), ANKRD1(5), ATF3(2), CYR61(2), DUSP14(3), EIF4E(2), EIF4EBP1(4), HBEGF(2), IFNG(2), IFRD1(10), IL18(1), IL1A(2), IL1R1(4), JUND(2), MYOG(4), NR4A3(6), WDR1(4) 6261577 60 42 56 14 21 6 5 10 18 0 0.135 1.000 1.000 143 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(8), NFKBIA(1), PLCB1(21), PRKCA(8), RELA(7) 4828342 48 37 46 11 13 6 4 12 13 0 0.148 1.000 1.000 144 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(2), EHHADH(4), HADHA(5), SDS(4) 2837256 18 15 17 6 4 3 3 2 6 0 0.453 1.000 1.000 145 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6) 7746845 86 54 76 19 18 7 14 19 28 0 0.0904 1.000 1.000 146 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(4), CHRNB1(4), CHRNG(8), MUSK(16), PIK3CA(80), PIK3R1(12), PTK2(11), PTK2B(16), RAPSN(3), SRC(5), TERT(9), YWHAH(3) 9576201 174 102 127 35 44 38 41 27 23 1 4.97e-05 1.000 1.000 147 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(8), BIRC2(7), BIRC3(10), CASP10(8), CASP3(2), CASP7(4), CASP8(18), CASP9(3), DFFA(4), DFFB(3), GZMB(2), PRF1(13), SCAP(14), SREBF1(15), SREBF2(15) 10628071 126 77 119 22 34 13 16 27 36 0 0.0119 1.000 1.000 148 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(4), CREBBP(46), DFFA(4), DFFB(3), GZMA(4), GZMB(2), HMGB2(3), PRF1(13), SET(7) 6199182 87 60 83 22 27 10 13 18 19 0 0.101 1.000 1.000 149 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(7), F13B(17), HSD17B1(4), HSD17B2(3), HSD17B3(2), HSD17B4(7), HSD17B7(5), HSD3B1(4), HSD3B2(2) 4751597 51 40 51 14 7 10 10 15 9 0 0.206 1.000 1.000 150 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(46), EP300(27), ESR1(8), MAPK1(3), MAPK3(3), PELP1(8), SRC(5) 8597548 100 68 95 24 36 10 15 16 23 0 0.0488 1.000 1.000 151 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(3), CALM3(1), CCL2(1), CCR5(4), FOS(1), GNAQ(3), JUN(5), MAPK14(2), MAPK8(6), PLCG1(22), PRKCA(8), PTK2B(16), SYT1(5) 8104830 79 59 75 17 31 11 9 10 18 0 0.0133 1.000 1.000 152 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), ESRRA(2), HDAC5(13), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), PPARA(7), PPP3CA(13), PPP3CB(6), PPP3CC(6), SLC2A4(5), SYT1(5), YWHAH(3) 11828647 130 84 126 28 33 17 17 28 35 0 0.00542 1.000 1.000 153 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(5), CPS1(24), GLS(11), GLUD1(4), GOT1(3) 4578154 49 39 48 12 15 4 6 16 8 0 0.202 1.000 1.000 154 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(21), CREM(6), FHL5(5), FSHB(1), FSHR(24), GNAS(38), XPO1(13) 5652287 108 73 100 26 42 15 10 30 10 1 0.146 1.000 1.000 155 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF4E(2), EIF4EBP1(4), GSK3B(6), IGF1(2), IGF1R(20), INPPL1(27), PDK2(1), PDPK1(1), PIK3CA(80), PIK3R1(12), PPP2CA(4), PTEN(36), RPS6(1), RPS6KB1(6) 11527374 220 113 155 42 44 38 45 34 54 5 0.000618 1.000 1.000 156 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(4), BAX(1), BCL2(4), CASP8(18), FADD(3), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), NFKB1(8), NSMAF(10), RAF1(9), RELA(7), RIPK1(3), SMPD1(6), TNFRSF1A(6), TRADD(2), TRAF2(4) 12013615 129 78 118 29 37 18 10 16 45 3 0.0368 1.000 1.000 157 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(6), GNAQ(3), GNB1(2), GNGT1(3), HTR2C(10), PLCB1(21), TUB(7) 4198897 52 39 50 13 14 5 6 14 13 0 0.270 1.000 1.000 158 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IGF1(2), IGF1R(20), IRS1(27), JUN(5), MAP2K1(7), MAPK3(3), MAPK8(6), PIK3CA(80), PIK3R1(12), PTPN11(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5) 14548500 234 119 178 46 50 46 43 41 51 3 5.46e-05 1.000 1.000 159 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(8), CHPT1(4), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(5), PCYT1A(9), PCYT1B(6), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), WBSCR22(5) 8225990 90 56 85 17 20 14 13 18 24 1 0.0136 1.000 1.000 160 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(3), DAG1(13), GNAQ(3), ITPKA(2), ITPKB(14) 3549388 39 29 38 12 15 1 7 8 8 0 0.416 1.000 1.000 161 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), PRKCE(14) 4620560 84 57 82 29 20 6 17 31 10 0 0.516 1.000 1.000 162 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(3), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(6), NDUFV1(6), NDUFV2(1) 4057689 36 28 35 8 6 7 6 8 9 0 0.274 1.000 1.000 163 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(4), LDLR(12), NR0B2(3), NR1H3(5), NR1H4(6), RXRA(13) 3196091 43 32 42 14 21 3 3 6 10 0 0.316 1.000 1.000 164 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(2), GLS(11), GLUD1(4), OAT(3), PRODH(1) 3232073 25 19 24 8 6 4 2 7 6 0 0.463 1.000 1.000 165 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(22), PRKCA(8), PTK2B(16) 3956875 51 40 47 12 26 6 3 4 12 0 0.0644 1.000 1.000 166 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(5), EGF(11), EGFR(19), ELK1(4), FOS(1), GRB2(4), HRAS(1), JAK1(19), JUN(5), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SRF(5), STAT1(11), STAT3(7), STAT5A(10) 22007050 309 142 249 56 73 57 48 51 75 5 1.20e-06 1.000 1.000 167 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(53), AXIN1(15), BTRC(9), CCND1(2), CREBBP(46), CSNK1A1(5), CSNK1D(4), CSNK2A1(5), CTBP1(5), CTNNB1(27), DVL1(8), FZD1(11), GSK3B(6), HDAC1(9), MAP3K7(11), MYC(6), NLK(15), PPARD(8), PPP2CA(4), TLE1(13), WIF1(3), WNT1(10) 17175559 275 133 240 60 72 30 26 43 99 5 0.00849 1.000 1.000 168 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(7), GOSR1(2), GOSR2(3), SNAP25(2), SNAP29(2), STX10(4), STX11(7), STX12(3), STX16(10), STX17(2), STX18(2), STX19(4), STX2(6), STX3(2), STX4(4), STX5(1), STX6(6), STX7(4), STX8(4), TSNARE1(8), USE1(5), VAMP1(1), VAMP2(1), VAMP4(1), VAMP5(1), VAMP7(2), VTI1A(3), VTI1B(3), YKT6(4) 9778185 105 64 102 19 33 18 14 15 25 0 0.00468 1.000 1.000 169 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(9), ACP2(5), ACP5(3), ACP6(3), ACPP(5), ACPT(6), ENPP1(7), ENPP3(12), FLAD1(5), LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), PHPT1(2), RFK(2), TYR(15) 8825734 102 68 93 23 19 14 19 20 30 0 0.0625 1.000 1.000 170 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGB1(11), ITGB2(12), SELE(6), SELL(6) 7097884 85 54 80 26 26 5 12 20 22 0 0.179 1.000 1.000 171 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(5), MAPK14(2), MAPK8(6), NFKB1(8), RELA(7), TNFRSF13B(7), TNFRSF13C(4), TNFRSF17(1), TNFSF13(6), TNFSF13B(4), TRAF2(4), TRAF3(7), TRAF5(4), TRAF6(6) 8508821 71 53 70 14 14 16 5 15 20 1 0.0686 1.000 1.000 172 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT5(4), FUT8(9), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7) 4623405 53 47 52 14 22 9 5 8 9 0 0.246 1.000 1.000 173 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(6), AOC2(10), AOC3(13), CES1(16), DDHD1(13), ESCO1(10), ESCO2(10), LIPA(3), NAT6(4), PLA1A(3), PNPLA3(4), PPME1(1), PRDX6(2), SH3GLB1(3) 14847075 98 64 92 12 22 9 8 20 39 0 0.0125 1.000 1.000 174 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(11), BMPR1A(12), BMPR1B(9), BMPR2(21) 3675816 53 42 51 13 8 3 9 7 24 2 0.438 1.000 1.000 175 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(6), CDO1(3), CSAD(7), GAD1(8), GAD2(15), GGT1(9) 3362127 48 38 46 17 16 6 5 8 13 0 0.433 1.000 1.000 176 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), NAT1(2), NAT2(6), XDH(23) 4685062 64 54 63 19 16 12 10 18 8 0 0.274 1.000 1.000 177 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(11), EGFR(19), ERBB3(43), NRG1(16) 6049811 89 63 79 25 31 16 11 23 8 0 0.112 1.000 1.000 178 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(8), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(3), ST8SIA1(12) 3309705 47 41 45 16 21 2 7 10 7 0 0.465 1.000 1.000 179 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(4), CREM(6), FOS(1), JUN(5), MAPK3(3), OPRK1(17), POLR2A(24), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9) 7550521 99 68 94 26 24 17 15 17 26 0 0.0900 1.000 1.000 180 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(4), CAT(6), EPX(16), LPO(11), MPO(9), MTHFR(10), PRDX6(2), SHMT1(2), SHMT2(11), TPO(27) 6785949 98 73 94 25 34 11 7 22 23 1 0.119 1.000 1.000 181 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(4), IFNG(2), IFNGR1(10), JAK1(19), JAK2(12), PLA2G2A(2), PTPRU(26), REG1A(4), STAT1(11) 6722624 90 62 86 25 25 16 9 11 26 3 0.255 1.000 1.000 182 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(8), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), WBSCR22(5) 8792934 90 55 84 19 21 12 13 17 26 1 0.0326 1.000 1.000 183 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(8), ASPH(9), COPS5(3), CREB1(4), EDN1(4), EP300(27), EPO(3), HIF1A(5), JUN(5), LDHA(7), NOS3(15), P4HB(3), VHL(2) 9947001 95 61 88 21 23 13 15 17 27 0 0.0674 1.000 1.000 184 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(8), IFNB1(3), JAK1(19), PTPRU(26), REG1A(4), STAT1(11), STAT2(6), TYK2(12) 7312970 89 60 85 24 30 10 8 10 29 2 0.277 1.000 1.000 185 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(7), PRKCA(8), TGM2(12) 2905955 32 27 31 11 17 4 0 6 5 0 0.340 1.000 1.000 186 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(7), ACO2(11), FH(4), IDH1(4), IDH2(4), MDH1(3), SDHB(4), SUCLA2(3) 5225598 40 29 39 11 13 7 4 5 11 0 0.379 1.000 1.000 187 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(4), CD34(4), CD3E(2), CD4(11), CD58(7), CD8A(4), CSF3(1), IL3(1), KITLG(4) 3626395 38 32 32 13 4 4 7 7 16 0 0.750 1.000 1.000 188 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(4), GRB2(4), HRAS(1), PTK2B(16), SHC1(7), SOS1(9), SRC(5) 5184522 46 37 45 12 15 6 4 12 9 0 0.255 1.000 1.000 189 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(6), NR1I3(3), PTGS1(13), PTGS2(7) 3139721 34 26 34 10 13 4 4 6 6 1 0.357 1.000 1.000 190 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(12), MBTPS1(12), MBTPS2(7), SCAP(14), SREBF1(15), SREBF2(15) 6929133 77 50 75 19 25 6 10 13 23 0 0.124 1.000 1.000 191 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(11), ACO1(7), ACO2(11), ACSS1(16), ACSS2(12), FH(4), IDH1(4), IDH2(4), MDH1(3), SUCLA2(3) 7805636 75 49 73 18 20 15 7 12 21 0 0.129 1.000 1.000 192 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(10), AKT3(8), CISH(4), GRB2(4), IARS(11), IL13RA1(5), IL2RG(9), IL4(4), IL4R(7), INPP5D(8), JAK1(19), JAK2(12), JAK3(12), NR0B2(3), PI3(2), PIK3CA(80), PPP1R13B(15), RPS6KB1(6), SERPINA4(5), SHC1(7), SOS1(9), SOS2(18), SRC(5), STAT6(7), TYK2(12) 21613417 285 135 224 53 60 56 49 48 69 3 5.68e-05 1.000 1.000 193 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ESCO1(10), ESCO2(10), NAT6(4), PNPLA3(4), SH3GLB1(3) 9727397 50 39 48 7 12 4 5 8 21 0 0.0701 1.000 1.000 194 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(7), GAD1(8), HDC(11), PNMT(11), TH(7), TPH1(4) 3530034 48 41 47 17 16 7 4 7 14 0 0.563 1.000 1.000 195 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(14), AMT(4), ATIC(5), ATP6V0C(1), GART(10), MTHFD1(7), MTHFD1L(8), MTHFD2(1), MTHFR(10), MTHFS(3), MTR(19), SHMT1(2), SHMT2(11), TYMS(1) 10488007 96 62 92 23 25 14 14 17 25 1 0.0210 1.000 1.000 196 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(14), PDXK(4), PDXP(2), PNPO(2), PSAT1(7) 2838566 29 23 29 11 4 5 4 8 6 2 0.626 1.000 1.000 197 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL1(1), FOSL2(10), IFNAR1(8), IFNAR2(4), IFNB1(3), MAPK8(6), NFKB1(8), RELA(7), TNFRSF11A(4), TNFSF11(5), TRAF6(6) 6488091 63 50 63 19 15 11 7 15 15 0 0.339 1.000 1.000 198 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(7), FDFT1(3), FDPS(12), HMGCR(7), IDI1(2), LSS(14), MVD(2), MVK(15), NQO1(3), NQO2(3), PMVK(1), SQLE(9), VKORC1(1) 6438087 79 43 68 19 20 9 6 18 26 0 0.210 1.000 1.000 199 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(5), GSS(2), NFKB1(8), NOX1(7), RELA(7), TNF(3), XDH(23) 5813886 55 40 55 15 12 12 6 14 11 0 0.239 1.000 1.000 200 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF3(1), EPO(3), FLT3(12), IGF1(2), IL11(3), IL1A(2), IL3(1), KITLG(4), TGFB1(3), TGFB2(9), TGFB3(9) 4856420 50 39 47 17 15 7 5 12 11 0 0.533 1.000 1.000 201 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(8), IFNAR2(4), IFNB1(3), JAK1(19), STAT1(11), STAT2(6), TYK2(12) 6345965 64 44 61 18 16 7 9 9 21 2 0.472 1.000 1.000 202 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), SDS(4) 7113853 82 46 72 26 18 9 10 14 31 0 0.532 1.000 1.000 203 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM2(3), CALM3(1), CD3E(2), ELK1(4), FOS(1), FYN(9), GRB2(4), HRAS(1), JUN(5), LAT(3), LCK(4), MAP2K1(7), MAP2K4(9), MAP3K1(16), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKBIA(1), PIK3CA(80), PIK3R1(12), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), PTPN7(7), RAC1(1), RAF1(9), RASA1(19), RELA(7), SHC1(7), SOS1(9), SYT1(5), VAV1(13), ZAP70(13) 28059091 389 154 327 73 114 64 55 63 90 3 2.72e-08 1.000 1.000 204 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(23), CALR(2), CANX(3), CD4(11), CD74(4), CD8A(4), CD8B(2), CIITA(20), CREB1(4), CTSB(3), CTSS(5), HLA-A(22), HLA-B(29), HLA-C(7), HLA-DMA(1), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(4), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), HLA-E(6), HLA-F(8), HLA-G(5), HSP90AA1(13), HSP90AB1(10), HSPA5(4), IFI30(3), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), KIR2DL3(4), KIR3DL1(10), KIR3DL2(3), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), LGMN(7), LTA(4), NFYB(1), NFYC(3), PDIA3(5), PSME1(3), PSME2(2), RFX5(12), RFXANK(6), RFXAP(2), TAP1(5), TAP2(10), TAPBP(7) 27215112 348 133 320 62 55 39 62 76 105 11 7.74e-05 1.000 1.000 205 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(10), IFNGR2(2), JAK1(19), JAK2(12), STAT1(11) 4820354 56 41 53 18 9 11 7 8 18 3 0.681 1.000 1.000 206 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(13), PARK2(13), SNCA(1), SNCAIP(16), UBE2E2(1), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1) 3773034 51 42 49 19 15 8 8 12 8 0 0.468 1.000 1.000 207 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(53), ASAH1(4), CAMP(3), CASP3(2), CERK(7), CREB1(4), CREB5(7), CXCL2(2), DAG1(13), EPHB2(15), FOS(1), GNAQ(3), ITPKA(2), ITPKB(14), JUN(5), MAP2K4(9), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5) 16714024 224 117 215 53 71 23 26 33 64 7 0.00366 1.000 1.000 208 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(8), EIF1(1), EIF2B1(4), EIF2B2(4), EIF2B3(9), EIF2B4(11), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), ELAVL1(9), FLT1(19), FLT4(31), HIF1A(5), HRAS(1), KDR(17), NOS3(15), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), PTK2(11), PXN(6), SHC1(7), VHL(2) 19919320 297 135 240 55 77 50 60 53 56 1 8.06e-07 1.000 1.000 209 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(21), AKT1(3), ASAH1(4), GNAI1(3), GNB1(2), GNGT1(3), ITGAV(18), ITGB3(6), MAPK1(3), MAPK3(3), PDGFA(2), PDGFRA(13), PIK3CA(80), PIK3R1(12), PLCB1(21), PRKCA(8), PTK2(11), RAC1(1), SMPD1(6), SMPD2(3), SPHK1(10), SRC(5) 16104154 238 120 186 49 56 47 52 34 47 2 4.19e-05 1.000 1.000 210 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(4), BLVRB(1), HMOX1(7), IL10(2), IL10RA(5), IL10RB(2), IL1A(2), JAK1(19), STAT1(11), STAT3(7), STAT5A(10), TNF(3) 7151718 73 55 70 21 15 9 7 18 22 2 0.460 1.000 1.000 211 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(5), BRAF(18), CAMP(3), CREB1(4), CREB5(7), MAPK1(3), RAF1(9), SNX13(7), SRC(5), TERF2IP(5) 6555879 70 51 63 18 18 10 8 13 21 0 0.296 1.000 1.000 212 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(5), EGR1(12), HRAS(1), KLK2(1), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), NGFR(7), RAF1(9) 4788308 54 40 49 18 20 7 6 10 11 0 0.328 1.000 1.000 213 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(6), CHST11(4), CHST12(6), CHST13(5), PAPSS1(6), PAPSS2(6), SULT1A1(9), SULT1A2(8), SULT1E1(3), SULT2A1(4), SULT2B1(1), SUOX(7) 5409524 65 46 64 18 26 10 6 12 11 0 0.121 1.000 1.000 214 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(9), ALOX15(10), ALOX15B(4), ALOX5(11), ALOX5AP(2), DPEP1(3), GGT1(9), LTA4H(4), PLA2G2A(2), PLA2G6(8), PTGDS(1), PTGES(1), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7) 8782231 99 64 98 25 38 10 10 20 19 2 0.0321 1.000 1.000 215 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(33), CR2(25), FCGR2B(3), HLA-DRA(7), HLA-DRB1(1), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21) 8911059 133 81 115 34 33 18 17 26 39 0 0.0978 1.000 1.000 216 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(21), GNAS(38), GNB1(2), GNGT1(3), PRKACA(6), PRKAR1A(4) 3908004 74 51 70 21 36 5 3 15 14 1 0.408 1.000 1.000 217 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(3), IL12B(2), IL13(4), IL15(1), IL16(18), IL18(1), IL1A(2), IL3(1), IL4(4), LTA(4), TNF(3) 5828745 51 41 51 18 11 7 7 14 12 0 0.548 1.000 1.000 218 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMC2(5), PSMC3(9), PSMD1(10), PSMD11(4), PSMD12(5), PSMD13(2), PSMD2(17), PSMD6(5) 9386180 94 56 94 18 25 13 18 18 20 0 0.0226 1.000 1.000 219 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(14), ABCC2(17), ABCG2(5), BCHE(19), CES1(16), CES2(9), CYP3A4(3), CYP3A5(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3) 13418172 125 75 118 29 27 18 15 27 38 0 0.0753 1.000 1.000 220 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(11), CSF1(5), CSF3(1), HLA-DRA(7), HLA-DRB1(1), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL11(3), IL12A(3), IL12B(2), IL13(4), IL15(1), IL1A(2), IL3(1), IL4(4), IL7(2), LTA(4), PDGFA(2), TGFB1(3), TGFB2(9), TGFB3(9), TNF(3) 7800711 85 63 77 26 23 12 10 17 23 0 0.442 1.000 1.000 221 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(6), CYB5R3(4), GCK(9), GFPT1(7), GNE(11), GNPDA1(4), GNPDA2(7), HEXA(2), HEXB(3), HK1(17), HK2(12), HK3(11), PGM3(13), RENBP(3), UAP1(5) 9926324 114 72 110 28 38 19 17 26 14 0 0.0196 1.000 1.000 222 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(4), ATP6V0C(1), CAT(6), EPX(16), LPO(11), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), SHMT1(2), SHMT2(11), TPO(27) 6889067 92 71 88 27 29 11 8 21 22 1 0.255 1.000 1.000 223 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(9), HK1(17), HK2(12), HK3(11), IMPA1(7), PGM1(3), PGM3(13), TGDS(5) 5996018 77 56 74 25 24 14 13 20 6 0 0.207 1.000 1.000 224 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(10), AKT3(8), CDKN1A(5), ELK1(4), GRB2(4), HRAS(1), MAP2K1(7), MAP2K2(3), NGFR(7), NTRK1(9), PIK3CA(80), PIK3CD(15), SHC1(7), SOS1(9) 9455546 172 107 122 40 47 39 36 36 14 0 0.000901 1.000 1.000 225 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(4), GRB2(4), HRAS(1), IGF1R(20), IRS1(27), MAP2K1(7), MAPK1(3), MAPK3(3), PIK3CA(80), PIK3R1(12), RAF1(9), SHC1(7), SOS1(9), YWHAH(3) 11143161 192 111 140 41 44 42 42 29 33 2 0.000500 1.000 1.000 226 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRK(1), CRKL(2), DOCK1(20), ELK1(4), FOS(1), GAB1(4), GRB2(4), HGF(20), HRAS(1), ITGA1(7), ITGB1(11), JUN(5), MAP2K1(7), MAP2K2(3), MAP4K1(4), MAPK1(3), MAPK3(3), MAPK8(6), MET(10), PAK1(5), PIK3CA(80), PIK3R1(12), PTEN(36), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAF1(9), RAP1A(3), RAP1B(6), RASA1(19), SOS1(9), SRC(5), STAT3(7) 25867255 352 156 282 74 75 53 60 72 87 5 6.43e-05 1.000 1.000 227 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(5), BIRC2(7), BIRC3(10), CASP3(2), CASP8(18), CFLAR(1), FADD(3), JUN(5), MAP2K4(9), MAP3K3(9), MAP3K7(11), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), NR2C2(6), RALBP1(10), RIPK1(3), TNF(3), TNFAIP3(11), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4) 15957910 160 86 154 32 39 21 19 29 49 3 0.0175 1.000 1.000 228 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(8), CDKN1A(5), EPO(3), EPOR(3), GRIN1(11), HIF1A(5), JAK2(12), NFKB1(8), NFKBIA(1), RELA(7), SOD2(2) 7412793 65 43 64 17 14 16 7 8 19 1 0.158 1.000 1.000 229 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(9), HK1(17), HK2(12), HK3(11), IMPA1(7), IMPA2(2), ISYNA1(4), PGM1(3), PGM3(13), TGDS(5) 6826018 83 60 79 27 28 14 13 22 6 0 0.166 1.000 1.000 230 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CAMKK1(5), CAMKK2(2), CREB1(4), SYT1(5) 6759791 65 47 64 21 16 9 14 10 16 0 0.324 1.000 1.000 231 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(26), ARHGEF1(12), GNA12(1), GNA13(7), GNAQ(3), GNB1(2), GNGT1(3), MYL2(9), MYLK(25), PLCB1(21), PPP1R12B(16), PRKCA(8), ROCK1(20) 12130833 153 93 145 31 40 19 17 31 40 6 0.0157 1.000 1.000 232 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8) 10253111 101 60 95 28 32 13 13 21 22 0 0.203 1.000 1.000 233 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(15), ACVR1C(5), AKT1(3), AKT2(10), AKT3(8), ARRB1(3), ARRB2(2), ATF2(4), ATF4(2), BDNF(9), BRAF(18), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1F(14), CACNA1G(27), CACNA1H(40), CACNA1I(26), CACNA1S(26), CACNA2D1(19), CACNA2D2(7), CACNA2D3(22), CACNA2D4(12), CACNB1(4), CACNB2(19), CACNB3(4), CACNB4(7), CACNG1(5), CACNG2(3), CACNG3(6), CACNG4(2), CACNG5(9), CACNG6(3), CACNG7(11), CACNG8(4), CASP3(2), CD14(1), CDC25B(6), CDC42(3), CHUK(5), CRK(1), CRKL(2), DAXX(11), DDIT3(5), DUSP1(3), DUSP10(8), DUSP14(3), DUSP16(12), DUSP2(1), DUSP3(1), DUSP4(2), DUSP5(9), DUSP6(4), DUSP7(1), DUSP8(2), DUSP9(8), ECSIT(6), EGF(11), EGFR(19), ELK1(4), ELK4(1), FAS(3), FASLG(5), FGF1(3), FGF10(5), FGF11(1), FGF12(9), FGF13(15), FGF14(7), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(3), FGF3(1), FGF5(4), FGF6(7), FGF7(5), FGF8(1), FGF9(10), FGFR1(18), FGFR2(11), FGFR3(9), FGFR4(18), FLNA(28), FLNB(33), FLNC(38), FOS(1), GADD45B(1), GNA12(1), GNG12(12), GRB2(4), HRAS(1), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), JUN(5), JUND(2), KRAS(37), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP2K7(38), MAP3K1(16), MAP3K10(13), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K6(10), MAP3K7(11), MAP3K8(2), MAP4K1(4), MAP4K2(10), MAP4K3(5), MAP4K4(13), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK7(8), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MAPKAPK2(3), MAPKAPK3(5), MAPKAPK5(4), MAPT(11), MAX(3), MEF2C(5), MKNK1(5), MKNK2(8), MOS(11), MRAS(4), MYC(6), NF1(32), NFATC2(26), NFATC4(16), NFKB1(8), NFKB2(9), NLK(15), NR4A1(5), NRAS(4), NTF3(5), NTRK1(9), NTRK2(16), PAK1(5), PAK2(12), PDGFA(2), PDGFB(6), PDGFRA(13), PDGFRB(12), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PPM1A(5), PPM1B(14), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PPP5C(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PTPN5(9), PTPN7(7), PTPRR(10), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF2(16), RASA1(19), RASA2(10), RASGRF1(15), RASGRF2(15), RASGRP1(7), RASGRP2(8), RASGRP3(6), RASGRP4(6), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KA5(5), RPS6KA6(20), RRAS(1), RRAS2(3), SOS1(9), SOS2(18), SRF(5), STK3(5), STK4(3), STMN1(2), TAOK1(11), TAOK2(20), TAOK3(12), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), TNF(3), TNFRSF1A(6), TP53(200), TRAF2(4), TRAF6(6), ZAK(8) 167017703 2324 348 2093 590 760 300 281 398 565 20 5.88e-15 1.000 1.000 234 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), AKT1(3), AKT2(10), AKT3(8), ARHGAP5(26), BAD(4), BCAR1(10), BCL2(4), BIRC2(7), BIRC3(10), BRAF(18), CAPN2(10), CAV1(5), CAV2(1), CAV3(2), CCND1(2), CCND2(2), CCND3(1), CDC42(3), CHAD(7), COL11A1(47), COL11A2(18), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), COMP(6), CRK(1), CRKL(2), CTNNB1(27), DIAPH1(14), DOCK1(20), EGF(11), EGFR(19), ELK1(4), ERBB2(23), FARP2(6), FIGF(5), FLNA(28), FLNB(33), FLNC(38), FLT1(19), FN1(33), FYN(9), GRB2(4), GSK3B(6), HGF(20), HRAS(1), IBSP(4), IGF1(2), IGF1R(20), ILK(9), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAV(18), ITGB1(11), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), JUN(5), KDR(17), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), MAP2K1(7), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MET(10), MYL2(9), MYL7(3), MYL9(2), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PARVA(2), PARVB(5), PARVG(5), PDGFA(2), PDGFB(6), PDGFC(8), PDGFD(10), PDGFRA(13), PDGFRB(12), PDPK1(1), PGF(3), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP5K1C(14), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PRKCA(8), PRKCG(17), PTEN(36), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF1(11), RELN(52), RHOA(20), ROCK1(20), ROCK2(16), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SPP1(4), SRC(5), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TLN1(28), TLN2(32), TNC(27), TNN(31), TNR(26), TNXB(68), VASP(2), VAV1(13), VAV2(13), VAV3(14), VCL(11), VEGFB(2), VEGFC(12), VTN(10), VWF(38), ZYX(7) 217369081 2695 338 2535 853 832 388 316 567 564 28 0.000334 1.000 1.000 235 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(53), APC2(16), AXIN1(15), AXIN2(20), BTRC(9), CACYBP(2), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CCND1(2), CCND2(2), CCND3(1), CER1(3), CHD8(27), CREBBP(46), CSNK1A1(5), CSNK1A1L(7), CSNK1E(9), CSNK2A1(5), CSNK2A2(8), CTBP1(5), CTBP2(8), CTNNB1(27), CTNNBIP1(2), CUL1(24), CXXC4(4), DAAM1(15), DAAM2(16), DKK1(12), DKK2(8), DKK4(5), DVL1(8), DVL2(10), DVL3(15), EP300(27), FBXW11(9), FOSL1(1), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD4(9), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GSK3B(6), JUN(5), LEF1(5), LRP5(31), LRP6(8), MAP3K7(11), MAPK10(4), MAPK8(6), MAPK9(5), MMP7(2), MYC(6), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NKD1(8), NKD2(2), NLK(15), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PORCN(5), PPARD(8), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRICKLE1(20), PRICKLE2(20), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PSEN1(5), RAC1(1), RAC2(2), RAC3(4), RBX1(1), RHOA(20), ROCK1(20), ROCK2(16), RUVBL1(9), SENP2(7), SFRP1(7), SFRP2(6), SFRP4(5), SFRP5(1), SIAH1(3), SMAD2(9), SMAD3(6), SMAD4(31), SOX17(13), TBL1X(8), TBL1XR1(8), TBL1Y(2), TCF7(9), TCF7L1(8), TCF7L2(12), TP53(200), VANGL1(5), VANGL2(10), WIF1(3), WNT1(10), WNT10A(6), WNT10B(2), WNT11(3), WNT16(14), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4) 94584557 1538 330 1356 336 500 196 166 258 404 14 <1.00e-15 1.000 1.000 236 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(10), ATM(49), BUB1(13), BUB1B(13), BUB3(4), CCNA1(10), CCNA2(1), CCNB1(3), CCNB3(21), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNH(3), CDAN1(13), CDC14A(19), CDC14B(7), CDC20(7), CDC25A(5), CDC25B(6), CDC25C(11), CDC6(8), CDC7(7), CDH1(33), CDK2(4), CDK4(2), CDKN1A(5), CDKN2A(17), CHEK1(6), CHEK2(10), DTX4(12), E2F1(4), E2F2(5), E2F3(3), E2F4(2), E2F5(4), EP300(27), ESPL1(21), GSK3B(6), HDAC1(9), HDAC2(6), HDAC3(7), HDAC4(29), HDAC5(13), HDAC6(9), HDAC8(3), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), MPEG1(10), MPL(5), PCNA(2), PLK1(16), PRKDC(56), PTPRA(15), PTTG1(2), RB1(14), RBL1(12), SKP2(6), SMAD4(31), TBC1D8(13), TFDP1(5), TGFB1(3), TP53(200), WEE1(6) 64404145 938 323 800 186 249 117 122 181 259 10 2.66e-10 1.000 1.000 237 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY7(18), ADCY8(37), ADCY9(17), ADORA2A(2), ADORA2B(2), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), ATP2A1(12), ATP2A2(4), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(23), ATP2B4(16), AVPR1A(17), AVPR1B(3), BDKRB1(4), BDKRB2(3), BST1(3), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1F(14), CACNA1G(27), CACNA1H(40), CACNA1I(26), CACNA1S(26), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CCKAR(7), CCKBR(16), CD38(5), CHRM1(6), CHRM2(19), CHRM3(12), CHRM5(4), CHRNA7(6), CYSLTR1(8), CYSLTR2(1), DRD1(4), EDNRA(4), EDNRB(33), EGFR(19), ERBB2(23), ERBB3(43), ERBB4(59), F2R(6), GNA11(6), GNA14(5), GNA15(4), GNAL(3), GNAQ(3), GNAS(38), GRIN1(11), GRIN2A(20), GRIN2C(10), GRIN2D(10), GRM1(43), GRM5(37), GRPR(6), HRH1(5), HRH2(6), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), LHCGR(18), LTB4R2(6), MYLK(25), MYLK2(8), NOS1(39), NOS3(15), NTSR1(10), OXTR(8), P2RX1(4), P2RX2(7), P2RX3(7), P2RX4(7), P2RX5(7), P2RX7(2), PDE1A(7), PDE1B(5), PDE1C(14), PDGFRA(13), PDGFRB(12), PHKA1(10), PHKA2(15), PHKB(7), PHKG1(2), PHKG2(11), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PPID(5), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), PTAFR(4), PTGER3(8), PTGFR(5), PTK2B(16), RYR1(68), RYR2(106), RYR3(81), SLC25A4(3), SLC25A5(3), SLC25A6(5), SLC8A1(19), SLC8A2(18), SLC8A3(12), SPHK1(10), SPHK2(8), TACR1(4), TACR2(2), TACR3(15), TBXA2R(9), TNNC1(2), TNNC2(1), TRHR(7), TRPC1(11), VDAC1(3), VDAC2(2), VDAC3(7) 157553223 2308 323 2185 712 845 268 302 470 412 11 1.18e-06 1.000 1.000 238 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(10), ANAPC1(17), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC4(2), ANAPC5(5), ANAPC7(6), ATM(49), ATR(28), BUB1(13), BUB1B(13), BUB3(4), CCNA1(10), CCNA2(1), CCNB1(3), CCNB3(21), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNE2(3), CCNH(3), CDC14A(19), CDC14B(7), CDC16(7), CDC20(7), CDC23(6), CDC25A(5), CDC25B(6), CDC25C(11), CDC26(2), CDC27(5), CDC6(8), CDC7(7), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2A(17), CDKN2B(1), CDKN2C(1), CDKN2D(4), CHEK1(6), CHEK2(10), CREBBP(46), CUL1(24), DBF4(7), E2F1(4), E2F2(5), E2F3(3), EP300(27), ESPL1(21), FZR1(8), GADD45B(1), GSK3B(6), HDAC1(9), HDAC2(6), MAD1L1(9), MAD2L1(4), MAD2L2(1), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), MDM2(8), PCNA(2), PKMYT1(6), PLK1(16), PRKDC(56), PTTG1(2), RB1(14), RBL1(12), RBL2(7), RBX1(1), SFN(1), SKP2(6), SMAD2(9), SMAD3(6), SMAD4(31), SMC1A(7), SMC1B(9), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9), TP53(200), WEE1(6), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3) 79647586 1039 319 897 219 276 120 133 201 300 9 2.37e-08 1.000 1.000 239 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(8), ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), ADRA1A(19), ADRA1B(5), ADRA2A(9), ADRA2B(10), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), AGTR2(4), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), C5AR1(6), CALCR(6), CALCRL(10), CCKAR(7), CCKBR(16), CGA(1), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CNR1(13), CNR2(3), CRHR1(12), CRHR2(4), CTSG(4), CYSLTR1(8), CYSLTR2(1), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), EDNRA(4), EDNRB(33), F2(11), F2R(6), F2RL1(1), F2RL2(4), F2RL3(4), FPR1(8), FSHB(1), FSHR(24), GABBR1(18), GABBR2(15), GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), GABRB1(10), GABRB2(6), GABRB3(13), GABRD(8), GABRE(7), GABRG1(11), GABRG2(16), GABRG3(9), GABRP(6), GABRQ(12), GABRR1(7), GABRR2(7), GALR1(6), GALR2(11), GALR3(4), GH1(2), GH2(2), GHR(9), GHRHR(4), GHSR(8), GIPR(6), GLP1R(1), GLP2R(10), GLRA1(7), GLRA2(4), GLRA3(7), GLRB(10), GNRHR(5), GPR156(10), GPR35(5), GPR50(11), GPR63(3), GPR83(4), GRIA1(22), GRIA2(26), GRIA3(11), GRIA4(13), GRID1(23), GRID2(23), GRIK1(12), GRIK2(17), GRIK3(19), GRIK4(14), GRIK5(18), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), GRIN3A(21), GRIN3B(7), GRM1(43), GRM2(27), GRM3(22), GRM4(15), GRM5(37), GRM6(18), GRM7(27), GRM8(27), GRPR(6), GZMA(4), HCRTR1(6), HCRTR2(8), HRH1(5), HRH2(6), HRH3(7), HRH4(8), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), LEP(3), LEPR(14), LHB(3), LHCGR(18), LTB4R(2), LTB4R2(6), MAS1(3), MC1R(6), MC2R(3), MC3R(11), MC4R(6), MC5R(6), MCHR1(8), MCHR2(6), MLNR(4), MTNR1A(4), MTNR1B(8), NMBR(3), NMUR1(6), NMUR2(6), NPBWR1(19), NPBWR2(9), NPFFR1(2), NPFFR2(12), NPY1R(5), NPY2R(7), NPY5R(4), NR3C1(9), NTSR1(10), NTSR2(5), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OXTR(8), P2RX1(4), P2RX2(7), P2RX3(7), P2RX4(7), P2RX5(7), P2RX7(2), P2RY1(3), P2RY10(11), P2RY11(3), P2RY13(4), P2RY14(5), P2RY2(5), P2RY4(13), P2RY6(10), P2RY8(8), PARD3(17), PRL(1), PRLHR(8), PRLR(5), PRSS1(3), PRSS3(3), PTAFR(4), PTGDR(8), PTGER2(7), PTGER3(8), PTGER4(12), PTGFR(5), PTH2R(11), RXFP1(9), RXFP2(12), SCTR(5), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), SSTR5(3), TAAR1(6), TAAR2(4), TAAR5(5), TAAR6(8), TACR1(4), TACR2(2), TACR3(15), TBXA2R(9), THRA(7), THRB(4), TRHR(7), TRPV1(8), TSHB(3), TSHR(12), TSPO(1), UTS2R(4), VIPR1(3), VIPR2(5) 130010615 2065 313 1975 676 740 238 282 508 293 4 4.56e-05 1.000 1.000 240 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(6), ACTN1(7), ACTN2(26), ACTN4(16), APC(53), APC2(16), ARAF(13), ARHGEF1(12), ARHGEF12(14), ARHGEF4(14), ARHGEF6(11), ARHGEF7(10), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), ARPC5L(3), BAIAP2(5), BCAR1(10), BDKRB1(4), BDKRB2(3), BRAF(18), CD14(1), CDC42(3), CFL1(1), CFL2(1), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CRK(1), CRKL(2), CSK(8), CYFIP1(14), CYFIP2(21), DIAPH1(14), DIAPH2(10), DIAPH3(18), DOCK1(20), EGF(11), EGFR(19), EZR(5), F2(11), F2R(6), FGD1(16), FGD3(17), FGF1(3), FGF10(5), FGF11(1), FGF12(9), FGF13(15), FGF14(7), FGF17(5), FGF18(4), FGF19(1), FGF2(2), FGF20(3), FGF21(5), FGF22(4), FGF23(3), FGF3(1), FGF5(4), FGF6(7), FGF7(5), FGF8(1), FGF9(10), FGFR1(18), FGFR2(11), FGFR3(9), FGFR4(18), FN1(33), GIT1(4), GNA12(1), GNA13(7), GNG12(12), GSN(12), HRAS(1), IQGAP1(15), IQGAP2(13), IQGAP3(19), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAD(17), ITGAE(16), ITGAL(22), ITGAM(10), ITGAV(18), ITGAX(13), ITGB1(11), ITGB2(12), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), KRAS(37), LIMK1(6), LIMK2(3), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MOS(11), MRAS(4), MSN(11), MYH10(36), MYH14(24), MYH9(42), MYL2(9), MYL7(3), MYL9(2), MYLK(25), MYLK2(8), NCKAP1(13), NCKAP1L(14), NRAS(4), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDGFA(2), PDGFB(6), PDGFRA(13), PDGFRB(12), PFN1(1), PFN2(1), PFN3(3), PFN4(1), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PPP1R12B(16), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), RDX(7), RHOA(20), ROCK1(20), ROCK2(16), RRAS(1), RRAS2(3), SCIN(10), SLC9A1(12), SOS1(9), SOS2(18), SSH1(13), SSH2(22), SSH3(11), TIAM1(38), TIAM2(25), VAV1(13), VAV2(13), VAV3(14), VCL(11), WAS(4), WASF1(8), WASF2(7), WASL(5) 161732935 2024 312 1862 579 651 287 263 367 441 15 2.05e-06 1.000 1.000 241 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(8), ACTG1(1), CHAD(7), COL11A1(47), COL11A2(18), COL17A1(13), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), COMP(6), DES(3), DSC1(2), DSC2(13), DSC3(7), DSG1(5), DSG2(6), DSG3(15), DSG4(7), FN1(33), GJA1(13), GJA10(5), GJA3(4), GJA4(8), GJA5(7), GJA8(8), GJA9(2), GJB1(2), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GJB7(3), GJC1(5), GJC2(4), GJD2(8), GJD4(3), IBSP(4), INA(7), ITGA6(10), ITGB4(24), KRT1(7), KRT10(5), KRT12(5), KRT13(10), KRT14(3), KRT15(3), KRT16(11), KRT17(7), KRT18(3), KRT19(5), KRT2(12), KRT20(4), KRT23(10), KRT24(6), KRT25(8), KRT27(11), KRT28(11), KRT3(10), KRT31(6), KRT32(6), KRT33A(10), KRT33B(8), KRT34(9), KRT35(7), KRT36(6), KRT37(2), KRT38(3), KRT39(8), KRT4(7), KRT40(3), KRT5(6), KRT6A(12), KRT6B(7), KRT6C(11), KRT7(5), KRT71(3), KRT72(14), KRT73(16), KRT74(7), KRT75(40), KRT76(5), KRT77(2), KRT78(4), KRT79(8), KRT8(7), KRT81(5), KRT82(6), KRT83(4), KRT84(7), KRT85(5), KRT86(4), KRT9(2), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), LMNA(11), LMNB1(4), LMNB2(6), NES(17), PRPH(5), RELN(52), SPP1(4), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNC(27), TNN(31), TNR(26), TNXB(68), VIM(10), VTN(10), VWF(38) 145932319 1803 308 1728 675 573 254 187 431 341 17 0.751 1.000 1.000 242 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(22), CD36(5), CD44(8), CD47(1), CHAD(7), COL11A1(47), COL11A2(18), COL1A1(19), COL1A2(34), COL2A1(18), COL3A1(16), COL4A1(33), COL4A2(18), COL4A4(19), COL4A6(11), COL5A1(31), COL5A2(19), COL5A3(21), COL6A1(11), COL6A2(26), COL6A3(54), COL6A6(42), DAG1(13), FN1(33), FNDC1(24), FNDC3A(10), FNDC4(6), FNDC5(3), GP5(14), GP6(4), GP9(3), HMMR(9), HSPG2(73), IBSP(4), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAV(18), ITGB1(11), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), LAMA1(60), LAMA2(42), LAMA3(29), LAMA4(26), LAMA5(44), LAMB1(17), LAMB2(27), LAMB3(22), LAMB4(25), LAMC1(24), LAMC2(14), LAMC3(21), RELN(52), SDC1(2), SDC2(2), SDC3(4), SDC4(5), SPP1(4), SV2A(18), SV2B(7), SV2C(12), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNC(27), TNN(31), TNR(26), TNXB(68), VTN(10), VWF(38) 131162178 1637 294 1555 540 508 216 163 388 346 16 0.0586 1.000 1.000 243 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(10), ABLIM1(14), ABLIM2(14), ABLIM3(7), ARHGEF12(14), CDC42(3), CDK5(3), CFL1(1), CFL2(1), DCC(35), DPYSL2(4), DPYSL5(12), EFNA1(2), EFNA2(2), EFNA4(5), EFNA5(5), EFNB1(5), EFNB2(5), EFNB3(13), EPHA1(15), EPHA2(28), EPHA3(32), EPHA4(17), EPHA5(32), EPHA6(32), EPHA7(13), EPHA8(17), EPHB1(33), EPHB2(15), EPHB3(13), EPHB4(17), EPHB6(22), FES(13), FYN(9), GNAI1(3), GNAI2(4), GNAI3(8), GSK3B(6), HRAS(1), ITGB1(11), KRAS(37), L1CAM(18), LIMK1(6), LIMK2(3), LRRC4C(4), MAPK1(3), MAPK3(3), MET(10), NCK1(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NGEF(7), NRAS(4), NRP1(13), NTN1(7), NTN4(4), NTNG1(24), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PLXNA1(39), PLXNA2(24), PLXNA3(24), PLXNB1(30), PLXNB2(22), PLXNB3(13), PLXNC1(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTK2(11), RAC1(1), RAC2(2), RAC3(4), RASA1(19), RGS3(16), RHOA(20), RHOD(2), RND1(2), ROBO1(37), ROBO2(36), ROBO3(16), ROCK1(20), ROCK2(16), SEMA3A(16), SEMA3C(7), SEMA3D(17), SEMA3E(19), SEMA3F(11), SEMA3G(6), SEMA4A(11), SEMA4B(1), SEMA4C(13), SEMA4D(13), SEMA4F(9), SEMA4G(5), SEMA5A(28), SEMA5B(26), SEMA6A(17), SEMA6B(8), SEMA6C(11), SEMA6D(26), SEMA7A(9), SLIT1(9), SLIT2(38), SLIT3(21), SRGAP1(14), SRGAP3(12), UNC5A(14), UNC5B(11), UNC5C(19), UNC5D(24) 115257765 1597 292 1502 462 485 209 207 354 332 10 5.17e-05 1.000 1.000 244 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), AKT1(3), AKT2(10), AKT3(8), AMOTL1(11), ASH1L(40), CASK(7), CDC42(3), CDK4(2), CGN(16), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CRB3(2), CSNK2A1(5), CSNK2A2(8), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), CTTN(12), EPB41(15), EPB41L1(10), EPB41L2(12), EPB41L3(39), EXOC3(6), EXOC4(12), F11R(2), GNAI1(3), GNAI2(4), GNAI3(8), HCLS1(3), HRAS(1), IGSF5(5), INADL(18), JAM2(2), JAM3(6), KRAS(37), LLGL1(10), LLGL2(9), MAGI1(26), MAGI2(28), MAGI3(11), MLLT4(29), MPDZ(30), MPP5(4), MRAS(4), MYH1(22), MYH10(36), MYH11(31), MYH13(28), MYH14(24), MYH15(14), MYH2(39), MYH3(32), MYH4(25), MYH6(24), MYH7(35), MYH7B(20), MYH8(20), MYH9(42), MYL2(9), MYL7(3), MYL9(2), NRAS(4), OCLN(8), PARD3(17), PARD6B(3), PARD6G(2), PPM1J(2), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PPP2R3A(11), PPP2R3B(15), PPP2R4(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), PTEN(36), RAB13(3), RAB3B(4), RHOA(20), RRAS(1), RRAS2(3), SPTAN1(22), SRC(5), SYMPK(10), TJAP1(4), TJP1(26), TJP2(17), TJP3(11), VAPA(3), YES1(4), ZAK(8) 113799022 1461 282 1367 427 462 199 181 324 287 8 0.000764 1.000 1.000 245 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(12), CADM1(21), CADM3(13), CD2(4), CD22(5), CD226(2), CD274(4), CD276(8), CD28(1), CD34(4), CD4(11), CD40(3), CD40LG(5), CD58(7), CD6(11), CD80(5), CD86(7), CD8A(4), CD8B(2), CD99(1), CDH1(33), CDH15(10), CDH2(20), CDH3(12), CDH4(25), CDH5(12), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CNTN1(23), CNTN2(12), CNTNAP1(20), CNTNAP2(40), CTLA4(4), ESAM(6), F11R(2), GLG1(18), HLA-A(22), HLA-B(29), HLA-C(7), HLA-DMA(1), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(4), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), HLA-E(6), HLA-F(8), HLA-G(5), ICAM1(4), ICAM2(3), ICAM3(5), ICOS(4), ICOSLG(2), ITGA4(16), ITGA6(10), ITGA8(12), ITGA9(9), ITGAL(22), ITGAM(10), ITGAV(18), ITGB1(11), ITGB2(12), ITGB7(6), ITGB8(18), JAM2(2), JAM3(6), L1CAM(18), MADCAM1(2), MAG(21), MPZ(2), MPZL1(2), NCAM1(9), NCAM2(27), NEGR1(9), NEO1(16), NFASC(36), NLGN1(21), NLGN2(10), NLGN3(13), NRCAM(12), NRXN1(43), NRXN2(30), NRXN3(37), OCLN(8), PDCD1(5), PDCD1LG2(2), PTPRC(21), PTPRF(21), PTPRM(34), PVR(3), PVRL1(4), PVRL2(9), PVRL3(6), SDC1(2), SDC2(2), SDC3(4), SDC4(5), SELE(6), SELL(6), SELP(11), SELPLG(9), SIGLEC1(22), SPN(4), VCAM1(9), VCAN(45) 86443972 1258 278 1183 361 362 172 165 270 283 6 9.83e-06 1.000 1.000 246 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRB1(9), ADRB2(8), ADRB3(6), ANXA6(3), ARRB1(3), ARRB2(2), ATP1A4(21), ATP1B1(7), ATP1B2(4), ATP1B3(4), ATP2A2(4), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(23), CACNA1A(34), CACNA1B(32), CACNA1C(44), CACNA1D(43), CACNA1E(53), CACNA1S(26), CACNB1(4), CACNB3(4), CALM1(2), CALM2(3), CALM3(1), CALR(2), CAMK1(3), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CASQ1(8), CASQ2(3), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), GJA1(13), GJA4(8), GJA5(7), GJB1(2), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GNA11(6), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAZ(17), GNB1(2), GNB2(4), GNB3(2), GNB4(4), GNB5(3), GNG12(12), GNG13(3), GNG2(1), GNG7(4), GNGT1(3), GRK4(11), GRK5(1), GRK6(5), ITPR1(34), ITPR2(33), ITPR3(44), KCNB1(16), KCNJ3(18), KCNJ5(6), MIB1(4), NME7(1), PEA15(1), PKIA(2), PKIG(1), PLCB3(17), PRKACA(6), PRKACB(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RGS1(4), RGS10(5), RGS11(6), RGS14(4), RGS16(3), RGS17(4), RGS18(9), RGS19(4), RGS2(5), RGS20(7), RGS3(16), RGS4(7), RGS5(2), RGS6(14), RGS7(4), RGS9(13), RYR1(68), RYR2(106), RYR3(81), SFN(1), SLC8A1(19), SLC8A3(12), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(4) 109710073 1547 276 1483 524 555 170 208 302 302 10 0.0283 1.000 1.000 247 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(7), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADM(1), ARRB1(3), ARRB2(2), ATF2(4), ATF3(2), ATF4(2), ATF5(5), ATP2A2(4), ATP2A3(11), CACNB3(4), CALCA(2), CALM1(2), CALM2(3), CALM3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CNN1(3), CNN2(1), CORIN(13), CRHR1(12), DGKZ(10), ETS2(4), FOS(1), GABPA(4), GABPB2(4), GBA2(6), GJA1(13), GNAQ(3), GNB1(2), GNB2(4), GNB3(2), GNB4(4), GNB5(3), GNG12(12), GNG13(3), GNG2(1), GNG7(4), GNGT1(3), GRK4(11), GRK5(1), GRK6(5), GSTO1(1), GUCA2A(1), GUCA2B(4), GUCY1A3(17), IGFBP1(11), IGFBP2(5), IGFBP3(5), IGFBP4(1), IGFBP6(1), IL1B(4), ITPR1(34), ITPR2(33), ITPR3(44), JUN(5), MAFF(1), MIB1(4), MYL2(9), MYL4(1), MYLK2(8), NFKB1(8), NOS1(39), NOS3(15), OXT(1), OXTR(8), PDE4B(6), PDE4D(5), PKIA(2), PKIG(1), PLCB3(17), PLCD1(7), PLCG1(22), PLCG2(19), PRKACA(6), PRKACB(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RAMP2(2), RAMP3(3), RGS1(4), RGS10(5), RGS11(6), RGS14(4), RGS16(3), RGS17(4), RGS18(9), RGS19(4), RGS2(5), RGS20(7), RGS3(16), RGS4(7), RGS5(2), RGS6(14), RGS7(4), RGS9(13), RLN1(4), RYR1(68), RYR2(106), RYR3(81), SFN(1), SLC8A1(19), SP1(5), TNXB(68), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(4) 101288116 1318 259 1258 441 460 139 159 276 277 7 0.0783 1.000 1.000 248 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(5), ACVR1B(15), ACVR2A(10), ACVR2B(5), AMHR2(9), BMP2(7), BMP7(7), BMPR1A(12), BMPR1B(9), BMPR2(21), CCL1(3), CCL11(1), CCL13(1), CCL15(2), CCL16(1), CCL18(3), CCL19(2), CCL2(1), CCL20(3), CCL22(2), CCL23(1), CCL24(2), CCL25(1), CCL27(2), CCL3(1), CCL5(3), CCL7(1), CCL8(2), CCR1(7), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CCR9(6), CD27(2), CD40(3), CD40LG(5), CD70(3), CLCF1(3), CNTF(3), CNTFR(6), CRLF2(2), CSF1(5), CSF1R(17), CSF2RA(10), CSF2RB(12), CSF3(1), CSF3R(13), CX3CL1(9), CX3CR1(4), CXCL10(1), CXCL2(2), CXCL5(1), CXCL9(2), CXCR3(2), CXCR6(2), EDA(5), EDA2R(3), EDAR(8), EGF(11), EGFR(19), EPO(3), EPOR(3), FAS(3), FASLG(5), FLT1(19), FLT3(12), FLT3LG(1), FLT4(31), GDF5(13), GH1(2), GH2(2), GHR(9), HGF(20), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL13(4), IL13RA1(5), IL15(1), IL15RA(5), IL17B(3), IL17RA(10), IL17RB(6), IL18(1), IL18R1(6), IL18RAP(3), IL19(1), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), IL1RAP(6), IL20(1), IL20RA(5), IL21(4), IL21R(10), IL22(2), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL25(4), IL26(4), IL2RA(2), IL2RB(3), IL2RG(9), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL6ST(6), IL7(2), IL7R(15), IL9R(2), INHBA(13), INHBB(12), INHBC(7), INHBE(2), KDR(17), KIT(13), KITLG(4), LEP(3), LEPR(14), LIF(4), LIFR(15), LTA(4), LTBR(2), MET(10), MPL(5), NGFR(7), OSM(4), OSMR(10), PDGFB(6), PDGFC(8), PDGFRA(13), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(2), PRL(1), PRLR(5), RELT(8), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFRSF11A(4), TNFRSF11B(5), TNFRSF12A(1), TNFRSF13B(7), TNFRSF13C(4), TNFRSF14(2), TNFRSF17(1), TNFRSF19(8), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(4), TNFRSF25(5), TNFRSF4(5), TNFRSF8(7), TNFRSF9(11), TNFSF10(9), TNFSF11(5), TNFSF13(6), TNFSF13B(4), TNFSF14(3), TNFSF15(5), TNFSF18(2), TNFSF4(1), TNFSF8(4), TPO(27), TSLP(1), VEGFB(2), VEGFC(12), XCL1(1), XCR1(5) 103787609 1161 258 1104 383 307 158 148 260 282 6 0.153 1.000 1.000 249 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(28), ACACB(40), AKT1(3), AKT2(10), AKT3(8), ARAF(13), BAD(4), BRAF(18), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CBL(5), CBLB(2), CBLC(7), CRK(1), CRKL(2), EIF4EBP1(4), ELK1(4), EXOC7(14), FASN(27), FBP1(4), FBP2(6), FLOT2(9), FOXO1(5), G6PC2(1), GCK(9), GRB2(4), GSK3B(6), GYS1(8), GYS2(9), HRAS(1), IKBKB(10), INPP5D(8), INSR(17), IRS1(27), IRS2(10), IRS4(25), KRAS(37), LIPE(7), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MKNK1(5), MKNK2(8), NRAS(4), PCK1(12), PCK2(10), PDE3A(19), PDE3B(23), PDPK1(1), PFKL(8), PFKM(2), PFKP(21), PHKA1(10), PHKA2(15), PHKB(7), PHKG1(2), PHKG2(11), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PKLR(9), PPARGC1A(11), PPP1CA(2), PPP1CC(4), PPP1R3A(31), PPP1R3B(7), PPP1R3C(4), PPP1R3D(4), PRKAA1(7), PRKAA2(10), PRKAB1(11), PRKAB2(4), PRKACA(6), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCI(7), PRKCZ(2), PRKX(6), PTPN1(3), PTPRF(21), PYGB(14), PYGL(11), PYGM(14), RAF1(9), RAPGEF1(11), RHEB(2), RHOQ(5), RPS6(1), RPS6KB1(6), RPS6KB2(9), SH2B2(5), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SLC2A4(5), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SORBS1(12), SOS1(9), SOS2(18), SREBF1(15), TRIP10(11), TSC1(10), TSC2(14) 93739153 1195 255 1067 325 371 196 142 203 275 8 3.52e-06 1.000 1.000 250 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(7), ACTN2(26), ACTN4(16), DES(3), DMD(68), MYBPC1(9), MYBPC2(15), MYBPC3(12), MYH3(32), MYH6(24), MYH7(35), MYH8(20), MYL1(2), MYL2(9), MYL3(4), MYL4(1), MYL9(2), MYOM1(15), NEB(72), TCAP(4), TMOD1(3), TNNC2(1), TNNI1(1), TNNI2(6), TNNT1(6), TNNT2(3), TNNT3(7), TPM1(5), TPM2(2), TPM3(4), TPM4(4), TTN(569), VIM(10) 79893365 1001 255 966 305 269 120 174 322 99 17 0.0336 1.000 1.000 251 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(9), ACTB(8), ACTG1(1), ACTN1(7), ACTN2(26), ACTN4(16), ACVR1B(15), ACVR1C(5), BAIAP2(5), CDC42(3), CDH1(33), CREBBP(46), CSNK2A1(5), CSNK2A2(8), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), CTNND1(26), EGFR(19), EP300(27), ERBB2(23), FARP2(6), FER(14), FGFR1(18), FYN(9), IGF1R(20), INSR(17), IQGAP1(15), LEF1(5), LMO7(22), MAP3K7(11), MAPK1(3), MAPK3(3), MET(10), MLLT4(29), NLK(15), PARD3(17), PTPN1(3), PTPN6(6), PTPRB(26), PTPRF(21), PTPRJ(30), PTPRM(34), PVRL1(4), PVRL2(9), PVRL3(6), PVRL4(10), RAC1(1), RAC2(2), RAC3(4), RHOA(20), SMAD2(9), SMAD3(6), SMAD4(31), SNAI1(2), SNAI2(13), SORBS1(12), SRC(5), SSX2IP(10), TCF7(9), TCF7L1(8), TCF7L2(12), TGFBR1(8), TGFBR2(17), TJP1(26), VCL(11), WAS(4), WASF1(8), WASF2(7), WASF3(20), WASL(5), YES1(4) 70241524 989 253 915 250 275 138 124 198 244 10 7.49e-06 1.000 1.000 252 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRA2A(9), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), AGTR1(1), AGTR2(4), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), CCKAR(7), CCKBR(16), CCR1(7), CCR10(3), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CCR9(6), CCRL2(1), CHML(8), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), CMKLR1(6), CNR1(13), CNR2(3), CX3CR1(4), CXCR3(2), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), EDNRA(4), EDNRB(33), F2R(6), F2RL1(1), F2RL2(4), F2RL3(4), FPR1(8), FSHR(24), GALR1(6), GALR2(11), GALR3(4), GALT(3), GHSR(8), GNB2L1(3), GPR17(6), GPR173(7), GPR174(3), GPR27(8), GPR3(3), GPR35(5), GPR37(13), GPR37L1(8), GPR4(5), GPR50(11), GPR6(11), GPR63(3), GPR83(4), GPR85(4), GPR87(6), GRPR(6), HCRTR1(6), HCRTR2(8), HRH1(5), HRH2(6), HRH3(7), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14), LHCGR(18), LTB4R(2), MAS1(3), MC1R(6), MC3R(11), MC4R(6), MC5R(6), MLNR(4), MTNR1A(4), MTNR1B(8), NMBR(3), NMUR1(6), NMUR2(6), NPY1R(5), NPY2R(7), NPY5R(4), NTSR1(10), NTSR2(5), OPN1SW(2), OPN3(4), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OR10A5(5), OR11A1(6), OR12D3(4), OR1C1(5), OR1F1(5), OR1Q1(7), OR2H1(2), OR5V1(7), OR7A5(3), OR7C1(7), OR8B8(7), OXTR(8), P2RY1(3), P2RY10(11), P2RY11(3), P2RY12(10), P2RY13(4), P2RY14(5), P2RY2(5), P2RY6(10), PTAFR(4), PTGDR(8), PTGER2(7), PTGER4(12), PTGFR(5), RGR(3), RHO(9), RRH(3), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), SUCNR1(4), TBXA2R(9), TRHR(7) 71364139 1082 251 1029 401 407 118 161 233 163 0 0.0693 1.000 1.000 253 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(10), ABL2(16), AKT1(3), AKT2(10), AKT3(8), ARAF(13), AREG(2), BAD(4), BRAF(18), BTC(2), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CBL(5), CBLB(2), CBLC(7), CDKN1A(5), CDKN1B(1), CRK(1), CRKL(2), EGF(11), EGFR(19), EIF4EBP1(4), ELK1(4), ERBB2(23), ERBB3(43), ERBB4(59), EREG(3), GAB1(4), GRB2(4), GSK3B(6), HBEGF(2), HRAS(1), JUN(5), KRAS(37), MAP2K1(7), MAP2K2(3), MAP2K4(9), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK9(5), MYC(6), NCK1(6), NCK2(8), NRAS(4), NRG1(16), NRG2(9), NRG3(24), NRG4(2), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PRKCA(8), PRKCG(17), PTK2(11), RAF1(9), RPS6KB1(6), RPS6KB2(9), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SRC(5), STAT5A(10), STAT5B(13), TGFA(3) 60301365 927 249 794 202 270 163 126 176 186 6 2.25e-11 1.000 1.000 254 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADRB1(9), CSNK1D(4), DRD1(4), DRD2(10), EGF(11), EGFR(19), GJA1(13), GJD2(8), GNA11(6), GNAI1(3), GNAI2(4), GNAI3(8), GNAQ(3), GNAS(38), GRB2(4), GRM1(43), GRM5(37), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), HRAS(1), HTR2A(8), HTR2B(5), HTR2C(10), ITPR1(34), ITPR2(33), ITPR3(44), KRAS(37), MAP2K1(7), MAP2K2(3), MAP2K5(1), MAP3K2(6), MAPK1(3), MAPK3(3), MAPK7(8), NPR1(11), NPR2(10), NRAS(4), PDGFA(2), PDGFB(6), PDGFC(8), PDGFD(10), PDGFRA(13), PDGFRB(12), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKG1(12), PRKG2(15), PRKX(6), RAF1(9), SOS1(9), SOS2(18), SRC(5), TJP1(26), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9) 77500575 1068 248 998 349 342 165 128 245 182 6 0.0303 1.000 1.000 255 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(10), AKT3(8), BCL2L1(1), CBL(5), CBLB(2), CBLC(7), CCND1(2), CCND2(2), CCND3(1), CISH(4), CLCF1(3), CNTF(3), CNTFR(6), CREBBP(46), CRLF2(2), CSF2RA(10), CSF2RB(12), CSF3(1), CSF3R(13), EP300(27), EPO(3), EPOR(3), GH1(2), GH2(2), GHR(9), GRB2(4), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(2), IL11(3), IL11RA(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL13(4), IL13RA1(5), IL13RA2(7), IL15(1), IL15RA(5), IL19(1), IL20(1), IL20RA(5), IL21(4), IL21R(10), IL22(2), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL26(4), IL2RA(2), IL2RB(3), IL2RG(9), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL6ST(6), IL7(2), IL7R(15), IL9R(2), IRF9(7), JAK1(19), JAK2(12), JAK3(12), LEP(3), LEPR(14), LIF(4), LIFR(15), MPL(5), MYC(6), OSM(4), OSMR(10), PIAS1(10), PIAS2(14), PIAS3(10), PIAS4(8), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIM1(2), PRL(1), PRLR(5), PTPN11(8), PTPN6(6), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SOCS5(5), SOCS7(5), SOS1(9), SOS2(18), SPRED1(13), SPRED2(9), SPRY1(2), SPRY3(8), SPRY4(6), STAM(9), STAM2(6), STAT1(11), STAT2(6), STAT3(7), STAT4(9), STAT5A(10), STAT5B(13), STAT6(7), TPO(27), TSLP(1), TYK2(12) 85135139 980 242 883 279 247 146 154 201 227 5 0.00494 1.000 1.000 256 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(7), ACTN2(26), ACTN4(16), ARHGAP5(26), BCAR1(10), CD99(1), CDC42(3), CDH5(12), CLDN1(4), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(3), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(4), CLDN3(2), CLDN4(5), CLDN5(4), CLDN6(9), CLDN8(2), CLDN9(7), CTNNA1(17), CTNNA2(24), CTNNA3(22), CTNNB1(27), CTNND1(26), CYBA(1), CYBB(8), ESAM(6), EZR(5), F11R(2), GNAI1(3), GNAI2(4), GNAI3(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGAM(10), ITGB1(11), ITGB2(12), ITK(5), JAM2(2), JAM3(6), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MLLT4(29), MMP2(10), MMP9(20), MSN(11), MYL2(9), MYL7(3), MYL9(2), NCF1(3), NCF2(3), NCF4(3), NOX1(7), NOX3(7), OCLN(8), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PRKCA(8), PRKCG(17), PTK2(11), PTK2B(16), PTPN11(8), PXN(6), RAC1(1), RAC2(2), RAP1A(3), RAP1B(6), RAPGEF3(4), RAPGEF4(15), RASSF5(4), RHOA(20), RHOH(1), ROCK1(20), ROCK2(16), SIPA1(9), THY1(1), TXK(2), VASP(2), VAV1(13), VAV2(13), VAV3(14), VCAM1(9), VCL(11) 72767133 986 241 887 270 305 140 130 182 218 11 2.55e-05 1.000 1.000 257 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(13), BRAF(18), CACNA1A(34), CRHR1(12), GNA11(6), GNA12(1), GNA13(7), GNAI1(3), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAS(38), GNAZ(17), GRIA1(22), GRIA2(26), GRIA3(11), GRID2(23), GRM1(43), GRM5(37), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), HRAS(1), IGF1(2), IGF1R(20), ITPR1(34), ITPR2(33), ITPR3(44), KRAS(37), LYN(7), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), NOS1(39), NOS3(15), NPR1(11), NPR2(10), NRAS(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), PRKCA(8), PRKCG(17), PRKG1(12), PRKG2(15), RAF1(9), RYR1(68) 64514207 975 238 889 265 326 139 118 230 155 7 2.94e-05 1.000 1.000 258 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(10), ACTN1(7), ACTR2(2), ACTR3(2), AKT1(3), AKT2(10), AKT3(8), ANGPTL2(6), ARHGEF6(11), ARHGEF7(10), BCAR1(10), BRAF(18), CAV1(5), CDC42(3), CDKN2A(17), CRK(1), CSE1L(7), DOCK1(20), EPHB2(15), FYN(9), GRB2(4), GRB7(6), ILK(9), ITGA1(7), ITGA10(12), ITGA11(16), ITGA2(12), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGB3BP(1), MAP2K4(9), MAP2K7(38), MAP3K11(9), MAPK1(3), MAPK10(4), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), MRAS(4), MYLK(25), MYLK2(8), P4HB(3), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PIK3CA(80), PIK3CB(13), PKLR(9), PLCG1(22), PLCG2(19), PTEN(36), PTK2(11), RAF1(9), RHO(9), ROCK1(20), ROCK2(16), SHC1(7), SOS1(9), SOS2(18), SRC(5), TERF2IP(5), TLN1(28), TLN2(32), VASP(2), WAS(4), ZYX(7) 71632210 879 236 804 228 280 135 105 142 205 12 2.32e-05 1.000 1.000 259 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(6), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ADK(4), ADSL(5), ADSS(6), ADSSL1(9), AK1(1), AK5(5), AK7(5), ALLC(6), AMPD1(12), AMPD2(17), AMPD3(19), APRT(3), ATIC(5), CANT1(5), DCK(4), DGUOK(4), ENPP1(7), ENPP3(12), ENTPD1(4), ENTPD2(6), ENTPD3(6), ENTPD4(13), ENTPD5(2), ENTPD6(6), ENTPD8(7), FHIT(1), GART(10), GDA(6), GMPR(3), GMPR2(1), GMPS(7), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), GUK1(4), IMPDH1(6), ITPA(1), NME2(3), NME4(2), NME6(3), NME7(1), NPR1(11), NPR2(10), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT2(5), NUDT5(1), NUDT9(2), PAPSS1(6), PAPSS2(6), PDE10A(18), PDE11A(11), PDE1A(7), PDE1C(14), PDE2A(16), PDE3B(23), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE5A(7), PDE6D(1), PDE6G(1), PDE6H(1), PDE7A(6), PDE7B(4), PDE8A(13), PDE8B(6), PDE9A(8), PFAS(12), PKLR(9), PNPT1(5), POLA1(8), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), PPAT(7), PRIM1(2), PRIM2(7), PRPS1(3), PRPS2(3), PRUNE(5), RFC5(2), RRM1(5), RRM2(3), RRM2B(4), XDH(23), ZNRD1(2) 95626467 1029 235 997 337 315 134 156 218 203 3 0.144 1.000 1.000 260 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), AKAP1(3), AKAP10(3), AKAP11(17), AKAP12(20), AKAP2(16), AKAP3(11), AKAP4(11), AKAP5(1), AKAP6(32), AKAP7(2), AKAP8(11), AKAP9(41), ARHGEF1(12), CALM1(2), CALM2(3), CALM3(1), CHMP1B(1), GNA11(6), GNA12(1), GNA13(7), GNA14(5), GNA15(4), GNAI2(4), GNAI3(8), GNAL(3), GNAO1(1), GNAQ(3), GNAZ(17), GNB1(2), GNB2(4), GNB3(2), GNB5(3), GNG10(1), GNG12(12), GNG13(3), GNG7(4), GNGT1(3), GNGT2(3), HRAS(1), IL18BP(2), ITPR1(34), KCNJ3(18), KRAS(37), NRAS(4), PALM2(8), PDE1A(7), PDE1B(5), PDE1C(14), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE7A(6), PDE7B(4), PDE8A(13), PDE8B(6), PLCB3(17), PPP3CA(13), PPP3CC(6), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), PRKD1(23), PRKD3(6), RHOA(20), RRAS(1), SLC9A1(12), USP5(6) 68517235 877 234 797 270 243 133 128 190 180 3 0.0120 1.000 1.000 261 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ATF4(2), CACNA1C(44), CACNA1D(43), CACNA1F(14), CACNA1S(26), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CDC42(3), CGA(1), EGFR(19), ELK1(4), FSHB(1), GNA11(6), GNAQ(3), GNAS(38), GNRH1(2), GNRH2(2), GNRHR(5), GRB2(4), HBEGF(2), HRAS(1), ITPR1(34), ITPR2(33), ITPR3(44), JUN(5), KRAS(37), LHB(3), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP2K7(38), MAP3K1(16), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK7(8), MAPK8(6), MAPK9(5), MMP14(7), MMP2(10), NRAS(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLD1(22), PLD2(19), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCD(10), PRKX(6), PTK2B(16), RAF1(9), SOS1(9), SOS2(18), SRC(5) 74436188 1020 232 950 309 341 150 121 200 197 11 0.00129 1.000 1.000 262 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(5), ACVR1B(15), ACVRL1(7), AKT1(3), AURKB(5), BMPR1A(12), BMPR2(21), BUB1(13), CDIPT(1), CDKL2(4), CDS1(5), CDS2(3), CLK1(4), CLK2(15), CLK4(5), COL4A3BP(5), CSNK2A1(5), CSNK2A2(8), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), IMPA1(7), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPPL1(27), ITPKA(2), ITPKB(14), MAP3K10(13), MOS(11), NEK1(6), NEK3(2), OCRL(10), PAK4(9), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3CA(80), PIK3CB(13), PIK3CG(24), PIM2(2), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCG1(22), PLCG2(19), PLK3(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), PRKCZ(2), PRKD1(23), PRKG1(12), RAF1(9), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KB1(6), STK11(6), TGFBR1(8), VRK1(2) 66015677 845 230 757 182 233 115 127 153 210 7 4.35e-08 1.000 1.000 263 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM2(3), CALM3(1), CALML3(1), CDIPT(1), CDS1(5), CDS2(3), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), FN3K(4), IMPA1(7), IMPA2(2), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPP5B(10), INPP5D(8), INPP5E(8), INPPL1(27), ITPK1(6), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), OCRL(10), PI4KA(22), PI4KB(10), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3C3(16), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PRKCA(8), PRKCG(17), PTEN(36), PTPMT1(1), SYNJ1(11), SYNJ2(20) 72886715 893 229 791 209 270 122 124 162 203 12 1.59e-07 1.000 1.000 264 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(13), BID(2), BRAF(18), CASP3(2), CD244(2), CD247(4), FAS(3), FASLG(5), FCGR3A(5), FYN(9), GRB2(4), GZMB(2), HCST(1), HLA-A(22), HLA-B(29), HLA-C(7), HLA-E(6), HLA-G(5), HRAS(1), ICAM1(4), ICAM2(3), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IFNG(2), IFNGR1(10), IFNGR2(2), ITGAL(22), ITGB2(12), KIR2DL3(4), KIR3DL1(10), KIR3DL2(3), KLRC1(4), KLRC2(2), KLRC3(9), KLRD1(3), KLRK1(5), KRAS(37), LAT(3), LCK(4), LCP2(10), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MICA(2), MICB(5), NCR1(3), NCR2(4), NCR3(1), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NRAS(4), PAK1(5), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRF1(13), PRKCA(8), PRKCG(17), PTK2B(16), PTPN11(8), PTPN6(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SH2D1A(1), SH2D1B(1), SH3BP2(7), SHC1(7), SHC2(3), SHC3(12), SHC4(8), SOS1(9), SOS2(18), SYK(9), TNF(3), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(3), TNFSF10(9), TYROBP(4), ULBP1(5), ULBP2(1), ULBP3(1), VAV1(13), VAV2(13), VAV3(14), ZAP70(13) 66497158 943 229 810 213 240 159 125 183 230 6 2.42e-10 1.000 1.000 265 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), AKT2(10), AKT3(8), BCL10(2), CARD11(27), CBL(5), CBLB(2), CBLC(7), CD247(4), CD28(1), CD3E(2), CD4(11), CD40LG(5), CD8A(4), CD8B(2), CDC42(3), CDK4(2), CHUK(5), CTLA4(4), FOS(1), FYN(9), GRAP2(5), GRB2(4), HRAS(1), ICOS(4), IFNG(2), IKBKB(10), IL10(2), IL4(4), ITK(5), JUN(5), KRAS(37), LAT(3), LCK(4), LCP2(10), MALT1(3), MAP3K8(2), NCK1(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(4), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDCD1(5), PDK1(3), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKCQ(14), PTPN6(6), PTPRC(21), RASGRP1(7), RHOA(20), SOS1(9), SOS2(18), TEC(4), TNF(3), VAV1(13), VAV2(13), VAV3(14), ZAP70(13) 59500548 781 228 666 193 219 139 112 153 155 3 1.37e-06 1.000 1.000 266 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(21), ADCY8(37), ARAF(13), ATF4(2), BRAF(18), CACNA1C(44), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CAMK4(10), CREBBP(46), EP300(27), GNAQ(3), GRIA1(22), GRIA2(26), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), GRM1(43), GRM5(37), HRAS(1), ITPR1(34), ITPR2(33), ITPR3(44), KRAS(37), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), NRAS(4), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PPP1CA(2), PPP1CC(4), PPP1R12A(3), PPP1R1A(1), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), RAF1(9), RAP1A(3), RAP1B(6), RAPGEF3(4), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA6(20) 58236784 847 226 780 238 255 133 109 175 168 7 6.48e-05 1.000 1.000 267 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADCY9(17), ASIP(2), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CREB1(4), CREB3L1(5), CREB3L2(4), CREB3L3(6), CREB3L4(3), CREBBP(46), CTNNB1(27), DCT(16), DVL1(8), DVL2(10), DVL3(15), EDN1(4), EDNRB(33), EP300(27), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD4(9), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GNAI1(3), GNAI2(4), GNAI3(8), GNAO1(1), GNAQ(3), GNAS(38), GSK3B(6), HRAS(1), KIT(13), KITLG(4), KRAS(37), LEF1(5), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MC1R(6), MITF(11), NRAS(4), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), POMC(9), PRKACA(6), PRKACB(6), PRKACG(9), PRKCA(8), PRKCG(17), PRKX(6), RAF1(9), TCF7(9), TCF7L1(8), TCF7L2(12), TYR(15), TYRP1(9), WNT1(10), WNT10A(6), WNT10B(2), WNT11(3), WNT16(14), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4) 63871358 983 219 885 297 342 138 121 180 198 4 0.000615 1.000 1.000 268 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(5), ACVR1B(15), ACVR1C(5), ACVR2A(10), ACVR2B(5), ACVRL1(7), AMHR2(9), BMP2(7), BMP4(6), BMP5(11), BMP6(12), BMP7(7), BMP8A(1), BMP8B(3), BMPR1A(12), BMPR1B(9), BMPR2(21), CDKN2B(1), CHRD(10), COMP(6), CREBBP(46), CUL1(24), DCN(10), E2F4(2), E2F5(4), EP300(27), FST(5), GDF5(13), GDF6(19), GDF7(4), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(13), INHBB(12), INHBC(7), INHBE(2), LEFTY1(3), LEFTY2(3), LTBP1(22), MAPK1(3), MAPK3(3), MYC(6), NODAL(1), NOG(2), PITX2(5), PPP2CA(4), PPP2CB(4), PPP2R1A(13), PPP2R1B(8), PPP2R2A(9), PPP2R2B(8), PPP2R2C(7), RBL1(12), RBL2(7), RBX1(1), RHOA(20), ROCK1(20), ROCK2(16), RPS6KB1(6), RPS6KB2(9), SMAD1(4), SMAD2(9), SMAD3(6), SMAD4(31), SMAD5(2), SMAD6(7), SMAD7(7), SMAD9(13), SMURF1(7), SMURF2(5), SP1(5), TFDP1(5), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), THBS1(17), THBS2(18), THBS3(11), THBS4(16), TNF(3), ZFYVE16(14), ZFYVE9(10) 57977819 783 216 735 219 230 91 106 139 211 6 0.00547 1.000 1.000 269 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(10), AKT3(8), CASP8(18), CCL3(1), CCL5(3), CD14(1), CD40(3), CD80(5), CD86(7), CHUK(5), CXCL10(1), CXCL9(2), FADD(3), FOS(1), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(4), IFNB1(3), IKBKB(10), IKBKE(12), IL12A(3), IL12B(2), IL1B(4), IRAK1(7), IRAK4(3), IRF3(3), IRF5(6), IRF7(4), JUN(5), LBP(3), LY96(5), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP2K7(38), MAP3K7(11), MAP3K8(2), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK9(5), MYD88(4), NFKB1(8), NFKB2(9), NFKBIA(1), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), RAC1(1), RELA(7), RIPK1(3), SPP1(4), STAT1(11), TBK1(8), TICAM1(8), TIRAP(1), TLR1(8), TLR2(4), TLR3(6), TLR4(27), TLR5(11), TLR6(4), TLR7(6), TLR8(13), TLR9(15), TNF(3), TOLLIP(6), TRAF3(7), TRAF6(6) 52553952 653 214 580 160 173 92 105 134 144 5 1.80e-05 1.000 1.000 270 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2L1(1), CDC42(3), CDK2(4), CDKN1B(1), CDKN2A(17), CREB1(4), CREB5(7), EBP(2), ERBB4(59), F2RL2(4), GAB1(4), GRB2(4), GSK3A(4), GSK3B(6), IFI27(1), IGF1(2), IGFBP1(11), INPPL1(27), IRS1(27), IRS2(10), IRS4(25), MET(10), MYC(6), NOLC1(12), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PARD3(17), PDK1(3), PIK3CA(80), PIK3CD(15), PPP1R13B(15), PREX1(21), PTEN(36), PTK2(11), PTPN1(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SLC2A4(5), SOS1(9), SOS2(18), TSC1(10), TSC2(14), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3) 45360712 644 210 555 145 170 96 92 116 163 7 4.26e-06 1.000 1.000 271 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(6), ADCY1(21), ADCY2(20), ADCY3(18), ADCY4(9), ADCY5(20), ADCY6(18), ADCY7(18), ADCY8(37), ADK(4), ADSL(5), ADSS(6), AK1(1), AK5(5), ALLC(6), AMPD1(12), AMPD2(17), AMPD3(19), APRT(3), ATIC(5), ATP1B1(7), ATP5A1(3), ATP5B(9), ATP5C1(5), ATP5F1(3), ATP5G2(2), ATP5G3(2), ATP5J(3), ATP5J2(1), CANT1(5), DCK(4), DGUOK(4), ENPP1(7), ENPP3(12), ENTPD1(4), ENTPD2(6), FHIT(1), GART(10), GDA(6), GMPS(7), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(14), GUCY2D(16), GUCY2F(15), GUK1(4), IMPDH1(6), ITPA(1), NME2(3), NPR1(11), NPR2(10), NT5E(5), NT5M(6), NUDT2(5), PAPSS1(6), PAPSS2(6), PDE1A(7), PDE4A(11), PDE4B(6), PDE4C(7), PDE4D(5), PDE5A(7), PDE6B(14), PDE6C(5), PDE6G(1), PDE7B(4), PDE8A(13), PDE9A(8), PFAS(12), PKLR(9), POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14), PPAT(7), PRPS1(3), PRPS2(3), PRUNE(5), RRM1(5), RRM2(3) 75053874 817 209 792 274 236 118 127 172 161 3 0.293 1.000 1.000 272 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(10), AKT3(8), BTK(4), FCER1A(5), FYN(9), GAB2(12), GRB2(4), HRAS(1), IL13(4), IL3(1), IL4(4), INPP5D(8), KRAS(37), LAT(3), LCP2(10), LYN(7), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), MAPK9(5), MS4A2(2), NRAS(4), PDK1(3), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCG1(22), PLCG2(19), PRKCA(8), PRKCD(10), PRKCE(14), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SOS1(9), SOS2(18), SYK(9), TNF(3), VAV1(13), VAV2(13), VAV3(14) 42224578 628 206 520 132 178 116 91 128 111 4 6.57e-10 1.000 1.000 273 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(8), BCAR1(10), CAPN1(7), CAPN10(10), CAPN11(6), CAPN2(10), CAPN3(8), CAPN5(12), CAPN6(7), CAPN7(6), CAPN9(5), CAPNS1(3), CAV1(5), CAV2(1), CAV3(2), CDC42(3), CRK(1), CSK(8), DOCK1(20), FYN(9), GIT2(5), GRB2(4), ILK(9), ITGA10(12), ITGA11(16), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGA7(19), ITGA8(12), ITGA9(9), ITGAD(17), ITGAE(16), ITGAL(22), ITGAM(10), ITGAV(18), ITGAX(13), ITGB1(11), ITGB2(12), ITGB3(6), ITGB4(24), ITGB5(7), ITGB6(5), ITGB7(6), ITGB8(18), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAPK10(4), MAPK12(1), MAPK4(8), MAPK6(3), MAPK7(8), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PDPK1(1), PIK3R2(13), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(11), RHO(9), ROCK1(20), ROCK2(16), SDCCAG8(7), SHC1(7), SHC3(12), SORBS1(12), SOS1(9), SRC(5), TLN1(28), TNS1(39), VASP(2), VAV2(13), VAV3(14), VCL(11), ZYX(7) 78342943 849 206 823 249 274 111 107 151 200 6 0.00345 1.000 1.000 274 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(14), AMY2A(7), AMY2B(18), ASCC3(37), ATP13A2(16), DDX18(14), DDX19A(5), DDX23(12), DDX4(9), DDX41(9), DDX47(1), DDX50(12), DDX51(7), DDX52(7), DDX54(17), DDX55(5), DDX56(8), DHX58(11), ENPP1(7), ENPP3(12), ENTPD7(10), EP400(47), ERCC2(9), ERCC3(8), G6PC2(1), GAA(8), GANC(9), GBA(12), GBE1(7), GCK(9), GPI(6), GUSB(10), GYS1(8), GYS2(9), HK1(17), HK2(12), HK3(11), IFIH1(10), LYZL1(4), MGAM(19), MOV10L1(9), NUDT5(1), NUDT8(1), PGM1(3), PGM3(13), PYGB(14), PYGL(11), PYGM(14), RAD54B(3), RAD54L(4), RUVBL2(9), SETX(24), SI(35), SKIV2L2(13), SMARCA2(31), SMARCA5(10), TREH(3), UGDH(8), UGP2(9), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), UXS1(8) 72395410 772 201 741 219 203 88 114 175 189 3 0.0505 1.000 1.000 275 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(25), ABCA10(21), ABCA12(44), ABCA13(63), ABCA2(27), ABCA3(21), ABCA4(22), ABCA5(24), ABCA6(18), ABCA7(22), ABCA8(14), ABCA9(19), ABCB1(33), ABCB10(14), ABCB11(11), ABCB4(29), ABCB5(21), ABCB6(12), ABCB7(5), ABCB8(13), ABCB9(5), ABCC1(14), ABCC10(14), ABCC11(20), ABCC12(18), ABCC2(17), ABCC3(14), ABCC4(20), ABCC5(11), ABCC6(17), ABCC8(23), ABCC9(45), ABCD1(10), ABCD2(5), ABCD3(4), ABCD4(8), ABCG1(13), ABCG2(5), ABCG4(4), ABCG5(3), ABCG8(6), CFTR(15), TAP1(5), TAP2(10) 69095352 764 199 726 196 219 109 101 153 175 7 9.26e-06 1.000 1.000 276 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(10), AKT3(8), BAD(4), CASP9(3), CDC42(3), HRAS(1), KDR(17), KRAS(37), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPKAPK2(3), MAPKAPK3(5), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NOS3(15), NRAS(4), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCG1(22), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PRKCA(8), PRKCG(17), PTGS2(7), PTK2(11), PXN(6), RAC1(1), RAC2(2), RAC3(4), RAF1(9), SH2D2A(7), SHC2(3), SPHK1(10), SPHK2(8), SRC(5) 42137879 603 198 493 121 183 115 84 114 106 1 5.40e-12 1.000 1.000 277 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(8), ALG6(4), CCKBR(16), CCR2(5), CCR3(12), CCR5(4), CELSR1(43), CELSR2(41), CELSR3(58), CHRM2(19), CHRM3(12), CIDEB(2), CXCR3(2), DRD4(5), EDNRA(4), EMR2(10), EMR3(4), F2R(6), FSHR(24), GHRHR(4), GNRHR(5), GPR116(14), GPR132(5), GPR133(16), GPR135(11), GPR143(4), GPR17(6), GPR18(3), GPR55(9), GPR56(10), GPR61(9), GPR84(3), GRM1(43), GRPR(6), HRH4(8), LGR6(15), LPHN2(23), LPHN3(23), LTB4R2(6), NTSR1(10), OR2M4(6), P2RY11(3), P2RY13(4), PTGFR(5), SMO(15), SSTR2(4), TAAR5(5), TSHR(12), VN1R1(4) 38993861 570 194 552 152 186 77 74 142 89 2 2.97e-05 1.000 1.000 278 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(8), BAD(4), BCL2(4), CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAMK2B(7), CAMK4(10), CD3E(2), CD69(4), CDKN1A(5), CNR1(13), CREBBP(46), CSNK2A1(5), CTLA4(4), EGR2(9), EGR3(9), EP300(27), FCER1A(5), FCGR3A(5), FOS(1), FOSL1(1), GATA3(19), GATA4(4), GSK3A(4), GSK3B(6), HRAS(1), ICOS(4), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL13(4), IL1B(4), IL2RA(2), IL3(1), IL4(4), ITK(5), JUNB(5), KPNA5(8), MAP2K7(38), MAPK14(2), MAPK8(6), MAPK9(5), MEF2A(2), MEF2B(6), MEF2D(8), MYF5(6), NCK2(8), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB2(9), NFKBIB(8), NFKBIE(1), NPPB(3), NUP214(29), OPRD1(4), P2RX7(2), PAK1(5), PIN1(2), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTPRC(21), RELA(7), RPL13A(4), SFN(1), SLA(6), SP1(5), SP3(5), TGFB1(3), TNF(3), TRAF2(4), TRPV6(9), VAV1(13), VAV2(13), VAV3(14), XPO5(4) 53400927 621 193 593 184 193 88 81 120 135 4 0.00837 1.000 1.000 279 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), AKT2(10), AKT3(8), BCL10(2), BLNK(5), BTK(4), CARD11(27), CD19(5), CD22(5), CD72(1), CD79A(8), CD79B(3), CD81(6), CHUK(5), CR2(25), FCGR2B(3), FOS(1), GSK3B(6), HRAS(1), IFITM1(4), IKBKB(10), INPP5D(8), JUN(5), KRAS(37), LILRB3(6), LYN(7), MALT1(3), NFAT5(13), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NRAS(4), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PLCG2(19), PPP3CA(13), PPP3CB(6), PPP3CC(6), PPP3R1(3), PTPN6(6), RAC1(1), RAC2(2), RAC3(4), RASGRP3(6), SYK(9), VAV1(13), VAV2(13), VAV3(14) 43634866 607 193 499 138 172 121 88 106 118 2 2.92e-08 1.000 1.000 280 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(2), AKT1(3), AKT2(10), AKT3(8), ANGPTL2(6), ARHGAP1(8), ARHGAP4(4), ARHGEF11(25), BTK(4), CDC42(3), CFL1(1), CFL2(1), GDI1(5), GDI2(6), INPPL1(27), ITPR1(34), ITPR2(33), ITPR3(44), LIMK1(6), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PDK1(3), PIK3CA(80), PIK3CD(15), PIK3CG(24), PIK3R1(12), PITX2(5), PPP1R13B(15), PTEN(36), RACGAP1(8), RHO(9), ROCK1(20), ROCK2(16), RPS4X(2), SAG(4), WASF1(8), WASL(5) 41110513 579 192 495 132 159 84 90 96 138 12 1.18e-05 1.000 1.000 281 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(25), BDKRB1(4), BDKRB2(3), C1QA(5), C1QB(1), C1QC(2), C1S(10), C2(2), C3(34), C3AR1(10), C4BPA(5), C4BPB(3), C5(13), C5AR1(6), C6(13), C7(7), C8A(8), C8B(11), C9(8), CD46(3), CD55(3), CFB(8), CFH(27), CFI(14), CPB2(10), CR1(33), CR2(25), F10(8), F11(5), F12(3), F13A1(19), F13B(17), F2(11), F2R(6), F3(2), F5(22), F7(11), F8(29), F9(9), FGA(12), FGB(6), FGG(5), KLKB1(6), KNG1(11), MASP1(3), MASP2(6), MBL2(4), PLAT(7), PLAUR(6), PLG(18), PROC(4), PROS1(11), SERPINA1(7), SERPINA5(8), SERPINC1(5), SERPIND1(5), SERPINE1(3), SERPINF2(8), SERPING1(8), TFPI(5), THBD(2), VWF(38) 53047600 623 191 591 162 157 82 93 139 151 1 0.00212 1.000 1.000 282 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(53), AXIN1(15), CCND1(2), CCND2(2), CCND3(1), CSNK1E(9), CTNNB1(27), DVL1(8), DVL2(10), DVL3(15), FBXW2(2), FOSL1(1), FZD1(11), FZD10(20), FZD2(13), FZD3(12), FZD5(5), FZD6(9), FZD7(12), FZD8(14), FZD9(2), GSK3B(6), JUN(5), LDLR(12), MAPK10(4), MAPK9(5), MYC(6), PAFAH1B1(15), PPP2R5C(6), PPP2R5E(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCI(7), PRKCQ(14), PRKCZ(2), PRKD1(23), RAC1(1), RHOA(20), SFRP4(5), TCF7(9), WNT1(10), WNT10A(6), WNT10B(2), WNT11(3), WNT16(14), WNT2(6), WNT2B(13), WNT3(5), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7) 35204697 533 190 485 156 168 55 54 106 143 7 0.0240 1.000 1.000 283 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(10), CD14(1), CD19(5), CD1A(13), CD1B(7), CD1C(10), CD1D(13), CD1E(11), CD2(4), CD22(5), CD33(9), CD34(4), CD36(5), CD37(2), CD38(5), CD3E(2), CD4(11), CD44(8), CD5(4), CD55(3), CD7(5), CD8A(4), CD8B(2), CD9(1), CR1(33), CR2(25), CSF1(5), CSF1R(17), CSF2RA(10), CSF3(1), CSF3R(13), DNTT(5), EPO(3), EPOR(3), FCER2(4), FCGR1A(4), FLT3(12), FLT3LG(1), GP5(14), GP9(3), HLA-DRA(7), HLA-DRB1(1), HLA-DRB5(1), IL11(3), IL11RA(2), IL1A(2), IL1B(4), IL1R1(4), IL1R2(11), IL2RA(2), IL3(1), IL3RA(5), IL4(4), IL4R(7), IL5RA(8), IL6R(3), IL7(2), IL7R(15), IL9R(2), ITGA1(7), ITGA2(12), ITGA2B(13), ITGA3(11), ITGA4(16), ITGA5(10), ITGA6(10), ITGAM(10), ITGB3(6), KIT(13), KITLG(4), MME(10), MS4A1(2), TFRC(2), THPO(6), TNF(3), TPO(27) 47760133 543 187 504 137 134 68 76 124 139 2 0.000897 1.000 1.000 284 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG1(8), ALG10(14), ALG10B(10), ALG11(8), ALG12(10), ALG13(8), ALG14(2), ALG2(3), ALG3(4), ALG6(4), ALG8(3), ALG9(2), B3GNT1(4), B3GNT2(5), B3GNT6(5), B3GNT7(6), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), B4GALT5(4), B4GALT7(6), C1GALT1(3), C1GALT1C1(6), CHPF(4), CHST1(20), CHST11(4), CHST12(6), CHST13(5), CHST14(2), CHST2(15), CHST3(8), CHST4(7), CHST6(11), CHST7(7), CHSY1(9), DPAGT1(6), EXT1(22), EXT2(7), EXTL1(8), EXTL2(2), EXTL3(12), FUT11(3), FUT8(9), GALNT1(4), GALNT10(8), GALNT11(6), GALNT12(3), GALNT13(9), GALNT14(12), GALNT2(7), GALNT3(4), GALNT4(6), GALNT5(12), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GALNTL5(3), GANAB(19), GCNT1(1), GCNT3(4), GCNT4(4), HS2ST1(3), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), HS3ST5(8), HS6ST1(7), HS6ST2(9), HS6ST3(9), MAN1A1(4), MAN1A2(5), MAN1B1(6), MAN1C1(10), MAN2A1(10), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), MGAT5B(7), NDST1(13), NDST2(13), NDST3(18), NDST4(17), OGT(7), RPN1(4), RPN2(6), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7), ST6GAL1(1), ST6GALNAC1(5), STT3B(5), UST(10), WBSCR17(27), XYLT1(11), XYLT2(43) 64548851 767 182 696 266 250 90 86 146 191 4 0.852 1.000 1.000 285 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2(4), BCR(14), BLNK(5), BTK(4), CD19(5), CD22(5), CD81(6), CR2(25), CSK(8), DAG1(13), FLOT2(9), GRB2(4), GSK3A(4), GSK3B(6), INPP5D(8), ITPR1(34), ITPR2(33), ITPR3(44), LYN(7), MAP4K1(4), MAPK1(3), MAPK3(3), NFATC1(16), NFATC2(26), NR0B2(3), PDK1(3), PIK3CA(80), PIK3CD(15), PIK3R1(12), PLCG2(19), PPP1R13B(15), PPP3CA(13), PPP3CB(6), PPP3CC(6), PTPRC(21), RAF1(9), SHC1(7), SOS1(9), SOS2(18), SYK(9), VAV1(13) 43360160 573 179 498 146 173 88 78 111 119 4 4.78e-05 1.000 1.000 286 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(4), IMPA1(7), IMPA2(2), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPP5B(10), INPP5E(8), INPPL1(27), IPMK(2), ISYNA1(4), ITPK1(6), ITPKA(2), ITPKB(14), MINPP1(6), MIOX(6), OCRL(10), PI4KA(22), PI4KB(10), PIK3C3(16), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIP4K2A(8), PIP4K2B(4), PIP4K2C(2), PIP5K1A(3), PIP5K1B(2), PIP5K1C(14), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCD3(9), PLCD4(6), PLCE1(17), PLCG1(22), PLCG2(19), PLCZ1(10), PTEN(36), PTPMT1(1), SYNJ1(11), SYNJ2(20) 43509924 571 177 489 122 172 88 83 101 121 6 1.13e-07 1.000 1.000 287 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(10), AKT3(8), BCR(14), BTK(4), CD19(5), CDKN2A(17), DAPP1(1), FLOT2(9), GAB1(4), ITPR1(34), ITPR2(33), ITPR3(44), LYN(7), NR0B2(3), PDK1(3), PHF11(5), PIK3CA(80), PITX2(5), PLCG2(19), PPP1R13B(15), PREX1(21), PTEN(36), PTPRC(21), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SAG(4), SYK(9), TEC(4), VAV1(13) 32336925 464 177 395 118 133 72 63 90 99 7 0.000654 1.000 1.000 288 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(7), BMP4(6), BMP5(11), BMP6(12), BMP7(7), BMP8A(1), BMP8B(3), BTRC(9), CSNK1A1(5), CSNK1A1L(7), CSNK1D(4), CSNK1E(9), CSNK1G1(7), CSNK1G2(7), CSNK1G3(10), DHH(2), FBXW11(9), GAS1(4), GLI1(23), GLI2(18), GLI3(60), GSK3B(6), HHIP(20), IHH(7), LRP2(61), PRKACA(6), PRKACB(6), PRKACG(9), PRKX(6), PTCH1(29), PTCH2(13), RAB23(2), SHH(6), SMO(15), STK36(9), SUFU(6), WNT1(10), WNT10A(6), WNT10B(2), WNT11(3), WNT16(14), WNT2(6), WNT2B(13), WNT3(5), WNT3A(8), WNT4(2), WNT5A(8), WNT5B(4), WNT6(4), WNT7A(6), WNT7B(7), WNT8A(2), WNT8B(1), WNT9A(7), WNT9B(4), ZIC2(7) 35642666 541 173 498 159 190 71 56 94 124 6 0.0210 1.000 1.000 289 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(18), CPEB1(6), EGFR(19), ERBB2(23), ERBB4(59), ETS1(8), ETS2(4), ETV6(9), ETV7(5), FMN2(44), GRB2(4), KRAS(37), MAP2K1(7), MAPK1(3), MAPK3(3), NOTCH1(31), NOTCH2(33), NOTCH3(26), NOTCH4(22), PIWIL1(6), PIWIL2(10), PIWIL3(6), PIWIL4(9), RAF1(9), SOS1(9), SOS2(18), SPIRE1(9), SPIRE2(6) 30573969 443 172 380 112 116 81 48 113 84 1 0.00193 1.000 1.000 290 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(4), AKT1(3), CALM1(2), CALM2(3), CALM3(1), CALR(2), CAMK1(3), CAMK1G(8), CAMK4(10), CREBBP(46), CSNK1A1(5), EDN1(4), ELSPBP1(3), F2(11), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(6), HAND1(5), HAND2(7), HRAS(1), IGF1(2), LIF(4), MAP2K1(7), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), MEF2C(5), MYH2(39), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NKX2-5(7), NPPA(2), PIK3CA(80), PIK3R1(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RAF1(9), RPS6KB1(6), SYT1(5) 29760415 455 172 390 105 140 70 72 77 95 1 1.45e-06 1.000 1.000 291 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(3), AKT2(10), AKT3(8), BRD4(15), CAP1(2), CBL(5), CDC42(3), CDKN2A(17), F2RL2(4), FLOT2(9), GRB2(4), GSK3A(4), GSK3B(6), IGFBP1(11), INPPL1(27), IRS1(27), IRS2(10), IRS4(25), LNPEP(12), MAPK1(3), MAPK3(3), PARD3(17), PDK1(3), PIK3CA(80), PIK3CD(15), PIK3R1(12), PTEN(36), PTPN1(3), RAF1(9), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SERPINB6(4), SFN(1), SHC1(7), SLC2A4(5), SORBS1(12), SOS1(9), SOS2(18), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3) 34898199 490 172 415 112 136 82 61 78 126 7 5.46e-05 1.000 1.000 292 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(10), ACTB(8), ACTG1(1), ARHGEF2(13), ARPC5L(3), CD14(1), CDC42(3), CDH1(33), CLDN1(4), CTNNB1(27), CTTN(12), EZR(5), FYN(9), HCLS1(3), ITGB1(11), KRT18(3), LY96(5), NCK1(6), NCK2(8), NCL(7), OCLN(8), PRKCA(8), RHOA(20), ROCK1(20), ROCK2(16), TLR4(27), TLR5(11), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9), WAS(4), WASL(5), YWHAQ(4), YWHAZ(3) 30824890 392 171 360 102 96 58 50 104 82 2 0.00321 1.000 1.000 293 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(10), ACTB(8), ACTG1(1), ARHGEF2(13), ARPC5L(3), CD14(1), CDC42(3), CDH1(33), CLDN1(4), CTNNB1(27), CTTN(12), EZR(5), FYN(9), HCLS1(3), ITGB1(11), KRT18(3), LY96(5), NCK1(6), NCK2(8), NCL(7), OCLN(8), PRKCA(8), RHOA(20), ROCK1(20), ROCK2(16), TLR4(27), TLR5(11), TUBA1A(3), TUBA1B(3), TUBA1C(3), TUBA3C(10), TUBA3D(8), TUBA3E(10), TUBA4A(3), TUBA8(6), TUBAL3(8), TUBB1(6), TUBB2A(4), TUBB2B(4), TUBB3(10), TUBB6(7), TUBB8(9), WAS(4), WASL(5), YWHAQ(4), YWHAZ(3) 30824890 392 171 360 102 96 58 50 104 82 2 0.00321 1.000 1.000 294 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(53), AR(24), ASAH1(4), BRAF(18), CAMP(3), CCL13(1), CCL15(2), CCL16(1), DAG1(13), EGFR(19), GNA11(6), GNA15(4), GNAI1(3), GNAQ(3), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), MAPK10(4), MAPK14(2), PHKA2(15), PIK3CA(80), PIK3CD(15), PIK3R1(12), PITX2(5), PTX3(3), RAF1(9), SRC(5) 31270437 464 170 397 121 129 63 85 90 89 8 0.000617 1.000 1.000 295 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(4), BRAF(18), CHUK(5), CREB1(4), DAXX(11), ELK1(4), FOS(1), GRB2(4), HRAS(1), IKBKB(10), JUN(5), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP2K5(1), MAP2K6(1), MAP2K7(38), MAP3K1(16), MAP3K10(13), MAP3K11(9), MAP3K12(15), MAP3K13(12), MAP3K2(6), MAP3K3(9), MAP3K4(26), MAP3K5(10), MAP3K6(10), MAP3K7(11), MAP3K8(2), MAP3K9(5), MAP4K1(4), MAP4K2(10), MAP4K3(5), MAP4K4(13), MAP4K5(4), MAPK1(3), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK3(3), MAPK4(8), MAPK6(3), MAPK7(8), MAPK8(6), MAPK9(5), MAPKAPK2(3), MAPKAPK3(5), MAPKAPK5(4), MAX(3), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MKNK1(5), MKNK2(8), MYC(6), NFKB1(8), NFKBIA(1), PAK1(5), PAK2(12), RAC1(1), RAF1(9), RELA(7), RIPK1(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA4(11), RPS6KA5(5), RPS6KB1(6), RPS6KB2(9), SHC1(7), SP1(5), STAT1(11), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TRADD(2), TRAF2(4) 55598953 582 169 557 153 178 74 64 96 164 6 0.00373 1.000 1.000 296 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(3), APOA1(8), CD36(5), CITED2(4), CPT1B(7), CREBBP(46), DUSP1(3), DUT(3), EHHADH(4), EP300(27), HSD17B4(7), HSPA1A(4), JUN(5), LPL(9), MAPK1(3), MAPK3(3), ME1(1), MYC(6), NCOA1(20), NCOR1(30), NCOR2(40), NFKBIA(1), NR0B2(3), NR1H3(5), NR2F1(11), NRIP1(18), PDGFA(2), PIK3CA(80), PIK3R1(12), PPARA(7), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), PTGS2(7), RB1(14), RELA(7), RXRA(13), SP1(5), STAT5A(10), STAT5B(13), TNF(3) 37038167 496 169 436 121 126 78 79 90 118 5 0.000149 1.000 1.000 297 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(40), ASH2L(4), CARM1(8), CTCFL(14), DOT1L(18), EED(7), EHMT1(18), EHMT2(19), EZH1(8), EZH2(5), FBXO11(13), HCFC1(19), HSF4(8), JMJD4(4), JMJD6(3), KDM6A(14), MEN1(11), NSD1(27), OGT(7), PAXIP1(7), PPP1CA(2), PPP1CC(4), PRDM2(38), PRDM7(2), PRDM9(23), PRMT1(3), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), RBBP5(5), SATB1(19), SETD1A(24), SETD2(20), SETD7(3), SETD8(1), SETDB1(17), SETDB2(12), SETMAR(3), SMYD3(3), STK38(6), SUV39H1(6), SUV39H2(2), SUV420H1(18), SUV420H2(6), SUZ12(3), WHSC1(25), WHSC1L1(18) 69604920 539 168 517 139 154 66 73 103 135 8 0.0193 1.000 1.000 298 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(4), BRAF(18), CAMP(3), CREB1(4), CREB5(7), CREBBP(46), CRKL(2), DAG1(13), EGR1(12), EGR2(9), EGR3(9), EGR4(7), ELK1(4), FRS2(5), GNAQ(3), JUN(5), MAP1B(25), MAP2K4(9), MAP2K7(38), MAPK1(3), MAPK10(4), MAPK3(3), MAPK8(6), MAPK8IP1(4), MAPK8IP2(8), MAPK8IP3(12), MAPK9(5), NTRK1(9), OPN1LW(10), PIK3C2G(14), PIK3CA(80), PIK3CD(15), PIK3R1(12), PTPN11(8), RPS6KA3(6), SHC1(7), SRC(5), TERF2IP(5), TH(7) 30050203 449 167 385 109 136 71 70 72 96 4 1.84e-05 1.000 1.000 299 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(40), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADIPOQ(5), ADIPOR1(5), ADIPOR2(6), AGRP(2), AKT1(3), AKT2(10), AKT3(8), CAMKK1(5), CAMKK2(2), CD36(5), CHUK(5), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), G6PC2(1), IKBKB(10), IRS1(27), IRS2(10), IRS4(25), JAK1(19), JAK2(12), JAK3(12), LEP(3), LEPR(14), MAPK10(4), MAPK8(6), MAPK9(5), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NPY(2), PCK1(12), PCK2(10), POMC(9), PPARA(7), PPARGC1A(11), PRKAA1(7), PRKAA2(10), PRKAB1(11), PRKAB2(4), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKCQ(14), PTPN11(8), RELA(7), RXRA(13), RXRB(5), RXRG(7), SLC2A1(8), SLC2A4(5), SOCS3(3), STAT3(7), STK11(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4), TYK2(12) 48560096 556 166 534 161 173 69 57 111 138 8 0.0421 1.000 1.000 300 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(6), DAG1(13), DGKA(9), ETFA(2), GCA(3), ITGA9(9), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), MAP2K1(7), MAPK1(3), MAPK3(3), NR1I3(3), PAK1(5), PDE3A(19), PDE3B(23), PI3(2), PIK3C2G(14), PIK3CA(80), PIK3CD(15), PIK3R1(12), PSME1(3), RIPK3(5), RPS4X(2), SGCB(5), VASP(2) 28496501 379 165 320 98 102 66 69 70 68 4 0.000331 1.000 1.000 301 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(10), AKT3(8), BRAF(18), CAB39(2), EIF4B(5), EIF4EBP1(4), FIGF(5), HIF1A(5), IGF1(2), MAPK1(3), MAPK3(3), PDPK1(1), PGF(3), PIK3CA(80), PIK3CB(13), PIK3CD(15), PIK3CG(24), PIK3R1(12), PIK3R2(13), PIK3R3(8), PIK3R5(12), PRKAA1(7), PRKAA2(10), RHEB(2), RICTOR(25), RPS6(1), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA6(20), RPS6KB1(6), RPS6KB2(9), STK11(6), TSC1(10), TSC2(14), ULK1(20), ULK2(11), ULK3(2), VEGFB(2), VEGFC(12) 31058180 433 164 365 101 129 64 81 67 88 4 0.000235 1.000 1.000 302 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(3), BDKRB2(3), CALM1(2), CALM2(3), CALM3(1), CAV1(5), CHRM1(6), CHRNA1(7), FLT1(19), FLT4(31), KDR(17), NOS3(15), PDE2A(16), PDE3A(19), PDE3B(23), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKG1(12), PRKG2(15), RYR2(106), SLC7A1(9), SYT1(5), TNNI1(1) 23680532 361 164 340 116 105 45 44 85 81 1 0.189 1.000 1.000 303 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(4), ATP8A1(9), AVPR1A(17), AVPR1B(3), AVPR2(11), BDKRB1(4), BDKRB2(3), BRS3(3), C3AR1(10), CCKAR(7), CCKBR(16), CCR1(7), CCR10(3), CCR2(5), CCR3(12), CCR5(4), CCR6(2), CCR7(4), CCR8(4), CX3CR1(4), CXCR3(2), CXCR6(2), EDNRA(4), EDNRB(33), FPR1(8), FSHR(24), GALR1(6), GALR2(11), GALR3(4), GALT(3), GHSR(8), GNB2L1(3), GNRHR(5), GRPR(6), LHCGR(18), MC1R(6), MC2R(3), MC3R(11), MC4R(6), MC5R(6), NMBR(3), NPY1R(5), NPY2R(7), NPY5R(4), NTSR1(10), NTSR2(5), OPRD1(4), OPRK1(17), OPRL1(7), OPRM1(8), OXTR(8), SSTR1(10), SSTR2(4), SSTR3(9), SSTR4(16), TAC4(3), TACR1(4), TACR2(2), TACR3(15), TRHR(7), TSHR(12) 30722818 462 164 437 165 168 50 75 91 77 1 0.131 1.000 1.000 304 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(9), ADCY6(18), ADCY8(37), CACNA1A(34), CACNA1B(32), GNAS(38), GNAT3(5), GNB1(2), GNB3(2), GNG13(3), GRM4(15), ITPR3(44), KCNB1(16), PDE1A(7), PLCB2(8), PRKACA(6), PRKACB(6), PRKACG(9), PRKX(6), SCNN1A(3), SCNN1B(9), SCNN1G(6), TAS1R1(9), TAS1R2(14), TAS1R3(12), TAS2R1(4), TAS2R10(4), TAS2R13(4), TAS2R14(7), TAS2R16(7), TAS2R3(3), TAS2R38(6), TAS2R39(3), TAS2R4(4), TAS2R40(2), TAS2R41(1), TAS2R42(6), TAS2R43(3), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R60(3), TAS2R7(4), TAS2R8(4), TAS2R9(3), TRPM5(8) 33328508 431 160 413 149 151 54 54 91 80 1 0.340 1.000 1.000 305 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(3), AKT1(3), AKT2(10), AKT3(8), BAD(4), BTK(4), CDKN2A(17), DAPP1(1), GRB2(4), GSK3A(4), GSK3B(6), IARS(11), IGFBP1(11), INPP5D(8), PDK1(3), PIK3CA(80), PPP1R13B(15), PTEN(36), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KB1(6), SFN(1), SHC1(7), SOS1(9), SOS2(18), TEC(4), YWHAB(2), YWHAE(5), YWHAG(1), YWHAH(3), YWHAQ(4), YWHAZ(3) 21127023 318 158 255 72 66 59 49 60 80 4 0.00231 1.000 1.000 306 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(7), INPP1(2), INPP4A(7), INPP4B(11), INPP5A(8), INPPL1(27), ITPKA(2), ITPKB(14), MIOX(6), OCRL(10), PIK3C2A(17), PIK3C2B(20), PIK3C2G(14), PIK3CA(80), PIK3CB(13), PIK3CG(24), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), PLCD1(7), PLCG1(22), PLCG2(19) 26220818 374 156 307 75 103 67 70 61 71 2 3.03e-06 1.000 1.000 307 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(5), ADAM17(9), ATP6AP1(6), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), CASP3(2), CCL5(3), CDC42(3), CHUK(5), CSK(8), EGFR(19), F11R(2), GIT1(4), HBEGF(2), IGSF5(5), IKBKB(10), JAM2(2), JAM3(6), JUN(5), LYN(7), MAP2K4(9), MAPK10(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPK8(6), MAPK9(5), MET(10), NFKB1(8), NFKB2(9), NFKBIA(1), NOD1(13), PAK1(5), PLCG1(22), PLCG2(19), PTPN11(8), PTPRZ1(32), RAC1(1), RELA(7), SRC(5), TCIRG1(6), TJP1(26) 41180324 433 155 412 127 107 65 47 94 117 3 0.137 1.000 1.000 308 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(10), AKT3(8), BAD(4), BCR(14), BLNK(5), BTK(4), CD19(5), CSK(8), DAG1(13), EPHB2(15), GRB2(4), ITPKA(2), ITPKB(14), LYN(7), MAP2K1(7), MAP2K2(3), MAPK1(3), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PI3(2), PIK3CA(80), PIK3CD(15), PIK3R1(12), PLCG2(19), PPP1R13B(15), RAF1(9), SERPINA4(5), SHC1(7), SOS1(9), SOS2(18), SYK(9), VAV1(13) 30894092 387 155 323 96 112 62 58 76 77 2 0.000713 1.000 1.000 309 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(5), APC(53), ATF2(4), AXIN1(15), BMP10(6), BMP2(7), BMP4(6), BMP5(11), BMP7(7), BMPR1A(12), BMPR2(21), CHRD(10), CTNNB1(27), DVL1(8), FZD1(11), GATA4(4), GSK3B(6), MAP3K7(11), MEF2C(5), MYL2(9), NKX2-5(7), NOG(2), NPPA(2), NPPB(3), RFC1(14), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TGFBR2(17), TGFBR3(9), WNT1(10) 21326728 331 154 307 82 78 31 40 59 116 7 0.0488 1.000 1.000 310 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(14), AMY2A(7), AMY2B(18), ENPP1(7), ENPP3(12), GAA(8), GANAB(19), GBE1(7), GCK(9), GPI(6), GUSB(10), GYS1(8), GYS2(9), HK1(17), HK2(12), HK3(11), MGAM(19), PGM1(3), PGM3(13), PYGB(14), PYGL(11), PYGM(14), RNPC3(1), SI(35), UCHL1(3), UCHL3(4), UGDH(8), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5), UXS1(8) 33290788 357 154 335 108 89 42 48 90 87 1 0.207 1.000 1.000 311 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(5), CDC40(8), CLK2(15), CLK3(13), CLK4(5), COL2A1(18), CPSF1(28), CPSF2(7), CPSF3(3), CPSF4(2), CSTF1(10), CSTF2(5), CSTF2T(12), CSTF3(9), DDIT3(5), DDX1(11), DDX20(3), DHX15(13), DHX16(9), DHX38(14), DHX8(18), DHX9(13), DICER1(10), DNAJC8(5), FUS(2), GIPC1(6), METTL3(2), NCBP1(7), NCBP2(3), NONO(5), NUDT21(3), NXF1(5), PABPN1(4), PAPOLA(7), PHF5A(1), POLR2A(24), PPM1G(4), PRPF18(2), PRPF3(8), PRPF4(7), PRPF4B(13), PRPF8(18), PSKH1(7), PTBP1(10), PTBP2(4), RBM17(2), RBM5(9), RNGTT(4), RNMT(9), RNPS1(1), SF3A1(6), SF3A2(2), SF3A3(2), SF3B1(13), SF3B2(16), SF3B4(9), SNRPA(7), SNRPA1(5), SNRPB(2), SNRPB2(2), SNRPD1(2), SNRPD2(5), SNRPD3(4), SNRPE(2), SNRPG(1), SNRPN(10), SPOP(4), SRPK1(8), SRPK2(8), SRRM1(17), SUPT5H(16), U2AF1(5), U2AF2(15), XRN2(15) 62004493 584 153 561 130 182 72 88 86 154 2 0.000598 1.000 1.000 312 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(10), AKT3(8), ANKRD6(9), APC(53), AXIN1(15), AXIN2(20), CER1(3), CSNK1A1(5), CTNNB1(27), DACT1(10), DKK1(12), DKK2(8), DKK3(4), DKK4(5), DVL1(8), FSTL1(3), GSK3A(4), GSK3B(6), LRP1(54), MVP(11), NKD1(8), NKD2(2), PIN1(2), PSEN1(5), PTPRA(15), SENP2(7), SFRP1(7), TSHB(3), WIF1(3) 23600918 330 153 305 89 95 35 45 62 85 8 0.0713 1.000 1.000 313 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(8), ARHGDIB(1), BAG4(5), BCL2(4), BID(2), BIRC2(7), BIRC3(10), CASP2(3), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CFLAR(1), CHUK(5), CRADD(6), DAXX(11), DFFA(4), DFFB(3), FADD(3), GSN(12), LMNA(11), LMNB1(4), LMNB2(6), MAP2K7(38), MAP3K1(16), MAP3K5(10), MAPK8(6), MDM2(8), NFKB1(8), NFKBIA(1), NUMA1(26), PAK2(12), PRKCD(10), PRKDC(56), PSEN1(5), PSEN2(3), PTK2(11), RASA1(19), RB1(14), RELA(7), RIPK1(3), SPTAN1(22), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(4), TRAF2(4) 40491706 432 148 413 115 122 53 65 67 119 6 0.0334 1.000 1.000 314 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(4), AK3(5), CAD(20), CANT1(5), CTPS2(3), DCK(4), DCTD(1), DHODH(4), DPYD(20), DPYS(8), DUT(3), ENTPD1(4), ENTPD3(6), ENTPD4(13), ENTPD5(2), ENTPD6(6), ENTPD8(7), ITPA(1), NME2(3), NME4(2), NME6(3), NME7(1), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT2(5), PNPT1(5), POLA1(8), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(7), RFC5(2), RRM1(5), RRM2(3), RRM2B(4), TK1(1), TK2(4), TXNRD1(10), TXNRD2(4), TYMS(1), UCK1(6), UCK2(1), UMPS(5), UPB1(6), UPP1(2), UPP2(7), UPRT(6), ZNRD1(2) 47451760 456 145 441 130 146 52 64 85 109 0 0.0225 1.000 1.000 315 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(9), APH1A(1), CREBBP(46), CTBP1(5), CTBP2(8), DLL1(16), DLL3(9), DLL4(5), DTX1(18), DTX2(6), DTX3(7), DTX3L(2), DTX4(12), DVL1(8), DVL2(10), DVL3(15), EP300(27), HDAC1(9), HDAC2(6), HES1(1), JAG1(16), JAG2(17), LFNG(2), MAML1(6), MAML2(12), MAML3(9), MFNG(1), NCOR2(40), NCSTN(12), NOTCH1(31), NOTCH2(33), NOTCH3(26), NOTCH4(22), NUMB(3), NUMBL(5), PSEN1(5), PSEN2(3), PSENEN(2), PTCRA(2), RBPJ(7), RBPJL(9), RFNG(3), SNW1(7) 40371949 493 145 472 169 167 63 63 78 119 3 0.216 1.000 1.000 316 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), AOX1(14), CARM1(8), COMT(5), DBH(7), DCT(16), DDC(12), ECH1(5), ESCO1(10), ESCO2(10), FAH(7), GOT1(3), GOT2(2), GSTZ1(2), HEMK1(1), HGD(6), HPD(4), LCMT1(1), LCMT2(11), MAOA(4), MAOB(3), METTL6(5), MIF(1), NAT6(4), PNMT(11), PNPLA3(4), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SH3GLB1(3), TAT(5), TH(7), TPO(27), TYR(15), TYRP1(9), WBSCR22(5) 34823559 353 140 324 84 89 34 40 76 110 4 0.0177 1.000 1.000 317 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(10), AKT3(8), ASAH1(4), BRAF(18), DAG1(13), DRD2(10), EGFR(19), EPHB2(15), GRB2(4), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), PI3(2), PIK3CB(13), PITX2(5), PLCB1(21), PLCB2(8), PLCB3(17), PLCB4(18), RAF1(9), RGS20(7), SHC1(7), SOS1(9), SOS2(18), SRC(5), STAT3(7), TERF2IP(5) 34279235 412 139 390 134 138 54 51 82 83 4 0.245 1.000 1.000 318 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(19), GABBR1(18), GPRC5A(1), GPRC5B(14), GPRC5C(9), GPRC5D(2), GRM1(43), GRM2(27), GRM3(22), GRM4(15), GRM5(37), GRM7(27), GRM8(27) 12307253 261 138 251 83 102 27 34 60 38 0 0.0587 1.000 1.000 319 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(5), CD28(1), CSK(8), CTLA4(4), DAG1(13), EPHB2(15), FBXW7(32), GRAP2(5), GRB2(4), ITK(5), ITPKA(2), ITPKB(14), LAT(3), LCK(4), LCP2(10), MAPK1(3), NCK1(6), NFAT5(13), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PLCG1(22), PTPRC(21), RAF1(9), RASGRP1(7), RASGRP2(8), RASGRP3(6), RASGRP4(6), SOS1(9), SOS2(18), VAV1(13), ZAP70(13) 32696127 363 138 338 102 125 38 40 71 87 2 0.0620 1.000 1.000 320 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AGK(6), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), AKR1A1(3), AKR1B1(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CEL(16), DAK(7), DGAT1(10), DGAT2(2), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), GK(4), GK2(9), GLA(3), GLB1(7), GPAM(11), LCT(24), LIPA(3), LIPC(5), LIPF(7), LIPG(4), LPL(9), MGLL(2), PNLIP(6), PNLIPRP1(3), PNPLA3(4), PPAP2A(3), PPAP2B(2), PPAP2C(6) 34304628 356 137 336 101 98 40 49 70 97 2 0.0764 1.000 1.000 321 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), ASCC3(37), ATP13A2(16), DDX18(14), DDX19A(5), DDX23(12), DDX4(9), DDX41(9), DDX47(1), DDX50(12), DDX51(7), DDX52(7), DDX54(17), DDX55(5), DDX56(8), DHX58(11), ENTPD7(10), EP400(47), ERCC2(9), ERCC3(8), FPGS(7), GCH1(1), GGH(2), IFIH1(10), MOV10L1(9), NUDT5(1), NUDT8(1), QDPR(5), RAD54B(3), RAD54L(4), RUVBL2(9), SETX(24), SKIV2L2(13), SMARCA2(31), SMARCA5(10), SPR(2) 36810663 409 136 396 122 135 45 52 80 95 2 0.150 1.000 1.000 322 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(4), CDK5(3), CDK5R1(5), CFL1(1), CHN1(4), LIMK1(6), MAP3K1(16), MYL2(9), MYLK(25), NCF2(3), PAK1(5), PDGFRA(13), PIK3CA(80), PIK3R1(12), PLD1(22), PPP1R12B(16), RAC1(1), RALBP1(10), RPS6KB1(6), TRIO(47), VAV1(13), WASF1(8) 20487306 309 136 255 68 76 58 50 62 60 3 0.000241 1.000 1.000 323 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(9), AKT1(3), APC(53), ASAH1(4), CAMP(3), CAV3(2), DAG1(13), DLG4(4), EPHB2(15), GNAI1(3), GNAQ(3), ITPR1(34), ITPR2(33), ITPR3(44), KCNJ3(18), KCNJ5(6), KCNJ9(3), MAPK1(3), PITX2(5), PTX3(3), RAC1(1), RHO(9), RYR1(68) 26855057 339 136 327 111 121 35 43 64 69 7 0.120 1.000 1.000 324 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(16), AR(24), ESR1(8), ESR2(9), ESRRA(2), HNF4A(7), NPM1(1), NR0B1(5), NR1D1(9), NR1D2(8), NR1H2(7), NR1H3(5), NR1I2(9), NR1I3(3), NR2C2(6), NR2E1(4), NR2F1(11), NR2F2(5), NR2F6(5), NR3C1(9), NR4A1(5), NR4A2(15), NR5A1(9), NR5A2(4), PGR(18), PPARA(7), PPARD(8), PPARG(4), RARA(4), RARB(10), RARG(2), ROR1(11), RORA(7), RORC(7), RXRA(13), RXRB(5), RXRG(7), THRA(7), THRB(4), VDR(4) 24589043 304 135 294 109 109 41 35 68 50 1 0.418 1.000 1.000 325 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(10), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(6), CDC42(3), CFL1(1), CFL2(1), FLNA(28), FLNC(38), FSCN1(6), FSCN3(13), GDI1(5), GDI2(6), LIMK1(6), MYH2(39), MYLK(25), MYLK2(8), PAK1(5), PAK2(12), PAK3(6), PAK4(9), PAK6(10), PAK7(10), PFN1(1), PFN2(1), RHO(9), ROCK1(20), ROCK2(16), RPS4X(2), VASP(2), WASF1(8), WASL(5) 28057152 319 135 313 109 114 37 44 54 66 4 0.230 1.000 1.000 326 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), AVP(4), CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), HDAC5(13), IGF1(2), IGF1R(20), INSR(17), MAP2K6(1), MAPK14(2), MAPK7(8), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MYOD1(7), NFATC1(16), NFATC2(26), PIK3CA(80), PIK3R1(12), PPP3CA(13), PPP3CB(6), PPP3CC(6), SYT1(5), YWHAH(3) 20358100 302 134 249 85 87 54 60 45 54 2 0.00164 1.000 1.000 327 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(16), ACSS2(12), ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH7A1(2), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), G6PC2(1), GALM(4), GAPDH(3), GAPDHS(5), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKL(8), PFKM(2), PFKP(21), PGAM1(1), PGAM2(5), PGAM4(2), PGK1(4), PGK2(3), PGM1(3), PGM3(13), PKLR(9), TPI1(3) 34076688 369 134 348 117 97 66 46 79 81 0 0.116 1.000 1.000 328 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACADL(3), ACADM(7), ACOX1(3), ACOX2(8), ACOX3(13), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADIPOQ(5), ANGPTL4(3), APOA1(8), APOA5(7), AQP7(8), CD36(5), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), CYP27A1(6), CYP4A11(4), CYP4A22(5), CYP7A1(7), CYP8B1(6), DBI(1), EHHADH(4), FABP2(1), FABP3(1), FABP4(1), FABP5(2), FABP6(4), FABP7(1), FADS2(4), GK(4), GK2(9), HMGCS2(4), ILK(9), LPL(9), ME1(1), MMP1(3), NR1H3(5), OLR1(4), PCK1(12), PCK2(10), PDPK1(1), PLTP(5), PPARA(7), PPARD(8), PPARG(4), RXRA(13), RXRB(5), RXRG(7), SCD(1), SCP2(5), SLC27A1(4), SLC27A2(8), SLC27A4(10), SLC27A5(5), SLC27A6(11), SORBS1(12), UBC(9), UCP1(4) 38366394 380 134 371 122 129 45 50 80 76 0 0.221 1.000 1.000 329 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(10), AKT3(8), BAD(4), BCL2(4), GRB2(4), GSK3A(4), GSK3B(6), IL4R(7), IRS1(27), IRS2(10), JAK1(19), JAK3(12), MAP4K1(4), MAPK1(3), MAPK3(3), PDK1(3), PIK3CA(80), PIK3CD(15), PIK3R1(12), PPP1R13B(15), RAF1(9), SHC1(7), SOCS1(1), SOS1(9), SOS2(18), STAT6(7) 21432466 304 134 240 60 79 57 48 43 73 4 3.73e-05 1.000 1.000 330 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(21), AKT1(3), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CREB1(4), GNAS(38), GRB2(4), HRAS(1), MAPK1(3), MAPK14(2), MAPK3(3), PIK3CA(80), PIK3R1(12), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), RAC1(1), RPS6KA1(9), RPS6KA5(5), SOS1(9) 17108683 264 133 211 57 78 50 46 41 46 3 0.000217 1.000 1.000 331 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(15), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), CDIPT(1), CDS1(5), CDS2(3), CHAT(6), CHKA(2), CHKB(3), CHPT1(4), CRLS1(1), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKI(16), DGKQ(5), DGKZ(10), ESCO1(10), ESCO2(10), ETNK1(3), ETNK2(2), GNPAT(4), GPAM(11), GPD1(8), GPD1L(4), GPD2(8), LCAT(4), LYPLA1(1), LYPLA2(2), NAT6(4), PCYT1A(9), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(5), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLD1(22), PLD2(19), PNPLA3(4), PPAP2A(3), PPAP2B(2), PPAP2C(6), PTDSS1(6), PTDSS2(3), SH3GLB1(3) 38300543 355 133 338 98 111 32 49 74 87 2 0.0422 1.000 1.000 332 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(9), GRB2(4), HRAS(1), INSR(17), IRS1(27), JAK2(12), MAP2K1(7), MAPK1(3), MAPK3(3), PIK3CA(80), PIK3R1(12), PLCG1(22), PRKCA(8), PTPN6(6), RAF1(9), RPS6KA1(9), SHC1(7), SLC2A4(5), SOCS1(1), SOS1(9), SRF(5), STAT5A(10), STAT5B(13) 19411108 281 132 227 56 70 61 50 41 55 4 3.99e-06 1.000 1.000 333 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(49), BMPR1B(9), CCND2(2), CDK4(2), CDKN1B(1), DMC1(8), EGR1(12), ESR2(9), FSHR(24), GJA4(8), INHA(6), LHCGR(18), MLH1(8), MSH5(5), NCOR1(30), NR5A1(9), NRIP1(18), PGR(18), PRLR(5), PTGER2(7), SMPD1(6), VDR(4), ZP2(12) 20542440 270 132 255 58 64 39 38 58 67 4 0.00157 1.000 1.000 334 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(28), ACACB(40), ACAT1(6), ACAT2(5), ACOT12(7), ACSS1(16), ACSS2(12), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), DLAT(8), DLD(10), GLO1(2), GRHPR(2), HAGH(5), HAGHL(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), LDHD(2), MDH1(3), ME1(1), ME2(7), ME3(7), PC(18), PCK1(12), PCK2(10), PDHA1(1), PDHA2(11), PDHB(4), PKLR(9) 27388341 315 130 296 100 86 51 37 59 81 1 0.327 1.000 1.000 335 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), F10(8), F11(5), F12(3), F2(11), F2R(6), F5(22), F8(29), F9(9), FGA(12), FGB(6), FGG(5), KLKB1(6), PROC(4), PROS1(11), SERPINC1(5), SERPING1(8) 26059769 265 130 260 78 61 45 32 70 55 2 0.113 1.000 1.000 336 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(14), ATP4A(20), ATP4B(4), ATP5A1(3), ATP5B(9), ATP5C1(5), ATP5F1(3), ATP5G2(2), ATP5G3(2), ATP5J(3), ATP5J2(1), ATP5L(1), ATP6AP1(6), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), COX10(2), COX15(5), COX4I1(4), COX4I2(3), COX5B(1), COX6B1(2), COX7A1(1), COX7B(3), COX7C(1), COX8A(1), COX8C(4), CYC1(5), LHPP(3), NDUFA1(1), NDUFA10(3), NDUFA12(2), NDUFA13(2), NDUFA3(1), NDUFA8(6), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(1), NDUFB11(2), NDUFB2(1), NDUFB3(3), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFB8(2), NDUFB9(2), NDUFC2(2), NDUFS1(7), NDUFS2(6), NDUFS3(3), NDUFS4(3), NDUFS5(3), NDUFS6(4), NDUFS7(4), NDUFS8(2), NDUFV1(6), NDUFV2(1), PPA1(4), PPA2(3), SDHA(11), SDHB(4), SDHC(2), SDHD(1), TCIRG1(6), UQCRB(2), UQCRC1(3), UQCRC2(5), UQCRFS1(3), UQCRQ(1) 32635977 359 129 340 102 103 56 44 64 91 1 0.0450 1.000 1.000 337 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(7), ACTN2(26), BCAR1(10), BCR(14), CAPN1(7), CAPNS1(3), CAPNS2(2), CAV1(5), CRKL(2), CSK(8), FYN(9), GRB2(4), HRAS(1), ITGA1(7), ITGB1(11), JUN(5), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MAPK8(6), PPP1R12B(16), PTK2(11), PXN(6), RAF1(9), RAP1A(3), ROCK1(20), SHC1(7), SOS1(9), SRC(5), TLN1(28), VCL(11), ZYX(7) 27571226 279 129 268 80 109 29 30 57 52 2 0.0267 1.000 1.000 338 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(4), CHUK(5), DAXX(11), EGF(11), EGFR(19), ETS1(8), ETS2(4), FOS(1), HOXA7(4), HRAS(1), IKBKB(10), JUN(5), MAP2K1(7), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP2K7(38), MAP3K1(16), MAP3K5(10), MAPK1(3), MAPK13(4), MAPK14(2), MAPK3(3), MAPK8(6), NFKB1(8), NFKBIA(1), PPP2CA(4), PRKCA(8), PRKCD(10), PRKCE(14), PRKCG(17), PRKCH(7), PRKCQ(14), RAF1(9), RELA(7), RIPK1(3), SP1(5), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRAF2(4) 28766217 316 129 304 92 111 41 32 56 72 4 0.0139 1.000 1.000 339 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(5), CAD(20), CANT1(5), CTPS2(3), DCK(4), DCTD(1), DHODH(4), DPYD(20), DPYS(8), DUT(3), ENTPD1(4), ITPA(1), NME2(3), NT5E(5), NT5M(6), NUDT2(5), POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14), RRM1(5), RRM2(3), TK1(1), TK2(4), TXNRD1(10), TYMS(1), UCK1(6), UCK2(1), UMPS(5), UNG(2), UPB1(6), UPP1(2) 33571699 328 129 318 104 90 45 49 61 83 0 0.237 1.000 1.000 340 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(13), EEF1A2(7), EEF1B2(4), EEF1D(3), EEF1G(4), EEF2(17), EEF2K(11), EIF1AX(2), EIF1AY(1), EIF2AK1(5), EIF2AK2(6), EIF2AK3(21), EIF2B1(4), EIF2B2(4), EIF2B3(9), EIF2B4(11), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(4), EIF4EBP2(4), EIF4G1(25), EIF4G3(22), EIF5(6), EIF5A(5), EIF5B(28), ETF1(7), GSPT2(9), PABPC1(10), PABPC3(15), PAIP1(3), SLC35A4(9) 25609736 295 129 279 60 73 41 45 61 72 3 0.000497 1.000 1.000 341 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BAD(4), BCL2(4), BCL2L1(1), CBL(5), CFLAR(1), CRKL(2), E2F1(4), FOS(1), GRB2(4), HRAS(1), IL2RA(2), IL2RB(3), IL2RG(9), IRS1(27), JAK1(19), JAK3(12), MAPK1(3), MAPK3(3), MYC(6), NMI(2), PIK3CA(80), PIK3R1(12), PTPN6(6), RAF1(9), RPS6KB1(6), SHC1(7), SOCS1(1), SOCS3(3), SOS1(9), STAT5A(10), STAT5B(13), SYK(9) 21165573 281 128 223 59 59 57 52 44 65 4 0.000236 1.000 1.000 342 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(15), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPS(6), CDIPT(1), CDS1(5), CDS2(3), CHAT(6), CHKA(2), CHKB(3), CLC(2), CPT1B(7), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), ETNK1(3), GNPAT(4), GPD1(8), GPD2(8), LCAT(4), LYPLA1(1), LYPLA2(2), PAFAH1B1(15), PAFAH2(4), PCYT1A(9), PCYT1B(6), PEMT(1), PISD(5), PLA2G1B(8), PLA2G2A(2), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLCB2(8), PLCG1(22), PLCG2(19), PPAP2A(3), PPAP2B(2), PPAP2C(6) 29176602 306 126 285 87 100 26 47 65 66 2 0.0750 1.000 1.000 343 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(8), AASDHPPT(1), AASS(10), ACAT1(6), ACAT2(5), AKR1B10(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), BBOX1(4), DLST(6), DOT1L(18), ECHS1(2), EHHADH(4), EHMT1(18), EHMT2(19), GCDH(7), HADH(2), HADHA(5), HSD17B4(7), HSD3B7(7), NSD1(27), OGDH(11), OGDHL(19), PIPOX(3), PLOD1(9), PLOD2(15), PLOD3(17), RDH11(1), RDH12(3), RDH13(7), SETD1A(24), SETD7(3), SETDB1(17), SHMT1(2), SHMT2(11), SPCS1(2), SPCS3(3), SUV39H1(6), SUV39H2(2), TMLHE(5) 33949841 379 126 350 107 117 44 51 65 101 1 0.0646 1.000 1.000 344 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(48), B3GALT4(8), CDR1(4), DGKI(16), IL6ST(6), PIGK(3), RPL10(5), RPL11(1), RPL12(3), RPL13A(4), RPL14(2), RPL15(1), RPL17(1), RPL18(1), RPL18A(1), RPL19(1), RPL22(9), RPL23(1), RPL24(2), RPL26(1), RPL27(1), RPL28(1), RPL29(2), RPL3(3), RPL31(2), RPL34(1), RPL35A(1), RPL36(1), RPL37(1), RPL38(1), RPL3L(3), RPL4(3), RPL5(3), RPL6(3), RPL7A(6), RPL8(3), RPL9(4), RPLP0(4), RPLP1(1), RPLP2(2), RPS10(1), RPS11(1), RPS13(2), RPS14(1), RPS15(2), RPS16(1), RPS18(1), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(1), RPS26(1), RPS27(1), RPS27A(4), RPS3(2), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), RPS6KA6(20), RPS6KB1(6), RPS6KB2(9), RPS7(1), RPS9(2), RPSA(5), SLC36A2(5), TBC1D10C(9), TSPAN9(3), UBA52(2), UBB(2), UBC(9) 30681489 298 126 283 93 80 32 46 61 77 2 0.709 1.000 1.000 345 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(3), AGXT2(13), AKR1B10(6), ALAS1(5), ALAS2(14), AMT(4), AOC2(10), AOC3(13), BHMT(5), CBS(9), CHDH(6), CHKA(2), CHKB(3), CTH(3), DAO(14), DLD(10), DMGDH(7), GAMT(1), GARS(3), GATM(3), GCAT(5), GLDC(9), GNMT(4), HSD3B7(7), MAOA(4), MAOB(3), PEMT(1), PHGDH(5), PIPOX(3), PISD(5), PSAT1(7), PSPH(2), RDH11(1), RDH12(3), RDH13(7), SARDH(12), SARS(9), SARS2(9), SDS(4), SHMT1(2), SHMT2(11), TARS(11), TARS2(13) 24954298 271 125 261 83 84 36 38 47 65 1 0.174 1.000 1.000 346 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(8), AANAT(2), ACAT1(6), ACAT2(5), ACMSD(6), AFMID(4), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AOC2(10), AOC3(13), AOX1(14), ASMT(5), CARM1(8), CAT(6), CYP1A1(7), CYP1A2(5), CYP1B1(4), DDC(12), ECHS1(2), EHHADH(4), GCDH(7), HAAO(1), HADH(2), HADHA(5), HEMK1(1), HSD17B4(7), INMT(4), KMO(6), KYNU(13), LCMT1(1), LCMT2(11), LNX1(5), MAOA(4), MAOB(3), METTL6(5), NFX1(5), OGDH(11), OGDHL(19), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), TDO2(9), TPH1(4), TPH2(10), WARS(4), WARS2(12), WBSCR22(5) 35456223 372 124 338 101 82 49 48 64 126 3 0.103 1.000 1.000 347 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(8), BAD(4), BAX(1), BCL2(4), BCL2L1(1), BCL2L2(4), BOK(2), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CD40(3), CD40LG(5), CRADD(6), DAXX(11), DFFA(4), DFFB(3), FADD(3), FAS(3), FASLG(5), IKBKE(12), LTA(4), MCL1(2), NFKB1(8), NFKBIA(1), NGFR(7), NR3C1(9), NTRK1(9), PTPN13(34), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(4), TRAF2(4), TRAF3(7), TRAF6(6) 25424180 240 123 230 71 61 30 30 56 62 1 0.196 1.000 1.000 348 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(5), B3GALNT1(5), B3GALT1(3), B3GALT2(8), B3GALT4(8), B3GALT5(2), B3GNT1(4), B3GNT2(5), B3GNT3(3), B3GNT4(9), B3GNT5(11), B4GALNT1(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), B4GALT6(6), FUT1(5), FUT2(2), FUT3(4), FUT4(2), FUT5(3), FUT6(6), FUT7(3), FUT9(7), GBGT1(4), GCNT2(1), PIGA(3), PIGB(10), PIGC(6), PIGG(15), PIGK(3), PIGL(5), PIGM(4), PIGN(6), PIGO(10), PIGP(1), PIGQ(9), PIGS(4), PIGT(11), PIGV(7), PIGX(3), PIGZ(10), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7), ST3GAL5(2), ST3GAL6(6), ST6GALNAC3(6), ST6GALNAC4(3), ST6GALNAC5(9), ST6GALNAC6(4), ST8SIA1(12), ST8SIA5(8), UGCG(3) 28384348 312 123 290 109 100 32 33 61 85 1 0.784 1.000 1.000 349 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(19), ADRA1B(5), ADRA1D(6), ADRA2A(9), ADRA2C(4), ADRB1(9), ADRB2(8), ADRB3(6), CHRM1(6), CHRM2(19), CHRM3(12), CHRM4(5), CHRM5(4), DRD1(4), DRD2(10), DRD3(7), DRD4(5), DRD5(13), HRH1(5), HRH2(6), HTR1A(17), HTR1B(10), HTR1D(5), HTR1E(13), HTR1F(7), HTR2A(8), HTR2B(5), HTR2C(10), HTR4(5), HTR5A(13), HTR6(7), HTR7(14) 15089408 276 122 263 100 110 28 43 63 32 0 0.142 1.000 1.000 350 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(10), AKT3(8), ARHGEF11(25), BCL2(4), CDC42(3), DLG4(4), GNA13(7), LPA(21), MAP2K4(9), MAP3K1(16), MAP3K5(10), MAPK8(6), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(15), PI3(2), PIK3CB(13), PLD1(22), PLD2(19), PLD3(8), PTK2(11), RDX(7), ROCK1(20), ROCK2(16), SERPINA4(5), SRF(5), TBXA2R(9) 28780249 313 122 296 68 84 43 39 45 97 5 0.00156 1.000 1.000 351 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AKR1A1(3), AKR1B1(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), CEL(16), DGAT1(10), DGKA(9), DGKB(10), DGKD(6), DGKE(8), DGKG(6), DGKH(14), DGKQ(5), DGKZ(10), GK(4), GLA(3), GLB1(7), LCT(24), LIPC(5), LIPF(7), LIPG(4), LPL(9), PNLIP(6), PNLIPRP1(3), PPAP2A(3), PPAP2B(2), PPAP2C(6) 28172803 296 121 277 92 83 28 42 57 84 2 0.324 1.000 1.000 352 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(9), ALOX15(10), ALOX5(11), CBR1(1), CBR3(4), CYP4F2(13), CYP4F3(13), EPX(16), GGT1(9), LPO(11), LTA4H(4), MPO(9), PLA2G1B(8), PLA2G2A(2), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PRDX1(1), PRDX2(2), PRDX6(2), PTGDS(1), PTGES2(4), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7), TPO(27) 16306513 225 121 211 59 85 20 20 61 36 3 0.0187 1.000 1.000 353 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(5), CASP2(3), CASP3(2), CASP8(18), CRADD(6), DFFA(4), DFFB(3), FADD(3), JUN(5), LMNA(11), LMNB1(4), LMNB2(6), MADD(18), MAP2K4(9), MAP3K1(16), MAP3K7(11), MAPK8(6), PAK1(5), PAK2(12), PRKDC(56), RB1(14), RIPK1(3), SPTAN1(22), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4) 22708199 258 121 249 71 64 29 44 38 80 3 0.187 1.000 1.000 354 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), AOX1(14), COMT(5), DBH(7), DCT(16), DDC(12), FAH(7), GOT1(3), GOT2(2), GSTZ1(2), HGD(6), HPD(4), MAOA(4), MAOB(3), PNMT(11), TAT(5), TH(7), TPO(27), TYR(15) 18556486 232 121 210 60 63 20 26 53 67 3 0.0825 1.000 1.000 355 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(16), CARM1(8), CCND1(2), CREBBP(46), EP300(27), ERCC3(8), ESR1(8), GRIP1(20), GTF2A1(3), GTF2E1(6), GTF2F1(6), HDAC1(9), HDAC2(6), HDAC3(7), HDAC4(29), HDAC5(13), HDAC6(9), MEF2C(5), NCOR2(40), NR0B1(5), NRIP1(18), PELP1(8), POLR2A(24), TBP(6) 26880867 329 120 313 81 108 46 40 54 77 4 0.00120 1.000 1.000 356 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKM(2), PFKP(21), PGAM1(1), PGK1(4), PGM1(3), PGM3(13), PKLR(9), TPI1(3) 28639423 312 120 293 100 79 49 40 72 72 0 0.254 1.000 1.000 357 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1A1(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), ALDOA(1), ALDOB(9), ALDOC(7), BPGM(4), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GCK(9), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHB(5), LDHC(1), PDHA1(1), PDHA2(11), PDHB(4), PFKM(2), PFKP(21), PGAM1(1), PGK1(4), PGM1(3), PGM3(13), PKLR(9), TPI1(3) 28639423 312 120 293 100 79 49 40 72 72 0 0.254 1.000 1.000 358 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(21), CALM1(2), CALM2(3), CALM3(1), CREB1(4), ELK1(4), FOS(1), GNAI1(3), GNAQ(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), JUN(5), MAP2K1(7), MAPK3(3), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), RAF1(9), RPS6KA3(6), SYT1(5) 20525662 278 120 262 69 111 34 27 44 61 1 0.00150 1.000 1.000 359 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(9), APC(53), AXIN1(15), BTRC(9), CTNNB1(27), DLL1(16), DVL1(8), FZD1(11), GSK3B(6), NOTCH1(31), PSEN1(5), WNT1(10) 12510776 200 120 179 60 49 18 17 36 75 5 0.378 1.000 1.000 360 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(21), AKT1(3), BAD(4), BAX(1), BCL2(4), BCL2L1(1), CSF2RB(12), IGF1(2), IGF1R(20), IL3(1), IL3RA(5), KIT(13), KITLG(4), PIK3CA(80), PIK3R1(12), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), YWHAH(3) 12867021 225 119 176 66 53 50 48 36 36 2 0.0143 1.000 1.000 361 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CFLAR(1), DAXX(11), DFFA(4), DFFB(3), FADD(3), FAF1(10), JUN(5), LMNA(11), LMNB1(4), LMNB2(6), MAP2K4(9), MAP3K1(16), MAP3K7(11), MAPK8(6), PAK1(5), PAK2(12), PRKDC(56), PTPN13(34), RB1(14), RIPK2(2), SPTAN1(22) 23814795 279 119 265 71 59 32 50 45 91 2 0.0984 1.000 1.000 362 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1C1(3), AKR1C2(1), AKR1C3(3), AKR1C4(5), ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), CYP1A1(7), CYP1A2(5), CYP1B1(4), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2F1(9), CYP2S1(8), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), DHDH(5), EPHX1(10), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), MGST1(3), MGST2(3), MGST3(3), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7) 33511006 296 119 279 79 68 34 42 68 84 0 0.105 1.000 1.000 363 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ACAT1(6), ACAT2(5), ACMSD(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), AOC2(10), AOC3(13), AOX1(14), ASMT(5), CAT(6), CYP19A1(12), CYP1A1(7), CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2D6(13), CYP2E1(6), CYP2F1(9), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(4), CYP4B1(11), CYP51A1(9), DDC(12), ECHS1(2), EHHADH(4), GCDH(7), HAAO(1), HADHA(5), KMO(6), KYNU(13), MAOA(4), MAOB(3), SDS(4), TDO2(9), TPH1(4), WARS(4), WARS2(12) 32277886 359 119 330 94 94 45 38 67 113 2 0.0665 1.000 1.000 364 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(3), CALM3(1), CAMK1(3), CAMK1G(8), ELK1(4), FPR1(8), GNA15(4), GNB1(2), GNGT1(3), HRAS(1), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), NCF1(3), NCF2(3), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), NFKB1(8), NFKBIA(1), PAK1(5), PIK3C2G(14), PLCB1(21), PPP3CA(13), PPP3CB(6), PPP3CC(6), RAC1(1), RAF1(9), RELA(7), SYT1(5) 22388699 250 118 237 74 80 32 31 43 64 0 0.0779 1.000 1.000 365 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(3), AGXT2(13), ALAS1(5), ALAS2(14), AMT(4), AOC2(10), AOC3(13), ATP6V0C(1), BHMT(5), CBS(9), CHDH(6), CHKA(2), CHKB(3), CPT1B(7), CTH(3), DAO(14), DLD(10), DMGDH(7), GAMT(1), GARS(3), GATM(3), GCAT(5), GLDC(9), MAOA(4), MAOB(3), PEMT(1), PISD(5), PLCB2(8), PLCG1(22), PLCG2(19), PSPH(2), SARDH(12), SARS(9), SHMT1(2), SHMT2(11), TARS(11) 24548785 259 118 249 78 78 33 33 50 65 0 0.165 1.000 1.000 366 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(5), AKR1D1(4), ARSD(5), ARSE(6), CARM1(8), CYP11B1(17), CYP11B2(8), CYP19A1(12), HEMK1(1), HSD11B1(4), HSD11B2(4), HSD17B1(4), HSD17B12(4), HSD17B2(3), HSD17B3(2), HSD17B7(5), HSD3B1(4), HSD3B2(2), LCMT1(1), LCMT2(11), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), SULT2B1(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), WBSCR22(5) 29329371 273 118 260 85 55 50 39 58 70 1 0.214 1.000 1.000 367 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(7), AARS2(15), ABAT(4), ACY3(3), ADSL(5), ADSS(6), ADSSL1(9), AGXT(3), AGXT2(13), ASL(5), ASNS(5), ASPA(2), ASRGL1(4), ASS1(10), CAD(20), CRAT(12), DARS(2), DARS2(4), DDO(6), DLAT(8), DLD(10), GAD1(8), GAD2(15), GOT1(3), GOT2(2), GPT(4), GPT2(3), NARS(5), NARS2(3), PC(18), PDHA1(1), PDHA2(11), PDHB(4) 22152893 230 117 220 80 74 32 28 41 54 1 0.495 1.000 1.000 368 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(7), AARS2(15), CARS(6), CARS2(7), DARS(2), DARS2(4), EARS2(3), EPRS(18), FARS2(9), FARSA(6), FARSB(3), GARS(3), HARS(9), HARS2(4), IARS(11), IARS2(12), KARS(7), LARS(9), LARS2(10), MARS(7), MARS2(5), MTFMT(2), NARS(5), NARS2(3), QARS(7), RARS(5), RARS2(6), SARS(9), SARS2(9), TARS(11), TARS2(13), VARS(23), VARS2(14), WARS(4), WARS2(12), YARS(8), YARS2(2) 31823951 290 117 282 79 86 36 48 54 65 1 0.0921 1.000 1.000 369 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(10), ADCY3(18), ADCY9(17), AK1(1), ARF1(5), ARF4(1), ARF6(1), ARL4D(1), ATP6V0A1(8), ATP6V0A2(9), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V0D2(5), ATP6V0E1(1), ATP6V1A(5), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), ERO1L(2), GNAS(38), PDIA4(6), PLCG1(22), PLCG2(19), PRKCA(8), SEC61A1(4), SEC61A2(4), SEC61B(1), SEC61G(1), TRIM23(9) 21715043 267 117 254 69 101 33 32 48 53 0 0.00852 1.000 1.000 370 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(8), ARHGAP4(4), ARHGAP5(26), ARHGAP6(12), ARHGEF1(12), ARHGEF11(25), ARHGEF5(7), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), BAIAP2(5), CFL1(1), DIAPH1(14), GSN(12), LIMK1(6), MYL2(9), MYLK(25), OPHN1(10), PFN1(1), PIP5K1A(3), PIP5K1B(2), PPP1R12B(16), ROCK1(20), SRC(5), TLN1(28), VCL(11) 26569801 277 116 264 70 89 38 32 45 67 6 0.0234 1.000 1.000 371 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(5), BTK(4), CALM1(2), CALM2(3), CALM3(1), CD79A(8), CD79B(3), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP2K1(7), MAP3K1(16), MAPK14(2), MAPK3(3), MAPK8(6), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SYK(9), SYT1(5), VAV1(13) 22434798 253 115 237 58 93 35 25 42 58 0 0.000548 1.000 1.000 372 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(4), CALM1(2), CALM2(3), CALM3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CDK5(3), F2(11), FYN(9), GNA11(6), GNAI1(3), GNB1(2), GNGT1(3), GRB2(4), HRAS(1), JAK2(12), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), MAPT(11), MYLK(25), PLCG1(22), PRKCA(8), PTK2B(16), RAF1(9), SHC1(7), SOS1(9), STAT1(11), STAT3(7), STAT5A(10), SYT1(5) 24410931 254 115 246 74 85 37 26 56 48 2 0.0501 1.000 1.000 373 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(8), F11(5), F12(3), F13B(17), F2(11), F5(22), F7(11), F8(29), F9(9), FGA(12), FGB(6), FGG(5), LPA(21), PLAT(7), PLG(18), SERPINB2(9), SERPINE1(3), SERPINF2(8), VWF(38) 20687247 242 115 236 62 61 28 33 66 53 1 0.0449 1.000 1.000 374 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(3), ACAA2(9), ACADM(7), ACADS(4), ACAT1(6), ACAT2(5), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH7A1(2), ALDH9A1(6), AOX1(14), AUH(7), BCAT1(6), BCAT2(9), BCKDHA(12), BCKDHB(3), DBT(4), DLD(10), ECHS1(2), EHHADH(4), HADH(2), HADHA(5), HADHB(6), HIBADH(3), HIBCH(2), HMGCS1(2), HMGCS2(4), HSD17B4(7), IVD(4), MCCC1(4), MCCC2(7), MCEE(5), MUT(7), OXCT1(10), OXCT2(6), PCCA(12), PCCB(5) 25210128 263 115 242 67 60 41 33 42 86 1 0.0504 1.000 1.000 375 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(4), GTF2B(3), GTF2E1(6), GTF2E2(4), GTF2F1(6), GTF2F2(3), GTF2H1(5), GTF2H3(3), GTF2H4(9), GTF2I(4), GTF2IRD1(13), STON1(7), TAF1(27), TAF10(1), TAF13(1), TAF1L(37), TAF2(10), TAF4(14), TAF4B(7), TAF5(2), TAF5L(7), TAF6(14), TAF6L(7), TAF7(7), TAF7L(8), TAF9B(4), TBPL1(3), TBPL2(5) 21129651 224 115 214 56 55 31 28 47 63 0 0.0797 1.000 1.000 376 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(11), AKT1(3), AKT2(10), AKT3(8), DAG1(13), GNAQ(3), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), NFKB1(8), NFKB2(9), NFKBIA(1), NFKBIB(8), NFKBIE(1), NFKBIL1(5), PDK1(3), PHKA2(15), PIK3CB(13), PITX2(5), PLD1(22), PLD2(19), PLD3(8), VN1R1(4) 26265937 296 113 285 81 102 32 43 58 57 4 0.0289 1.000 1.000 377 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(4), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH4A1(4), ALDH9A1(6), AMD1(7), AOC2(10), AOC3(13), ARG1(2), ARG2(3), ASL(5), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), DAO(14), GAMT(1), GATM(3), GLUD1(4), GOT1(3), GOT2(2), MAOA(4), MAOB(3), NOS1(39), NOS3(15), OAT(3), ODC1(3), OTC(4), P4HA1(5), P4HA2(8), P4HA3(6), P4HB(3), PYCR1(3), RARS(5), SMS(6) 25849437 291 111 270 82 84 30 44 57 76 0 0.136 1.000 1.000 378 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(9), ALDOC(7), DLAT(8), DLD(10), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(6), GAPDH(3), GAPDHS(5), GCK(9), GOT1(3), GOT2(2), GPI(6), HK1(17), HK2(12), HK3(11), LDHA(7), LDHAL6B(6), LDHB(5), LDHC(1), MDH1(3), PC(18), PCK1(12), PDHA1(1), PDHA2(11), PDHB(4), PDHX(5), PFKL(8), PFKM(2), PFKP(21), PGAM1(1), PGAM2(5), PGK1(4), PGK2(3), PKLR(9), TNFAIP1(5), TPI1(3) 24880392 257 111 247 103 85 52 23 49 48 0 0.659 1.000 1.000 379 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(8), ALG10(14), ALG10B(10), ALG11(8), ALG12(10), ALG13(8), ALG14(2), ALG2(3), ALG3(4), ALG5(4), ALG6(4), ALG8(3), ALG9(2), B4GALT1(3), B4GALT2(8), B4GALT3(2), DHDDS(2), DOLPP1(3), DPAGT1(6), DPM1(2), FUT8(9), GANAB(19), MAN1A1(4), MAN1A2(5), MAN1B1(6), MAN1C1(10), MAN2A1(10), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), MGAT5B(7), RFT1(4), RPN1(4), RPN2(6), ST6GAL1(1), STT3B(5) 24778247 233 111 214 70 49 30 23 49 80 2 0.579 1.000 1.000 380 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(10), AADAC(6), ABAT(4), ACADS(4), ACAT1(6), ACAT2(5), ACSM1(7), AKR1B10(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH5A1(5), ALDH7A1(2), ALDH9A1(6), BDH1(7), DDHD1(13), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADH(2), HADHA(5), HMGCS1(2), HMGCS2(4), HSD17B4(7), HSD3B7(7), ILVBL(8), L2HGDH(2), OXCT1(10), OXCT2(6), PDHA1(1), PDHA2(11), PDHB(4), PLA1A(3), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(7) 23741398 245 111 228 83 72 33 29 43 68 0 0.425 1.000 1.000 381 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(9), ALOX12B(12), ALOX15(10), ALOX15B(4), ALOX5(11), CBR1(1), CBR3(4), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2J2(4), CYP2U1(9), CYP4A11(4), CYP4A22(5), CYP4F2(13), CYP4F3(13), DHRS4(4), EPHX2(3), GGT1(9), GPX5(2), GPX7(3), LTA4H(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PTGDS(1), PTGES(1), PTGES2(4), PTGIS(8), PTGS1(13), PTGS2(7), TBXAS1(7) 22770913 243 110 232 66 88 25 25 60 43 2 0.0223 1.000 1.000 382 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(8), CALCR(6), CALCRL(10), CD97(8), CRHR1(12), CRHR2(4), ELTD1(22), EMR1(11), EMR2(10), GHRHR(4), GIPR(6), GLP1R(1), GLP2R(10), GPR64(14), LPHN1(22), LPHN2(23), LPHN3(23), SCTR(5), VIPR1(3), VIPR2(5) 15573293 207 109 202 49 52 32 23 64 36 0 0.00274 1.000 1.000 383 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(20), CPS1(24), EARS2(3), EPRS(18), GAD1(8), GAD2(15), GCLC(3), GCLM(3), GFPT1(7), GFPT2(6), GLS(11), GLS2(8), GLUD1(4), GLUD2(13), GLUL(5), GMPS(7), GNPNAT1(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), GSR(5), GSS(2), NADSYN1(11), PPAT(7), QARS(7) 23154336 218 109 212 76 58 28 32 50 50 0 0.508 1.000 1.000 384 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(4), ALAS1(5), ALAS2(14), BLVRA(4), BLVRB(1), COX10(2), COX15(5), CP(10), CPOX(4), EARS2(3), EPRS(18), FECH(7), FTH1(3), FTMT(8), GUSB(10), HCCS(4), HMBS(3), HMOX1(7), HMOX2(1), MMAB(2), PPOX(6), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), UROD(2), UROS(5) 24626477 223 109 214 69 44 35 31 54 59 0 0.419 1.000 1.000 385 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(18), ADRBK2(5), ARRB2(2), CALM1(2), CALM2(3), CALM3(1), CALML3(1), CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), CLCA1(10), CLCA2(8), CLCA4(18), CNGA3(9), CNGA4(19), CNGB1(19), GNAL(3), GUCA1A(2), GUCA1B(1), GUCA1C(3), PDC(3), PDE1C(14), PRKACA(6), PRKACB(6), PRKACG(9), PRKG1(12), PRKG2(15), PRKX(6) 17888812 217 109 203 63 62 23 26 49 57 0 0.142 1.000 1.000 386 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3E(2), CD4(11), CREBBP(46), CSK(8), GNAS(38), GNB1(2), GNGT1(3), HLA-DRA(7), HLA-DRB1(1), LCK(4), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTPRC(21), ZAP70(13) 13504037 216 108 199 77 80 21 23 39 52 1 0.689 1.000 1.000 387 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3E(2), CD4(11), CREBBP(46), CSK(8), GNAS(38), GNB1(2), GNGT1(3), HLA-DRA(7), HLA-DRB1(1), LCK(4), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTPRC(21), ZAP70(13) 13504037 216 108 199 77 80 21 23 39 52 1 0.689 1.000 1.000 388 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(19), ELK1(4), GNAS(38), GNB1(2), GNGT1(3), GRB2(4), HRAS(1), IGF1R(20), ITGB1(11), KLK2(1), MAP2K1(7), MAP2K2(3), MAPK1(3), MAPK3(3), MKNK1(5), MKNK2(8), MYC(6), NGFR(7), PDGFRA(13), PPP2CA(4), PTPRR(10), RAF1(9), RPS6KA1(9), RPS6KA5(5), SHC1(7), SOS1(9), SRC(5), STAT3(7) 19421324 223 108 209 86 86 28 20 55 33 1 0.716 1.000 1.000 389 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACAA2(9), ACADL(3), ACADM(7), ACADS(4), ACADSB(8), ACADVL(3), ACAT1(6), ACAT2(5), ACOX1(3), ACOX3(13), ACSL1(4), ACSL3(7), ACSL4(6), ACSL5(7), ACSL6(9), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CPT1A(14), CPT1B(7), CPT1C(10), CPT2(7), CYP4A11(4), CYP4A22(5), ECHS1(2), EHHADH(4), GCDH(7), HADH(2), HADHA(5), HADHB(6), HSD17B4(7) 28695790 263 106 245 61 61 41 39 43 79 0 0.00310 1.000 1.000 390 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(28), ACAT1(6), ACAT2(5), ACYP1(1), ACYP2(3), ADH5(4), AKR1B1(6), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), DLAT(8), DLD(10), GLO1(2), GRHPR(2), HAGH(5), HAGHL(2), LDHA(7), LDHB(5), LDHC(1), LDHD(2), MDH1(3), ME1(1), ME2(7), ME3(7), PC(18), PCK1(12), PDHA1(1), PDHA2(11), PDHB(4), PKLR(9) 21636561 237 106 221 84 63 36 31 42 65 0 0.716 1.000 1.000 391 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(8), CDC7(7), CDK2(4), CDT1(5), DIAPH2(10), GMNN(2), MCM10(13), MCM2(13), MCM3(5), MCM4(16), MCM5(10), MCM6(11), MCM7(7), NACA(19), PCNA(2), POLA2(4), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), PRIM1(2), RFC1(14), RFC2(3), RFC3(4), RFC4(1), RFC5(2), RPA1(3), RPA2(4), RPA3(1), RPA4(6), RPS27A(4), UBA52(2), UBB(2), UBC(9) 29739675 257 105 247 64 83 30 28 42 74 0 0.0488 1.000 1.000 392 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(2), ARG2(3), ASL(5), ASS1(10), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), DAO(14), EPRS(18), GAMT(1), GATM(3), GLUD1(4), GLUD2(13), GOT1(3), GOT2(2), LAP3(4), NOS1(39), NOS3(15), OAT(3), OTC(4), P4HA1(5), P4HA2(8), P4HA3(6), PRODH(1), PYCR1(3), PYCR2(4), PYCRL(2), RARS(5), RARS2(6) 20996436 229 105 217 72 70 27 34 49 49 0 0.303 1.000 1.000 393 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(8), AASDH(10), AASDHPPT(1), AASS(10), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), ATP6V0C(1), BBOX1(4), DLST(6), DOT1L(18), ECHS1(2), EHHADH(4), EHMT1(18), EHMT2(19), GCDH(7), HADHA(5), PLOD1(9), PLOD2(15), PLOD3(17), SDS(4), SHMT1(2), SHMT2(11), TMLHE(5) 21645601 254 105 230 70 65 32 37 39 80 1 0.0650 1.000 1.000 394 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(7), CAMK2D(2), CAMK2G(10), DAG1(13), ITPKA(2), ITPKB(14), ITPR1(34), ITPR2(33), ITPR3(44), NFAT5(13), PDE6A(9), PDE6B(14), PDE6C(5), PDE6D(1), PDE6G(1), PDE6H(1), SLC6A13(8), TF(15) 20936097 229 105 222 82 84 27 33 41 41 3 0.296 1.000 1.000 395 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(5), ELK1(4), FOS(1), IKBKB(10), IRAK1(7), JUN(5), LY96(5), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP3K7(11), MAPK14(2), MAPK8(6), MYD88(4), NFKB1(8), NFKBIA(1), PPARA(7), RELA(7), TIRAP(1), TLR10(9), TLR2(4), TLR3(6), TLR4(27), TLR6(4), TLR7(6), TLR9(15), TOLLIP(6), TRAF6(6) 21361429 205 105 197 56 48 29 24 47 56 1 0.0574 1.000 1.000 396 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(1), ATF2(4), CALM1(2), CALM2(3), CALM3(1), EGFR(19), ELK1(4), GNAQ(3), GRB2(4), HRAS(1), JUN(5), MAP2K1(7), MAP2K2(3), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8(6), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), PAK1(5), PRKCA(8), PTK2(11), PTK2B(16), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SRC(5), SYT1(5) 19637730 195 104 184 56 58 19 23 35 59 1 0.128 1.000 1.000 397 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(28), ACACB(40), ACADM(7), ACAT1(6), ACAT2(5), ACSS1(16), ACSS2(12), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH7A1(2), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), HIBCH(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), MCEE(5), MLYCD(8), MUT(7), PCCA(12), PCCB(5), SUCLA2(3), SUCLG1(2), SUCLG2(8) 23267028 264 104 243 56 64 42 31 52 74 1 0.00275 1.000 1.000 398 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(8), ARSB(2), FUCA1(1), FUCA2(2), GALNS(3), GBA(12), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), HGSNAT(5), HPSE(11), HPSE2(10), HYAL1(7), HYAL2(8), IDS(4), IDUA(4), LCT(24), MAN2B1(19), MAN2B2(19), MAN2C1(11), MANBA(10), NAGLU(8), NEU1(3), NEU2(7), NEU3(5), NEU4(3), SPAM1(10) 20139847 226 104 221 58 69 37 38 33 49 0 0.0125 1.000 1.000 399 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(14), ATP4B(4), ATP6AP1(6), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(6), ATP6V0C(1), ATP6V0D1(8), ATP6V1A(5), ATP6V1B1(24), ATP6V1B2(4), ATP6V1C1(3), ATP6V1C2(15), ATP6V1D(3), ATP6V1E1(3), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(15), ATP7A(16), ATP7B(15), COX10(2), COX4I1(4), COX5B(1), COX6B1(2), COX7A1(1), COX7B(3), COX7C(1), COX8A(1), NDUFA1(1), NDUFA10(3), NDUFA8(6), NDUFB2(1), NDUFB4(1), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(6), NDUFV1(6), NDUFV2(1), PPA2(3), SDHA(11), SDHB(4), SHMT1(2), UQCRB(2), UQCRC1(3), UQCRFS1(3) 22369586 245 104 229 69 70 33 36 42 62 2 0.115 1.000 1.000 400 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(4), BRAF(18), CREB1(4), CREB5(7), DUSP4(2), DUSP6(4), DUSP9(8), EEF2K(11), EIF4E(2), GRB2(4), MAP2K1(7), MAP2K2(3), MAP3K8(2), MAPK1(3), MAPK3(3), MKNK1(5), MKNK2(8), MOS(11), NFKB1(8), RAP1A(3), RPS6KA1(9), RPS6KA2(12), RPS6KA3(6), SHC1(7), SOS1(9), SOS2(18), TRAF3(7) 17285756 185 102 172 64 52 27 13 42 51 0 0.672 1.000 1.000 401 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(3), CALM3(1), CHUK(5), EGR2(9), EGR3(9), GNAQ(3), MAP3K1(16), MYC(6), NFATC1(16), NFATC2(26), NFKB1(8), NFKBIA(1), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RELA(7), SYT1(5), VIP(7), VIPR2(5) 16402640 215 102 202 57 75 28 17 38 57 0 0.0189 1.000 1.000 402 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(6), B4GALT1(3), B4GALT2(8), FBP2(6), GAA(8), GALE(1), GALK1(4), GALK2(3), GALT(3), GANAB(19), GCK(9), GLA(3), GLB1(7), HK1(17), HK2(12), HK3(11), LALBA(1), LCT(24), MGAM(19), PFKM(2), PFKP(21), PGM1(3), PGM3(13) 19015189 203 101 185 77 73 26 21 42 41 0 0.694 1.000 1.000 403 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), FPGT(7), FUK(7), GMDS(1), GMPPA(7), GMPPB(6), HK1(17), HK2(12), HK3(11), HSD3B7(7), KHK(2), LHPP(3), MPI(3), MTMR1(7), MTMR2(9), MTMR6(9), PFKFB1(6), PFKFB2(5), PFKFB3(8), PFKFB4(5), PFKL(8), PFKM(2), PFKP(21), PGM2(1), PHPT1(2), PMM1(3), PMM2(2), RDH11(1), RDH12(3), RDH13(7), SORD(3), TPI1(3), TSTA3(9) 21716824 236 101 229 75 85 39 30 29 53 0 0.0704 1.000 1.000 404 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(6), AKR1B10(6), B4GALT1(3), B4GALT2(8), G6PC2(1), GAA(8), GALE(1), GALK1(4), GALK2(3), GALT(3), GANC(9), GCK(9), GLA(3), GLB1(7), HK1(17), HK2(12), HK3(11), HSD3B7(7), LALBA(1), LCT(24), MGAM(19), PFKL(8), PFKM(2), PFKP(21), PGM1(3), PGM3(13), RDH11(1), RDH12(3), RDH13(7), UGP2(9) 22544622 229 101 215 91 87 29 26 42 45 0 0.810 1.000 1.000 405 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(16), DYRK1B(15), GLI2(18), GLI3(60), GSK3B(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), SHH(6), SMO(15), SUFU(6) 9753396 181 101 173 70 66 24 13 39 37 2 0.450 1.000 1.000 406 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(20), CPS1(24), EPRS(18), GAD1(8), GAD2(15), GCLC(3), GCLM(3), GFPT1(7), GLS(11), GLS2(8), GLUD1(4), GLUL(5), GMPS(7), GOT1(3), GOT2(2), GPT(4), GPT2(3), GSS(2), NADSYN1(11), PPAT(7), QARS(7) 19463962 185 100 181 61 48 26 28 39 44 0 0.408 1.000 1.000 407 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(3), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH7A1(2), ALDH9A1(6), AMDHD1(1), AOC2(10), AOC3(13), ASPA(2), CARM1(8), CNDP1(5), DDC(12), FTCD(7), HAL(4), HARS(9), HARS2(4), HDC(11), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(11), MAOA(4), MAOB(3), METTL6(5), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), PRPS1(3), PRPS2(3), UROC1(12), WBSCR22(5) 23170694 247 100 226 56 56 26 35 47 81 2 0.0225 1.000 1.000 408 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(7), CAPN2(10), CAPNS1(3), CAPNS2(2), CXCR3(2), EGF(11), EGFR(19), HRAS(1), ITGA1(7), ITGB1(11), MAPK1(3), MAPK3(3), MYL2(9), MYLK(25), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PTK2(11), PXN(6), TLN1(28) 19153213 201 100 192 67 73 30 18 34 45 1 0.227 1.000 1.000 409 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(4), CDC42(3), CREB1(4), DAXX(11), DDIT3(5), ELK1(4), GRB2(4), HMGN1(2), HRAS(1), HSPB1(2), HSPB2(1), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP3K5(10), MAP3K7(11), MAP3K9(5), MAPK14(2), MAPKAPK2(3), MAPKAPK5(4), MAX(3), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MKNK1(5), MYC(6), PLA2G4A(7), RAC1(1), RIPK1(3), RPS6KA5(5), SHC1(7), STAT1(11), TGFB1(3), TGFB2(9), TGFB3(9), TGFBR1(8), TRADD(2), TRAF2(4) 21478710 206 100 198 54 53 30 26 33 61 3 0.0560 1.000 1.000 410 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(4), BCR(14), BLNK(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), JUN(5), LYN(7), MAP2K1(7), MAP3K1(16), MAPK1(3), MAPK3(3), MAPK8IP3(12), PAPPA(29), RAC1(1), RPS6KA1(9), RPS6KA3(6), SHC1(7), SOS1(9), SYK(9), VAV1(13), VAV2(13), VAV3(14) 18753018 196 100 188 67 60 27 22 44 43 0 0.347 1.000 1.000 411 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(9), AZIN1(4), CBX3(4), CLDN5(4), CLOCK(8), CRY1(3), CRY2(7), DAZAP2(4), DNAJA1(9), ETV6(9), G0S2(3), GFRA1(10), GSTM3(2), GSTP1(1), HERPUD1(2), HSPA8(5), IDI1(2), KLF9(3), MYF6(4), NCKAP1(13), NCOA4(7), NR1D2(8), PER1(6), PER2(15), PPP1R3C(4), PPP2CB(4), PSMA4(4), PURA(2), SF3A3(2), SUMO3(7), TOB1(1), TUBB3(10), UCP3(4), UGP2(9), VAPA(3), ZFR(16) 21427966 208 99 199 63 57 18 28 41 63 1 0.485 1.000 1.000 412 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(17), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC4(2), ANAPC5(5), ANAPC7(6), BTRC(9), CDC16(7), CDC20(7), CDC23(6), CDC26(2), CDC27(5), CUL1(24), CUL2(9), CUL3(8), FBXW11(9), FBXW7(32), FZR1(8), ITCH(4), RBX1(1), SKP2(6), SMURF1(7), SMURF2(5), TCEB1(1), UBA1(4), UBE2C(1), UBE2D3(1), UBE2E1(2), UBE2E2(1), UBE2E3(3), VHL(2), WWP1(13), WWP2(15) 23536448 232 99 209 43 74 29 29 32 67 1 0.000109 1.000 1.000 413 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(10), CALM1(2), CALM2(3), CALM3(1), CRKL(2), GNAQ(3), GRB2(4), HRAS(1), JUN(5), MAP2K1(7), MAP2K2(3), MAP2K3(11), MAP2K4(9), MAP3K1(16), MAPK1(3), MAPK14(2), MAPK3(3), MAPK8(6), PAK1(5), PLCG1(22), PRKCA(8), PTK2B(16), RAC1(1), RAF1(9), SHC1(7), SOS1(9), SRC(5), SYT1(5) 16689733 178 99 168 43 63 18 19 30 47 1 0.0174 1.000 1.000 414 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), DDC(12), EPX(16), ESCO1(10), ESCO2(10), GOT1(3), GOT2(2), HPD(4), LPO(11), MAOA(4), MAOB(3), MIF(1), MPO(9), NAT6(4), PNPLA3(4), PRDX6(2), SH3GLB1(3), TAT(5), TPO(27) 20038770 187 98 171 42 50 16 16 44 59 2 0.105 1.000 1.000 415 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(8), POLA2(4), POLB(6), POLD1(15), POLD2(6), POLD3(4), POLE(34), POLE2(5), POLE3(4), POLE4(1), POLG(10), POLG2(5), POLH(7), POLI(3), POLK(10), POLL(4), POLM(13), POLQ(37), PRIM1(2), PRIM2(7), REV1(9), REV3L(50), RFC5(2) 23776885 246 98 236 68 60 37 29 37 79 4 0.335 1.000 1.000 416 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(3), CALM3(1), DLG4(4), GRIN1(11), GRIN2A(20), GRIN2B(26), GRIN2C(10), GRIN2D(10), NOS1(39), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), PRKCA(8), SYT1(5) 14963506 203 98 194 65 70 26 22 39 46 0 0.131 1.000 1.000 417 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(6), ANXA2(3), ANXA3(1), ANXA4(6), ANXA5(4), ANXA6(3), CYP11A1(6), EDN1(4), EDNRA(4), EDNRB(33), HPGD(3), HSD11B1(4), HSD11B2(4), PLA2G4A(7), PRL(1), PTGDR(8), PTGDS(1), PTGER2(7), PTGER4(12), PTGFR(5), PTGIS(8), PTGS1(13), PTGS2(7), S100A6(1), SCGB1A1(3), TBXAS1(7) 12108188 161 98 149 49 39 13 25 42 41 1 0.425 1.000 1.000 418 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(17), BAIAP2(5), CASP1(3), CASP3(2), CASP7(4), CASP8(18), GAPDH(3), INSR(17), ITCH(4), MAGI1(26), MAGI2(28), RERE(30), WWP1(13), WWP2(15) 14068619 185 97 176 48 43 23 24 32 61 2 0.157 1.000 1.000 419 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(21), CAP1(2), CCNB1(3), CDC25C(11), GNAI1(3), GNAS(38), GNB1(2), GNGT1(3), HRAS(1), MAPK1(3), MAPK3(3), MYT1(22), PIN1(2), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RPS6KA1(9), SRC(5) 12084317 171 97 162 54 64 22 12 36 35 2 0.304 1.000 1.000 420 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(5), CREBBP(46), DUSP1(3), EP300(27), IKBKB(10), IL1B(4), MAP2K3(11), MAP2K6(1), MAP3K7(11), MAPK11(1), MAPK14(2), MYD88(4), NFKB1(8), NFKBIA(1), NR3C1(9), RELA(7), TGFBR1(8), TGFBR2(17), TLR2(4), TNF(3) 17360728 182 97 175 48 44 21 27 35 55 0 0.0929 1.000 1.000 421 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ACADL(3), ACADM(7), ACADSB(8), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), AOC2(10), AOC3(13), CNDP1(5), DPYD(20), DPYS(8), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), MLYCD(8), SDS(4), SMS(6), UPB1(6) 17035869 203 96 189 49 44 25 28 44 62 0 0.0219 1.000 1.000 422 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(22), EXT2(7), EXTL1(8), EXTL2(2), EXTL3(12), GLCE(6), HS2ST1(3), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), HS3ST5(8), HS6ST1(7), HS6ST2(9), HS6ST3(9), NDST1(13), NDST2(13), NDST3(18), NDST4(17) 12130671 180 96 170 61 59 27 19 49 25 1 0.488 1.000 1.000 423 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(4), DLG4(4), EPHB2(15), F2(11), F2RL1(1), F2RL2(4), F2RL3(4), JUN(5), MAP2K5(1), MAPK1(3), MAPK7(8), MAPK8(6), MYEF2(8), PLD1(22), PLD2(19), PLD3(8), PTK2(11), RAF1(9), RASAL1(11), SRC(5), TEC(4), VAV1(13) 16061421 176 96 174 48 58 24 19 32 43 0 0.0884 1.000 1.000 424 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACAA2(9), ACADL(3), ACADM(7), ACADS(4), ACADSB(8), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH9A1(6), AOX1(14), BCAT1(6), BCKDHA(12), BCKDHB(3), ECHS1(2), EHHADH(4), HADHA(5), HADHB(6), HIBADH(3), IVD(4), MCCC1(4), MCCC2(7), MCEE(5), MUT(7), OXCT1(10), PCCA(12), PCCB(5), SDS(4) 21103575 231 96 212 60 45 39 32 38 76 1 0.0999 1.000 1.000 425 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(7), ACTN2(26), BCAR1(10), CSK(8), CTNNA1(17), CTNNA2(24), CTNNB1(27), PTK2(11), PXN(6), SRC(5), VCL(11) 11204907 152 95 142 53 54 10 20 36 29 3 0.592 1.000 1.000 426 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(9), ACP2(5), ACP5(3), ACPP(5), ACPT(6), ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), CYP19A1(12), CYP1A1(7), CYP1A2(5), CYP2A13(11), CYP2A6(8), CYP2A7(9), CYP2B6(8), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2D6(13), CYP2E1(6), CYP2F1(9), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(4), CYP4B1(11), CYP51A1(9), PON1(3) 17197789 199 95 189 65 80 22 19 34 44 0 0.246 1.000 1.000 427 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(4), ARSD(5), ARSE(6), ASAH1(4), B4GALT6(6), CERK(7), DEGS1(1), DEGS2(2), ENPP7(4), GAL3ST1(12), GALC(5), GBA(12), GLA(3), GLB1(7), LCT(24), NEU1(3), NEU2(7), NEU3(5), NEU4(3), PPAP2A(3), PPAP2B(2), PPAP2C(6), SGMS1(4), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(6), SMPD2(3), SMPD3(10), SMPD4(12), SPHK1(10), SPHK2(8), SPTLC1(5), SPTLC2(4), UGCG(3), UGT8(6) 20903003 211 95 204 74 70 29 31 37 44 0 0.407 1.000 1.000 428 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(7), ACTN2(26), CAPN1(7), CAPNS1(3), CAPNS2(2), ITGA1(7), ITGB1(11), ITGB3(6), PTK2(11), PXN(6), RAC1(1), SPTAN1(22), SRC(5), TLN1(28) 16715768 146 95 140 53 69 15 13 27 22 0 0.453 1.000 1.000 429 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(5), CSNK1D(4), DRD1(4), DRD2(10), GRM1(43), PLCB1(21), PPP1CA(2), PPP1R1B(3), PPP2CA(4), PPP3CA(13), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9) 9390687 151 94 145 39 44 20 18 34 35 0 0.0343 1.000 1.000 430 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(8), BCL2(4), BID(2), BIRC2(7), BIRC3(10), CASP10(8), CASP3(2), CASP6(1), CASP7(4), CASP8(18), CASP9(3), CFLAR(1), CHUK(5), DFFA(4), DFFB(3), FADD(3), GAS2(2), LMNA(11), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), SPTAN1(22), TNFRSF10A(2), TNFRSF10B(2), TNFRSF25(5), TNFSF10(9), TRADD(2), TRAF2(4) 19570967 161 94 153 40 37 27 12 37 47 1 0.152 1.000 1.000 431 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(8), GTF2A1(3), GTF2B(3), GTF2E1(6), GTF2F1(6), HDAC3(7), NCOA1(20), NCOA2(27), NCOA3(15), NCOR2(40), POLR2A(24), RARA(4), RXRA(13), TBP(6) 14567533 182 94 179 66 57 35 23 31 33 3 0.519 1.000 1.000 432 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAA2(9), ACAD8(5), ACAD9(8), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), AKR1B10(6), AKR1C4(5), AKR1D1(4), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), BAAT(6), CEL(16), CYP27A1(6), CYP7A1(7), HADHB(6), HSD3B7(7), LIPA(3), RDH11(1), RDH12(3), RDH13(7), SLC27A5(5), SOAT1(11), SOAT2(3), SRD5A1(2) 18514509 209 93 194 53 48 32 39 36 54 0 0.0310 1.000 1.000 433 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ACADM(7), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AOC2(10), AOC3(13), CNDP1(5), DPYD(20), DPYS(8), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), HIBCH(2), MLYCD(8), SMS(6), SRM(1), UPB1(6) 15819734 181 93 167 40 40 21 24 38 58 0 0.0105 1.000 1.000 434 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(5), CHIA(4), CHIT1(5), CMAS(6), CTBS(3), CYB5R1(3), CYB5R3(4), GFPT1(7), GFPT2(6), GNE(11), GNPDA1(4), GNPDA2(7), GNPNAT1(6), HEXA(2), HEXB(3), HK1(17), HK2(12), HK3(11), LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), NANS(6), NPL(4), PGM3(13), PHPT1(2), RENBP(3), UAP1(5) 16801825 177 93 170 47 47 29 24 41 36 0 0.0260 1.000 1.000 435 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(5), EGF(11), EGFR(19), GRB2(4), HRAS(1), MAP2K1(7), MAPK1(3), MAPK3(3), PTPRB(26), RAF1(9), RASA1(19), SHC1(7), SOS1(9), SPRY1(2), SPRY3(8), SPRY4(6), SRC(5) 14639398 144 93 138 44 38 20 12 40 33 1 0.446 1.000 1.000 436 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(3), ERCC3(8), GTF2B(3), GTF2E1(6), GTF2E2(4), GTF2F2(3), GTF2H1(5), GTF2H4(9), ILK(9), MNAT1(3), POLR1A(19), POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3B(11), POLR3D(5), POLR3E(6), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(14), TAF7(7), TBP(6) 20533691 185 92 182 64 57 19 27 31 51 0 0.629 1.000 1.000 437 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), P4HB(3), SLC23A1(7), SLC23A2(10), SLC2A1(8), SLC2A3(10) 14684253 153 92 147 54 45 28 17 29 32 2 0.278 1.000 1.000 438 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(21), GNAS(38), GNB1(2), GNGT1(3), PPP2CA(4), PRKAA1(7), PRKAA2(10), PRKAB1(11), PRKAB2(4), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9) 9024175 151 90 142 37 57 15 12 24 41 2 0.143 1.000 1.000 439 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), CDC42(3), CREB1(4), CREB5(7), DUSP1(3), DUSP10(8), EEF2K(11), EIF4E(2), ELK1(4), HSPB1(2), IL1R1(4), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K10(13), MAP3K4(26), MAP3K5(10), MAP3K7(11), MAPK1(3), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(2), MAPKAPK2(3), MAPKAPK5(4), MKNK1(5), MKNK2(8), MYEF2(8), NFKB1(8), NR2C2(6), SRF(5), TRAF6(6) 19513196 196 90 191 54 45 40 25 35 50 1 0.0311 1.000 1.000 440 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(11), AGT(4), AGTR1(1), AGTR2(4), CMA1(2), COL4A1(33), COL4A2(18), COL4A3(15), COL4A4(19), COL4A5(19), COL4A6(11), REN(7) 14801470 144 89 141 48 35 30 16 29 32 2 0.314 1.000 1.000 441 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(15), CHAT(6), COMT(5), DBH(7), DDC(12), GAD1(8), GAD2(15), HDC(11), MAOA(4), PAH(6), PNMT(11), SLC18A3(16), TH(7), TPH1(4) 8421070 129 89 123 46 44 15 11 26 32 1 0.428 1.000 1.000 442 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(5), B4GALT5(4), C1GALT1(3), C1GALT1C1(6), GALNT1(4), GALNT10(8), GALNT11(6), GALNT12(3), GALNT13(9), GALNT14(12), GALNT2(7), GALNT3(4), GALNT4(6), GALNT5(12), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GALNTL5(3), GCNT1(1), GCNT3(4), GCNT4(4), OGT(7), ST3GAL1(5), ST3GAL2(9), ST6GALNAC1(5), WBSCR17(27) 18955878 173 89 169 66 60 21 21 33 37 1 0.902 1.000 1.000 443 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(3), AGPAT2(3), AGPAT3(5), AGPAT4(7), AGPAT6(6), AGPS(6), CHPT1(4), ENPP2(11), ENPP6(7), PAFAH1B1(15), PAFAH1B2(1), PAFAH1B3(2), PAFAH2(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), PLD1(22), PLD2(19), PPAP2A(3), PPAP2B(2), PPAP2C(6) 13582604 172 89 160 39 46 20 31 42 33 0 0.0123 1.000 1.000 444 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(9), ALDH3A1(14), ALDH3B1(4), ALDH3B2(7), AOC2(10), AOC3(13), DDC(12), EPX(16), GOT1(3), GOT2(2), HPD(4), LPO(11), MAOA(4), MAOB(3), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), TAT(5), TPO(27) 12842204 158 89 143 42 45 14 16 38 43 2 0.239 1.000 1.000 445 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(11), ACO1(7), ACO2(11), CLYBL(3), CS(1), DLD(10), DLST(6), FH(4), IDH1(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), OGDH(11), OGDHL(19), PC(18), PCK1(12), PCK2(10), SDHA(11), SDHB(4), SDHC(2), SDHD(1), SUCLA2(3), SUCLG1(2), SUCLG2(8) 17518974 173 88 164 57 59 26 19 24 45 0 0.372 1.000 1.000 446 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(20), CALM1(2), CALM2(3), CALM3(1), CAPN2(10), CAPNS1(3), CAPNS2(2), EP300(27), HDAC1(9), HDAC2(6), MEF2D(8), NFATC1(16), NFATC2(26), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), SYT1(5) 14300668 171 88 161 44 61 20 21 28 41 0 0.0121 1.000 1.000 447 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(28), ACADL(3), ACADM(7), ACADSB(8), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH6A1(6), ALDH9A1(6), ECHS1(2), EHHADH(4), HADHA(5), LDHA(7), LDHB(5), LDHC(1), MCEE(5), MLYCD(8), MUT(7), PCCA(12), PCCB(5), SDS(4), SUCLA2(3), SUCLG1(2), SUCLG2(8) 19421267 212 88 194 50 48 35 28 40 61 0 0.0392 1.000 1.000 448 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(41), MAP2(40), PPP1CA(2), PPP2CA(4), PRKACB(6), PRKACG(9), PRKAG1(5), PRKAR2A(3), PRKAR2B(9), PRKCE(14) 10666615 133 87 126 44 23 13 22 43 30 2 0.756 1.000 1.000 449 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(10), ABAT(4), ACADS(4), ACAT1(6), ACAT2(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH5A1(5), ALDH9A1(6), ECHS1(2), EHHADH(4), GAD1(8), GAD2(15), HADHA(5), L2HGDH(2), OXCT1(10), PDHA1(1), PDHA2(11), PDHB(4), SDHB(4), SDS(4) 15106691 171 87 159 62 42 22 21 33 53 0 0.684 1.000 1.000 450 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(5), IFNA1(1), IFNB1(3), IKBKB(10), IL1A(2), IL1B(4), IL1R1(4), IL1RAP(6), IL1RN(1), IRAK1(7), IRAK2(11), IRAK3(9), JUN(5), MAP2K3(11), MAP2K6(1), MAP3K1(16), MAP3K7(11), MAPK14(2), MAPK8(6), MYD88(4), NFKB1(8), NFKBIA(1), RELA(7), TGFB1(3), TGFB2(9), TGFB3(9), TNF(3), TOLLIP(6), TRAF6(6) 17372497 171 87 164 44 39 26 16 34 55 1 0.0997 1.000 1.000 451 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(34), C5(13), C6(13), C7(7), ICAM1(4), IL1A(2), ITGA4(16), ITGAL(22), ITGB1(11), ITGB2(12), SELP(11), SELPLG(9), TNF(3), VCAM1(9) 14536352 166 87 156 45 50 17 20 44 35 0 0.0354 1.000 1.000 452 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(6), ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), FPGT(7), GCK(9), GMDS(1), GMPPA(7), GMPPB(6), HK1(17), HK2(12), HK3(11), KHK(2), MPI(3), PFKFB1(6), PFKFB3(8), PFKFB4(5), PFKM(2), PFKP(21), PMM1(3), PMM2(2), SORD(3), TPI1(3) 13995465 161 86 156 51 64 25 18 22 32 0 0.0962 1.000 1.000 453 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(11), CS(1), DLAT(8), DLD(10), DLST(6), FH(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), OGDH(11), PC(18), PDHA1(1), PDHA2(11), PDHB(4), PDHX(5), PDK1(3), PDK2(1), PDK3(6), PDK4(5), PDP2(5), SDHA(11), SDHB(4), SDHC(2), SDHD(1), SUCLA2(3), SUCLG1(2), SUCLG2(8) 16636416 156 86 147 58 43 26 19 28 40 0 0.754 1.000 1.000 454 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(5), FADD(3), IKBKB(10), IL1A(2), IL1R1(4), IRAK1(7), MAP3K1(16), MAP3K7(11), MYD88(4), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TLR4(27), TNF(3), TNFAIP3(11), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6) 14231498 139 86 133 31 32 19 14 36 38 0 0.0367 1.000 1.000 455 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(11), F2R(6), F2RL3(4), GNAI1(3), GNB1(2), GNGT1(3), HRAS(1), ITGA1(7), ITGB1(11), MAP2K1(7), MAPK1(3), MAPK3(3), PLA2G4A(7), PLCB1(21), PRKCA(8), PTGS1(13), PTK2(11), RAF1(9), SRC(5), SYK(9), TBXAS1(7) 14280107 151 84 143 35 52 15 18 36 29 1 0.0119 1.000 1.000 456 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CALM2(3), CALM3(1), CDKN1A(5), GNAQ(3), MARCKS(2), NFATC1(16), NFATC2(26), NFATC3(5), NFATC4(16), PLCG1(22), PPP3CA(13), PPP3CB(6), PPP3CC(6), PRKCA(8), SP1(5), SP3(5), SYT1(5) 12309203 149 83 142 36 59 24 15 19 32 0 0.00258 1.000 1.000 457 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(3), ATG5(3), ATG7(9), BECN1(8), GABARAPL1(6), IFNA1(1), IFNA10(6), IFNA13(3), IFNA16(4), IFNA17(4), IFNA2(2), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(16), PIK3R4(10), PRKAA1(7), PRKAA2(10), ULK1(20), ULK2(11), ULK3(2) 12349690 138 83 130 35 26 18 21 39 33 1 0.182 1.000 1.000 458 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(10), CD2(4), CD33(9), CD5(4), CD7(5), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(3), IL12B(2), IL13(4), IL3(1), IL4(4), ITGAX(13), TLR2(4), TLR4(27), TLR7(6), TLR9(15) 10910712 119 82 113 41 32 14 15 41 17 0 0.378 1.000 1.000 459 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(17), EPHB1(33), FYN(9), ITGA1(7), ITGB1(11), L1CAM(18), LYN(7), RAP1B(6), SELP(11) 9261404 123 82 119 38 46 12 15 36 13 1 0.136 1.000 1.000 460 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(19), IL13(4), IL4(4), JUNB(5), MAF(4), MAP2K3(11), MAPK14(2), NFATC1(16), NFATC2(26), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9) 7104277 130 82 121 42 46 19 12 16 37 0 0.119 1.000 1.000 461 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(4), ALDH18A1(9), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), AMD1(7), AOC2(10), AOC3(13), ARG1(2), ARG2(3), ASL(5), ASS1(10), CPS1(24), GATM(3), MAOA(4), MAOB(3), NAGS(1), ODC1(3), OTC(4), SAT1(2), SMS(6), SRM(1) 17246108 174 82 163 35 43 18 27 38 48 0 0.00790 1.000 1.000 462 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(14), BST1(3), CD38(5), ENPP1(7), ENPP3(12), NADK(11), NADSYN1(11), NMNAT1(4), NMNAT2(1), NMNAT3(3), NNMT(3), NNT(10), NT5C1A(8), NT5C1B(12), NT5C2(9), NT5E(5), NT5M(6), NUDT12(6) 12611311 130 82 120 42 32 16 20 20 41 1 0.433 1.000 1.000 463 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(7), ABAT(4), ADSL(5), ADSS(6), AGXT(3), AGXT2(13), ASL(5), ASNS(5), ASPA(2), CAD(20), CRAT(12), DARS(2), DDO(6), GAD1(8), GAD2(15), GOT1(3), GOT2(2), GPT(4), GPT2(3), NARS(5), PC(18) 15266820 148 81 142 57 52 20 17 26 33 0 0.621 1.000 1.000 464 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(7), CARS(6), DARS(2), EPRS(18), FARS2(9), GARS(3), HARS(9), IARS(11), KARS(7), LARS(9), LARS2(10), MARS(7), MARS2(5), NARS(5), QARS(7), RARS(5), SARS(9), TARS(11), WARS(4), WARS2(12), YARS(8) 18803806 164 81 159 44 47 21 28 30 38 0 0.109 1.000 1.000 465 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(8), AGT(4), AGTR2(4), EDN1(4), EDNRA(4), EDNRB(33), EGF(11), EGFR(19), FOS(1), HRAS(1), JUN(5), MYC(6), NFKB1(8), PLCG1(22), PRKCA(8), RELA(7) 12064525 145 81 132 39 39 19 14 36 37 0 0.117 1.000 1.000 466 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(8), CBS(9), CTH(3), GGT1(9), HEMK1(1), LCMT1(1), LCMT2(11), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), METTL6(5), PAPSS1(6), PAPSS2(6), PRMT2(9), PRMT3(9), PRMT5(5), PRMT6(4), PRMT7(6), PRMT8(7), SCLY(4), SEPHS1(4), SEPHS2(3), WBSCR22(5) 14594112 142 80 134 45 36 18 24 23 40 1 0.275 1.000 1.000 467 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(10), CCNB1(3), CCND1(2), CCND2(2), CCND3(1), CCNE1(5), CCNH(3), CDC25A(5), CDK2(4), CDK4(2), CDK6(4), CDKN1A(5), CDKN1B(1), CDKN2A(17), CDKN2B(1), CDKN2C(1), CDKN2D(4), E2F1(4), RB1(14), RBL1(12), TFDP1(5) 9427471 105 79 103 35 20 20 13 24 27 1 0.509 1.000 1.000 468 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(4), ASNS(5), ASRGL1(4), CA1(1), CA12(1), CA13(4), CA14(5), CA2(7), CA3(4), CA4(6), CA5A(3), CA5B(1), CA6(3), CA7(3), CA8(4), CA9(7), CPS1(24), CTH(3), GLS(11), GLS2(8), GLUD1(4), GLUD2(13), GLUL(5), HAL(4) 12455509 134 79 128 41 30 15 25 34 30 0 0.385 1.000 1.000 469 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(7), CCR2(5), CCR3(12), CCR5(4), CCR7(4), CD28(1), CD4(11), CXCR3(2), IFNG(2), IFNGR1(10), IFNGR2(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18R1(6), IL4(4), IL4R(7), TGFB1(3), TGFB2(9), TGFB3(9) 11727453 123 79 115 40 29 11 19 29 35 0 0.542 1.000 1.000 470 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(46), EP300(27), LPL(9), NCOA1(20), NCOA2(27), PPARG(4), RXRA(13) 10837065 146 79 139 35 45 22 21 29 29 0 0.0201 1.000 1.000 471 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(25), APOA1(8), APOA4(8), APOC2(2), APOE(2), CETP(7), CYP7A1(7), DGAT1(10), HMGCR(7), LCAT(4), LDLR(12), LIPC(5), LPL(9), LRP1(54), SCARB1(4), SOAT1(11) 16067661 175 79 167 53 63 16 26 32 36 2 0.200 1.000 1.000 472 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(8), CREB1(4), CREBBP(46), EP300(27), NCOA3(15), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), RARA(4), RXRA(13) 12122086 156 78 148 45 48 20 21 23 44 0 0.146 1.000 1.000 473 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(6), ALOX15(10), ALOX5(11), CYP1A2(5), CYP2C18(5), CYP2C19(8), CYP2C8(1), CYP2C9(1), CYP2E1(6), CYP2J2(4), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), HSD3B7(7), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8), RDH11(1), RDH12(3), RDH13(7) 14022676 134 78 126 46 46 14 23 31 19 1 0.460 1.000 1.000 474 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IL2RA(2), IL2RB(3), IL2RG(9), JAK1(19), JAK3(12), JUN(5), LCK(4), MAP2K1(7), MAPK3(3), MAPK8(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13), SYK(9) 13632147 142 78 132 32 31 23 14 34 38 2 0.0500 1.000 1.000 475 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(21), ADRB2(8), GNAS(38), PLCE1(17), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9) 8699774 123 78 117 46 50 15 12 21 24 1 0.687 1.000 1.000 476 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(14), AP2M1(8), ARF1(5), BAD(4), BTK(4), EEA1(15), GRASP(2), GSK3A(4), GSK3B(6), LYN(7), PDPK1(1), PFKL(8), PFKM(2), PFKP(21), PLCG1(22), PRKCE(14), PRKCZ(2), RAB5A(3), RAC1(1), RPS6KB1(6), VAV2(13) 14633280 165 78 159 49 57 25 20 24 38 1 0.143 1.000 1.000 477 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(5), AKR1D1(4), ARSB(2), ARSD(5), ARSE(6), CYP11B1(17), CYP11B2(8), HSD11B1(4), HSD11B2(4), HSD17B2(3), HSD17B3(2), HSD3B1(4), HSD3B2(2), SRD5A1(2), STS(8), SULT1E1(3), SULT2A1(4), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5) 15957014 133 77 128 51 33 29 16 27 28 0 0.583 1.000 1.000 478 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(10), B3GAT2(7), B3GAT3(4), B4GALT7(6), CHPF(4), CHST11(4), CHST12(6), CHST13(5), CHST14(2), CHST3(8), CHST7(7), CHSY1(9), DSE(8), UST(10), XYLT1(11), XYLT2(43) 8160116 144 77 110 44 59 10 19 14 41 1 0.548 1.000 1.000 479 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(6), BCAT2(9), IARS(11), IARS2(12), ILVBL(8), LARS(9), LARS2(10), PDHA1(1), PDHA2(11), PDHB(4), VARS(23), VARS2(14) 10887719 118 76 116 37 34 14 17 30 23 0 0.387 1.000 1.000 480 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(4), B3GNT2(5), B3GNT7(6), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), CHST1(20), CHST2(15), CHST4(7), CHST6(11), FUT8(9), ST3GAL1(5), ST3GAL2(9), ST3GAL3(2), ST3GAL4(7) 7319452 119 76 114 41 59 11 13 16 20 0 0.402 1.000 1.000 481 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(5), ELK1(4), FOS(1), GRB2(4), HRAS(1), IL6R(3), IL6ST(6), JAK1(19), JAK2(12), JAK3(12), JUN(5), MAP2K1(7), MAPK3(3), PTPN11(8), RAF1(9), SHC1(7), SOS1(9), SRF(5), STAT3(7) 13991149 127 76 118 39 27 20 15 34 28 3 0.372 1.000 1.000 482 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ACAA2(9), ADH1A(4), ADH1B(3), ADH4(2), ADH6(6), ADH7(2), ADHFE1(8), AKR1C4(5), AKR1D1(4), ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH9A1(6), BAAT(6), CEL(16), CYP27A1(6), CYP7A1(7), HADHB(6), SOAT2(3), SRD5A1(2) 13605777 159 75 147 43 33 19 29 30 48 0 0.150 1.000 1.000 483 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(8), ARHGDIB(1), BIRC2(7), BIRC3(10), CASP1(3), CASP10(8), CASP2(3), CASP3(2), CASP4(7), CASP6(1), CASP7(4), CASP8(18), CASP9(3), DFFA(4), DFFB(3), GZMB(2), LMNA(11), LMNB1(4), LMNB2(6), PRF1(13) 11316287 118 75 113 29 27 14 19 22 36 0 0.224 1.000 1.000 484 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(5), CSF1R(17), EGF(11), EGFR(19), GRB2(4), MET(10), PDGFRA(13), PRKCA(8), SH3GLB1(3), SH3GLB2(8), SH3KBP1(17), SRC(5) 11398215 120 75 112 56 32 18 9 26 35 0 0.977 1.000 1.000 485 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(21), ADRB2(8), CFTR(15), GNAS(38), PRKACB(6), PRKACG(9), PRKAR1A(4), PRKAR1B(8), PRKAR2A(3), PRKAR2B(9), SLC9A3R1(1) 7688595 122 75 116 35 46 12 11 22 30 1 0.355 1.000 1.000 486 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(5), ELK1(4), EPO(3), EPOR(3), FOS(1), GRB2(4), HRAS(1), JAK2(12), JUN(5), MAP2K1(7), MAPK3(3), MAPK8(6), PLCG1(22), PTPN6(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13) 12603739 130 75 126 31 38 20 15 27 29 1 0.0336 1.000 1.000 487 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(6), DCXR(1), GUSB(10), RPE(5), UGDH(8), UGP2(9), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2A1(6), UGT2A3(7), UGT2B10(6), UGT2B11(2), UGT2B15(4), UGT2B17(6), UGT2B28(11), UGT2B4(5), UGT2B7(7), XYLB(6) 15889679 140 75 132 30 20 15 26 33 46 0 0.0607 1.000 1.000 488 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(8), FUCA1(1), FUCA2(2), GLB1(7), HEXA(2), HEXB(3), LCT(24), MAN2B1(19), MAN2B2(19), MAN2C1(11), MANBA(10), NEU1(3), NEU2(7), NEU3(5), NEU4(3) 11920709 124 75 120 31 42 18 17 18 29 0 0.0481 1.000 1.000 489 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(3), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), HGSNAT(5), HPSE(11), HPSE2(10), HYAL1(7), HYAL2(8), IDS(4), IDUA(4), LCT(24), NAGLU(8), SPAM1(10) 11967757 126 75 124 39 37 25 20 19 25 0 0.219 1.000 1.000 490 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(6), GPLD1(13), PGAP1(11), PIGA(3), PIGB(10), PIGC(6), PIGG(15), PIGK(3), PIGL(5), PIGM(4), PIGN(6), PIGO(10), PIGP(1), PIGQ(9), PIGS(4), PIGT(11), PIGV(7), PIGW(5), PIGX(3), PIGZ(10) 13899980 142 75 129 39 34 15 17 32 43 1 0.295 1.000 1.000 491 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(4), BLVRA(4), BLVRB(1), CP(10), CPOX(4), EPRS(18), FECH(7), GUSB(10), HCCS(4), HMBS(3), HMOX1(7), HMOX2(1), PPOX(6), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5), UROD(2), UROS(5) 16012915 136 75 131 44 30 21 16 31 38 0 0.505 1.000 1.000 492 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(5), CREBBP(46), EP300(27), FADD(3), HDAC3(7), IKBKB(10), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6) 13090035 137 75 132 38 42 21 14 24 36 0 0.125 1.000 1.000 493 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(11), ACE2(11), AGT(4), AGTR1(1), AGTR2(4), ANPEP(10), CMA1(2), CPA3(4), CTSA(5), CTSG(4), ENPEP(15), LNPEP(12), MAS1(3), MME(10), NLN(7), REN(7), THOP1(6) 12388106 116 74 113 42 32 14 18 24 28 0 0.613 1.000 1.000 494 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(3), CHUK(5), CRADD(6), IKBKB(10), JUN(5), LTA(4), MAP2K3(11), MAP2K4(9), MAP2K6(1), MAP3K1(16), MAP4K2(10), MAPK14(2), MAPK8(6), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TANK(3), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4) 14086534 125 74 122 37 31 17 14 18 43 2 0.291 1.000 1.000 495 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(4), ARSB(2), ARSD(5), ARSE(6), ASAH1(4), GAL3ST1(12), GALC(5), GBA(12), GLA(3), GLB1(7), LCT(24), NEU1(3), NEU2(7), NEU3(5), NEU4(3), PPAP2A(3), PPAP2B(2), PPAP2C(6), SMPD1(6), SMPD2(3), SPTLC1(5), SPTLC2(4), UGCG(3) 14163863 134 72 130 51 43 18 25 20 28 0 0.673 1.000 1.000 496 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(6), ALDH1A2(6), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH3B1(4), ALDH3B2(7), ALDH9A1(6), AOC2(10), AOC3(13), ASPA(2), CNDP1(5), DDC(12), HAL(4), HARS(9), HDC(11), HNMT(2), MAOA(4), MAOB(3), PRPS1(3), PRPS2(3) 14306377 159 72 143 38 39 13 20 29 57 1 0.186 1.000 1.000 497 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(19), POLR1B(8), POLR1C(4), POLR1D(4), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLR3A(21), POLR3B(11), POLR3G(2), POLR3H(1), POLR3K(1), ZNRD1(2) 13759882 124 72 121 36 40 13 22 25 24 0 0.167 1.000 1.000 498 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), G6PD(6), GPI(6), H6PD(7), PFKL(8), PFKM(2), PFKP(21), PGD(8), PGLS(1), PGM1(3), PGM3(13), PRPS1(3), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TALDO1(6), TKT(5), TKTL1(11), TKTL2(12) 14222969 152 70 144 44 40 30 18 32 32 0 0.0567 1.000 1.000 499 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(4), B3GNT2(5), B3GNT3(3), B3GNT4(9), B3GNT5(11), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT4(6), FUT1(5), FUT2(2), FUT3(4), FUT4(2), FUT5(3), FUT6(6), FUT7(3), FUT9(7), GCNT2(1), ST3GAL6(6), ST8SIA1(12) 9479775 102 70 95 38 30 13 12 21 26 0 0.781 1.000 1.000 500 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(8), B4GALNT1(4), GLB1(7), HEXA(2), HEXB(3), LCT(24), SLC33A1(5), ST3GAL1(5), ST3GAL2(9), ST3GAL5(2), ST6GALNAC3(6), ST6GALNAC4(3), ST6GALNAC5(9), ST6GALNAC6(4), ST8SIA1(12), ST8SIA5(8) 9662814 111 70 108 44 43 12 15 20 21 0 0.723 1.000 1.000 501 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(2), MRPS7(1), RPL10A(6), RPL10L(14), RPL11(1), RPL12(3), RPL13A(4), RPL14(2), RPL18(1), RPL18A(1), RPL19(1), RPL22L1(1), RPL23A(3), RPL24(2), RPL26(1), RPL27(1), RPL28(1), RPL29(2), RPL3(3), RPL31(2), RPL34(1), RPL35A(1), RPL36A(3), RPL37(1), RPL38(1), RPL3L(3), RPL6(3), RPL8(3), RPL9(4), RPS10(1), RPS11(1), RPS13(2), RPS16(1), RPS18(1), RPS2(1), RPS20(4), RPS21(1), RPS23(1), RPS24(1), RPS26(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS7(1), RPS9(2), RPSA(5) 13258046 105 70 101 40 24 15 15 25 26 0 0.937 1.000 1.000 502 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(6), POLD1(15), POLD2(6), POLE(34), POLG(10), POLL(4), POLQ(37) 9812143 112 69 109 39 32 19 11 15 35 0 0.647 1.000 1.000 503 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(5), CSF1R(17), DDX20(3), E2F1(4), E2F4(2), ETS1(8), ETS2(4), ETV3(1), FOS(1), HDAC2(6), HDAC5(13), HRAS(1), JUN(5), NCOR2(40), RBL1(12), RBL2(7), SIN3A(15), SIN3B(15) 15152563 159 69 156 39 46 17 21 30 42 3 0.0876 1.000 1.000 504 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(8), ICAM1(4), ITGA4(16), ITGAL(22), ITGAM(10), ITGB1(11), ITGB2(12), SELE(6), SELL(6), SELP(11) 9332300 106 69 101 35 35 5 13 28 25 0 0.263 1.000 1.000 505 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(4), ASNS(5), CA1(1), CA12(1), CA14(5), CA2(7), CA3(4), CA4(6), CA5A(3), CA5B(1), CA6(3), CA7(3), CA8(4), CA9(7), CPS1(24), CTH(3), GLS(11), GLS2(8), GLUD1(4), GLUL(5), HAL(4) 11147941 113 69 107 35 24 13 22 26 28 0 0.467 1.000 1.000 506 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(7), ACO2(11), CS(1), DLD(10), DLST(6), FH(4), IDH1(4), IDH2(4), IDH3A(2), IDH3B(1), IDH3G(5), MDH1(3), PC(18), PCK1(12), SDHA(11), SDHB(4), SUCLA2(3), SUCLG1(2), SUCLG2(8) 12082327 116 68 110 37 43 18 10 15 30 0 0.288 1.000 1.000 507 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(11), EGFR(19), MAP2K1(7), MAP3K1(16), MAPK14(2), NCOR2(40), RARA(4), RXRA(13), THRA(7), THRB(4) 10081298 123 68 115 38 49 14 11 21 25 3 0.280 1.000 1.000 508 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(8), F2(11), F2R(6), F3(2), F5(22), F7(11), FGA(12), FGB(6), FGG(5), PROC(4), PROS1(11), SERPINC1(5), TFPI(5) 9627975 108 68 107 31 30 15 15 31 17 0 0.248 1.000 1.000 509 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(5), ALDH1A3(9), ALDH1B1(7), ALDH2(13), ALDH3A1(14), ALDH3A2(6), ALDH7A1(2), ALDH9A1(6), CYP2C19(8), CYP2C9(1), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ECHS1(2), EHHADH(4), ESCO1(10), ESCO2(10), HADHA(5), NAT6(4), PNPLA3(4), SH3GLB1(3), YOD1(1) 18120585 133 68 121 34 32 14 16 22 49 0 0.246 1.000 1.000 510 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(2), IL22RA1(2), IL22RA2(1), JAK1(19), JAK2(12), JAK3(12), SOCS3(3), STAT1(11), STAT3(7), STAT5A(10), STAT5B(13), TYK2(12) 10743415 109 68 105 35 27 15 13 20 31 3 0.552 1.000 1.000 511 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(5), ARFGAP1(5), ARFGAP3(6), ARFGEF2(31), CLTA(2), CLTB(2), COPA(13), GBF1(22), GPLD1(13), KDELR1(2), KDELR2(3), KDELR3(2) 9535763 106 67 106 29 33 18 16 20 19 0 0.0934 1.000 1.000 512 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(14), AMT(4), ATIC(5), FTCD(7), GART(10), MTFMT(2), MTHFD1(7), MTHFD1L(8), MTHFD2(1), MTHFR(10), MTHFS(3), MTR(19), SHMT1(2), SHMT2(11), TYMS(1) 11082523 104 67 100 28 27 14 14 21 27 1 0.0689 1.000 1.000 513 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), MDH1(3), ME1(1), ME3(7), PGK1(4), PGK2(3), PKLR(9), RPE(5), RPIA(2), TKT(5), TKTL1(11), TKTL2(12), TPI1(3) 11828319 104 67 103 57 30 24 12 21 17 0 0.978 1.000 1.000 514 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(6), GABRA1(21), GABRA2(10), GABRA3(11), GABRA4(9), GABRA5(8), GABRA6(11), GPHN(13), NSF(2), SRC(5), UBQLN1(6) 7007410 102 66 99 31 21 10 23 35 13 0 0.328 1.000 1.000 515 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(4), B4GALT1(3), B4GALT2(8), B4GALT3(2), B4GALT5(4), DPAGT1(6), DPM1(2), FUT8(9), MAN1A1(4), MAN1B1(6), MGAT1(5), MGAT2(3), MGAT3(10), MGAT4A(4), MGAT4B(4), MGAT5(11), RPN1(4), RPN2(6), ST6GAL1(1) 11666192 100 66 97 38 31 13 11 20 25 0 0.700 1.000 1.000 516 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(16), LPO(11), MPO(9), PRDX1(1), PRDX2(2), PRDX6(2), TPO(27), TYR(15) 5631167 83 66 78 26 27 10 8 25 12 1 0.404 1.000 1.000 517 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C9(8), MASP1(3), MASP2(6), MBL2(4) 12484355 114 65 108 33 35 15 13 23 28 0 0.223 1.000 1.000 518 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), AMD1(7), BHMT(5), CBS(9), CTH(3), DNMT1(19), DNMT3A(7), DNMT3B(15), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), MTAP(2), MTFMT(2), MTR(19), SRM(1), TAT(5) 12127607 121 65 119 53 37 14 25 25 20 0 0.862 1.000 1.000 519 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(8), GALNT2(7), GALNT3(4), GALNT4(6), GALNT6(7), GALNT7(2), GALNT8(7), GALNT9(3), GCNT1(1), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), WBSCR17(27) 8464373 97 65 94 36 39 8 13 18 18 1 0.821 1.000 1.000 520 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), G6PD(6), GPI(6), H6PD(7), PFKM(2), PFKP(21), PGD(8), PGLS(1), PGM1(3), PGM3(13), PRPS1(3), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TAL1(5), TALDO1(6), TKT(5) 11985956 126 65 119 35 33 24 14 28 27 0 0.0534 1.000 1.000 521 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(5), C1QB(1), C1S(10), C2(2), C3(34), C5(13), C6(13), C7(7), C8A(8), C8B(11), C9(8), MASP1(3) 12189996 115 64 109 30 36 13 15 26 25 0 0.127 1.000 1.000 522 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(10), G6PD(6), GCLC(3), GCLM(3), GGT1(9), GPX5(2), GPX7(3), GSR(5), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), IDH1(4), IDH2(4), MGST1(3), MGST2(3), MGST3(3), OPLAH(25), TXNDC12(3) 12868773 115 64 107 39 32 17 11 23 31 1 0.675 1.000 1.000 523 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(13), CNR2(3), DNMT1(19), MTNR1A(4), MTNR1B(8), PTAFR(4), PTGDR(8), PTGER2(7), PTGER4(12), PTGFR(5), TBXA2R(9) 6518288 92 64 88 43 39 12 15 16 10 0 0.682 1.000 1.000 524 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(4), JAK1(19), JAK2(12), JAK3(12), PIAS1(10), PIAS3(10), PTPRU(26), REG1A(4), SOAT1(11) 8022420 108 64 96 32 31 16 9 12 37 3 0.551 1.000 1.000 525 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(5), DUSP1(3), IKBKAP(14), IKBKB(10), LTA(4), MAP3K1(16), NFKB1(8), NFKBIA(1), RELA(7), RIPK1(3), TANK(3), TNFAIP3(11), TNFRSF1B(3), TRAF1(4), TRAF2(4), TRAF3(7) 13153352 103 64 99 33 32 14 8 15 33 1 0.460 1.000 1.000 526 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(9), ALDOC(7), FBP1(4), FBP2(6), GOT1(3), GOT2(2), GPT(4), GPT2(3), MDH1(3), ME1(1), ME2(7), ME3(7), PGK1(4), PKLR(9), RPE(5), RPIA(2), TKT(5), TPI1(3) 10571491 85 63 85 46 22 20 10 16 17 0 0.964 1.000 1.000 527 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(9), ACP2(5), ACP5(3), ACP6(3), ACPP(5), ACPT(6), ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), CYP3A4(3), CYP3A43(5), CYP3A5(1), CYP3A7(4), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), PON1(3), PON2(3), PON3(5) 10574025 107 63 99 44 37 11 12 20 27 0 0.812 1.000 1.000 528 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(4), IL6R(3), JAK1(19), JAK2(12), JAK3(12), PIAS3(10), PTPRU(26), REG1A(4), SRC(5), STAT3(7) 8918107 102 63 94 31 31 15 9 16 28 3 0.434 1.000 1.000 529 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(9), CLOCK(8), CRY1(3), CRY2(7), CSNK1D(4), CSNK1E(9), NPAS2(14), NR1D1(9), PER1(6), PER2(15), PER3(13) 9979085 97 61 94 27 33 12 10 18 24 0 0.149 1.000 1.000 530 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(4), CHUK(5), IFNG(2), IKBKB(10), IL4(4), JUN(5), MAP3K1(16), MAP3K5(10), MAP4K5(4), MAPK14(2), MAPK8(6), NFKB1(8), NFKBIA(1), RELA(7), TNFRSF9(11), TRAF2(4) 11327837 99 60 91 22 25 11 7 17 38 1 0.131 1.000 1.000 531 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(17), KHK(2), LCT(24), MPI(3), PGM1(3), PYGL(11), PYGM(14), TPI1(3), TREH(3) 7844858 80 60 79 28 34 15 7 10 14 0 0.292 1.000 1.000 532 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(9), CYP51A1(9), DHCR24(4), DHCR7(7), EBP(2), FDFT1(3), FDPS(12), GGCX(4), GGPS1(4), HMGCR(7), HSD17B7(5), IDI1(2), IDI2(3), LSS(14), MVD(2), MVK(15), NQO1(3), NSDHL(4), PMVK(1), SQLE(9), TM7SF2(4), VKORC1(1) 11247026 124 60 110 32 29 12 13 26 44 0 0.381 1.000 1.000 533 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(4), CD3E(2), CXCR3(2), ETV5(7), IFNG(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), IL18(1), IL18R1(6), JAK2(12), JUN(5), MAP2K6(1), MAPK14(2), MAPK8(6), STAT4(9), TYK2(12) 10910334 95 60 95 31 18 15 18 19 24 1 0.410 1.000 1.000 534 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(12), FOS(1), GRB2(4), HRAS(1), IL3(1), IL3RA(5), JAK2(12), MAP2K1(7), MAPK3(3), PTPN6(6), RAF1(9), SHC1(7), SOS1(9), STAT5A(10), STAT5B(13) 10370215 100 60 96 33 28 16 12 23 20 1 0.439 1.000 1.000 535 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(8), FUCA1(1), FUCA2(2), GLB1(7), HEXA(2), HEXB(3), LCT(24), MAN2C1(11), MANBA(10), NEU1(3), NEU2(7), NEU3(5), NEU4(3) 9669989 86 60 85 29 26 15 10 13 22 0 0.526 1.000 1.000 536 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(5), FUT1(5), FUT2(2), FUT9(7), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(5), ST3GAL2(9), ST3GAL4(7), ST8SIA1(12) 5935240 72 59 69 27 31 7 6 20 8 0 0.520 1.000 1.000 537 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(14), CD38(5), ENPP1(7), ENPP3(12), NADSYN1(11), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(10), NT5E(5), NT5M(6) 8519417 78 59 72 28 9 9 14 16 29 1 0.783 1.000 1.000 538 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), NCK1(6), NCKAP1(13), NTRK1(9), PIR(1), PSMA7(3), RAC1(1), WASF1(8), WASF2(7), WASF3(20), WASL(5) 8950930 92 58 84 34 29 8 9 14 29 3 0.802 1.000 1.000 539 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(5), B3GALNT1(5), B3GALT5(2), FUT1(5), FUT2(2), FUT9(7), GBGT1(4), GLA(3), HEXA(2), HEXB(3), NAGA(8), ST3GAL1(5), ST3GAL2(9), ST8SIA1(12) 6300423 72 58 68 32 29 7 6 20 10 0 0.815 1.000 1.000 540 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(4), IL2RG(9), IL4(4), IL4R(7), IRS1(27), JAK1(19), JAK3(12), RPS6KB1(6), SHC1(7), STAT6(7) 8642708 105 57 93 28 23 13 12 11 43 3 0.628 1.000 1.000 541 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(5), CBS(9), CTH(3), DNMT1(19), DNMT3A(7), DNMT3B(15), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), MTR(19) 10172520 104 57 102 45 35 10 22 18 19 0 0.819 1.000 1.000 542 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(4), CD2(4), CD3E(2), CD4(11), CXCR3(2), IFNG(2), IL12A(3), IL12B(2), IL12RB1(6), IL12RB2(13), JAK2(12), STAT4(9), TYK2(12) 8587845 82 57 77 33 15 12 15 16 23 1 0.865 1.000 1.000 543 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), B4GALT7(6), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), XYLT1(11), XYLT2(43) 3795896 90 56 59 30 33 4 12 8 32 1 0.865 1.000 1.000 544 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), B4GALT7(6), HS3ST1(6), HS3ST2(12), HS3ST3A1(3), HS3ST3B1(5), XYLT1(11), XYLT2(43) 3795896 90 56 59 30 33 4 12 8 32 1 0.865 1.000 1.000 545 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(5), DUSP1(3), IKBKAP(14), IKBKB(10), MAP3K1(16), NFKB1(8), NFKBIA(1), RELA(7), TNFAIP3(11), TRAF3(7), TRAF6(6) 10622692 88 55 84 24 27 10 7 13 31 0 0.348 1.000 1.000 546 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(6), ACAT2(5), ACOT11(5), ACYP1(1), ACYP2(3), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ECHS1(2), EHHADH(4), ESCO1(10), ESCO2(10), FN3K(4), GCDH(7), HADHA(5), NAT6(4), PNPLA3(4), SH3GLB1(3), YOD1(1) 15238840 93 55 87 17 19 13 14 11 36 0 0.0353 1.000 1.000 547 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(9), ARG1(2), ARG2(3), ASL(5), CKB(5), CKM(1), CKMT1A(4), CKMT1B(1), CKMT2(7), CPS1(24), GAMT(1), GATM(3), GLUD1(4), NAGS(1), OAT(3), ODC1(3), OTC(4), PYCR1(3), SMS(6) 10237158 92 55 92 27 30 9 14 24 15 0 0.191 1.000 1.000 548 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(5), ACAD9(8), ADH1A(4), ADH1B(3), ADH4(2), ADH5(4), ADH6(6), ADH7(2), ADHFE1(8), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), ESCO1(10), ESCO2(10), NAT6(4), PNPLA3(4), SH3GLB1(3) 14646158 92 54 89 15 21 8 16 18 29 0 0.0109 1.000 1.000 549 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(8), ESR2(9), ITPKA(2), PDE1A(7), PDE1B(5), PLCB1(21), PLCB2(8), PRL(1), TRH(5), VIP(7) 6511891 73 54 70 28 23 10 11 19 10 0 0.628 1.000 1.000 550 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(1), CD3E(2), CD4(11), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21), THY1(1) 6611545 78 54 69 35 19 7 10 19 23 0 0.934 1.000 1.000 551 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(10), G6PD(6), GCLC(3), GCLM(3), GGT1(9), GPX5(2), GSS(2), GSTA1(4), GSTA2(2), GSTA3(3), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(4), GSTP1(1), GSTZ1(2), IDH1(4), IDH2(4), MGST1(3), MGST2(3), MGST3(3), PGD(8) 10549227 84 53 80 28 23 15 8 18 20 0 0.544 1.000 1.000 552 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(10), CCNA2(1), CCND1(2), CCNE1(5), CCNE2(3), CDK2(4), CDK4(2), CDKN1B(1), CDKN2A(17), E2F1(4), E2F2(5), E2F4(2), PRB1(3) 5251336 59 53 58 22 9 14 7 14 14 1 0.619 1.000 1.000 553 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(3), GLB1(7), GNS(8), GUSB(10), HEXA(2), HEXB(3), IDS(4), IDUA(4), LCT(24), NAGLU(8) 8396178 75 52 74 30 22 14 10 12 17 0 0.655 1.000 1.000 554 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(1), CD3E(2), CD8A(4), ICAM1(4), ITGAL(22), ITGB2(12), PTPRC(21), THY1(1) 6301491 71 52 67 30 19 7 11 17 17 0 0.743 1.000 1.000 555 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(3), ACOX3(13), ELOVL2(7), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(4), FASN(27), HADHA(5), HSD17B12(4), PECR(1), SCD(1) 8331084 73 51 66 30 29 8 12 6 18 0 0.697 1.000 1.000 556 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(9), DLL1(16), FURIN(6), NOTCH1(31), PSEN1(5) 5399864 67 51 64 31 21 8 7 13 18 0 0.779 1.000 1.000 557 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(15), EGF(11), EGFR(19), HGS(5), RAB5A(3), TF(15), TFRC(2) 7533894 70 50 68 32 20 10 6 19 14 1 0.887 1.000 1.000 558 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(3), ACADM(7), ACADS(4), ACADVL(3), ACSL1(4), ACSL3(7), ACSL4(6), CPT1A(14), CPT2(7), EHHADH(4), HADHA(5), PECR(1), SCP2(5), SLC25A20(4) 9861974 74 50 71 18 19 6 11 14 24 0 0.112 1.000 1.000 559 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD4(11), FYN(9), HLA-DRA(7), HLA-DRB1(1), LCK(4), PTPRC(21), ZAP70(13) 5308172 68 50 61 32 20 8 10 18 12 0 0.939 1.000 1.000 560 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(13), FADS2(4), PLA2G10(2), PLA2G12B(3), PLA2G1B(8), PLA2G2A(2), PLA2G2D(1), PLA2G2E(3), PLA2G3(11), PLA2G4A(7), PLA2G5(1), PLA2G6(8) 5934758 66 49 57 23 27 3 9 21 6 0 0.569 1.000 1.000 561 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(8), ESR1(8), GREB1(26), HSPB1(2), HSPB2(1), MTA1(10), MTA3(3), PDZK1(2), TUBA8(6) 6370233 67 49 65 30 25 12 9 6 15 0 0.726 1.000 1.000 562 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(6), DCXR(1), GUSB(10), RPE(5), UCHL1(3), UCHL3(4), UGDH(8), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(10), UGT1A5(4), UGT1A6(9), UGT1A7(5), UGT1A9(3), UGT2B15(4), UGT2B4(5) 10246111 87 49 82 21 19 9 17 16 26 0 0.103 1.000 1.000 563 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(8), POLR2A(24), POLR2B(13), POLR2C(4), POLR2E(3), POLR2F(4), POLR2G(1), POLR2I(2), POLRMT(14) 7864391 73 49 71 25 25 9 15 11 13 0 0.374 1.000 1.000 564 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(15), CHAT(6), CHKA(2), PCYT1A(9), PDHA1(1), PDHA2(11), PEMT(1), SLC18A3(16) 4073466 61 48 61 29 25 6 7 17 6 0 0.778 1.000 1.000 565 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(9), DHCR7(7), FDFT1(3), FDPS(12), HMGCR(7), HMGCS1(2), IDI1(2), LSS(14), MVD(2), MVK(15), NSDHL(4), PMVK(1), SQLE(9) 7684414 87 48 76 23 21 7 6 20 33 0 0.432 1.000 1.000 566 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(8), ICAM1(4), ITGAL(22), ITGAM(10), ITGB2(12), SELE(6), SELL(6) 6070330 68 48 66 27 24 4 8 15 17 0 0.602 1.000 1.000 567 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(19), JAK2(12), JAK3(12), MAPK1(3), MAPK3(3), STAT3(7), TYK2(12) 6836561 68 48 64 23 14 11 10 11 19 3 0.697 1.000 1.000 568 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(4), CYP11A1(6), CYP11B1(17), CYP11B2(8), CYP17A1(7), CYP21A2(6), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2) 5430778 67 47 66 25 23 12 7 16 9 0 0.593 1.000 1.000 569 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(4), CYP11A1(6), CYP11B1(17), CYP11B2(8), CYP17A1(7), CYP21A2(6), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2) 5430778 67 47 66 25 23 12 7 16 9 0 0.593 1.000 1.000 570 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(9), CTH(3), GGT1(9), MARS(7), MARS2(5), MAT1A(7), MAT2B(3), PAPSS1(6), PAPSS2(6), SCLY(4), SEPHS1(4) 7240494 68 47 65 27 21 8 13 9 17 0 0.635 1.000 1.000 571 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(4), IL13RA1(5), IL13RA2(7), IL4R(7), JAK1(19), JAK2(12), TYK2(12) 6138326 66 47 63 22 14 12 10 8 19 3 0.642 1.000 1.000 572 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(4), IL13RA1(5), IL13RA2(7), IL4R(7), JAK1(19), JAK2(12), TYK2(12) 6138326 66 47 63 22 14 12 10 8 19 3 0.642 1.000 1.000 573 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(11), AGT(4), AGTR1(1), AGTR2(4), BDKRB2(3), KNG1(11), NOS3(15), REN(7) 5745741 56 46 52 20 15 5 8 8 20 0 0.614 1.000 1.000 574 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(6), CARS2(7), CDO1(3), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHAL6A(1), LDHAL6B(6), LDHB(5), LDHC(1), MPST(3), SDS(4), SULT1B1(6), SULT1C2(2), SULT1C4(4), SULT4A1(1) 7348727 64 46 64 22 20 15 7 9 13 0 0.435 1.000 1.000 575 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(9), ENO1(3), GPI(6), HK1(17), PFKL(8), PGAM1(1), PGK1(4), PKLR(9), TPI1(3) 5416318 60 45 60 23 18 17 4 14 7 0 0.380 1.000 1.000 576 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(9), CAPN1(7), CAPNS1(3), CAPNS2(2), CDK5(3), CDK5R1(5), CSNK1A1(5), CSNK1D(4), GSK3B(6), MAPT(11), PPP2CA(4) 5398060 59 44 58 19 19 12 6 11 11 0 0.285 1.000 1.000 577 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(21), EIF2AK4(10), EIF2B5(9), EIF2S1(2), EIF2S2(3), EIF2S3(1), EIF5(6), GSK3B(6), PPP1CA(2) 6782053 60 43 60 16 13 3 12 19 13 0 0.351 1.000 1.000 578 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(3), CAMK1G(8), HDAC9(12), MEF2A(2), MEF2B(6), MEF2C(5), MEF2D(8), MYOD1(7), YWHAH(3) 4522191 54 43 53 21 14 4 8 11 17 0 0.656 1.000 1.000 579 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMC3(9), PSMD14(1), RPN1(4), RPN2(6), UBE2A(1), UBE3A(5) 7567166 63 43 63 17 16 5 18 11 13 0 0.222 1.000 1.000 580 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(4), ALAS1(5), ALAS2(14), CPOX(4), FECH(7), HMBS(3), PPOX(6), UROD(2), UROS(5) 4429524 50 42 49 14 13 12 3 12 10 0 0.354 1.000 1.000 581 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(7), ACO2(11), AFMID(4), CS(1), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(8), MTHFD2(1) 7857617 59 42 58 22 17 16 5 8 13 0 0.486 1.000 1.000 582 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(6), DHRS1(3), DHRS3(3), DHRS7(7), DHRSX(6), HSD3B7(7), PON1(3), PON2(3), PON3(5), RDH11(1), RDH12(3), RDH13(7) 5275506 54 41 52 20 19 8 7 13 7 0 0.554 1.000 1.000 583 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(7), MMP2(10), MMP9(20), RECK(6), TIMP1(1), TIMP2(1), TIMP3(10), TIMP4(1) 4405603 57 41 54 28 21 12 3 9 10 2 0.820 1.000 1.000 584 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(4), ALAS1(5), ALAS2(14), CPO(4), FECH(7), GATA1(3), HBB(2), HMBS(3), UROD(2), UROS(5) 4580122 49 40 48 16 13 9 4 12 11 0 0.525 1.000 1.000 585 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(5), ADSS(6), IMPDH1(6), MTHFD2(1), NME2(3), OAZ1(3), POLB(6), POLD1(15), POLG(10), PRPS2(3), RRM1(5), SRM(1) 7314719 64 40 63 19 20 16 5 9 14 0 0.239 1.000 1.000 586 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(7), ACO2(11), CS(1), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(8), MTHFD2(1) 7504146 55 39 54 22 16 15 5 8 11 0 0.605 1.000 1.000 587 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(8), BCL2(4), CASP3(2), CASP9(3), DAXX(11), FAS(3), FASLG(5), HSPB1(2), HSPB2(1), IL1A(2), MAPKAPK2(3), MAPKAPK3(5), TNF(3) 6646269 56 39 56 20 17 7 4 15 13 0 0.540 1.000 1.000 588 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(6), IARS(11), LARS(9), LARS2(10), PDHA1(1), PDHA2(11), PDHB(4) 5872001 52 39 51 21 8 7 10 16 11 0 0.831 1.000 1.000 589 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(7), ALPL(9), ALPP(11), ALPPL2(6), FPGS(7), GCH1(1), GGH(2), SPR(2) 3816869 45 38 44 21 25 4 1 7 8 0 0.552 1.000 1.000 590 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(11), CS(1), FH(4), IDH2(4), MDH1(3), OGDH(11), SDHA(11), SUCLA2(3) 5524992 48 37 44 19 16 8 3 5 16 0 0.773 1.000 1.000 591 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(9), FARSA(6), FARSB(3), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(8), YARS2(2) 5102813 44 36 44 18 15 7 4 11 7 0 0.765 1.000 1.000 592 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(3), B3GALT2(8), B3GALT5(2), B3GNT5(11), FUT1(5), FUT2(2), FUT3(4), ST3GAL3(2), ST3GAL4(7) 4237363 44 36 41 19 19 5 2 5 13 0 0.888 1.000 1.000 593 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(6), CYP11A1(6), CYP11B2(8), CYP17A1(7), HSD11B1(4), HSD11B2(4), HSD3B1(4), HSD3B2(2) 4055785 41 33 41 21 12 4 6 11 8 0 0.947 1.000 1.000 594 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(2), EHHADH(4), HADH(2), HADHA(5), HSD17B4(7), NTAN1(5), SIRT1(8), SIRT2(4), SIRT5(4), SIRT7(5), VNN2(4) 6946391 53 33 49 14 13 8 7 7 18 0 0.249 1.000 1.000 595 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(10), CKM(1), EIF4E(2), FBL(6), GPT(4), LDHA(7), LDHB(5), LDHC(1), MAPK14(2), NCL(7) 5260807 45 33 44 18 11 12 2 11 9 0 0.769 1.000 1.000 596 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(6), ACAT2(5), BDH1(7), HMGCS1(2), HMGCS2(4), OXCT1(10), OXCT2(6) 4217793 40 32 38 16 12 7 4 5 12 0 0.797 1.000 1.000 597 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(3), MTMR1(7), MTMR2(9), MTMR6(9), NFS1(1), PHPT1(2), THTPA(2), TPK1(5) 3760869 38 32 37 12 8 5 7 5 13 0 0.485 1.000 1.000 598 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(12), GOT1(3), GOT2(2), TAT(5), TYR(15) 2759002 37 32 30 13 7 5 4 10 10 1 0.796 1.000 1.000 599 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(2), ADORA2B(2), ADORA3(8), LTB4R(2), P2RY1(3), P2RY2(5), P2RY6(10) 3494679 37 32 36 21 23 2 1 5 6 0 0.858 1.000 1.000 600 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(9), CLOCK(8), CRY1(3), CRY2(7), CSNK1E(9), PER1(6) 4959498 42 31 40 14 16 6 3 5 12 0 0.634 1.000 1.000 601 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(3), ENO3(4), FARS2(9), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(8) 4872049 43 31 43 16 14 9 4 9 7 0 0.465 1.000 1.000 602 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(8), TAX1BP3(1), UBE2A(1), UBE2C(1), UBE2D3(1), UBE2E1(2), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(5), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(2), UBE2S(3), UBE3A(5) 6163233 42 31 42 13 18 6 4 6 8 0 0.180 1.000 1.000 603 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(8), AASDH(10), AASDHPPT(1), AASS(10), KARS(7) 4083810 36 30 36 11 7 6 8 7 8 0 0.453 1.000 1.000 604 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(11), CS(1), MDH1(3), ME1(1), PC(18), PDHA1(1), SLC25A1(3), SLC25A11(2) 5427701 40 30 39 20 15 6 6 7 6 0 0.888 1.000 1.000 605 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(8), PSMA7(3), PSMB1(2), PSMB10(2), PSMB2(2), PSMB3(3), PSMB4(3), PSMB5(1), PSMB6(3), PSMB8(5), PSMB9(2) 5126308 46 30 46 14 15 4 10 8 9 0 0.371 1.000 1.000 606 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(4), FUT1(5), FUT2(2), FUT9(7), GCNT2(1), ST8SIA1(12) 3596976 31 28 29 16 11 2 3 11 4 0 0.875 1.000 1.000 607 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(5), CDC25B(6), CDKN1A(5), CHEK1(6), NEK1(6), WEE1(6) 4029715 34 28 34 11 7 6 4 7 10 0 0.717 1.000 1.000 608 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(8), NDUFA1(1), SDHA(11), SDHB(4), SDHC(2), SDHD(1), UQCRC1(3) 3879239 33 27 33 12 11 4 5 6 7 0 0.472 1.000 1.000 609 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(2), ACTR3(2), ARPC1A(5), ARPC1B(1), ARPC2(3), ARPC4(2), CDC42(3), RAC1(1), WASF1(8), WASL(5) 4764757 36 25 36 19 8 5 4 6 13 0 0.972 1.000 1.000 610 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(6), CTH(3), GOT1(3), GOT2(2), LDHA(7), LDHB(5), LDHC(1), MPST(3) 4012305 30 23 30 13 10 8 5 2 5 0 0.732 1.000 1.000 611 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(6), EPHX2(3), HSD3B7(7), RDH11(1), RDH12(3), RDH13(7) 2812442 27 23 26 11 10 5 3 4 5 0 0.674 1.000 1.000 612 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(5), FUT2(2), FUT3(4), FUT5(3), FUT6(6), ST3GAL3(2) 2988972 22 19 22 15 12 3 2 2 3 0 0.956 1.000 1.000 613 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(6), ALDH1A2(6), RDH5(3) 2289730 15 15 15 10 4 1 1 5 4 0 0.982 1.000 1.000 614 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(3), RAB27A(4), RAB3A(1), RAB4A(1), RAB5A(3) 2489670 16 12 16 16 6 1 4 2 3 0 0.991 1.000 1.000 615 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(5), PGLYRP2(6) 1060870 11 10 11 6 8 1 2 0 0 0 0.806 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 299280 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000